Abstracts Archive - Page 1779 of 2607 - ACR Meeting Abstracts

Abstract Number: 2704 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Psoriasis
Vishal Deshmukh¹, Melinda Pedraza¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, Timothy Seo¹, Benoit Melchior¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Psoriasis is an auto-immune disease of the skin, characterized by inflammation and fibrosis producing patches of red, itchy and scaly skin. Wnt signaling plays…
Abstract Number: 2705 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Autophagy Genes and Their Association with Spinal Damage in Patients with Ankylosing Spondylitis
Min-Chan Park¹, Hye Won Kim², Jason Jungsik Song¹ and Yong-Beom Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: However, a role of autophagy in ankylosing spondylitis has not been clearly elucidated and the association of autophagy-related gene expression levels with inflammatory or…
Abstract Number: 2706 • 2016 ACR/ARHP Annual Meeting
Elevated Levels of Serum Myeloid Related Protein 8/14 in Ankylosing Spondylitis: Associated with Peripheral Arthritis and Active Disease
Latika Gupta¹, Shruti Bhattacharya¹, Vikas Agarwal² and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²clinical Immunology, sanjay Gandhi Postgraduate Institute of Medical Sciences, lucknow, India
Background/Purpose: Monocytes of patients with Ankylosing Spondylitis (AS) show Toll-like receptor 4 (TLR4) over-expression. Myeloid-related proteins (MRP) 8/14 protein complexes are calcium-binding proteins, which act…
Abstract Number: 2707 • 2016 ACR/ARHP Annual Meeting
Autoantibodies Against CD74 – a New Diagnostic Marker for Spondyloarthritis (SpA)
Torsten Matthias¹, Eva Schweikhard², Sandra Reuter¹, Maria Köhler³, Joachim Georgi³, Niklas Thomas Baerlecken⁴ and Torsten Witte⁵, ¹Aesku.Kipp.Institute, Wendelsheim, Germany, ²Aesku.Diagnostics, Wendelsheim, Germany, ³Department of Internal medicine and Rheumatology, Helios Ostseeklinik Damp, Germany, Damp, Germany, ⁴Clinical Immunology and Rheumatology, MD, Hannover, Germany, ⁵Hannover Medical School, Hanover, Germany
Background/Purpose: Spondyloarthritis (SpA) is a common debilitating inflammatory disorder. Pathogenesis of axial SpA (axSpA) including ankylosing spondylitis (AS) is still largely unclear. Diagnosis is difficult,…
Abstract Number: 2708 • 2016 ACR/ARHP Annual Meeting
Type 17 Immunity in Spondyloarthritis Is Expanded Across Multiple Lymphocyte Subsets
Davide Simone¹, Hussein Al Mossawi¹, Anna Ridley², Jelle De Wit¹, Takuya Sekine¹, Nuha Ansar¹, Karen Doig¹ and Paul Bowness¹, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: The spondyloarthritides (SpA) are a group of chronic inflammatory disorders involving the axial spine and the peripheral joints. Genetic, functional and clinical trial evidences…
Abstract Number: 2709 • 2016 ACR/ARHP Annual Meeting
Which Cells Correspond to the Typical Signals for Fatty and Inflammatory Lesions Seen in Magnetic Resonance Imaging in Ankylosing Spondylitis ? -a Prospective Study Using Biopsy Material Obtained during Spinal Surgery-
Xenofon Baraliakos¹, Heinrich Boehm², Ahmend Samir², Georg Schett³ and Jürgen Braun⁴, ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Clinic for spinal surgery, Bad Berka, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Rheumazentrum Ruhrgebiet, Herne, Germany
Background/Purpose: The occurrence of bone marrow edema (BME) and fat metaplasia detected by magnetic resonance imaging (MRI) were shown to be significantly associated with syndesmophyte…
Abstract Number: 2710 • 2016 ACR/ARHP Annual Meeting
Bacterial Dysbiosis Associates with Functional Intraepithelial Lymphocyte Changes in Inflammatory Bowel Disease and Spondyloarthritis
Neha Ohri^1,2,3, Mark Gerich^3,4, Blair Fennimore^3,5, Diana Ir⁶, Charles Robertson⁶, Daniel Frank⁶, Liron Caplan⁷, Brandie Wagner⁸ and Kristine Kuhn^9,10, ¹Division of Rheumatology, Mount Sinai West, New York City, NY, ²Division of Rheumatology, University of Colorado, Aurora, CO, ³Mucosal Inflammation Program, University of Colorado, Aurora, CO, ⁴Division of Gastroenterology, University of Colorado, Aurora, CO, ⁵Department of Gastroenterology, University of Colorado, Aurora, CO, ⁶Division of Infectious Disease, University of Colorado, Aurora, CO, ⁷Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ⁸Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, ⁹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ¹⁰Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: The microbiome is hypothesized to influence human health and disease. Changes in resident bacteria, termed dysbiosis, occur in spondyloarthritis (SpA) and inflammatory bowel disease…
Abstract Number: 2711 • 2016 ACR/ARHP Annual Meeting
Tissue-Resident IL-23 Responsive Innate T Cells in Mice Comprise Tcrαβ+ and TCRγδ+ Subsets with Overlapping Function
Katia Urso, Imtiyaz Hossain and Joerg Ermann, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Multiple lines of evidence suggest a critical role for the IL-23/IL-17A axis in spondyloarthritis. In susceptible inbred strains, hydrodynamic injection of IL-23 minicircles into…
Abstract Number: 2712 • 2016 ACR/ARHP Annual Meeting
Inverse Correlation Between IL-10-Producing Bregs and IFN-Gamma-Producing NK Cells in Psoriatic Arthritis and Psoriasis
Athanasios Mavropoulos¹, Areti Varna¹, Christos Liaskos¹, Efterpi Zafiriou², Marianna Vlychou³, Christina Katsiari⁴, Dimitrios Bogdanos⁵ and Lazaros I. Sakkas⁶, ¹Department of Rheumatology, School of Health Sciences, University of Thessaly, Larissa, Greece, ²Dermatology, University of Thessaly, Larissa, Greece, ³Radiology, University of Thessaly, Larissa, Greece, ⁴Department of Rheumatology, University of Thessaly, Larrisa, Thessaly, Greece, ⁵Department of Rheumatology, University of Thessaly, Larissa, Greece, ⁶University, Athens, Greece
Background/Purpose: A recent study from our group has shown functional impairment and numerical decrease of transitional and memory IL-10-producing regulatory B cells (Bregs) in patients…
Abstract Number: 2713 • 2016 ACR/ARHP Annual Meeting
Differentially Expressed Microrna As Candidate Biomarker for Disease Activity in Ankylosing Spondylitis
Marina N. Magrey¹, Abdul Haseeb² and Tariq M Haqqi², ¹Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Differentially Expressed MicroRNA as candidate Biomarker for Disease Activity in Ankylosing Spondylitis Background/Purpose: MicroRNAs (miRNAs) have evolved as a novel class of biomarkers We proposed…
Abstract Number: 2714 • 2016 ACR/ARHP Annual Meeting
Association of Polymorphisms of Activation-Induced Cytidine Deaminase with Ankylosing Spondylitis
Seung Cheol Shim¹, In-Seol Yoo¹, Chan Keol Park¹, Ji-Young Kim¹, Young Mo Kim², Dong-Hyuk Sheen³ and Seok-Rae Park⁴, ¹Division of Rheumatology, Department of Internal Medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, The Republic of, ²Department of Orthopedic Surgery, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, The Republic of, ³Division of Rheumatology, Eulji University, Daejeon, Korea, The Republic of, ⁴Department of Microbiology, College of Medicine, Konyang University, Daejeon, Korea, The Republic of
Background/Purpose: There was a biased repertoire of the immunoglobulin (Ig) heavy chain variable (VH) segment gene in B cells in patients with ankylosing spondylitis (AS).…
Abstract Number: 2715 • 2016 ACR/ARHP Annual Meeting
Genetic Variants in TNF, TNFRSF1A, and IL23R Are Associated with Risk of Ankylosing Spondylitis
Jacob Sode^1,2,3, Ulla Vogel⁴, Steffen Bank⁵, Paal Skytt Andersen⁶, Merete Lund Hetland⁷, Henning Locht², Niels H. H. Heegaard⁸ and Vibeke Andersen⁹, ¹Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark, ²Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark, ³Department of Rheumatology, Skåne University Hospital, Lund, Sweden, ⁴National Research Centre for the Working Environment, Copenhagen, Denmark, ⁵Institute of Human Genetics, University of Aarhus, Aarhus, Denmark, ⁶Microbiology & Infection Control, Statens Serum Institut, Copenhagen S, Denmark, ⁷DANBIO Registry and Departments of Rheumatology, Rigshospitalet (Glostrup and Blegdamsvej), University of Copenhagen, Glostrup, Denmark, ⁸Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen, Denmark, ⁹Odense University Hospital, OPEN (Odense Patient data Explorative Network), Odense, Denmark
Background/Purpose: The objective of this study was to evaluate single nucleotide polymorphisms (SNPs) involved in TNFα signaling, NF-κB activation, interferon-γ signaling, or pattern recognition receptor…
Abstract Number: 2716 • 2016 ACR/ARHP Annual Meeting
Does Secretory Immunoglobulin a Influence Disease Activity in Patients with Reactive Arthritis and Undifferentiated Spondylarthritis?
fabian Alexander salas-Cuestas¹, Consuelo Romero Sanchez^2,3, WILSON BAUTISTA-MOLANO⁴, Juan Manuel Bello-Gualtero^5,6, Ivonne Arias C⁷, Daniel Herrera⁸ and Rafael Valle-Oñate^6,9, ¹School of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, Bogota DC, Colombia, ²Rheumatology, School of Medicine HMC / UMNG, Bogota, Colombia, ³Rheumatology and Immunology, Hospital Militar Central, Bogota DC, Colombia, ⁴Rheumatology Department, School of Medicine, UMNG / HMC, Bogotá, Colombia, ⁵Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, ⁶Rheumatology and Immunology Department,Hospital Militar Central, Bogota, Colombia, ⁷3. Instituto de Genética Humana, School of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia., Bogota DC, Colombia, ⁸Genetic, Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia, ⁹School of Medicine, Universidad Militar Nueva Granada, Bogota, Colombia
Background/Purpose: Spondylarthropathies (SpA) comprise a group of rheumatic diseases such as ankylosing spondylitis (AS), arthritis/spondylitis with inflammatory bowel disease, arthritis/spondylitis with psoriasis (PsA), reactive arthritis…
Abstract Number: 2717 • 2016 ACR/ARHP Annual Meeting
Sclerostin and Dickkopf-1 but Not Periostin May Have a Role in Psoriatic Arthritis
E.Figen Tarhan¹, Burak DEMİREL², Leyla Didem Kozaci³, Mustafa Ozmen⁴, İlay Türkmen⁵, Nazmiye Hanim Bas Tomas⁶ and Servet Akar⁷, ¹Rheumatology, Mugla Sitki Kocman University, Mugla, Turkey, ²Internal Medicine, Izmir Katip Celebi University,, İzmir, Turkey, ³Biochemistry, Adnan Menderes University School of Medicine, Aydin, Turkey, ⁴Rheumatology, Izmir Ataturk Research and Training Hospital, Izmir, Turkey, ⁵Department of Musculoskeletal and regenerative Medicine, Health Science Institute, Yildirim Beyazit University School of Medicine, ankara, Turkey, ⁶Rheumatology, İzmir Atatürk Eğitim ve Araştırma Hastanesi, İZMİR, Turkey, ⁷Department of Rheumatology, İzmir Katip Çelebi University, School of Medicine, İzmir, Turkey, İzmir, Turkey
Background/Purpose:Psoriatic arthritis (PsA) is a chronic inflammatory disease. It is characteristically associated both peripheral (arthritis, enthesitis and dactylitis) and axial skeletal involvement. A range of…
Abstract Number: 2718 • 2016 ACR/ARHP Annual Meeting
Plasma Levels of the M2 Macrophage Markers, CD163 and CD206, Changes Reversely and Soluble CD163 Is Associated with Disease Activity in Spondyloarthritis
Line Dam Heftdal^1,2, René Østgård^3,4, Malene Hvid^3,5, Bent Deleuran^2,3,5, Holger Jon Møller⁵ and Stinne Greisen^2,3, ¹Department of Biomedicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Department of Rheumatology, Regional Hospital Silkeborg, Silkeborg, Denmark, ⁵Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: Spondyloarthritis (SpA) covers a group of interrelated auto-inflammatory disorders where TNFa is a central mediator of disease. T cells and macrophages are abundant in…

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