Abstract Number: 2689 • 2016 ACR/ARHP Annual Meeting
Comparison of the 2016 ACR/EULAR and the 2002 AECG Classification Criteria in a Cohort of Patients with Suspected Primary SjöGren’s Syndrome
Background/Purpose: New consensual classification criteria for primary Sjögren’s syndrome (pSS) have been recently developed, validated, and submitted to ACR and EULAR committees. They differ substantially…Abstract Number: 2690 • 2016 ACR/ARHP Annual Meeting
Detection of Dorsal Root Ganglionitis with Magnetic Resonance Neurography in Sensory Ataxic Neuropathy Associated with SjöGren’s Syndrome
Background/Purpose: Sensory ataxic neuropathy (SAN) is one of the neurologic complications in Sjögrenfs syndrome (SS). The underlying pathology was lymphocytic infiltration to the dorsal root…Abstract Number: 2691 • 2016 ACR/ARHP Annual Meeting
Clinical, Radiological and Functional Characteristics of Clinically Significant Pulmonary Involvement in Primary SjöGren’s Syndrome
Background/Purpose: Prevalence of symptomatic pulmonary disease in primary Sjögren’s Syndrome (pSS) ranges between 9% and 27%. Xerotrachea, small airway disease and interstitial lung disease (ILD)…Abstract Number: 2692 • 2016 ACR/ARHP Annual Meeting
Pulmonary Involvement, As Part of the Essdai, in Primary Sjogren’s Syndrome
Background/Purpose: In previous studies in primary Sjögren’s syndrome (pSS), the prevalence of pulmonary involvement varied greatly depending on differences in inclusion criteria, imaging modalities and…Abstract Number: 2693 • 2016 ACR/ARHP Annual Meeting
Evolution of Disease Activity over a 5-Year Period in the 395 Patients with Primary SjöGren’s Syndrome of the Assess Prospective Cohort
Background/Purpose: Little is known about the natural history of primary Sjögren’s syndrome due to the limited number of prospective cohorts followed up in a yearly…Abstract Number: 2694 • 2016 ACR/ARHP Annual Meeting
Treatment of ZAP-70 Mutant SKG Mice with Anti-IL-23 Antibody Alters Fecal Microbiota Composition and Prevents Outgrowth of Bacteria Associated with Susceptibility to Spondyloarthritis and Ileitis
Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from spondyloarthritis (SpA), or for people at-risk of…Abstract Number: 2695 • 2016 ACR/ARHP Annual Meeting
Genetic Association of Ankylosing Spondylitis with TBX21 Influences T-Bet and Pro-Inflammatory Cytokine Expression in Humans and SKG Mice As a Model of Spondyloarthritis and Alters Host Microbiome and Response to Microbial Stimuli
Background/Purpose: TBX21 encodes the transcription factor T-bet and is genome-wide significant associated with ankylosing spondylitis (AS). T-bet is implicated in innate and adaptive immunity. However,…Abstract Number: 2696 • 2016 ACR/ARHP Annual Meeting
Identification of a Potential Commensal Immunologic Target in Enthesitis-Related Arthritis
Identification of a Potential Commensal Immunologic Target in Enthesitis-related Arthritis Background/Purpose: Research in inflammatory bowel disease (IBD) has identified commensal organisms that stimulate humoral and…Abstract Number: 2697 • 2016 ACR/ARHP Annual Meeting
Modulator Role of Inducible Costimulator (ICOS) in Spondyloarthritis Animal Model
Background/Purpose: HLA-B27/hβ2m transgenic rats (B27 rats), a model of spondylarthritis (SpA) develop spontaneous colitis and arthritis. Recently, in vitro studies demonstrated that altered dendritic cells…Abstract Number: 2698 • 2016 ACR/ARHP Annual Meeting
Regulation of Inflammation By Interleukin-27 in a Rat Model of Spondyloarthritis (SpA)
Background/Purpose: SpA is a chronic inflammatory rheumatic disorder with osteo-articular and extra-articular manifestations. HLA-B27/human β2-microglobulin transgenic rats (B27 rat) spontaneously develop a phenotype closely resembling…Abstract Number: 2699 • 2016 ACR/ARHP Annual Meeting
Spa-Associated HLA-B*27 Subtypes Accumulate More in Endoplasmic Reticulum (ER) Compartment and in Association with β2-Microglobulin (β2m) Than Non-Associated HLA-B Alleles
Background/Purpose: Mechanisms underlying the striking association of SpA with the MHC class I molecule HLA-B27 remain poorly understood. SpA-like disease develops spontaneously in B*2705 transgenic…Abstract Number: 2700 • 2016 ACR/ARHP Annual Meeting
The Lymphatic System: A Gatekeeper for Migration of Pathogenic T-Cells Towards Synovial Joints and Entheses in Psoriasis
Background/Purpose: Psoriasis (PsO) is a common inflammatory skin disease that is characterized by acanthosis, impaired immune cell migration, and remodeling of the vascular and lymphatic…Abstract Number: 2701 • 2016 ACR/ARHP Annual Meeting
Increased Frequency of Regulatory CD19+CD24high Cd38high B Cells in Patients with Ankylosing Spondylitis (AS)
Background/Purpose: CD19+CD24highCD38high B cells have been described to have a regulatory capacity and their frequency is altered in the peripheral blood of patients with various…Abstract Number: 2702 • 2016 ACR/ARHP Annual Meeting
Taking Fly for Understanding the Molecular Role of HLA-B27/hB2m in Spondyloarthritis
Background/Purpose: After more than 40 years of researches, the mechanisms underlying the association of HLA-B27 with spondyloarthritis (SpA) remain poorly understood. The Drosophila has been…Abstract Number: 2703 • 2016 ACR/ARHP Annual Meeting
Apremilast May Improve Atherosclerosis By Promoting Cholesterol Efflux and Inhibiting Foam Cell Formation in Atherosclerotic Plaques
Background/Purpose: Atherosclerosis is characterized by the accumulation of lipid-laden macrophages in the arterial walls. Patients with inflammatory arthritis and psoriasis are at greater risk of…
ACR Meeting Abstracts