Abstracts Archive - Page 1766 of 2425 - ACR Meeting Abstracts

Abstract Number: 1150 • 2015 ACR/ARHP Annual Meeting
Novel Chitosan Hydrogels for the Treatment of Osteoarthritis: Mechanical Support, Lubrication and Prevention of Cartilage Degradation in a Rabbit Model of Osteoarthritis
Yves Henrotin^1,2, Frédéric Oprenyeszk¹, Fanny Comblain³, Jean-Emile Dubuc⁴, Christelle Boileau⁵, Mickaël Chausson⁶, Renaud Lecler⁶, Guillem Rocasalbas⁶, Pierre Douette⁶ and Sandrine Gautier⁶, ¹Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium, ²Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium, ³University of Liège, Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium, ⁴Clinical University Saint Luc, Orthopaedic Department, Clinical University Saint Luc, Brussels, Belgium, ⁵Artialis S.A.,11 Avenue de l’Hôpital, Tour Giga+3, Liege, Belgium, ⁶Synolyne Pharma, rue Haute Claire 4, Herstal, Belgium
Background/Purpose: Chitosan, a glucosamine polysaccharide, is a good candidate for viscosupplementation in OA joints. Herein, we report the physico-chemical properties and the effects of an…
Abstract Number: 1151 • 2015 ACR/ARHP Annual Meeting
The Proteomic Profile of Histological Samples Derived from a Surgical Mouse Model of Osteoarthritis Reveals an Unexpected Mode of Action for the Anti-Aggrecanase-2 Monoclonal Antibody CRB0017
Gianfranco Caselli¹, Riccardo Chiusaroli², Michela Visintin³, Tiziana Piepoli², Ornella Letari², Adriana Grotti², Marco Lanza², Antonella De Palma⁴, Dario di Silvestre⁴, Pierluigi Mauri⁴ and Lucio Claudio Rovati², ¹Pharmacology & Toxicology, Rottapharm Biotech Srl, Monza, Italy, ²Rottapharm Biotech Srl, Monza, Italy, ³Rottapharm Biotech Srl, Trieste, Italy, ⁴Institute for Biomedical Technologies - CNR, Segrate, Italy
Background/Purpose : CRB0017 is a novel therapeutic monoclonal antibody that recognizes the spacer domain of aggrecanase-2, a key enzyme in the degradation of extracellular matrix…
Abstract Number: 1152 • 2015 ACR/ARHP Annual Meeting
Comprehensive Novel Proteomic Analysis of RA Synovial Fluid Highlights the Distinct Protein Profiles of Bone and Cartilage Metabolism
Yasushi Kondo¹, Katsuya Suzuki¹, Masaru Takeshita², Yoshiaki Kassai³, Keiko Koga³, Yuumi Gotou⁴, Takahiro Miyazaki³, Rimpei Morita⁵, Yasuo Niki⁶, Atsuko Murota¹, Ayumi Nishikawa¹, Hironari Hanaoka¹, Yuko Kaneko⁷, Hidekata Yasuoka⁷, Kunihiro Yamaoka¹, Akihiko Yoshimura⁵ and Tsutomu Takeuchi⁸, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, ⁴Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, ⁵Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan, ⁶Department of Orthopaedic Surgery, Keio University, Tokyo, Japan, ⁷Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ⁸Dept. of Internal Medicine, School of Medicine Keio University, Tokyo, Japan
Background/Purpose: Growing interest has arisen in the search for specific pathophysiology and biomarker for rheumatoid arthritis (RA) utilizing synovial fluid (SF) proteomic analysis. However the…
Abstract Number: 1153 • 2015 ACR/ARHP Annual Meeting
Colonic Intraepithelial Lymphocytes Produce IL-6 in Response to Resident Bacteria to Modulate Epithelial Barrier Function
Gaurav Mehta¹, Emilie H. Regner², Neha Ohri², Sean P. Colgan² and Kristine A. Kuhn², ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Dysbiosis of colon bacteria has emerged as a likely contributor to diseases such as rheumatoid arthritis and spondyloarthropathies. Interactions between the microbiota and distal…
Abstract Number: 1154 • 2015 ACR/ARHP Annual Meeting
Ajulemic Acid Is a Novel Cannabinoid That Suppresses the Secretion of TNF-α and IFN-α from the Peripheral Blood Mononuclear Cells of DM Patients In Vitro
Paul Alves^1,2, Elizabeth Robinson^1,2, Muhammad Bashir^1,3, Rui Feng⁴ and Victoria P. Werth^1,2, ¹Dermatology, Veterans Affairs Medical Center, Philadelphia, PA, ²Dermatology, University of Pennsylvania, Philadelphia, PA, ³Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ⁴Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: DM is an autoimmune disease with cutaneous symptoms often accompanied by inflammatory muscle and/or lung disease. Current therapies for DM are often toxic and…
Abstract Number: 1155 • 2015 ACR/ARHP Annual Meeting
Free Fatty Acids Promote Inflammation in Bone of Rheumatic Patients Via Osteoblast
Klaus W. Frommer¹, Andreas Schäffler², Uwe Lange^1,3, Stefan Rehart⁴, Jürgen Steinmeyer^5,6, Markus Rickert⁷, Ulf Müller-Ladner^1,8 and Elena Neumann¹, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Bad Nauheim, Germany, ³Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁵Experimental Orthopedics, Justus-Liebig-University of Giessen, Giessen, Germany, ⁶Dept Orthopedics and Experimental Orthopedics, University Hospital of Giessen and Marburg, Giessen, Germany, ⁷Dept of Orthopedics and Orthopedic Surgery, University Hospital of Giessen and Marburg, Gießen, Germany, ⁸Internal Medicine/Rheumatology, Justus-Liebig-University of Giessen, Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: A pathophysiological link of free fatty acids (FFA) to inflammation is supported by the observation that chronically elevated serum FFA levels as found in…
Abstract Number: 1156 • 2015 ACR/ARHP Annual Meeting
Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis
MIN-YOUNG JUNG¹, Hae-Rim Kim², HYUN-SOOK KIM³, HO-YOUN KIM¹ and Sang Heon Lee⁴, ¹Konkuk university hospital, Seoul, South Korea, ²Division of Rheumatology, Konkuk University School of Medicine, Seoul, South Korea, ³Soonchenhyang university school of medicine, Seoul, South Korea, ⁴Konkuk University Hospital, Seoul, South Korea
Background/Purpose: This study aimed to determine the regulatory effect of Th17 cytokines on osteoclastogenesis in rheumatoid arthritis (RA). Methods: The expression of interleukin (IL)-17 and…
Abstract Number: 1157 • 2015 ACR/ARHP Annual Meeting
Specific Profile of Serum Free Fatty Acids Is Found in Rheumatoid Arthritis Patients
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Patricia López¹, Javier Ballina-García² and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain
Background/Purpose: Lipidomics is an emerging field in biomedical research. Free Fatty Acids (FFA) are important mediators of the lipid metabolism which can play a role…
Abstract Number: 1158 • 2015 ACR/ARHP Annual Meeting
Active Non-Canonical NF-Kappab Signaling in Microvessels of Atherosclerotic Lesions in Coronary Arteries Is Associated with Inflammatory Cell Infiltration and Myocardial Infarction
Chrissta X. Maracle¹, Rabia Agca², Boy Helder¹, Hans W. Niessen³, Mike T. Nurmohamed² and Sander W. Tas⁴, ¹Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center, Amsterdam, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands, ³Pathology, VU University Medical Center, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Patients with chronic inflammatory diseases (CID) have higher risk of developing cardiovascular disease which may be in part due to increased systemic inflammatory burden.…
Abstract Number: 1159 • 2015 ACR/ARHP Annual Meeting
Transcription Factor SOX5 Promotes Rheumatoid Arthritis Synovial Fibroblast Migration and Invasion By Regulating MMP9 Expression
Wenfeng Tan¹, Yumeng Shi², Xiaoke Feng², Fang Wang², Xiaoxi Wang², Qiuyue Peng², Wenhua Xuan² and zhang miaojia³, ¹Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³the First Affiliated Hospitial of Nanjing Medical University, Nanjing, China
Background/Purpose: SOX5 is known as a transcription factor which primarily involved in in the regulation of embryonic development, cell fate, and chondrogenesis. To date, little…
Abstract Number: 1160 • 2015 ACR/ARHP Annual Meeting
DNA Hydroxylmethylation Regulates Pro-Inflammatory Cytokine Expression in Macrophages
Fangfang Sun^1,2, Renate E. Gay¹, Beat A. Michel¹, Shuang Ye², Steffen Gay¹, Michel Neidhart¹ and Emmanuel Karouzakis¹, ¹University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ²Department of Rheumatology, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China
Background/Purpose: Activated macrophages are found in the inflamed and hyperplasic synovial RA tissues. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
Abstract Number: 1161 • 2015 ACR/ARHP Annual Meeting
Synovial Th9 Cells Prolong Neutrophil Survival and Functionally Enhance the Infiltrating T Cells in Rheumatoid Arthritis
Dipendra Kumar Mitra¹ and Kaustav Chowdhury², ¹Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Delhi, India, ²TRANSPLANT IMMUNOLOGY AND IMMUNOGENETICS, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, India
Background/Purpose: Th-9 cells are distinct T cell subset secreting IL-9 and associated with allergic and parasitic diseases and produced by Th9 cells. Contribution of these…
Abstract Number: 1162 • 2015 ACR/ARHP Annual Meeting
IL37 Reduces Pro-Inflammatory Cytokine and Catabolic Enzyme Production in Human Chondrocytes: A Protective Role in Osteoarthritis?
Ellen van Geffen¹, Arjan van Caam², Elly Vitters², Henk van Beuningen², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is the most common joint disease, primarily characterized by progressive articular cartilage degradation. Cartilage destruction is assumed to be mediated by pro-inflammatory…
Abstract Number: 1163 • 2015 ACR/ARHP Annual Meeting
Dynamic Regulation of Enhancers and Super-Enhancers in Rheumatoid Arthritis Synovial Finroblasts
Sung-Ho Park¹, Christopher Sohn¹, Konstantinos Loupasakis², Angela Lee³, Eugenia Giannopoulou¹, Lionel B. Ivashkiv³ and George D. Kalliolias¹, ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ³Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Enhancers are regulatory elements that modulate transcriptional rates of genes. Super-enhancers (SupE) are extremely large enhancers associated primarily with highly expressed genes that have…
Abstract Number: 1164 • 2015 ACR/ARHP Annual Meeting
Four Types of Calcium Pyrophosphate Crystals Differentially Induce IL-1beta Production By Monocytes through ATP/Potassium Efflux/ROS Dependent Pathways
Laure Campillo-Gimenez¹, Pierre Gras², Félix Renaudin³, Marion Renaud³, Lorène Télot⁴, Amine Mellouk⁵, Pierre Bobé⁵, Jean-Michel Camadro⁴, Christèle Combes², Martine Cohen-Solal^3,6, Frederic Liote^3,6 and Hang-Korng Ea^3,6, ¹Hôpital Lariboisière, Centre Viggo Petersen, INSERM UMR1132, Paris Diderot University, Paris, France, ²ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ³INSERM UMR1132, Paris Diderot University, Paris, France, ⁴CNRS UMR7592, Jacques Monod Institute, Paris Diderot University, Paris, France, ⁵INSERM UMRS757, Paris Sud University, Orsay, France, ⁶AP-HP, Lariboisière Hospital, Rheumatology Department, Paris, France
Background/Purpose: Monoclinic and triclinic calcium pyrophosphate (m- and t-CPP) crystals are the 2 types of CPP crystals observed in human joints. Frequently asymptomatic, it can…

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