Abstract Number: 1679 • 2015 ACR/ARHP Annual Meeting
Vicm Is a Novel Biomarker of Macrophage Activity Evaluated in a Phase IIb Clinical Trial of Mavrilimumab
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease driven by chronic inflammation, upheld by sustained recruitment and infiltration of leucocytes, especially macrophages. Mavrilimumab is a…Abstract Number: 1680 • 2015 ACR/ARHP Annual Meeting
Selective JAK1 Inhibition with Filgotinib (GLPG0634) Decreases Plasma Markers of Inflammation and Joint Damage in Patients with Rheumatoid Arthritis
Background/Purpose: Among the 4 Janus kinase (JAK) family members, JAK1 often has a dominant role in the intracellular signaling for cytokines involved in auto-immune and…Abstract Number: 1681 • 2015 ACR/ARHP Annual Meeting
4-Week Treatment of Rheumatoid Arthritis Patients with the JAK1-Selective Inhibitor Filgotinib (GLPG0634) Changes Lipid Profile with a Preferential Increase in HDL
Background/Purpose: Patients with active rheumatoid arthritis (RA) present low levels of lipids - total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c) and…Abstract Number: 1682 • 2015 ACR/ARHP Annual Meeting
Suppression of Chronic Arthritis By a Novel Nuclear Factor of Activated T-Cell 5 (NFAT5) Inhibitor
Background/Purpose: We reported that nuclear factor of activated T-cells 5 (NFAT5), originally identified as an osmo-protective transcription factor, has a critical role in the pathogenesis…Abstract Number: 1683 • 2015 ACR/ARHP Annual Meeting
Epithelial Changes in Response to Tocilizumab Combined with Methotrexate in Rheumatoid Arthritis: Evaluated on Circulating Fragments of Type IV Collagen
Background/Purpose: It is well documented that epithelium turnover is markedly increased in the affected joints of rheumatoid arthritis (RA). This causes disruption of the well…Abstract Number: 1684 • 2015 ACR/ARHP Annual Meeting
Malignancies in Patients with Incident Psoriatic Arthritis 1970-2008 in Relation to a Comparator Cohort: A Population-Based Case-Control Study
Background/Purpose: In psoriatic arthritis (PsA), misdirected inflammation and therapeutic use of immunosuppressants causes global immune compromise. Similar immunocompromised states, as in rheumatoid arthritis and psoriasis…Abstract Number: 1685 • 2015 ACR/ARHP Annual Meeting
Metabolic Syndrome in Patients with Psoriatic Arthritis Is Associated to Peripheral Disease Activity
Background/Purpose: Psoriatic arthritis (PsA) is present in about 30% of cutaneous psoriasis (PsO) patients. Both PsO and PsA are frequently associated to comorbidities that have…Abstract Number: 1686 • 2015 ACR/ARHP Annual Meeting
Body Mass Index Is Associated with Hip Arthritis in Patients with Ankylosing Spondylitis
Background/Purpose: To evaluate the clinical courses and associated factors of hip arthritis in patients with ankylosing spondylitis (AS). Methods: In this retrospective analysis, we evaluated…Abstract Number: 1687 • 2015 ACR/ARHP Annual Meeting
Increased Carotid Intima-Media Thickness in Psoriatic Arthritis Patients Compared with Systemic Lupus Erythematosus Patients and Healthy Controls
Background/Purpose: The aim of this study was to investigate carotid intima-media thickness (IMT) in patients with psoriatic arthritis (PsA) and compare it with those in…Abstract Number: 1688 • 2015 ACR/ARHP Annual Meeting
Trends in Hospitalizations and Charges for Ankylosing Spondylitis, 1993-2012
Background/Purpose: In the last two decades, tumor necrosis factor alpha (TNFα) inhibitors have been approved for use, and recommended as part of clinical treatment…Abstract Number: 1689 • 2015 ACR/ARHP Annual Meeting
Cross Sectional Study Investigating the Effect of the Presence of Fibromyalgia on Common Clinical Disease Activity Indices in Patients with Psoriatic Arthritis
Background/Purpose: To study the effect of the presence of fibromyalgia (FMS) on common clinical disease activity indices in patients with psoriatic arthritis (PsA). Methods: Seventy…Abstract Number: 1690 • 2015 ACR/ARHP Annual Meeting
Fibromyalgia in Spondyloarthritis: Impact on Disease Activity Assessment
Background/Purpose: Spondyloarthritis (SpA) is the second most frequent inflammatory rheumatic disease, which main manifestations are spinal pain and peripheral arthritis or enthesitis. Fibromyalgia (FM), a…Abstract Number: 1691 • 2015 ACR/ARHP Annual Meeting
The Presence of Fibromialgia May Influence the Clinimetric Evaluation of Patients with Ankylosing Spondylitis, but Has No Impact on Disease Activity Assessment
Background/Purpose: Fibromyalgia (FM) can be present concomitantly in patients with Ankylosing Spondylitis (AS). It may overestimate the evaluation of disease activity, resulting in more intensive…Abstract Number: 1692 • 2015 ACR/ARHP Annual Meeting
Serious Infections in Psoriasis Patients with Psoriatic Arthritis in the Psoriasis Longitudinal Assessment and Registry Study
Background/Purpose: To describe the rates of serious infections in psoriasis patients with psoriatic arthritis(PsA) from PSOLAR. Methods: PSOLAR is an international, disease-based, observational study in…Abstract Number: 1693 • 2015 ACR/ARHP Annual Meeting
High Prevalence of Cardiac Disease in Patients with Ankylosing Spondylitis
Background/Purpose: Ankylosing spondylitis (AS) is associated with increased risk of concomitant cardiac disease, such as valvular regurgitation, conduction disturbances and decreased ventricular function (1). However,…
ACR Meeting Abstracts