Abstracts Archive - Page 1809 of 2607 - ACR Meeting Abstracts

Abstract Number: 3155 • 2016 ACR/ARHP Annual Meeting
Zygapophyseal Joint Fusion in Ankylosing Spondylitis Assessed Using Computed Tomography: Associations with Syndesmophytes and Spinal Motion
Sovira Tan¹, Jianhua Yao², Lawrence Yao³, John Flynn⁴ and Michael Ward¹, ¹NIAMS/NIH, Bethesda, MD, ²Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, ³Radiology and Imaging Sciences, NIH, Bethesda, MD, ⁴Dept of Medicine, Johns Hopkins University, Baltimore, MD
Background/Purpose: Both zygapophyseal joint (ZJ) fusion and syndesmophytes contribute to structural spine damage in Ankylosing Spondylitis (AS). However, because ZJs are difficult to visualize on…
Abstract Number: 3156 • 2016 ACR/ARHP Annual Meeting
Adding MRI of the Spine to the ASAS Classification Criteria for Axial Spondyloarthritis, Redundant or Beneficial? Results from the Spondyloarthritis Caught Early (SPACE)-Cohort
Zineb Ez-Zaitouni¹, Pauline Bakker¹, Miranda van Lunteren¹, Rosaline van den Berg², M. Reijnierse³, Karen M Fagerli⁴, Roberta Ramonda⁵, Robert Landewé⁶, Lennart T.H. Jacobsson⁷, Floris van Gaalen¹ and Désirée van der Heijde¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy, ⁶Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ⁷Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
Background/Purpose: The ASAS definition of a positive MRI is solely based on inflammation in the sacroiliac joints (SI), although spinal inflammatory lesions on MRI suggestive…
Abstract Number: 3157 • 2016 ACR/ARHP Annual Meeting
The Association Between Sonographic Enthesitis and Radiographic Damage in Psoriatic Arthritis
Ari Polachek¹, Dafna D Gladman², Richard J. Cook³, Vinod Chandran⁴ and Lihi Eder⁵, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵Medicine, University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is a common clinical finding and a key pathogenic feature in psoriatic arthritis (PsA). Ultrasound is emerging as a preferred method to assess…
Abstract Number: 3158 • 2016 ACR/ARHP Annual Meeting
What Predicts Absence of Spinal Damage in Patients with Spondyloarthritis after Prolonged Follow up?
Walter Maksymowych¹, Stephanie Wichuk¹, Praveena Chiowchanwisawakit², Robert G Lambert³ and Susanne J Pedersen⁴, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Medicine, Mahidol University, Bangkok, Thailand, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Rheumatology, Copenhagen University Hospitals, Copenhagen, Denmark
Background/Purpose: After 20 years of follow up the majority of patients with aspondyloarthritis (SpA) have developed new bone in the spine although disease may remain…
Abstract Number: 3159 • 2016 ACR/ARHP Annual Meeting
Validation of MRI Structural Lesions Using Computed Tomography in Patients with Axial Spondyloarthritis
Robert G. Lambert¹, Damien Loeuille², Marie Raynal³, Jean Melchior², Maria Antonietta D'Agostino⁴, Joel Paschke⁵ and Walter Maksymowych⁶, ¹Radiology, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, CHRU Vandoeuvre les Nancy, Nancy, France, ³Rheumatology, CHRU Nancy, Nancy, France, ⁴Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁵CaRE Arthritis, Edmonton, AB, Canada, ⁶Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: MRI can detect both inflammatory and structural lesions in the sacroiliac joints (SIJ) of patients with axial SpA. However, standard MRI sequences do not…
Abstract Number: 3160 • 2016 ACR/ARHP Annual Meeting
Scoring Syndesmophytes on CT Spine Images of Patients with Radiographic Axial Spondyloarthritis from the Sensitive Imaging of Axial Spondyloarthritis (SIAS) Cohort
F. de Bruin¹, R van den Berg², Xenofon Baraliakos³, Monique Reijnierse⁴ and Désirée van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁴Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Low dose Computed Tomography (CT) could potentially be more sensitive than radiographs in the follow up of patients with axial spondyloarthritis (axSpA). First goal…
Abstract Number: 3161 • 2016 ACR/ARHP Annual Meeting
The Association Between HLA Genetic Susceptibility Markers and Sonographic Enthesitis in Psoriatic Arthritis
Ari Polachek¹, Richard J. Cook², Vinod Chandran¹, Fatima Abji¹, Dafna D Gladman³ and Lihi Eder⁴, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is an important pathophysiologic component in psoriatic arthritis (PsA). Ultrasound is emerging as an optimal method to evaluate enthesitis. HLA genes are implicated…
Abstract Number: 3162 • 2016 ACR/ARHP Annual Meeting
Symmetric and Asymmetric Sacroiliitis Are Associated with Different Major Histocompatibility Class I Alleles in Psoriatic Arthritis
Jon T. Giles¹, Muhammad Haroon², Deepak R. Jadon³, Raj Sengupta⁴, Alison L Nightingale⁵, Eleanor Korendowych³, Jing Bi⁶, Neil J. McHugh³, Oliver FitzGerald⁷ and Robert Winchester⁶, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Kerry General Hospital, Co Kerry, Ireland, ³Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁴Rheumatology, Royal National Hospital for Rheumatic Diseases,, Bath, United Kingdom, ⁵Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ⁶Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁷St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland
Background/Purpose: HLA-B27 has been linked to sacroiliitis (SII) in psoriatic arthritis (PsA); however, the contribution to SII of other human leukocyte antigen (HLA) Class I…
Abstract Number: 3163 • 2016 ACR/ARHP Annual Meeting
SEC16A and Intracellular Trafficking Abnormalities in Axial Spondyloarthritis
Fanxing Zeng¹, Zhenbo Zhang¹, Vidya Ranganathan², Darren Orielly³, Proton Rahman⁴ and Nigil Haroon⁵, ¹Krembil research institute, Toronto, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NF, Canada, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada
Background/Purpose: The pathogenesis of Axial Spondyloarthritis (AxSpA) is not well understood. A rare 9 base-pair deletion of SEC16A was recently identified to be strongly associated with AxSpA in a multiplex…
Abstract Number: 3164 • 2016 ACR/ARHP Annual Meeting
Spondyloarthritis Pathogenesis Involves Interplay Between Gut Microbiota and Genetic Background
Tejpal Gill¹, Mark Asquith², Stephen Brooks³, James T. Rosenbaum² and Robert A. Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Oregon Health & Science University, Portland, OR, ³NIAMS/NIH, Bethesda, MD
Background/Purpose: HLA-B27 and human b2m expression in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). While aspects of rat SpA have been studied…
Abstract Number: 3165 • 2016 ACR/ARHP Annual Meeting
HLA-B27 Expression Is Accompanied By a Profoundly Altered IgA Response to the Intestinal Microbiota and Microbial Translocation to the Joint
Mark Asquith¹, Sean Davin¹, Patrick Stauffer¹, Claire Mitchell² and James T. Rosenbaum¹, ¹Oregon Health & Science University, Portland, OR, ²Division of Arthritis and Rheumatology, Oregon Health & Science University, Portland, OR
Background/Purpose: HLA-B27 is the strongest known genetic risk factor for ankylosing spondylitis and other spondyloarthropathies (SpAs). We have shown previously that Fisher 344 rats that…
Abstract Number: 3166 • 2016 ACR/ARHP Annual Meeting
HLA-B27 and Ankylosing Spondylitis Have Shared Effects on the Gut Microbiome
Mary-Ellen Costello¹, Mark Asquith², Kim-Anh Lê Cao³, Tammy Martin⁴, Sarah Diamond², Michelle Beaumont⁵, Timothy D. Spector⁵, James T. Rosenbaum² and Matthew A. Brown¹, ¹Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, ²Oregon Health & Science University, Portland, OR, ³Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Ophthalmology, Oregon Health & Science Univ, Portland, OR, ⁵Dept of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
Background/Purpose: Evidence for a discrete intestinal microbiome signature in the terminal ileum (TI) of ankylosing spondylitis (AS) patients, compared to healthy controls, has recently been…
Abstract Number: 3167 • 2016 ACR/ARHP Annual Meeting
Total and Glucocorticoid-Related Damage Accrual in the Systemic Lupus International Collaborating Clinics Inception Cohort
Jayne Little^1,2, Mark Lunt³, Benjamin Parker^1,2, Ian N. Bruce^2,4 and The Systemic Lupus International Collaborating Clinics (SLICC) Group, ¹Centre for Musculoskeletal Research, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁴Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom
Total and Glucocorticoid-Related Damage Accrual in The Systemic Lupus International Collaborating Clinics Inception Cohort. Jayne Little1, Mark Lunt1, Ben Parker1, Ian N. Bruce1 and The…
Abstract Number: 3168 • 2016 ACR/ARHP Annual Meeting
Economic Evaluation of Damage Accrual in an International SLE Inception Cohort
Megan Barber¹, Ian N. Bruce², Murray Urowitz³, John G. Hanly⁴, Li Su⁵, Juanita Romero-Diaz⁶, Caroline Gordon⁷, Sang-Cheol Bae⁸, Sasha Bernatsky⁹, Daniel J Wallace¹⁰, Joan T. Merrill¹¹, David A. Isenberg¹², Anisur Rahman¹³, Ellen M. Ginzler¹⁴, Michelle Petri¹⁵, Mary Anne Dooley¹⁶, Paul R. Fortin¹⁷, Dafna D. Gladman¹⁸, Jorge Sanchez-Guerrero¹⁹, Kristján Steinsson²⁰, Rosalind Ramsey-Goldman²¹, M Khamashta²², Cynthia Aranow²³, Graciela S. Alarcon²⁴, Barri J. Fessler²⁵, Susan Manzi²⁶, Ola Nived²⁷, Andreas Jönsen²⁸, Asad Zoma²⁹, Ronald F. van Vollenhoven³⁰, Manuel Ramos-Casals³¹, Guillermo Ruiz-Irastorza³², S. Sam Lim³³, Kenneth C. Kalunian³⁴, Murat Inanc³⁵, Diane L. Kamen³⁶, Christine A. Peschken³⁷, Søren Jacobsen³⁸, Anca Askanase³⁹, Jill P. Buyon⁴⁰, Chris Theriault⁴¹, Vernon Farewell⁴² and Ann E. Clarke⁴³, ¹Division of Rheumatology, University of Calgary, Caglary, AB, Canada, ²Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ³Medicine, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ⁵Nova Scotia Rehab Site, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ⁶Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ⁷NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁸Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of, ⁹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ¹⁰Cedars-Sinai Medical Center, West Hollywood, CA, ¹¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ¹³Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ¹⁴Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, ¹⁵Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁶Dooley Rheumatology, Chapel Hill Doctors, Chapel Hill, NC, ¹⁷Rheumatology, University of Laval, Quebec, QC, Canada, ¹⁸Rheumatology, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ¹⁹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²⁰Rheumatology, Univ. Hospital, Reykjavik, Iceland, ²¹FSM, Northwestern University, Chicago, IL, ²²Lupus Research Unit, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom, ²³Molecular Medicine and Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, ²⁴Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²⁵Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²⁶Lupus Center of Excellence, West Penn Allegheny Health System, Pittsburgh, PA, ²⁷Department of Rheumatology, University Hospital, Lund, Sweden, ²⁸Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ²⁹Rheumatology, Hairmyres Hospital, East Kilbride, Great Britain, ³⁰Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, ³¹Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ³²Universidad del Pais Vasco, Servicio de Medicina Interna, Hospital de Cruces, Bizkaia, Spain, ³³Medicine, Emory University School of Medicine, Atlanta, GA, ³⁴Division of Rheumatology, Allergy & Immunology, UCSD School of Medicine Center for Innovative Therapy, La Jolla, CA, ³⁵Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³⁶Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³⁷RR 149G, Univ of Manitoba, Winnipeg, MB, Canada, ³⁸Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ³⁹Rheumatology, Columbia University Medical Center, New York, NY, ⁴⁰Medicine, New York University School of Medicine, New York, NY, ⁴¹Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, ⁴²Medicine, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ⁴³Division of Rheumatology, University of Calgary, Calgary, AB, Canada
Background/Purpose: Little is known about the association of healthcare costs with damage accrual in SLE. We describe the costs associated with damage states across the disease…
Abstract Number: 3169 • 2016 ACR/ARHP Annual Meeting
Mortality Trends in Systemic Lupus Erythematosus: A General Population-Based Cohort Study
April Jorge¹, Na Lu^1,2, Sharan K. Rai³ and Hyon Choi¹, ¹Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Arthritis Research Canada, Vancouver, BC, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with an increased risk of mortality. Despite improvements in the recognition and treatment of SLE, it remains a challenging…

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