Abstracts Archive - Page 1751 of 2607 - ACR Meeting Abstracts

Abstract Number: 2281 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate (MSU) Crystals Induces Cartilage Degeneration By Accelerating Hypertrophy and Mineralization.
Nicole Yang¹, Anthony M. Reginato² and Changqi Sun³, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ²Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Previous studies have shown that abnormal loads induce meniscus cell damage and matrix degradation both in-vivo and in-vitro1,2. Monosodium urate (MSU) crystal is considered…
Abstract Number: 2282 • 2016 ACR/ARHP Annual Meeting
Ferritin Levels Are Associated with Urate and Gout – a Role for Iron Metabolism in Gout ?
Tahzeeb Fatima¹, Tony R. Merriman², Lisa K. Stamp³, Nicola Dalbeth⁴, Cory Iverson⁵ and Jeffrey N. Miner⁶, ¹University of Otago, Dunedin, New Zealand, ²Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵Ardea Biosciences, Inc., San Diego, CA, ⁶Discovery Biology, Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: Transferrin and its cell-surface receptor regulate iron uptake and ferritin sequesters free iron and acts as a store for excess iron. Ferritin has been…
Abstract Number: 2283 • 2016 ACR/ARHP Annual Meeting
Suppression of Monosodium Urate (MSU) Crystals-Induced Inflammatory Response By Inhibiting TGF-β Activated Kinase 1 (TAK1)
Anil Singh¹, Kayla O’Sullivan², Mukesh Chourasia³, Sadiq Umar⁴, Mahamudul Haque², Bhanupriya Madarampalli² and Salahuddin Ahmed², ¹Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Department of Pharmaceutical Science, Washington State University, College of Pharmacy, Spokane, WA
Background/Purpose: Methods: Results: Conclusion:
Abstract Number: 2284 • 2016 ACR/ARHP Annual Meeting
Differential Effect of MSU-Crystal Induced Inflammation on Macrophage Polarization
Rashid Ahmed¹, Nicole Yang², Changqi Sun³ and Anthony M. Reginato³, ¹Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ³Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI
Background/Purpose: Gouty arthritis is a common inflammatory joint disease that arises in response to the deposition of monosodium urate (MSU) crystals in soft joints, periarticular…
Abstract Number: 2285 • 2016 ACR/ARHP Annual Meeting
12/15-Lipoxygenase Inhibition By ML351 Protects Against Uric Acid Crystal-Induced Acute Arthritis in Mice
Roxana Coras¹, Alex Stubelius², Oswald Quehenberger³ and Monica Guma¹, ¹Medicine, UCSD, La Jolla, CA, ²Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA, ³Pharmacology, UCSD, La Jolla, CA
Background/Purpose: Treatment of acute gout involves the use of NSAIDs, colchicine or corticosteroids. Unfortunately, co-morbid conditions such as chronic kidney disease, peptic ulcer disease and…
Abstract Number: 2286 • 2016 ACR/ARHP Annual Meeting
Bioresponsive Glucocorticoid-Loaded Microparticles to Prevent Acute Gout Flares
Alex Stubelius¹, Wangzhong Sheng², Sangeun Lee¹, Adah Almutairi³ and Monica Guma⁴, ¹Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA, ²1Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, CA, ³Skaggs School of Pharmacy and Pharmaceutical Sciences., UCSD, La Jolla, CA, ⁴Medicine, UCSD, La Jolla, CA
Background/Purpose: Gout is a common and very painful form of arthritis triggered by deposits of monosodium urate (MSU) crystals in the joints. Lifestyle factors such…
Abstract Number: 2287 • 2016 ACR/ARHP Annual Meeting
Serum Urate and Its Association with Endothelial Dysfunction in Young Adults
Michael B. Saddekni¹, Kenneth G. Saag¹, Tanja Dudenbostel², Suzanne Oparil², David A. Calhoun², Daniel I. Feig³, Paul M. Muntner⁴, David T. Redden⁵, Phillip J. Foster¹, Elizabeth J. Rahn¹, Stephanie R. Biggers¹, Peng Li⁵ and Angelo L. Gaffo¹, ¹Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, ³Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Both serum urate (sUA) and endothelial dysfunction have been associated with hypertension and cardiovascular disease. Increasing sUA level has been associated with endothelial dysfunction…
Abstract Number: 2288 • 2016 ACR/ARHP Annual Meeting
Inflammatory Status and Serum Uric Acid Determine High-Density Lipoprotein Cholesterol Levels in a Non-Rheumatic Population
Mariano Andrés¹, María Amparo Quintanilla², Eliseo Pascual³, Pedro Morillas² and FAPRES study group, ¹Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ²Servicio de Cardiología, Hospital General Universitario de Elche, Elche, Spain, ³Departamento de Medicina Clínica, Emeritus Professor, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: In inflammatory disorders, highest incidence of cardiovascular (CV) events paradoxically occurs at lower lipid levels [ARD.70:482], especially for high-density lipoprotein cholesterol (HDLc). Current data…
Abstract Number: 2289 • 2016 ACR/ARHP Annual Meeting
Obesity and Echocardiographic Changes in the Different Stages of Gout
Rada Gancheva¹, Atanas Kundurdjiev², Mariana Ivanova¹, Todor Kundurzhiev³ and Zlatimir Kolarov¹, ¹Medical Faculty, Medical University, University Hospital "St. Iv. Rilski", Clinic of Rheumatology, Sofia, Bulgaria, ²Medical Faculty, Medical University, University Hospital "St. Iv. Rilski", Clinic of Nephrology, Sofia, Bulgaria, ³Medical University, Faculty of Public Health, Sofia, Bulgaria
Background/Purpose: Studies on gout and its stages as a cardiovascular (CV) risk factor are few and with contradictory results. We compared echocardiographic parameters, known as…
Abstract Number: 2290 • 2016 ACR/ARHP Annual Meeting
Crystal-Proven Gout and Disease Severity Factors Influencing the Prevalence of Cardiovascular Diseases
I.J.M. Disveld^1,2, J. Fransen³, L.B.E. Kienhorst⁴, H.J.E.M. Janssens⁵, S. Zoakman¹, A.J.W. Branten¹, C.M.A. de Gendt¹, A.J.L. de Jong⁶, H. Visser⁷ and M. Janssen¹, ¹Department of Rheumatology, Rijnstate Hospital Arnhem, Arnhem, Netherlands, ²Radboudumc Nijmegen, Nijmegen, Netherlands, ³Department of Rheumatolgy, Radboudumc Nijmegen, Nijmegen, Netherlands, ⁴UMC Utrecht, Utrecht, Netherlands, ⁵Rijnstate Hospital Arnhem, Arnhem, Netherlands, ⁶Department of Rheumatology, Rijnstate Arnhem, Arnhem, Netherlands, ⁷Department of Rheumatolgy, Rijnstate Hospital Arnhem, Arnhem, Netherlands
Background/Purpose: Gout is a health disorder affecting many patients worldwide. Clinical gout studies showed a high prevalence of cardiovascular diseases (CVD), raising the question whether…
Abstract Number: 2291 • 2016 ACR/ARHP Annual Meeting
Impact of Plasma Urate and Tophaceous Burden on Inflammatory Biomarkers of Cardiovascular Disease
John FitzGerald¹, Benjamin D. Levine², Jennifer Raymond³ and Maureen A. McMahon¹, ¹Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Gout and hyperuricemia have been associated with cardiovascular disease. Studies have documented the impact of serum urate levels on hypertension and that increased urate…
Abstract Number: 2292 • 2016 ACR/ARHP Annual Meeting
Decreased Endothelial and Smooth Muscle Responsiveness in the Vasculature of Gout Patients Compared with Healthy Controls: Relationship Between Flow- and Nitrate-Mediated Dilation, Serum Urate and CRP
Aaron Garza Romero¹, Stuart Katz², Virginia Pike³, Daisy Bang¹, Binita Shah⁴, Talia Igel^1,5, Bruce Cronstein⁶, Irina Dektiarev², Jonathan Samuels⁷, Michael H. Pillinger⁸ and Svetlana Krasnokutsky Samuels⁹, ¹Medicine/Rheumatology, NYU School of Medicine, New York, NY, ²Medicine/Cardiology, NYU School of Medicine, New York, NY, ³Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁴NYU School of Medicine, Division of Cardiology, New York, NY, ⁵Monash University School of Medicine, Melbourne, Australia, ⁶Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ⁷Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁸NYU School of Medicine, New York, NY, ⁹Svetlana Krasnokutsky, NYU Hospital for Joint Diseases, New York, NY
Background/Purpose: Gout is an independent risk factor for cardiovascular disease (CVD). Investigators studying the relationship between gout and CVD have focused on acute coronary outcomes,…
Abstract Number: 2293 • 2016 ACR/ARHP Annual Meeting
Cardiometabolic Risk and Subclinical Urate Deposits in Patients with Symptomatic Hyperuricemia and Metabolic Syndrome
Seoyoung C. Kim¹, Rajesh Garg², Stacy Smith³, Alyssa Wohlfahrt⁴, Anarosa Campos⁵, Kathleen Vanni⁴, Lauren K Lee⁶, Penny Wang⁶, Zhi Yu⁷, Marcelo Di Carli⁸ and Daniel H. Solomon⁹, ¹Rheumatology, Immunology and Allergy; Pharmacoepidemiologyand Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ²Endocrinology, Brigham & Women's Hospital, Boston, MA, ³Radiology/Division of Musculoskeletal Imaging & Intervention, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁴Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital, Boston, MA, ⁷Rheumatology Immunology & Allergy, Brigham and Women's Hospital, Boston, MA, ⁸Div. of Nuclear Medicine, Brigham and Women's Hospital, Boston, MA, ⁹Division of Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Elevated serum uric acid (sUA) levels, with and without gout, are associated with systemic inflammation, coronary artery disease (CAD), chronic kidney disease, and diabetes.…
Abstract Number: 2294 • 2016 ACR/ARHP Annual Meeting
Uric Acid Production and Blood Pressure: The Role of Uric Acid Concentration As Well As Uric Acid Production
Lieke E.J.M. Scheepers^1,2, A. Boonen^1,2, P.C. Dagnelie^2,3,4, M.T. Schram^3,5, C.J.H, van der Kallen^3,5, R.M.A. Henry^3,5, A.A. Kroon^3,5, C.D.A. Stehouwer^3,6 and I.C.W. Arts^3,4,7, ¹Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Centre+, Maastricht, The Netherlands, Maastricht, Netherlands, ²CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands, Maastricht, Netherlands, ³CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands, Maastricht, Netherlands, ⁴Department of Epidemiology, Maastricht University, Maastricht, The Netherlands, Maastricht, Netherlands, ⁵Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands, Maastricht, Netherlands, ⁶Internal Medicine, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands, Maastricht, Netherlands, ⁷MaCSBio Maastricht Centre for Systems Biology, Maastricht University, Maastricht, Netherlands
Background/Purpose: Blood pressure and hypertension are associated with uric acid, the end product of purine catabolism, but the underlying mechanism remainds unclear. During the final…
Abstract Number: 2295 • 2016 ACR/ARHP Annual Meeting
A Non-Linear Relationship Between Physical Activity and Serum Uric Acid Concentrations: Nhanes 2003-2004
Nicholas Holdgate¹, Carl Pieper^2,3, Tony Ning⁴, William E. Kraus^5,6 and Kim Huffman^1,5, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, ³Biostatistics and Bioinformatics, Duke Pepper Center, Durham, NC, ⁴Triangle Orthopedic Associates, Durham, NC, ⁵Duke Pepper Center, Durham, NC, ⁶Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Hyperuricemia is a known cardio-metabolic risk factor as well as risk factor for gout. Physical activity has been found to improve many other cardio-metabolic…

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