Abstracts Archive - Page 1759 of 2607 - ACR Meeting Abstracts

Abstract Number: 2402 • 2016 ACR/ARHP Annual Meeting
Predictive Value of the History and Labs in Distinguishing Inflammatory from Non-Inflammatory and Mechanical Joint Pain
Sonora Williams¹, Tracy R. Andrews², Yukiko Kimura³, Jennifer E. Weiss⁴, Suzanne C. Li⁵, Kathleen Haines⁶, Maddalena Allegretta⁷, Alisha Valdez⁷ and Ginger Janow⁸, ¹University of Florida, Gainesville, FL, ²Biostatistics, David & Alice Jurist Institute, Hackensack University Medical Center, hackensack, NJ, ³Pediatric Rheumatology, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁴Hackensack Univ Med Ctr, Hackensack, NJ, ⁵Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ⁶Department of Pediatrics, Hackensack University Medical Center, Hackensack, NJ, ⁷Rutgers New Jersey Medical School, Newark, NJ, ⁸Pediatric Rheumatology, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ
Predictive Value of the History and Labs in Distinguishing Inflammatory from Non-Inflammatory and Mechanical Joint Pain Background/Purpose: Joint pain is one of the most common…
Abstract Number: 2403 • 2016 ACR/ARHP Annual Meeting
Sleep Disruption in Children with Chronic Pain
Cara Hoffart¹, Santana Fortney² and Dustin Wallace³, ¹Rheumatology and Pain Management, Children's Mercy Hospital, Kansas City, MO, ²Children's Mercy Hospital, Kansas City, MO, ³Integrative Pain Management and Developmental and Behavioral, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Sleep disorders and fatigue are common in children with chronic pain syndromes, and contributes to psychosocial dysfunction, healthcare utilization, and school absences. We hypothesize…
Abstract Number: 2404 • 2016 ACR/ARHP Annual Meeting
Prevalence of Subclinical Entheseal Involvement in Children and Adolescents with Type 1 Diabetes: A Case Control Study
Alberto Batticciotto¹, Andrea Scaramuzza², Matteo Ferrari³, Maria Chiara Ditto⁴, Maria Chiara Gerardi⁴, Fabiola Atzeni¹ and Piercarlo Sarzi-Puttini⁴, ¹Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, ²Department of Pediatrics, University of Milan, Milano, Italy, ³Department of Pediatrics, University of Milan, Milan, Italy, ⁴Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milan, Italy
Background/Purpose: The clinical course of type one diabetes (T1D) is frequently complicated by musculoskeletal manifestations such as Dupuytren’s disease, trigger finger, shoulder adhesive capsulitis and…
Abstract Number: 2405 • 2016 ACR/ARHP Annual Meeting
Musculoskeletal Manifestations As Presenting Symptoms of Inflammatory Bowel Disease in Children and Adolescents
Rachel Levy¹, Gil Amarilyo^2,3, Jacob Amir⁴, Rotem Tal^2,3, Amit Assa^3,5, Firas Rinawi⁵ and Liora Harel^2,3, ¹The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel, ²Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel, ³Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel, ⁴Mayanei Hayeshua Medical Center, Bnei Brak, Israel, ⁵Institute of Gastroenterology Hepatology and Liver diseases, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
Background/Purpose: Extra intestinal manifestations occur in 40-50% of patients with inflammatory bowel disease (IBD), with musculoskeletal involvement in 25%. Data regarding musculoskeletal manifestations in…
Abstract Number: 2406 • 2016 ACR/ARHP Annual Meeting
Mental Health Care for Adolescents with Rheumatologic Conditions: Perspectives from Pediatric Behavioral Health Providers in North America
Andrea Knight¹, Michelle Vickery², Eyal Muscal³, Alaina Davis⁴, Julia Harris⁵, Aimee O. Hersh⁶, Martha Rodriguez⁷, Karen Onel⁸, Laura Schanberg⁹, Tamar Rubinstein¹⁰, Beth S. Gottlieb¹¹, Nina Washington¹², Elissa Weitzman^13,14 and Emily Von Scheven¹⁵, ¹Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ³Immunology, allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁴Pediatric Rheumatology, Monroe Carell Junior Children's Hospital at Vanderbilt, Nashville, TN, ⁵Children's Mercy Kansas City, Kansas City, MO, ⁶Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, ⁷Pediatrics, University of Chicago Medical Center, Chicago, IL, ⁸Division of Pediatric Rheumatology, University of Chicago, Chicago, IL, ⁹Pediatrics, Duke Medical Center, Durham, NC, ¹⁰Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, ¹¹Pediatric Rheumatology, The Steven and Alexandra Cohen Children's Medical Center of New York, The Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, ¹²Dept. of Pediatric Rheumatology, University of Mississippi Medical Center, Jackson, MS, ¹³Boston Children's Hospital, Boston, MA, ¹⁴Harvard Medical School, Boston, MA, ¹⁵Dept of Pediatric Rheumatology, Univ of California San Francisco, San Francisco, CA
Mental Health Care for Adolescents with Rheumatologic Conditions: Perspectives from Pediatric Behavioral Health Providers in North America Andrea Knight1, Michelle Vickery1, Natalie Stollon1, Eyal Muscal2,…
Abstract Number: 2407 • 2016 ACR/ARHP Annual Meeting
The Descriptive Epidemiology of Acute Rheumatic Fever and Post-Streptococcal Reactive Arthritis in Japan
Satoshi Sato, Yoji Uejima, Eisuke Suganuma, Tadamasa Takano and Yutaka Kawano, Division of Infectious Diseases and Immunology, Saitama Children's Medical Center, Saitama, Japan
Background/Purpose: Acute Rheumatic Fever (ARF) and Post-streptococcal reactive arthritis (PSRA) are well known as post-streptococcal syndromes with arthritis in children. ARF have been declining in…
Abstract Number: 2408 • 2016 ACR/ARHP Annual Meeting
Severe Juvenile Arthritis Associated with a De Novo Gain-of-Function Germline Mutation in MYD88
Keith A. Sikora¹, Joshua R. Bennett¹, Zuoming Deng², Wanxia Li Tsai³, April Brundidge³, Fatemeh Navid³, Gerlinde Layh-Schmitt³, Eric Hanson³, Massimo G. Gadina⁴, Louis M. Staudt⁵, Thomas A. Griffin⁶ and Robert A. Colbert³, ¹Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Biodata Mining & Discovery, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁵National Cancer Institute, National Institutes of Health, Bethesda, MD, ⁶Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC
Background/Purpose: Myeloid differentiation primary response 88 (MyD88) is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-κB. Germline loss-of-function…
Abstract Number: 2409 • 2016 ACR/ARHP Annual Meeting
Genetic Insights into Juvenile Idiopathic Arthritis Derived from Deep Whole Genome Sequencing
James Jarvis¹, Lai Ping Wong² and Kaiyu Jiang², ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY
Background/Purpose: Deep whole genome sequencing (WGS) provides an unprecedented opportunity to comprehensively study genetic landscapes at finer resolution than can be achieved with chip-based methods.…
Abstract Number: 2410 • 2016 ACR/ARHP Annual Meeting
Genetic Architecture of Systemic Juvenile Idiopathic Arthritis Distinguishes It from Oligoarticular and Polyarticular Forms of Juvenile Idiopathic Arthritis
Michael J. Ombrello¹, Victoria Arthur¹, Elaine F. Remmers², Anne Hinks³, Alexei Grom⁴, Dirk Föll⁵, Alberto Martini⁶, Marco Gattorno⁷, Seza Ozen⁸, Sampath Prahalad⁹, Andrew Zeft¹⁰, John F. Bohnsack¹¹, Norman Ilowite¹², Ricardo Russo¹³, Elizabeth D. Mellins¹⁴, Claudio A. Len¹⁵, Maria Odete E. Hilário¹⁶, Sheila Oliveira¹⁷, Rae S.M. Yeung¹⁸, Alan Rosenberg¹⁹, Lucy R. Wedderburn²⁰, Jordi Anton²¹, Johannes Peter Haas²², Angela Rösen-Wolff²³, Klaus Tenbrock²⁴, Susan D Thompson²⁵, Daniel L. Kastner²⁶, Patricia Woo²⁷, Wendy Thomson²⁸ and International Childhood Arthritis Genetics (INCHARGE) Consortium, ¹Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ²National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵University of Muenster, Muenster, Germany, ⁶Istituto Giannina Gaslini, Genoa, Italy, ⁷UO Pediatria 2, Istituto Giannina Gaslini, Genova, Italy, ⁸Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁹Pediatric Rheumatology, Emory University School of Medicine, Atlanta, GA, ¹⁰Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ¹¹Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT, ¹²Rheumatology, Children's Hospital Montefiore, Bronx, NY, ¹³Hospital de Pediatria Garrahan, Buenos Aires, Argentina, ¹⁴Dept of Pediatrics CCSR, Stanford University Med Ctr, Stanford, CA, ¹⁵Pediatrics, Universidade Federal de São Paulo, São Paulo,, Brazil, ¹⁶Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati, OH, ¹⁷Pediatric Rheumatology, Universidade F Rio De Janeiro, Rio De Janeiro, Brazil, ¹⁸Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁹Pediatrics, Pediatrics, Saskatoon, SK, Canada, ²⁰Institute of Child Health, UCL, London, United Kingdom, ²¹Unitat de Reumatologia Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain, ²²German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ²³Children's Hospital Dresden, Dresden, Germany, ²⁴University Aachen, Aachen, Germany, ²⁵Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ²⁶Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²⁷Great Ormond Street Hospital, University College London Medical School, London, United Kingdom, ²⁸Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom
Background/Purpose: JIA is a heterogeneous group of conditions that are unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA)…
Abstract Number: 2411 • 2016 ACR/ARHP Annual Meeting
Multiple Genetic Susceptibility Loci in Juvenile Idiopathic Arthritis Are Bound By a Set of Transcription Factors
Leah C. Kottyan¹, Halima Moncrieffe², Xiaoting Chen³, Mario Pujato⁴, John B. Harley⁵, Matthew Weirauch⁶ and Susan D. Thompson⁷, ¹3333 Burnet Ave., Cincinnati, Cincinnati, OH, ²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Childrens Hospital, Cincinnati, OH, ⁴1Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center; University of Cincinnati, Cincinnati, OH, ⁵Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ⁶Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Genome wide association studies (GWASs) and dense genotyping of immune-related disease regions have identified 17 loci associated with juvenile idiopathic arthritis (JIA) (p<5×10-8), 11…
Abstract Number: 2412 • 2016 ACR/ARHP Annual Meeting
Human Gut Microbial Species Correlate with Arthritis in the K/BxN Mouse Model
Matthew L. Stoll¹, Pamela F. Weiss², Jennifer E. Weiss³, Randy Q. Cron¹, Charles O. Elson⁴, Casey D Morrow⁵, Elliot J. Lefkowitz⁶ and Trenton R. Schoeb⁷, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ³Hackensack Univ Med Ctr, Hackensack, NJ, ⁴Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ⁶Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁷Genetics and Comparative Pathology Laboratory, University of Alabama at Birmingham, Birmingham, AL
Title: Human gut microbial species correlate with arthritis in the K/BxN mouse model Background/Purpose: Studies have identified abnormalities in the microbiota of patients with…
Abstract Number: 2413 • 2016 ACR/ARHP Annual Meeting
Inflammation Regulating microRNAs, Mir-146b, Mir-155 and Mir-192-5p Are Altered in Plasma and Synovial Fluid of Oligoarticular Juvenile Idiopathic Arthritis
Beata Derfalvi^1,2,3, Sarah Roberts⁴, Breanna Hargreaves⁴ and Sarah McAlpine⁴, ¹Pediatrics, Dalhousie University, Halifax, NS, Canada, ²IWK Health Centre, Halifax, NS, Canada, ³2nd. Dept. of Pediatrics, Semmelweis University, Budapest, Hungary, ⁴Dalhousie University, Halifax, NS, Canada
Background/Purpose: MicroRNAs (miRNAs) modulate gene expression by inhibiting the translation of targeted mRNAs and causing mRNA degradation in a transcript-specific manner. Several miRNAs have been reported…
Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
Abstract Number: 2415 • 2016 ACR/ARHP Annual Meeting
Next Generation Sequencing Analysis of Familial Haemophagocytic Lymphohistiocytosis (HLH) Related Genes in Macrophage Activation Syndrome (MAS) and Secondary HLH (secHLH)
Chiara Passarelli¹, Manuela Pardeo², Elisa Pisaneschi¹, Antonio Novelli¹, Fabrizio De Benedetti² and Claudia Bracaglia², ¹Ospedale Pediatrico Bambino Gesù IRCCS, Unit of Medical Genetics, Laboratory of Cytogenetics and Molecular Genetics, Rome, Italy, ²Division of Rheumatology, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy, Rome, Italy
Background/Purpose: Macrophage activation syndrome (MAS) is a severe complication of rheumatic disease, particularly of systemic JIA (sJIA). It is currently classified among the secondary forms…
Abstract Number: 2416 • 2016 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Peptides in Patients with Juvenile Idiopathic Arthritis and Rheumatoid Arthritis: Shared Expression of the Inherently Autoreactive 9G4 Idiotype
Hannah Peckham¹, Lauren Bourke¹, Anna Radziszewska¹, Maria J. Leandro², Debajit Sen¹, Geraldine Cambridge² and Yiannis Ioannou¹, ¹Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Rheumatoid factor (RF) positive polyarticular JIA (RF+ve pJIA) frequently progresses into adulthood with a clinical phenotype that ressembles rheumatoid arthritis (RA). Antibodies to cyclic…

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