Abstract Number: 1165 • 2015 ACR/ARHP Annual Meeting
Age-Dependent Effects of HLA-B27/β2m Expression on Host Immunity and the Intestinal Microbiota
Background/Purpose: The HLA-B27/β2m transgenic rat is a leading model of Anklylosing Spondylitis (AS) and other B27-associated spondyloarthopathies. The development of both bowel and joint inflammation…Abstract Number: 1166 • 2015 ACR/ARHP Annual Meeting
Expression and Function of Proviral Integration Site for Moloney Murine Leukemia Virus 1 (PIM-1) Kinase in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Background/Purpose: The Proviral Integration site of Moloney murine leukemia virus (PIM) kinases are important mediators of cell survival and considered as attractive targets in cancer…Abstract Number: 1167 • 2015 ACR/ARHP Annual Meeting
Treating Experimental Arthritis with Adenoviral Overexpression of IL-22 or with Blocking Antibodies Against Endogenous IL-22 Both Reduces Inflammation and Destruction
Background/Purpose: Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the…Abstract Number: 1168 • 2015 ACR/ARHP Annual Meeting
MiR125a-5p Mediates Angiogenic Mechanisms in Inflammatory Arthritis
Background/Purpose: MicroRNAs (miRNA) belong to a class of small, evolutionarily conserved, noncoding RNAs that function as post-transcriptional repressors of gene expression. An accumulating body of…Abstract Number: 1169 • 2015 ACR/ARHP Annual Meeting
Crossregulatory Mechanisms Between Synovial Fibroblasts and Macrophages Relevant in RA Pathogenesis
Background/Purpose: Macrophages and synovial fibroblasts function as key drivers of inflammation in rheumatoid arthritis (RA). We have developed a co-culture system that aims to define…Abstract Number: 1170 • 2015 ACR/ARHP Annual Meeting
The Alarmins S100A8/A9 Induce Canonical Wnt Signaling in Naïve Joints and Experimental OA
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we found increased expression of both the…Abstract Number: 1171 • 2015 ACR/ARHP Annual Meeting
Plasma Soluble ST2 Levels Are Independently Associated with Both Carotid Atherosclerosis and Compromised Cortical Volumetric Bone Mineral Density and Microstructure in Patients with Psoriatic Arthritis
Background/Purpose: Patients with PsA have both increased risk of subclinical atherosclerosis and lower cortical volumetric BMD (vBMD) compared with the general population, probably as a…Abstract Number: 1172 • 2015 ACR/ARHP Annual Meeting
Single Cell Sequencing of Non-Lesional Non-Sun Exposed Skin from SLE Patients with Proteinuria Supports Widespread Endothelial Activation
Background/Purpose: Given the widespread vasculopathy present in SLE, endothelial cell activation in the renal tubulointerstitium in lupus nephritis (LN) may be accompanied by similar activation…Abstract Number: 1173 • 2015 ACR/ARHP Annual Meeting
G Protein Coupled Receptor Kinase 3 Regulation of Inflammatory Arthritis
Background/Purpose: Chemokine receptors are G Protein Coupled Receptor (GPCR) family members that direct cell migration, differentiation, and survival in inflammatory conditions, but neutralization strategies…Abstract Number: 1174 • 2015 ACR/ARHP Annual Meeting
Class 3 Semaphorins Modulate the Invasive Capacity of Rheumatoid Arthritis Fibroblast-like Synoviocytes
Background/Purpose: The semaphorin family is a large group of proteins initially described as axon guidance molecules that play crucial roles in the development of the…Abstract Number: 1175 • 2015 ACR/ARHP Annual Meeting
Blood Outgrowth Endothelial Cells Isolated from Systemic Sclerosis Patients Exhibit a Pro-Inflammatory Phenotype
Background/Purpose: Vascular complications are a key pathological feature of systemic sclerosis (SSc) affecting the microcirculation and arterioles. Under normal circumstances the endothelium acts as a…Abstract Number: 1176 • 2015 ACR/ARHP Annual Meeting
Interleukin-37 Prevents New-Onset Joint Inflammation but Does Not Inhibit Existing Experimental Arthritis
Background/Purpose: Interleukin-37 (IL-37) is a recently identified cytokine with potent anti-inflammatory and immunosuppressive functions. This cytokine has been shown to be expressed in synovial tissue…Abstract Number: 1177 • 2015 ACR/ARHP Annual Meeting
Characterization of Different Phosphorylation Sites of Mcl-1 in Human Rheumatoid Arthritis Synovial Fibroblasts and Their Correlation with RA Pathogenesis
Background/Purpose: Myeloid cell leukemia (Mcl-1), a Bcl-2 family anti-apoptotic protein, is a critical determinant of rheumatoid arthritis synovial fibroblasts (RA-FLS) resistance to apoptosis. Phosphorylation of…Abstract Number: 1178 • 2015 ACR/ARHP Annual Meeting
Educational Impact of a Clinical Anatomy Workshop on 1st-Year Orthopedic and Rheumatology Fellows and a Comparison of Scores Between Specialties in Mexico
Background/Purpose: Office orthopedics, and community-based rheumatology overlap in the care of patients with regional pain syndromes. A thorough understanding of these syndromes requires proficiency in…Abstract Number: 1179 • 2015 ACR/ARHP Annual Meeting
An Evidence-Based Analysis and Revision of a Pediatric Rheumatology Academic Half-Day Program
Background/Purpose: The pediatric rheumatology (PR) academic half-day (AHD) is a weekly 2-hour block of protected time in our training program for trainees to discuss topics…
ACR Meeting Abstracts