Abstracts Archive - Page 1773 of 2425 - ACR Meeting Abstracts

Abstract Number: 1256 • 2015 ACR/ARHP Annual Meeting
Gas Chromatography/Time-of-Flight-Mass Spectrometry-Based Metabolomic Profiling in Cultured Fibroblast-like Synoviocytes from Rheumatoid Arthritis
Joong Kyong Ahn¹, Sooah Kim², Jiwon Hwang¹, Jungyeon Kim², Young Hee Eun³, Hyemin Jeong⁴, Ji-Min Oh⁵, Hyungjin Kim³, Jaejoon Lee³, Eun-Mi Koh³, Kyoung Heon Kim² and Hoon-Suk Cha⁶, ¹Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Biotechnology, Korea University Graduate School, Seoul, South Korea, ³Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁵Anyang SAM Hospital, Anyang, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and hyperplasia. Fibroblast-like synoviocytes (FLS) in RA exhibit a tumor cell-like…
Abstract Number: 1257 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Signatures of Salivary Gland Inflammation in Sjögren’s Syndrome
Michael Cole¹, Diana Quach¹, Hong L. Quach¹, Lisa F. Barcellos¹ and Lindsey A. Criswell², ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Sjögren’s Syndrome (SS, OMIM #270150) is a chronic, multi-system autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival…
Abstract Number: 1258 • 2015 ACR/ARHP Annual Meeting
Identification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed By Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract
Fanny Comblain¹, Cécile Lambert¹, Isabelle Lesponne², Christelle Sanchez¹, Jean-Emile Dubuc³ and Yves Henrotin^4,5, ¹University of Liège, Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium, ²Royal Canin Research Center, Aimargues, France, ³Clinical University Saint Luc, Orthopaedic Department, Clinical University Saint Luc, Brussels, Belgium, ⁴Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium, ⁵Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium
Background/Purpose: The goal of treatment in OA is to reduce pain and improve function. There is no cure for the disease, but some attempts to…
Abstract Number: 1259 • 2015 ACR/ARHP Annual Meeting
Verification of Haptoglobin and Von Willebrand Factor As Potential Biomarkers of Knee Osteoarthritis Using a Targeted Proteomics Approach in Serum
Patricia Fernandez-Puente¹, Valentina Calamia¹, Jesús Mateos¹, Lucia Lourido¹, Beatriz Rocha², Cristina Ruiz-Romero¹ and Francisco J. Blanco¹, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ²Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: The current diagnosis of osteoarthritis (OA) relies on the description of pain symptoms, affected joint stiffness, and radiography used as the reference technique…
Abstract Number: 1260 • 2015 ACR/ARHP Annual Meeting
Differential DNA Methylation and Reduced Expression of Transcription Factors in Human OA Cartilage
Oscar Alvarez-Garcia¹, Kathleen M. Fisch¹, Ryuichiro Akagi^2,3, Masahiko Saito⁴, Takahisa Sasho⁴, Andrew I. Su⁵ and Martin K. Lotz⁶, ¹The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, San Diego, CA, ³Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan, ⁴Orthopaedic Surgery, Chiba University, Chiba, Japan, ⁵Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁶Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: DNA methylation is the most characterized epigenetic mechanism and has been recently linked to knee osteoarthritis (OA) pathogenesis. The present study was design to…
Abstract Number: 1261 • 2015 ACR/ARHP Annual Meeting
Molecular Analysis of Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis: Targeting Endothelin-1 Receptor to Control Proliferation
Alexis Regent¹, Kim Heang Ly², Matthieu Groh³, Chabha Khifer⁴, Sebastien Lofek⁵, Mathieu Tamby⁶, Guilhem Clary⁷, Philippe Chafey⁷, Véronique Baud⁸, Cédric Broussard⁹, Christian Federici⁷, Francois Labrousse¹⁰, Laura Mesturoux¹¹, Claire Le Jeunne¹², Elisabeth Vidal¹³, Antoine P. Brezin¹⁴, Veronique Witko-Sarsat¹⁵, Loïc Guillevin¹² and Luc Mouthon¹⁵, ¹Service de médecine interne, Hôpital Cochin, Paris, France, ²CHU Dupuytren, Limoges, Limoges, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁴Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵Université Paris Descartes, Paris, France, ⁶Institut Cochin, U1016, Paris, France, ⁷Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁸Institut cochin, U1016, Paris, France, ⁹Inserm U 567, CNRS UMR 8104, Cochin Institute, Paris, France, ¹⁰Department of Pathology, Limoges University Hospital, Limoges, France, ¹¹CHU Limoges, Limoges, France, ¹²Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ¹³Internal Medecine, Limoges hospital, Paris, France, ¹⁴Université Paris Descartes, Hôpital Cochin, Paris, France, ¹⁵Labex Inflamex, Université Sorbonne Paris Cité, Paris, France
Background/Purpose: Vascular remodeling play a major role in the pathophysiology of giant cell arteritis (GCA) and the mechanisms underlying it are poorly understood. Methods: Vascular…
Abstract Number: 1262 • 2015 ACR/ARHP Annual Meeting
Epigenome-Wide DNA Methylation Patterns Associated with Fatigue in Primary Sjögren’s Syndrome
Katrine B Norheim¹, Juliana Imgenberg-Kreuz², Kristin Jonsdottir³, Emiel Janssen⁴, Ann-Christine Syvänen², Johanna K Sandling², Gunnel Nordmark⁵ and Roald Omdal⁶, ¹Dept of Internal Medicine, Clinical immunology Unit, Stavanger, Norway, ²Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ³Dept. of Pathology, Stavanger University Hospital, Stavanger, Norway, ⁴Dept. of Pathology, Stavanger university Hospital, Stavanger, Norway, ⁵Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁶Department of internal medicine, Clinical Immunology unit, Stavanger, Norway
Background/Purpose: Chronic fatigue is a common, often disabling, and poorly understood phenomenon of many diseases. Recent studies indicate that epigenetic mechanisms may be involved in…
Abstract Number: 1263 • 2015 ACR/ARHP Annual Meeting
Applications of Protein Microarray for Saliva Diagnostics in Autoimmune Diseases
Yeon-Ah Lee¹, Yong-Gil Kim², Seung-Jae Hong¹ and Paul J. Utz³, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: There have been many reports showing that saliva could be a source of biomarkers capable of detecting certain diseases. However, very few studies have…
Abstract Number: 1264 • 2015 ACR/ARHP Annual Meeting
Residential Proximity to Highways, DNA Methylation and Systemic Lupus Erythematosus
Cristina Lanata¹, Renuka Nayak², Joanne Nitiham¹, Kimberly Taylor³, Lisa F. Barcellos⁴, Sharon A. Chung⁵ and Lindsey A. Criswell^6,7, ¹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ⁵School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁶Rheumatology, UCSF, SAN FRANCISCO, CA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by autoantibody formation in which multiple genetic, epigenetic and environmental risk factors have been implicated. We…
Abstract Number: 1265 • 2015 ACR/ARHP Annual Meeting
Genetic and Epigenetic Mapping of Very Early RA Synovial Fibroblasts
Emmanuel Karouzakis¹, Andrew Filer², Stephen Eyre³, Karim Raza⁴, Christoph Kolling⁵, Renate E. Gay¹, Beat A. Michel¹, Jane Worthington³, Christopher Buckley⁶, Steffen Gay¹, Michel Neidhart¹ and Caroline Ospelt¹, ¹University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ²University of Birmingham, Birmingham, United Kingdom, ³University of Manchester,Institute of Inflammation and Repair, United Kingdom, Manchester, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, ⁵Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ⁶University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
Background/Purpose: Genome wide association studies (GWAS) studies from rheumatoid arthritis patients have identified SNPs, which are associated with changes in gene expression levels. Recent studies…
Abstract Number: 1266 • 2015 ACR/ARHP Annual Meeting
Rheumatologic Diagnoses, Characteristics and Needs of Somali Patients Referred to a Rheumatology Clinic Serving the Somali Population
Elizabeth Miller¹, Elie Gertner², Rosemary Quirk¹ and Maribet McCarty¹, ¹Hennepin County Medical Center, Minneapolis, MN, ²Section of Rheumatology, Regions Hospital and University of Minnesota, St. Paul, MN
Background/Purpose: With the growing immigrant and refugee population in the United States, the landscape of medicine is constantly changing. In order to provide quality healthcare,…
Abstract Number: 1267 • 2015 ACR/ARHP Annual Meeting
Drug Survival of Second Biologic DMARD Therapy in Patients with Rheumatoid Arthritis: Comparison of a Second Anti-TNF with a Second Non-Anti-TNF after Discontinuation of a First Anti-TNF
T Wilke¹, S Mueller¹, I Majer², M Heisen², A Fuchs³ and U Maywald³, ¹Institut für Pharmakoökonomie und Arzneimittellogistik (IPAM), Hochschule Wismar, Germany, ²Pharmerit International, Rotterdam, Netherlands, ³AOK PLUS, Dresden, Germany
Background/Purpose: There is limited information on drug survival (i.e., continuation versus discontinuation of drug treatment) of RA patients who received a 2nd bDMARD therapy after…
Abstract Number: 1268 • 2015 ACR/ARHP Annual Meeting
Utilization of Viscosupplementation: 2011 – 2013
Gurjit S. Kaeley¹, Myint Thway¹ and Sunita Dodani², ¹Rheumatology, University of Florida College of Medicine, Jacksonville, Jacksonville, FL, ²Cardiology and Epidemiology, University of Florida College of Medicine, Jacksonville, Jacksonville, FL
Background/Purpose: Viscosupplementation (VS) is approved in the USA as an option for knee osteoarthritis (OA) pain. Recent American Academy of Orthopedic Surgeons (AAOS) guidelines have…
Abstract Number: 1269 • 2015 ACR/ARHP Annual Meeting
Measuring the Rheumatologist Workforce in Canada: Preliminary Results of the Stand up and be Counted Survey
Claire E H Barber¹, Lauren Jewett², Vandana Ahluwalia³, Cory Baillie^4,5, Dianne Mosher⁶, Michel Zummer⁷, J Carter Thorne⁸, Janet Ellsworth⁹, Henry Averns¹⁰, Cheryl Barnabe¹¹, Alfred Cividino¹², Janet E. Pope¹³, Elizabeth M. Badley^14,15, Deborah M. Levy¹⁶, Thanu Ruban¹⁴, Katie Lundon¹⁷, Robert McDougall¹⁸, Julie Brophy¹, Diane Lacaille¹⁹, Deborah Marshall² and The Canadian Rheumatology Association (CRA) Human Resources Committee, ¹Rheumatology, University of Calgary, Calgary, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³William Osler Health Center, Brampton, ON, Canada, ⁴Canadian Rheumatology Association (President), Winnipeg, MB, Canada, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶Med, University of Calgary, Calgary, AB, Canada, ⁷Université de Montréal, Quebec, QC, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Consultant Rheumatologist Kingston Ontario, Kingston, ON, Canada, ¹¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ¹²Department of Medicine, McMaster University, Hamilton, AB, Canada, ¹³University of Western Ontario, London, ON, Canada, ¹⁴University of Toronto, Toronto, ON, Canada, ¹⁵Toronto Western Research Institute, Toronto, ON, Canada, ¹⁶Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁷Medicine, University of Toronto, Toronto, ON, Canada, ¹⁸University of Saskatchewan, Regina, SK, Canada, ¹⁹Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Given the rising burden of arthritis care, there is concern about access to rheumatologists in many regions. To better characterize the rheumatologist workforce, the…
Abstract Number: 1270 • 2015 ACR/ARHP Annual Meeting
Low Socioeconomic Status As a Predictor of Long-Term Direct Medical Costs Following Diagnosis of Granulomatosus with Polyangiitis: A General Population-Based Cohort Study
Natalie McCormick¹, Carlo Marra² and J Antonio Avina-Zubieta³, ¹Faculty of Pharmaceutical Sciences, University of British Columbia/Arthritis Research Canada, Vancouver, BC, Canada, ²Pharm Sciences, Univ of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Estimates of the healthcare costs of Granulomatosus with polyangiitis (GPA) and predictors of costs are scarce. In particular, while socioeconomic status (SES) is associated…

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