Abstracts Archive - Page 1805 of 2607 - ACR Meeting Abstracts

Abstract Number: 3094 • 2016 ACR/ARHP Annual Meeting
Factors Associated with Initial or Subsequent Choice of Biologic Disease Modifying Antirheumatic Drugs for the Treatment of Rheumatoid Arthritis
Yinzhu Jin¹, Rishi J. Desai¹, Jun Liu¹, Nam-Kyong Choi¹ and Seoyoung Kim^2,3, ¹Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, ²Division of Pharmacoepidemiology and Pharmocoeconomics, Brigham and Women's Hospital, Boston, MA, ³Brigham and Women’s Hospita and, Harvard Medical School,, Boston, MA
Background/Purpose: Treatment with disease-modifying antirheumatic drugs (DMARDs) is considered the standard of care for rheumatoid arthritis (RA). Over the past two decades, major advances have…
Abstract Number: 3095 • 2016 ACR/ARHP Annual Meeting
What Should be the Primary Target of ‘Treat to Target’ in Psa?
Laura C. Coates^1,2, Paul Emery³, Philip G. Conaghan¹ and Philip S. Helliwell¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: In 2013, Treat to Target (T2T) in SpA Recommendations by expert consensus stated that the target of treatment should be remission or inactive disease.…
Abstract Number: 3096 • 2016 ACR/ARHP Annual Meeting
Association Between Smoking and Psoriatic Arthritis Among Psoriasis Patients and the General Population: Data from National Inpatient Sample
Paras Karmacharya¹, Dilli Poudel¹, Rashmi Dhital² and Pragya Shrestha³, ¹Internal Medicine, Reading Health System, WEST READING, PA, ²Universal College of Medical Sciences, MBBS, Kathmandu, Nepal, ³Internal medicine, Reading Health System, West Reading, PA
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis affecting approximately 520,000 patients in the US and up to one third of patients with psoriasis. Studies…
Abstract Number: 3097 • 2016 ACR/ARHP Annual Meeting
Osteoclast Precursor Frequency and Imaging Findings Associated with Arthritis Onset in a Psoriasis Longitudinal Cohort
Ralf G. Thiele¹, Yahui Grace Chiu², Francisco Tausk³, Bethany A. Marston⁴, Changyong Feng⁵, Gregory Dieudonne⁶, Vaseem Chengazi⁶, Sharon Moorehead⁷, Debbie Campbell⁷ and Christopher T. Ritchlin⁸, ¹Medicine, University of Rochester Medical Center, Rochester, NY, ²Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ³Dermatology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Statistics, University of Rochester, Rochester, NY, ⁶Radiology, University of Rochester, Rochester, NY, ⁷Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY, ⁸Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Psoriasis (Ps) precedes joint inflammation by an average of 10 years psoriatic arthritis (PsA) patients. Reports have demonstrated abnormal musculoskeletal imaging findings in psoriasis…
Abstract Number: 3098 • 2016 ACR/ARHP Annual Meeting
The Occurrence of Peripheral Arthritis Mutilans in Psoriatic Arthritis Is Associated with Certain Major Histocompatibility Class I Alleles
Jon T. Giles¹, Deepak R. Jadon², Muhammad Haroon³, Jing Bi⁴, Eleanor Korendowych², William Tillett², Oliver FitzGerald⁵, Robert Winchester⁴ and Neil J. McHugh², ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ³St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, ⁴Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁵St. Vincent's University Hospital, Department of Rheumatology. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Several human leukocyte antigen (HLA) Class I loci encoding the major histocompatibility complex (MHC) have been implicated both in psoriatic arthritis (PsA) susceptibility and…
Abstract Number: 3099 • 2016 ACR/ARHP Annual Meeting
Higher Prevalence and Severity of Coronary Atherosclerosis in Psa Patients
Lydia Ho Pui TAM^1,2, Tsz Ho CHENG¹, Ho Man LAM¹, Ka Tat WONG³, Qing SHANG⁴, Edmund LI¹, Wang Kit LI⁵, Man Fei CHEUNG⁵, Uen-Lam MING¹, Tin-Long LUI⁵, Wing-Lam TAO¹, SY TSANG¹ and Lai-Shan TAM⁶, ¹Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong, ³Prince of Wales Hospital, Hong Kong, Hong Kong, ⁴Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Background/Purpose: Patients with psoriatic arthritis (PsA) have increased risk in cardiovascular diseases (CVD) including subclinical atherosclerosis. However, previous knowledge was limited to carotid atherosclerosis. The…
Abstract Number: 3100 • 2016 ACR/ARHP Annual Meeting
Can Achieving Sustained Minimal Disease Activity (MDA) Prevent Progression of Subclinical Atherosclerosis? a Prospective Cohort Study in Psoriatic Arthritis
Tsz Ho CHENG¹, Qing SHANG², PW Alex LEE¹, Priscilla WONG¹, Tracy Y. ZHU³, Chun-Kwok WONG⁴, JW Jack LEE⁵, M Mimi CHANG⁶, Edmund LI¹ and Lai-Shan TAM⁷, ¹Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China, ⁴Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Biostatistics Division, School of Public and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department of Medicine & Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong, ⁷Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Background/Purpose: Patients with PsA were reported to have a higher incidence of cardiovascular disease (CVD) and subclinical carotid atherosclerosis due to underlying inflammation. Minimal disease…
Abstract Number: 3101 • 2016 ACR/ARHP Annual Meeting
Lipoprotein Profile and Serum Glycoprotein Acetylation As Markers of Cardiovascular Risk in Systemic Lupus Erythematosus
Simantini Sakhardande¹, Monica Purmalek¹, Yenealem Temesgen-Oyelakin², Maureen Sampson³, Aditya Joshi⁴, Alice Fike⁵, Michael Davis⁶, Taufiq Salahuddin⁷, Balaji Natarajan⁷, Joseph Lerman⁷, Zerai G. Manna⁸, Amit Dey⁹, Marcus Chen⁷, Sarfaraz Hasni⁸, Nehal N. Mehta⁷, Alan Remaley⁷ and Mariana Kaplan¹⁰, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases,, National Institutes of Health, Bethesda, MD, ³Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, ⁴National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶NIH, Bethesda, MD, ⁷NHLBI, National Institutes of Health, Bethesda, MD, ⁸National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁹National Institutes of Health, Bethesda, MD, ¹⁰NIAMS/NIH, Bethesda, MD
Background/Purpose: The risk of atherosclerotic cardiovascular disease (CVD) is significantly increased in systemic SLE compared to age and gender matched controls. The implementation of nuclear…
Abstract Number: 3102 • 2016 ACR/ARHP Annual Meeting
Neutrophil Subsets, Arterial Inflammation, and Vascular Stiffness in Patients with Systemic Lupus Erythematosus
Monica Purmalek¹, Simantini Sakhardande¹, Yenealem Temesgen-Oyelakin², Aditya Joshi³, Joseph Lerman⁴, Michael Davis³, Alice Fike⁵, Amit Dey⁶, Taufiq Salahuddin⁷, Balaji Natarajan³, Martin P. Playford⁷, Heather Teague³, Zerai G. Manna⁵, Marcus Chen³, Sarfaraz Hasni⁵, Nehal N. Mehta⁷ and Mariana Kaplan¹, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases,, National Institutes of Health, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Clinical Center, NIH, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶National Institutes of Health, Bethesda, MD, ⁷NHLBI, National Institutes of Health, Bethesda, MD
Background/Purpose: Patients with systemic lupus erythematosus (SLE) show a striking increase in risk of atherosclerotic cardiovascular disease (CVD) not explained by Framingham risk, when compared…
Abstract Number: 3103 • 2016 ACR/ARHP Annual Meeting
Apolipoprotein L1 Risk Variants Associate with Prevalent Cardiovascular Disease in African American Systemic Lupus Erythematous Patients
Ashira Blazer¹, Robert M Clancy², H. Michael Belmont³, Peter M. Izmirly³, Androo Markham⁴ and Jill P. Buyon⁴, ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: Two Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2, located on chromosome 22q12.3, have been associated with excess renal risk in African Americans…
Abstract Number: 3104 • 2016 ACR/ARHP Annual Meeting
Early Proteinuria Response in Real Life Situation Predicts Long-Term Lupus Renal Outcome in Ethnically Diverse Group with Biopsy-Proven Nephritis
Michelle Lopes¹, Luciana Seguro¹, Maite Castro², Danielle Daffre³, Eduardo Ferreira Borba² and Eloisa Bonfa⁴, ¹Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ³São Paulo University, São Paulo, Brazil, ⁴Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
Background/Purpose: Treat to target strategies are becoming the best approach for several rheumatic disorders. Recently retrospective analyses of two important lupus trials have reported that…
Abstract Number: 3105 • 2016 ACR/ARHP Annual Meeting
Relationships Between a Serum Biomarker of B Cell Differentiation and B Cell Activating Factor Suggest Possible Distinct Pathways of Response to Rituximab in Patients with Systemic Lupus Erythematosus
Ricardo Marques¹, Laura Heretiu², David A. Isenberg³, Maria J. Leandro³ and Geraldine Cambridge³, ¹Serviço de Medicina Interna B, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal, ²Medicine, Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ³Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Rituximab (RTX) has been used off-label in refractory SLE with variable clinical outcomes in different cohorts, with no predictive response markers available. However, the…
Abstract Number: 3106 • 2016 ACR/ARHP Annual Meeting
A Simple Test for Assessing and Monitoring SLE Disease Activity Status
Chaim Putterman¹, Michael Rowe², Joseph Barten Legutki², Theodore M. Tarasow² and Kathryn Sykes², ¹Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ²HealthTell, Inc, san ramon, CA
Background/Purpose: SLE patients can experience chronically active disease, remissions and flares, or long periods of quiescence. Accurately assessing disease activity is crucial for prescribing appropriate…
Abstract Number: 3107 • 2016 ACR/ARHP Annual Meeting
Switching from Anabolic to Catabolic Metabolism – a Novel Immunomodulatory Therapy in RA
Zhen Yang¹, Yi Shen¹, Eric L. Matteson², Ebru Hosgur¹, Jison Hong³, Jorg Goronzy⁴ and Cornelia M. Weyand¹, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Medicine/Immunology & Rheumatology, Stanford University, Palo Alto, CA, ⁴Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Inflammatory activity in RA relies on numerous anabolic processes; including cellular proliferation, cell trafficking, secretion of proinflammatory cytokines and release of antibodies. Lasting reversal…
Abstract Number: 3108 • 2016 ACR/ARHP Annual Meeting
Citrullinated Aggrecan Peptides Are Targets of Auto-Reactive CD4+ T-Cells in Rheumatoid Arthritis
Hannes Uchtenhagen¹, Cliff Rims¹, Eddie James² and Jane H. Buckner², ¹Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: T-cell frequencies against citrullinated epitopes derived from major auto-antibody targets (vimentin, fibrinogen, α-enolase) are increased in rheumatoid arthritis (RA). Emerging serologic data suggests antibody reactivity…

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