Abstracts Archive - Page 1801 of 2607 - ACR Meeting Abstracts

Abstract Number: 3034 • 2016 ACR/ARHP Annual Meeting
A Selective JAK1 Inhibitor, Filgotinib Suppresses Lymphocytic Infiltration in Salivary Gland of Non Obese Diabetic Mice Via Suppression of BAFF and Chemokine Production of Salivary Gland Epithelial Cells
Jennifer Lee¹, Seo Hwa Kim², Haneul Kim³, Seung-Ki Kwok⁴, Ji Hyeon Ju⁵ and Sung-Hwan Park⁵, ¹Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ²Division of Rheumatology,, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁴[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Interferon(IFN) signatures are upregulated in patients with primary Sjogren’s syndrome (pSS) and interferons are considered to play a pathogenic role in pSS. Therefore, Janus…
Abstract Number: 3035 • 2016 ACR/ARHP Annual Meeting
Characterization of DC-STAMP+ T Cells, a CD3+CD4+ T Cell Subset Uniquely Present in Patients with Psoriatic Disease
Yahui Grace Chiu¹, Edward Schwarz², Richard Bell³, Dongge Li⁴, Nelson Huertas⁴, Cristy Bell⁵, Sharon Moorehead⁵, Debbie Campbell⁵, Changyong Feng⁶ and Christopher T. Ritchlin⁷, ¹Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Orthopedeatrics, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY, ⁶Statistics, University of Rochester, Rochester, NY, ⁷Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory joint disease that affects over 650,000 Americans. Bone damage occurs in half of these patients within the first…
Abstract Number: 3036 • 2016 ACR/ARHP Annual Meeting
IL-22 Is Dysregulated in Psoriatic Arthritis and Acts to Limit IFN-γ Driven Inflammatory Chemokine Production
Amara Ezeonyeji¹, Helen Baldwin², Milica Vukmanovic-Stejic³ and Michael R. Ehrenstein⁴, ¹Rheumatology, Medicine, University College London, London, United Kingdom, ²Rheumatology, Centre for Rheumatology Research, University College London, london, United Kingdom, ³Infection & Immunity, University College London, london, United Kingdom, ⁴Medicine, University College London, London, United Kingdom
Background/Purpose: IL-22 is an IL-10 family cytokine with both pro-inflammatory and anti-inflammatory effects and its dysregulation is associated with the development of autoimmune disease including…
Abstract Number: 3037 • 2016 ACR/ARHP Annual Meeting
Calprotectin Is Highly Upregulated in Inflamed Axial Entheses in SKG Mice
Zheni Stavre¹, Yukiko Maeda² and Ellen M. Gravallese³, ¹Internal Medicine-Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: SKG mice exhibit features of spondyloarthropathy (SpA) and inflammatory bowel disease (IBD). Their SpA-like phenotype is induced by a beta-glucan, curdlan, via the Dectin-1…
Abstract Number: 3038 • 2016 ACR/ARHP Annual Meeting
Enumeration and Preliminary Characterisation of Peri-Entheseal Bone Type 3 Innate Lymphoid Cells
Richard Cuthbert¹, Yasser El-Sherbiny¹, Evangelos M. Fragkakis¹, Robert Dunsmuir², Helena Marzo-Ortega³, Elena Jones¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals and University of Leeds, Leeds, United Kingdom
Background/Purpose: In an IL-23 overexpression animal model of spondyloarthropathy (SpA), primary entheseal disease is driven by innate like lymphocytes at peripheral and spinal enthesis with…
Abstract Number: 3039 • 2016 ACR/ARHP Annual Meeting
Anti-IL-17A, but Not Anti-TNF, Can Halt Pathological New Bone Formation in Experimental Spondyloarthritis
Melissa van Tok¹, Leonie van Duivenvoorde¹, Ina Kramer², Peter Ingold², Veronique Knaup¹, Joel Taurog³, Frank Kolbinger⁴ and Dominique Baeten⁵, ¹Academic Medical Center, Amsterdam, Netherlands, ²Novartis Institutes for Biomedical Research, Basel, Switzerland, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland, ⁵Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands
Background/Purpose: Secukinumab, a monocloncal antibody to IL-17A, suppresses signs and symptoms as well as inflammation in ankylosing spondylitis and psoriatic arthritis, and inhibits bone and…
Abstract Number: 3040 • 2016 ACR/ARHP Annual Meeting
Th17 Migration into the Synovial Fluid of Patients with Active Psoriatic Arthritis Is Enhanced By Regulatory T Cells
Helen Baldwin¹, Amara Ezeonyeji², Mohammed Rohan Butt² and Michael R. Ehrenstein³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Medicine, University College London, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Uncontrolled migration of Th17 cells into the skin and joints is a major driver in the pathogenesis of psoriatic arthritis (PsA). Modulation of T…
Abstract Number: 3041 • 2016 ACR/ARHP Annual Meeting
Age-Related Defects in the Immune System of Patients with GCA
Zhenke Wen¹, Yasuhiro Shimojima², Gerald Berry³, Ebru Hosgur¹, Joyce Liao⁴, Lindsy Forbess⁵, Michael Weisman⁶, Jorg Goronzy⁷ and Cornelia M. Weyand¹, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan, ³Pathology, Stanford University School of Medicine, Stanford, CA, ⁴Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ⁵Rheumatology, Cedars-Sinai, Los Angeles, CA, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Advancing age is the strongest risk factor for GCA, a disease that exclusively affects individuals >50 years of age. The immune system undergoes dramatic…
Abstract Number: 3042 • 2016 ACR/ARHP Annual Meeting
PD-1–Expressing T Cells in GCA Fail to Promote Immune Tolerance Functions
Ryu Watanabe¹, Hui Zhang², Ebru Hosgur², Gerald Berry³, Jorg Goronzy⁴ and Cornelia M. Weyand², ¹Medicine: Immunology/Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Pathology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: The vasculitic lesions in GCA are filled with differentiated effector T cells that sustain granuloma formation, vessel wall restructuring, neoangiogenesis and intimal hyperplasia. Persistent…
Abstract Number: 3043 • 2016 ACR/ARHP Annual Meeting
Dense Genotyping of Immune Related Loci in a Multi-Ethnic Behçet’s Disease Cohort Identifies Genetic Associations in a Long Noncoding RNA Near QSOX2, RASIP1/FUT2, and IL12A-AS1
Paul Renauer¹, Patrick Coit¹, Travis Hughes², Mikhail Ognenovski¹, Adam Adler³, Lourdes Ortiz-Fernández⁴, Vuslat Yilmaz⁵, Kenan Aksu⁶, Nursen Duzgun⁷, Gokhan Keser⁸, Ayse Cefle⁹, Ayten Yazici¹⁰, Andac Ergen¹¹, Erkan Alpsoy¹², Carlo Salvarani¹³, Bruno Casali¹⁴, Ina Koetter¹⁵, Alexandra Zhernakova¹⁶, Cisca Wijmenga¹⁷, Fujio Takeuchi¹⁸, Shinji Harihara¹⁹, Toshikatsu Kaburaki²⁰, Yeong Wook Song²¹, Francisco David Carmona²², Marta E. Alarcon Riquelme²³, Javier Martín²², Güher Saruhan-Direskeneli²⁴, María Francisca Gonzalez Escribano²⁵, Haner Direskeneli²⁶ and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, ³Oklahoma Medical Research Foundation, OK, OK, ⁴Immunology department, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ⁵Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey, ⁶İnternal Medicine Division of Rheumatology, Ege University Medical Faculty, Izmir, Turkey, ⁷Internal Medicines, Rheumatology Department, Ankara University School of Medicine, Ankara, Turkey, ⁸Rheumatology, Ege University Medical Faculty, Izmir, Turkey, ⁹Rheumatology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey, ¹⁰Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, ¹¹Okmeydaný Research and Education Hospital, Istanbul, Turkey, ¹²Department of Dermatology, Akdeniz University School of Medicine, Antalya, Turkey, ¹³Rheumatology, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ¹⁴Molecular Biology Laboratory, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ¹⁵Internal Medicine IV Rheumatology, Asklepios Klinik Altona, Hamburg, Germany, ¹⁶Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, Netherlands, ¹⁷Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, ¹⁸#504 Lab/ Dep of Internal Medicine (Allergy & Rheumatology), Faculty of Medicine, University of Toyko, Tokyo, Japan, ¹⁹Division of Anthropology, Department of Biological Science, The University of Tokyo Graduate School of Science, Tokyo, Japan, ²⁰Ophthalmology, The University of Tokyo School of Medicine, Bunkyo-ku, Japan, ²¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea, ²²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ²³Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain, ²⁴Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ²⁵Hospital Universitario Virgen del Rocío (IBiS,CSIC,US), Sevilla, Spain, ²⁶Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Behçet’s disease is a chronic relapsing inflammatory disease characterized by recurrent mucocutaneous involvement. We performed dense genotyping in immune related loci in a large…
Abstract Number: 3044 • 2016 ACR/ARHP Annual Meeting
Endothelin 1 Induces a Myofibroblastic Phenotype in Vascular Smooth Muscle Cells. A Mechanism Potentially Contributing to Vascular Remodeling and Intimal Hyperplasia in Giant Cell Arteritis
Ester Planas-Rigol¹, Nekane Terrades-Garcia², Marc Corbera-Bellalta², Ester Lozano², Marco Antonio Alba², Georgina Espígol-Frigolé³, Sergio Prieto-González², Marta Segarra², Jose Hernández-Rodríguez², Sara Preciado⁴, Rodolfo Lavilla⁴ and Maria C. Cid², ¹Vasculitis research unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Vasculitis Research Unit, Systemic Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁴Laboratory of Organic Chemistry, Faculty of Pharmacy. Barcelona Science Park, Barcelona, Spain
Background/Purpose: Giant cell arteritis (GCA) is a vascular inflammatory disease involving large and medium sized arteries, particularly the cranial vessels. Inflammation-induced vascular remodeling leads to…
Abstract Number: 3045 • 2016 ACR/ARHP Annual Meeting
Immunometabolism in ANCA-Associated Glomerulonephritis
Peter C. Grayson¹, Sean Eddy², Viji Nair², Hemang Parikh³, Maja Lindenmeyer⁴, Laura Mariani², Huateng Huang², Wenjun Ju³, Casey Greene⁵, Clemens Cohen⁴, Jeffrey Krischer³, Matthias Kretzler², Peter A. Merkel⁶ and Felix H. Eichinger², ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Division of Nephrology, University of Michigan, Ann Arbor, MI, ³University of South Florida, Tampa, FL, ⁴University of Munich, Munich, Germany, ⁵Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Mounting an inflammatory response requires immune cells to undergo major changes in metabolism. Mediators such as cytokines can specifically alter the metabolism of different…
Abstract Number: 3046 • 2016 ACR/ARHP Annual Meeting
Inflammatory Pathways As Shared Molecular Targets Across ANCA-Associated Vasculitis and Nephrotic Syndrome
Sean Eddy¹, Viji Nair¹, Hemang Parikh², Maja Lindenmeyer³, Laura Mariani¹, Felix H. Eichinger¹, Huateng Huang¹, Wenjun Ju², Casey Greene⁴, Peter C. Grayson⁵, Clemens Cohen³, Jeffrey Krischer², Peter A. Merkel⁶ and Matthias Kretzler¹, ¹Division of Nephrology, University of Michigan, Ann Arbor, MI, ²University of South Florida, Tampa, FL, ³University of Munich, Munich, Germany, ⁴Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Clinical trials in rare diseases typically test therapeutic efficacy in one disease defined by a particular clinical phenotype. Improved understanding of the molecular mechanisms…
Abstract Number: 3047 • 2016 ACR/ARHP Annual Meeting
Diabetes and BMI Modify the Association Between Painful Hip OA and All-Cause Mortality
Rebecca Cleveland¹, Todd A. Schwartz², Jordan B. Renner³, Leigh F. Callahan¹ and Joanne M. Jordan¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Individuals with specific comorbid conditions have increased risk of having hip osteoarthritis (OA). Some of these conditions are also associated with increased risk of…
Abstract Number: 3048 • 2016 ACR/ARHP Annual Meeting
Pain Severity As a Mediator of the Effect of Depressive Symptoms on Physical Performance in Knee Osteoarthritis
Alan Rathbun¹, Michelle Shardell², Michelle S. Yau³, Mona Baumgarten⁴, Elizabeth Stuart⁵ and Marc Hochberg⁶, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Depression is a significant comorbidity of knee osteoarthritis (OA) that occurs in approximately 20% of OA patients. Depressive symptoms are associated with both subsequent…

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