Abstracts Archive - Page 1749 of 2607 - ACR Meeting Abstracts

Abstract Number: 2251 • 2016 ACR/ARHP Annual Meeting
Secukinumab Vs Adalimumab for the Treatment of Ankylosing Spondylitis: A Cost per Responder Analysis at 52 Weeks from the US Perspective
Jessica Walsh¹, Efthalia Nikoglou², Gunda Praveen³, Yujin Park⁴ and Steffen Jugl⁵, ¹University of Utah School of Medicine, Salt Lake City, UT, ²Novartis Ireland, Ltd, Dublin, Ireland, ³Novartis Healthcare Pvt. Ltd., Hyderabad, India, Hyderabad, India, ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁵Novartis Pharma AG, Basel, Switzerland
Secukinumab vs adalimumab for the treatment of ankylosing spondylitis: A cost per responder analysis at 52 weeks from the US perspectiveJessica Walsh1, Efthalia Nikoglou2, Praveen…
Abstract Number: 2252 • 2016 ACR/ARHP Annual Meeting
Estimated Cost of SLE Hospitalizations
Kayla Neville¹, James Miceli¹, Jianhua Li², Samantha Nguyen³, Teja Kapoor³ and Anca Askanase³, ¹Rheumatology, Columbia University Medical Center, New York, NY, ²Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, ³Medicine, Division of Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: Systemic lupus erythematosus (SLE) treatment comes at a high price, with both direct costs related to healthcare resource utilization and indirect ones related to…
Abstract Number: 2253 • 2016 ACR/ARHP Annual Meeting
Treatment Persistence with Subcutaneous TNF-Alpha Inhibitors in France
Manon Belhassen¹, Christophe Hudry², Marie-Christine Woronoff³, Liliane Lamezec⁴, Najat Gouyette⁴, Marine Ginoux¹, Eric Van Ganse¹, Florence Tubach⁵ and Bruno Fautrel⁶, ¹PELyon, Pharmacoepidemiologie Lyon, France, Lyon, France, ²AP-HP Hôpital Cochin, Paris, France, ³INSERM-U-1098, DRCI-CHRU Besançon, Franche-Comté University, UBFC, Besançon France, Besançon, France, ⁴MSD France, Courbevoie, France, ⁵Université Pierre et Marie Curie (UPMC)-Paris 6; APHP, Pitié Salpêtrière Hospital, Département Biostatistics and Public health, Pharmacoepidémiology center (Cephepi), 7501875013, Paris, France ;, Paris, France, ⁶Rheumatology, Pitié Salpêtrière Hospital, Paris, France
Background/Purpose: Immune-mediated rheumatic disease (IMRD) including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), are severe and disabling chronic diseases in rheumatology. Biotherapies…
Abstract Number: 2254 • 2016 ACR/ARHP Annual Meeting
Patient Adherence with Biologic Therapy in Rheumatoid Arthritis: A Real-World Review of Compliance
Laurent Chanroux, Fara Mboge and Denise Baldock, Therapy Watch, Research Partnership, London, United Kingdom
Background/Purpose: Biologic agents (bDMARDs) have been shown to help control disease progression in rheumatoid arthritis (RA) and reduce joint damage. The aim of our research…
Abstract Number: 2255 • 2016 ACR/ARHP Annual Meeting
Characterization of Low-Density Granulocytes in Autoinflammatory Disorders
Pragnesh Mistry¹, Monica Purmalek¹, Anne Jones², Amanda K. Ombrello², Daniel L. Kastner², Ivona Aksentijevich² and Mariana Kaplan¹, ¹NIAMS/NIH, Bethesda, MD, ²Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD
Background/Purpose: Autoinflammatory disorders (AD) are characterized by recurrent fevers associated with systemic symptoms involving joints, skin, muscles, and eyes in the absence of adaptive immune…
Abstract Number: 2256 • 2016 ACR/ARHP Annual Meeting
Histopathologic Features and Tissue Interferon-Response Gene Scoring of Lesional Skin Samples for Diagnosis in Autoinflammatory Disorders
Kyawt W. Shwin^1,2, Chyi-Chia Richard Lee³, Adriana Almeida de Jesus⁴, Carmelo Carmona-Rivera⁵, Louise Malle⁴, Yanfeng Hou⁶, Gina A. Montealegre Sanchez⁴, Edward Cowen⁷ and Raphaela Goldbach-Mansky⁸, ¹Translational Autoinflammatory Diseases Studies, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, ²National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ³Dermatopathology Section, Laboratory of Pathology, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, ⁴National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, ⁵Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, ⁶Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, ⁷Dermatology Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, ⁸Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD
Background/Purpose: Many genetically defined autoinflammatory diseases (AID) are caused by innate immune dysregulation and present with “neutrophilic dermatoses”. This study systematically assesses immune-cell infiltrates, and…
Abstract Number: 2257 • 2016 ACR/ARHP Annual Meeting
Regulation of Mitochondrial Proton Gradient Is Critical for NLRP3 Inflammasome Activation
Jehad H. Edwan, Raphaela Goldbach-Mansky and Robert A. Colbert, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Self-activating mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS). NLRP3 is a key component of a multiprotein…
Abstract Number: 2258 • 2016 ACR/ARHP Annual Meeting
Role of NLRP12 on Disease Severity in Autoimmune Arthritis
Ryan Lupo and Peng Liu, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are cytoplasmic sensors that response to danger signals released by invading pathogen or self-damaged tissues. NLRP12 is a member…
Abstract Number: 2259 • 2016 ACR/ARHP Annual Meeting
Suppression of Monosodium Urate Crystal-Induced Cytokine Production Via Inhibition of Histone Deacetylases 1/2
Maartje Cleophas¹, Tania Crisan², Charles Dinarello³, M.G. Netea² and Leo .A.B. Joosten², ¹Department of Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ³Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO
Background/Purpose: Acute gout is a highly common and painful form of inflammatory arthritis, occurring mainly in men above the age of 50. The recurring flares…
Abstract Number: 2260 • 2016 ACR/ARHP Annual Meeting
Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4) in Monosodium Urate (MSU)-Crystal Induced Arthritis.
Anthony M. Reginato¹, Marwa Qadri², Changqi Sun³, Tannin Schmidt⁴, Nicole Yang⁵, Khaled Elsaid⁶ and Gregory Jay⁷, ¹Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Pharmaceutical Science, School of Pharmacy, MCHS University, Boston, MA, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ⁴Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ⁶Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, ⁷Emergency Medicine, Brown University, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including…
Abstract Number: 2261 • 2016 ACR/ARHP Annual Meeting
Methotrexate Inhibits Intracellular Redox Signaling Induced By the Reactive Oxygen Species; Malondialdehyde and Acetaldehyde
Andrew Chiou¹, Michael J. Duryee^1,2, Cleofes Sarmiento³, Matthew Zimmerman⁴, Carlos D. Hunter¹, Lynell W. Klassen⁵, James R. O'Dell⁵, Daniel R. Anderson³, Geoffrey M. Thiele³ and Ted R Mikuls⁶, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Research Services, Omaha VA Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁵Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Inflammatory diseases such as rheumatoid arthritis (RA) are associated with oxidative stress as a result of elevated levels of reactive oxygen species (ROS). Oxidative…
Abstract Number: 2262 • 2016 ACR/ARHP Annual Meeting
CR6086 a New Potent EP4 Receptor Antagonist with Immunomodulatory Activities
Tiziana Piepoli¹, Daniele Maggioni², Silvia Zerbi¹, Anna Stucchi¹, Laura Mennuni¹, Marco Lanza¹, Gianfranco Caselli¹ and Lucio Claudio Rovati¹, ¹Rottapharm Biotech, Monza, Italy, ²School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
Background/Purpose: In the early phase of rheumatoid arthritis (RA), PGE2 recruits different immune cells from the blood stream into target tissues. Via the EP4 receptor,…
Abstract Number: 2263 • 2016 ACR/ARHP Annual Meeting
Apolipoprotein E Regulates Inflammation and Joint Destruction during Antigen-Induced Arthritis (AIA)
Giuliana Ascone¹, Irene Di Ceglie¹, Wouter de Munter¹, Birgitte Walgreen², Annet Sloetjes¹, Peter M. van der Kraan¹, Ernst Lindhout³, Mike Martens³ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental, Radboud university medical center, Nijmegen, Netherlands, ³Future Diagnostics Solutions (FDs), Wijchen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease largely driven by immune complexes and their interaction with FcγRs present on macrophages within the synovium.…
Abstract Number: 2264 • 2016 ACR/ARHP Annual Meeting
Lack of Obesity-Related Changes in Adipocytes and Inflammatory Cells in the Infrapatellar Fat Pad (IFP): A Different Type of Fat?
Anja de Jong¹, I.R. klein-Wieringa¹, Stefan Andersen², Joanneke Kwekkeboom¹, Linda van Toorn¹, Badelog de Lange¹, Danny van Delft³, John Garcia⁴, Wu Wei⁵, Huub van der Heide³, Yvonne Bastiaansen-Jenniskens⁴, Gerjo van Osch⁴, Anne-Marie Zuurmond⁶, Vedrana Stojanovic-Susulic⁷, Rob Nelissen³, René Toes¹, Margreet Kloppenburg¹ and Andreea Ioan-Facsinay¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Charles River Nederland B.V., Leiden, Netherlands, ³Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Orthopaedics, Erasmus MC, Rotterdam, Netherlands, ⁵Orthopaedics, Erasmus MC, rotterdam, Netherlands, ⁶TNO, Leiden, Netherlands, ⁷Janssen, Pharmaceutical Companies Johnson & Johnson, Springhouse, PA
Background/Purpose: Obesity is associated with the development and progression of osteoarthritis (OA). Although the mechanisms involved in this association are poorly understood, it is well…
Abstract Number: 2265 • 2016 ACR/ARHP Annual Meeting
NET-Inducing Capacity Is a Biomarker in ANCA-Associated Vasculitis Independent of ANCA Antibodies
Tineke Kraaij¹, Sylvia Kamerling¹, Jaap Bakker², Francesca Brunini³, Charles Pusey³, Hans Ulrich Scherer⁴, René E.M. Toes⁵, Ton Rabelink¹, Cees van Kooten¹ and Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Chemistry, Leiden University Medical Center, Leiden, Netherlands, ³Imperial College, London, United Kingdom, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Neutrophil extracellular traps (NETs) play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). Sera of MPO-ANCA or PR3-ANCA positive patients can induce…

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