Abstracts Archive - Page 1772 of 2425 - ACR Meeting Abstracts

Abstract Number: 1241 • 2015 ACR/ARHP Annual Meeting
Identification and Validation of Diagnostic and Activity Urinary Metabolomic Biomarkers in Immune-Mediated Inflammatory Diseases
Arnald Alonso¹, Jesús Tornero², Antonio Fernandez-Nebro³, Juan D. Cañete⁴, Eugeni Domènech⁵, Javier P. Gisbert⁶, Carlos Ferrándiz⁵, Eduardo Fonseca⁷, Valle García⁸, Francisco Blanco⁷, Jesus Rodriguez⁹, Jordi Gratacós¹⁰, Patricia E. Carreira¹¹, Antonio Julià¹, Raül Tortosa¹, Maria López-Lasanta¹², Xavier Correig¹³ and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ³Rheumatology, Hospital Universitario Carlos Haya, Malaga, Spain, ⁴Unitat d’Artritis, Servei de Reumatologia, Hospital Clínic de Barcelona and Institut d’Investigacions Biomèdiques August Pí i Sunyer, Barcelona, Spain, ⁵Hospital Universitari Germans Trias I Pujol, Badalona, Spain, ⁶Hospital Universitario de la Princesa, Madrid, Spain, ⁷Complejo Hospitalario Juan Canalejo, A Coruña, Spain, ⁸Hospital Universitario Reina Sofía, Córdoba, Spain, ⁹Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁰Hospital Parc Taulí, Sabadell, Spain, ¹¹Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹²Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ¹³CIBERDEM, Metabolomics Platform, Reus, Spain
Background/Purpose: The recent advances in metabolomics have allowed the study of the regulatory processes linked to metabolism. The comprehensive analysis of the metabolome in biological samples…
Abstract Number: 1242 • 2015 ACR/ARHP Annual Meeting
Germ Line DNA Methylation Profiling Provides Novel Insights into the Parent-of-Origin Effect in Psoriatic Disease
Remy Pollock¹, Darren O'Reilly², Proton Rahman³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Parent-of-origin effects refer to the differential risk or pathogenicity of a disease that depends on the sex of the disease-transmitting parent. Excessive paternal transmission…
Abstract Number: 1243 • 2015 ACR/ARHP Annual Meeting
Identification of the Gene Expression Signatures Predicting the Responses to Three Biologics (infliximab, tocilizumab, and abatacept) in Rheumatoid Arthritis
Seiji Nakamura¹, Hiroshi Iijima¹, Yuko Hata², Yohei Ishizawa², Chun Ren Lim², Ryo Matoba², Katsuya Suzuki³, Koichi Amano⁴ and Tsutomu Takeuchi³, ¹Kanagawa, DNA Chip Research Inc., Yokohama, Japan, ²DNA Chip Research Inc., Yokohama, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁴Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
Background/Purpose: Employing genome-wide gene transcription on a unified platform, to identify molecular signatures for predicting therapeutic effects for rheumatoid arthritis (RA) with three biologics, infliximab…
Abstract Number: 1244 • 2015 ACR/ARHP Annual Meeting
Extracellular MicroRNAs in Synovial Fluid Reveal a Marked Proliferative Signature in Patients with Antibiotic-Refractory Lyme Arthritis
Robert B. Lochhead, Nancy D. Kim, Sheila Arvikar, Klemen Strle and Allen C. Steere, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Lyme arthritis (LA), caused by a tick-borne spirochete Borrelia burgdorferi, usually resolves appropriately with antibiotic treatment, called antibiotic-responsive LA. However, in some patients, arthritis…
Abstract Number: 1245 • 2015 ACR/ARHP Annual Meeting
Differential DNA Methylation Associated with Lupus Nephritis Shows Enrichment in Genes Involved in Regulation of TH2 Differentiation and Renal Development
Renuka Nayak¹, Sharon A. Chung², Joanne Nitiham³ and Lindsey A. Criswell³, ¹Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ²Russell/Englemen Rheumatology Research Center, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Genetic and epigenetic factors contribute to the progression of systemic lupus erythematosus (SLE). We have the ability to identify these factors and their influence…
Abstract Number: 1246 • 2015 ACR/ARHP Annual Meeting
Gene Expression Analysis of Adult Onset Still’s Disease and Systemic Juvenile Idiopathic Arthritis Suggest a Single Disease Continuum
N. Nirmala¹, Arndt Brachat², Eugen Feist³, Norbert Blank⁴, Christof Specker⁵, Matthias Witt⁶, Jan Zernicke⁷, Alberto Martini⁸ and Guido Junge⁹, ¹Novartis Institutes for Biomedical Research, Cambridge, MI, ²Novartis Institutes for Biomedical Research, Basel, Switzerland, ³Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany, ⁴University of Heidelberg, Heidelberg, Germany, ⁵Kliniken Essen Süd, Essen, Germany, ⁶Division for Rheumatology, University of Munich, Munich, Germany, ⁷Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁸Department of Pediatrics, G Gaslini Institute, Genova, Italy, ⁹Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder.1 The superimposable systemic clinical features of AOSD and the pediatric syndrome known as systemic juvenile…
Abstract Number: 1247 • 2015 ACR/ARHP Annual Meeting
Methylation Analysis of HLA-B Locus in Familial Behçet Syndrome
Eda Tahir Turanli¹, Pelinsu Koprulu², Serdal Ugurlu³, Hasan Yazici⁴ and Emire Seyahi³, ¹Molecular Biology and Genetics Department, Istanbul Technical University, Istanbul, Turkey, ²Molecular Biology Genetics and Biotechnology Program, Istanbul Technical University, Istanbul, Turkey, ³Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, ⁴Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: Our focus has been on the potential role of the epigenetic processes, mainly of the methylation, on the development of Beh�et syndrome (BS) using…
Abstract Number: 1248 • 2015 ACR/ARHP Annual Meeting
Discovery of Novel Serum Biomarkers for Osteoarthritis Using Affinity Proteomics
Lucía Lourido^1,2, Burcu Ayoglu³, Juan Fernández-Tajes⁴, Frauke Henjes³, Jochen M. Schwenk³, Cristina Ruiz-Romero^1,5, Peter Nilsson³ and Francisco J. Blanco², ¹Rheumatology Division. ProteoRed-ISCIII. Proteomic Group, Inibic- C. Hospitalario Universitario A Coruña, A Coruña, Spain, ²RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, ³Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden, Stockholm, Sweden, ⁴Wellcome Trust Centre For Human Genetics, McCarthy’s Group, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom, Oxford, England, ⁵CIBER-BBN Instituto de Salud Carlos III, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain
Background/Purpose: Osteoarthritis (OA) is the most common rheumatic disease. Despite active research in the OA biomarker field, no single protein is sufficiently reliable for its…
Abstract Number: 1249 • 2015 ACR/ARHP Annual Meeting
Differential Expression of SLE Susceptibility Genes By Interferon-Alpha and the HLA-DRB1*03:01 Haplotype in Ex Vivo B Cells
Carolina Duarte¹, Lora Boteva², Timothy Vyse¹ and Michelle Fernando¹, ¹Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ²MRC Human Genetics Unit, University of Edinburgh, Edinburgh, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex genetic autoimmune disease characterized by autoantibody production and up-regulation of type 1 interferons (IFNs). The strongest genetic association…
Abstract Number: 1250 • 2015 ACR/ARHP Annual Meeting
DNA Methylation and Its Relation to Immunological Phenotypes in Peripheral Blood: A Study of Anti-CCP Antibody Positivity from a Population-Based Pool
Sasha Bernatsky¹, Xiaojian Shao², Marie-Michelle Simon², Marvin J. Fritzler³, Philip Awadalla^4,5, Marie Hudson⁶, Ines Colmegna⁷, Tony Kwan² and Tomi Pastinen², ¹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²Department of Human Genetics, McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada, ³Medicine, University of Calgary, Calgary, AB, Canada, ⁴Medicine, Université de Montreal, Montreal, QC, Canada, ⁵Ontario Institute for Cancer Research, Toronto, ON, Canada, ⁶McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁷Rheumatology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: DNA methylation represents an important potential mediator of environmental influences on autoimmunity, including rheumatoid arthritis (RA). Genome-wide methylation in the context of clinical phenotypes…
Abstract Number: 1251 • 2015 ACR/ARHP Annual Meeting
Physiological Evidence for Diversification of the IFNα- or IFNβ-Mediated Response Programs in Different Autoimmune Diseases
Tamarah D. de Jong¹, Saskia Vosslamber¹, Elise Mantel¹, Sander de Ridder¹, John G. Wesseling¹, Tineke C.T.M. van der Pouw Kraan², Joep Killestein³, Ingrid E. Lundberg⁴, Jiri Vencovsky^5,6, Irene E.M. Bultink⁷, Alexandre E. Voskuyl⁸, Michiel Pegtel¹, Conny J. van der Laken⁹, Johannes W. Bijlsma⁸ and Cornelis L. Verweij¹, ¹Pathology, VU University medical center, Amsterdam, Netherlands, ²Molecular Cell Biology and Immunology, VU University medical center, Amsterdam, Netherlands, ³Neurology, VU University medical center, Amsterdam, Netherlands, ⁴Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology, Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁶Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁷Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, ⁸Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, ⁹Rheumatology, VU University medical center, Amsterdam, Netherlands
Background/Purpose: Presence of a type I interferon (IFN) signature is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM)…
Abstract Number: 1252 • 2015 ACR/ARHP Annual Meeting
Serum Biomarkers Associated with Disease Activity and Response to Ustekinumab in Patients with Ankylosing Spondylitis
Bidisha Dasgupta¹, Shannon Telesco², Joachim Sieper³ and Denis Poddubnyy⁴, ¹Janssen Research & Development, LLC., Spring House, PA, ²Janssen R & D, LLC, Spring House, PA, ³University Clinic Benjamin Franklin, Berlin, Germany, ⁴Rheumatology, Charité - Campus Benjamin Franklin, Berlin, Germany
Background/Purpose: A recent POC, open label trial (TOPAS)1 showed efficacy of ustekinumab (a monoclonal antibody against IL12 and IL23p40 in pts with active AS. To identify novel serum…
Abstract Number: 1253 • 2015 ACR/ARHP Annual Meeting
Identification and Validation of Novel Putative Salivary Proteomic Biomarkers in Sjögren’s Syndrome and Different Disease Subsets
Chiara Baldini¹, Daniela Martini¹, Nadia Ucciferri², Silvia Rocchiccioli², Letizia Mattii³, Antonietta Raffaella Maria Sabbatini³, Francesca Sernissi¹, Francesco Ferro¹, Nicoletta Luciano¹, Leonardo Lorenzini¹, Marta Mosca⁴, Stefano Bombardieri¹ and Antonella Cecchettini³, ¹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ²Institute of Clinical Physiology, Pisa, Italy, Pisa, Italy, ³Department of Clinical and Experimental Medicine, University of Pisa, Italy, Pisa, Italy, ⁴University of Pisa, Pisa, Italy
Background/Purpose: Salivary proteomics has recently appeared as a promising tool for the identification of novel diagnostic biomarkers for primary Sjögren’s syndrome (SS). However, to date…
Abstract Number: 1254 • 2015 ACR/ARHP Annual Meeting
Deciphering the Immunome of Clinically Effective Immune Tolerization in Rheumatoid Arthritis
Jing Yao Leong^1,2, Raymond Ong Jr.³, Juntao Li⁴, Theodorus van den Broek⁵, Roberto Spreafico⁴, Maura Rossetti¹ and Salvatore Albani^1,2, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁵Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA
Background/Purpose: We have previously described (Nature Medicine, PNAS, A&R, Nature Rheum, Lancet) how oral treatment with the pro-inflammatory, heat shock protein-derived dnaJP1 peptide induces detectable…
Abstract Number: 1255 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Patterns in CD4+ T Reveal Significant Contribution of DNA Methylation to Rheumatoid Arthritis
Shicheng Guo^1,2, Ting Jiang^1,2, Rongsheng Wang^1,2, Yi Shen^1,2, Xiao Zhu³, Fengmin Bai^1,2, Qin Ding^1,2, Guangjie Chen⁴ and Dongyi He^1,2, ¹Department of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, China, ²Arthritis Institute of integrated Traditional and Western medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China, ³Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Guangzhou, China, ⁴Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai, China
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Recent evidence showed more and more importance of the epigenetic…

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