Abstracts Archive - Page 1806 of 2425 - ACR Meeting Abstracts

Abstract Number: 1754 • 2015 ACR/ARHP Annual Meeting
BANK1 Controls the Development of SLE By Modulating TLR7 Signaling and Type I IFN-Induced Translation Initiation Pathway in B Cells
Ying-Yu Wu¹, Ramesh Kumar², Harini Bagavant¹ and Marta E. Alarcon Riquelme³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma Cty, OK, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK
Background/Purpose: BANK1 is a susceptibility gene for SLE, and we have shown that stimulation of TLR9 agonist leads to a reduction in the activation of…
Abstract Number: 1755 • 2015 ACR/ARHP Annual Meeting
The Lymphotoxin/Megakaryoblastic Leukemia 1/Actin Axis As a Master Regulator of TLR Signaling in Lupus
John D. Mountz¹, Jun Li², Jennie Hamilton³, PingAr Yang⁴, Qi Wu⁵, Bao Luo⁶, Yanna Ding³, Hao Li⁶, David Crossman⁷, Erik Malarkey⁸, Yong Zhou², Yang-Xin Fu⁹ and Hui-Chen Hsu⁵, ¹Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL, ²Medicine, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁸Cell, Development, and Integrated Biology, University of Alabama at Birmingham, Birmingham, AL, ⁹Department of Pathology, The University of Chicago, Chicago, IL
Background/Purpose: Marginal zone macrophages (MZMs) of the spleen are essential for rapid and tolerogenic clearance of apoptotic cells (ACs). MZMs are decreased in two…
Abstract Number: 1756 • 2015 ACR/ARHP Annual Meeting
The Oxidative Burst Mediates Anti-Inflammatory Clearance of Dead Cells in a Mouse Model of SLE and Inflammatory Arthritis
Jonas Hahn¹, Deborah Kienhöfer¹, Luis Munoz¹, Martin Herrmann², Gerhard Krönke³, Rikard Holmdahl⁴, Georg Schett⁵ and Markus Hoffmann¹, ¹Medicine III, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medicine III, Rheumatology and Immunology, University of Erlangen-Nuremberg, Osterreich, Germany, ³Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: The production of reactive oxygen species (ROS) via the oxidative burst has recently been implicated in regulation of inflammation and protection from arthritis, multiple…
Abstract Number: 1757 • 2015 ACR/ARHP Annual Meeting
Absence of Estrogen Receptor Alpha Is Protective Against Nephrotoxic Serum-Induced Nephritis
Chelsea Corradetti¹, Neelakshi Jog², Michael Madaio³ and Roberto Caricchio⁴, ¹Temple University, Philadelphia, PA, ²Rheumatology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Medicine, Medical College of Georgia, Augusta, GA, ⁴Medicine, Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Glomerulonephritis (GN) is one of the most serious manifestations of systemic lupus erythematous (SLE). Lupus GN is characterized by severe inflammation and necrosis and…
Abstract Number: 1758 • 2015 ACR/ARHP Annual Meeting
Alterations in Nuclear Structure Promote Lupus Autoimmunity in a Mouse Model
Namrata Singh¹, Duncan Johnstone², Kayla Martin³, Italo Tempera⁴, Mariana J. Kaplan⁵ and Michael Denny⁶, ¹Internal Medicine, University of Iowa, Iowa City, IA, ²Nephrology, Internal Medicine, Temple University School of Medicine, Philadelphia, PA, ³Microbiology and Immunology, Temple University, Philadelphia, PA, ⁴Micorbiology/Immunology, Fels Institute for Cancer Research, Philadelphia, PA, ⁵Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶Internal Medicine, Temple University School of Medicine, Philadelphia, PA
Background/Purpose: SLE is regarded as a failure of the immune system to maintain tolerance to self-antigens. Despite steady advances defining the importance of inflammatory mediators…
Abstract Number: 1759 • 2015 ACR/ARHP Annual Meeting
Activation of T-Follicular Helper Cells and B Cells in Ultraviolet Light-Induced Murine Model of Systemic Lupus Erythematosus
Misha Zarbafian¹, Mehran Ghoreishi² and Jan Dutz², ¹Medicine, University of British Columbia Vancouver Fraser Medical Program, Vancouver, BC, Canada, ²University of British Columbia Department of Dermatology and Skin Science, Vancouver, BC, Canada
Background/Purpose: Non-obese diabetic (NOD) mice repeatedly exposed to ultraviolet (UV) light and Toll-like receptor-7 (TLR7) agonist cream (imiquimod) develop lupus-like disease, modeling a possible cutaneous…
Abstract Number: 1760 • 2015 ACR/ARHP Annual Meeting
PD-1 Signaling Interferes with OX40 to Alter the Suppressive Function and Proliferation of CD4+ Regulatory T Cells in Lupus Mice
Maida Wong¹ and Bevra H. Hahn^2,3, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, ²Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ³Rheumatology, Professor Emeritus, Department of Medicine/Rheumatology, David Geffen School of Medicine UCLA, Los Angeles, CA
Background/Purpose: In systemic lupus erythematosus (SLE), the dysregulated production of autoantibodies is a consequence of disrupted T cell homeostasis. Programmed death-1 (PD1), a negative regulatory…
Abstract Number: 1762 • 2015 ACR/ARHP Annual Meeting
Reciprocal Roles of Intestinal Microbiota in the Pathogenesis of Organ-Specific Autoimmune Diseases in a Lymphopenia-Induced Autoimmunity Mouse Model
Toshiki Eri¹, Kimito Kawahata², Ei Bannai¹, Takeyuki Kanzaki³, Lisa Akahira¹, Kazuya Michishita¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ³Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan
Background/Purpose: Past studies reported lymphopenia mouse transfer model which transfer CD4+CD25- cells from wild-type BALB/c mouse into athymic nude BALB/c mice produce lupus-like systemic autoantibodies…
Abstract Number: 1763 • 2015 ACR/ARHP Annual Meeting
Neutrophil Netosis Formation during the UVB Induced-Skin Inflammation
Ming-Lin Liu^1,2, Meena Sharma^1,3, Shwetapadma Sahu^4,5 and Victoria Werth^4,6, ¹Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ²Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, ³Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, ⁴Dermatology, University of Pennsylvania, Philadelphia, PA, ⁵Philadelphia V.A. Medical Center, Philadelphia, PA, ⁶Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA
Background/Purpose: Excessive exposure to sunlight, particularly ultraviolet B (UVB), induces autoimmune skin inflammation and other skin diseases. Although UVB mainly causes damage to the epidermis,…
Abstract Number: 1764 • 2015 ACR/ARHP Annual Meeting
Type 1 Interferon in the Skin Stimulated By Ultraviolet B Light Generates Immune Suppression Mediated By Idoleamine 2,3-Dioxygenase 1
Clayton Sontheimer¹ and Keith B. Elkon², ¹Pediatric Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Photosensitivity is a common symptom in patients with systemic lupus erythematosus (SLE) and lupus skin lesions show local Type 1 Interferon (IFN-I) profiles similar…
Abstract Number: 1765 • 2015 ACR/ARHP Annual Meeting
MiR155 Deficient Mice Show Reduced Disease Severity in Pristane-Induced Lupus
Harald Leiss¹, Wilhelm Salzberger², Barbara Schwarzecker³, Irina Gessl¹, Nicolas Kozakowski⁴, Stephan Blüml⁵, Antonia Puchner¹, Birgit Niederreiter⁶, Carl-Walter Steiner², Josef S. Smolen⁷ and Georg H. Stummvoll², ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁷Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Background/Purpose: MicroRNAs (miRs) are an important class of regulators of gene expression that are associated with a variety of biological functions. Deregulation of endogenous miR155…
Abstract Number: 1766 • 2015 ACR/ARHP Annual Meeting
HPV Vaccination of Nzbxw/F1 Mice
Maria Teresa Arango¹, Lucija Tomljenovic², Miri Blank¹ and Yehuda Shoenfeld³, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²University of British Columbia, Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, Vancouver, BC, Canada, ³Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Human-papilloma virus vaccine (HPVv) is currently used worldwide. Still this vaccine has been linked to a variety of neurological and autoimmune manifestations. For instance,…
Abstract Number: 1767 • 2015 ACR/ARHP Annual Meeting
Noninvasive Assessment of Macrophage Activation in Experimental Glomerulonephritis Using Optical Imaging with Near-Infrared Light Serves As a Surrogate of Disease Activity
Sebastian Braehler¹, Dongyue Huang², Matthew Cheung², Walter Akers³ and Alfred Kim², ¹Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, ²Rheumatology, Washington University School of Medicine, Saint Louis, MO, ³Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: Glomerulonephritis (GN) represents a major cause of morbidity & mortality. The standard for diagnosing GN is through renal biopsy, but this is not performed…
Abstract Number: 1768 • 2015 ACR/ARHP Annual Meeting
Improved Tissue Clearing and 2-Photon Imaging of Mouse Kidneys Reveals Immune Cell Architecture in Nephrotoxic Nephritis
Matthew Cheung, Dongyue Huang and Alfred Kim, Rheumatology, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: Tissue clearing approaches such as CLARITY renders tissue transparent, and in combination with two-photon microscopy, enables microscopic visualization deep internal structures within unaltered organs.…
Abstract Number: 1769 • 2015 ACR/ARHP Annual Meeting
Role of Topical Administration of Peptidylarginine Deiminase Inhibitors in Murine Lupus
Erica Moore¹, Huw Lewis², Carolyne K. Smith¹, Venkataraman Subramaniam³, Victoria Hoffmann⁴, Paul Thompson⁵ and Mariana J. Kaplan¹, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Immuno Inflammation, GSK, Stevenage, United Kingdom, ³University of Massachusetts, Boston, MA, ⁴ORS, National Institutes of Health, Bethesda, MD, ⁵University of Massachusetts, Worcester, MA
Background/Purpose: Peptidylarginine deiminases (PADs), specifically PAD4, have recently been implicated in the pathogenesis of systemic lupus erythematosus (SLE) through their role in citrullinating histones in…

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