ACR Meeting Abstracts

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  • Abstract Number: 879 • 2015 ACR/ARHP Annual Meeting

    Diffuse Alveolar Hemorrhage Secondary to ANCA-Associated Vasculitis: Predictors of Respiratory Failure and Clinical Outcomes

    Rodrigo Cartin-Ceba1, Fernando Fervenza2, Steven R. Ytterberg3 and Ulrich Specks4, 1Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, MN, 3Rheumatology Division, Mayo Clinic, Rochester, MN, 4Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN

    Background/Purpose:   The interpretation of the literature on diffuse alveolar hemorrhage (DAH) secondary to ANCA-associated vasculitis (AAV) has been complicated by the small size of…
  • Abstract Number: 880 • 2015 ACR/ARHP Annual Meeting

    Extra-Corporeal Membrane Oxygenation and Diffuse Alveolar Haemorrhage: A Single Centre Case Series and Analysis of the ELSO Database

    Chai Yiing Ling1, Thomas Simpson2, Guy Glover2, Chris Meadows3, Nicholas Ioannou3, Boris Lams3 and David P. D'Cruz4, 1Louise Coote Lupus Unit, Guy's & St Thomas' Hospital, London, United Kingdom, 2Critical Care, Kings Health Partners, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, 3Kings Health Partners, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, 4Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom

    Background/Purpose: Diffuse alveolar haemorrhage (DAH) is a rare and potentially fatal complication of the systemic vasculitides and may present directly to the intensivist as a…
  • Abstract Number: 881 • 2015 ACR/ARHP Annual Meeting

    ANCA Associated Vasculitis with Hypocomplementemia Has More Diffuse Alveolar Hemorrhage and a Poor Prognosis

    Shoichi Fukui1, Naoki Iwamoto2, Masataka Umeda2, Ayako Nishino2, Yoshikazu Nakashima2, Tomohiro Koga2, Shin-ya Kawashiri2, Kunihiro Ichinose2, Yasuko Hirai1, Mami Tamai3, Hideki Nakamura1, Tomoki Origuchi4 and Atsushi Kawakami1, 1Nagasaki University, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 3Transitional Med/Immun/Rheum, Nagasaki University, Nagasaki, Japan, 4Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan

    Background/Purpose: ANCA associated vasculitis (AAV) is known as a systemic vasculitis with unknown etiology. Recently, relationship between AAV and complement have been shown and complement…
  • Abstract Number: 882 • 2015 ACR/ARHP Annual Meeting

    Lung Damage in ANCA Associated Vasculitis Assessed By Vasculitis Damage Index: Recurrent Pulmonary Infections Have a Significant Contribution

    Esra Aydın1, Bahtiyar Toz2, Burak Erer3, Nilufer Alpay Kanitez2, Mustafa Erelel4, Ahmet Gocmez5, Ahmet Gul3, Murat Inanc3, Lale Ocal3 and Sevil Kamali3, 1Department of Internal Medicine,, istanbul faculty of medicine, istanbul, Turkey, 2Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 3Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 4Department of Pulmonology, Istanbul University Istanbul Faculty of Medicine Department of Pulmonology, istanbul, Turkey, 5Department of Radiology, Istanbul University Istanbul Faculty of Medicine, istanbul, Turkey

    Background/Purpose: Vasculitis damage index (VDI) is a validated comprehensive damage tool which has been developed as an outcome measure and consists of different types of…
  • Abstract Number: 883 • 2015 ACR/ARHP Annual Meeting

    Evaluation of Thiopurine Metabolites Monitoring in Patients Treated with Azathioprine for Rheumatic Diseases

    Aurélie Chapdelaine1, Maxime Doré2, Yves Troyanov3 and Anne-Marie Mansour1, 1Internal Medicine, Université de Montréal, Montréal, QC, Canada, 2Pharmacy, Université de Montréal, Montréal, QC, Canada, 3Rheumatology, Université de Montréal, Montréal, QC, Canada

    Background/Purpose: The thiopurine azathioprine (AZA) is an inactive pro-drug that undergoes complex metabolic transformations leading to the formation of 6-thioguanine nucleotide (6-TGN), the active metabolite,…
  • Abstract Number: 884 • 2015 ACR/ARHP Annual Meeting

    Patient Perceptions of Treatment with Glucocorticoids in ANCA-Associated Vasculitis

    Joanna Robson1, Susan Ashdown2, Jill Dawson3, Ebony Easley4, Don Gebhart5, Katherine Kellom6, Georgia Lanier7, Nataliya Milman8, Jacqueline Peck9, Judy A. Shea10, Peter F. Cronholm4 and Peter A. Merkel11, 1Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 2NONE, Branbury, United Kingdom, 3Nuffield Department of Population Health HSRU, University of Oxford, Oxford, United Kingdom, 4Department of Family Medicine and Community Health, The University of Pennsylvania, Philadelphia, PA, 5NONE, Columbus, OH, 6PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, United Kingdom, 7NONE, Framingham, MA, 8Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, 9NONE, Oxford, United Kingdom, 10Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA, United Kingdom, 11Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) comprise a group of multisystem diseases of the small blood vessels…
  • Abstract Number: 885 • 2015 ACR/ARHP Annual Meeting

    a Retrospective Analysis of Low Dose Cyclophosphamide Therapy in Systemic Vasculitides

    Antigoni Grigoriou1, Shirish Sangle2, Chai Ling2 and David P. D'Cruz3, 1Rheumatology, St George's Univeristy Hospitals NHS Foundation Trust, London, United Kingdom, 2Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, UK, London, United Kingdom, 3Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom

    Background/Purpose: The 'Euro-Lupus’ low dose cyclophosphamide (CPM) protocol has been validated for use in lupus nephritis patients in randomised controlled trials. A recent controlled study…
  • Abstract Number: 886 • 2015 ACR/ARHP Annual Meeting

    Rituximab As a Cyclophosphimide Sparing Agent for Patients with Multi-Relapsing Antineutrophil Cytoplasmic Antibody Associated Small Vessel Vasculitis

    Sophia Lionaki1, George Fragoulis2, Aliki Venetsanopoulou2, Panayiotis Vlachoyiannopoulos2, John Boletis1, Haralampos M. Moutsopoulos2 and Athanasios G. Tzioufas2, 1Nephrology, Laiko Hospital, Department of Nephrology, Athens, Greece, 2Pathophysiology, School of Medicine, National University of Athens, Athens, Greece

    Background/Purpose: To evaluate the long term outcomes, of patients with multi-relapsing Antineutrophil Cytoplasmic Antibody (ANCA) associated Vasculitis (AAV), who received induction therapy with a rituximab…
  • Abstract Number: 887 • 2015 ACR/ARHP Annual Meeting

    Intravenous Immunoglobulin As Immunomodulating Agent in ANCA-Associated Vasculitides: A French Nationwide Study of 92 Patients

    Etienne Crickx1, Irène Machelart2, Estibaliz Lazaro3, Jean-Emmanuel Kahn4, Fleur Cohen5, Thierry Martin6, Alexandre Mania7, Pierre-Yves Hatron8, Gilles Hayem9, Claire Blanchard-Delaunay10, Claire De Moreuil11, Guillaume Le Guenno12, Frédéric Vandergheynst13, Francois Maurier14, Bruno Crestani15, Robin Dhote16, Nicolas Martin Silva17, Yann Ollivier18, Anas Mehdaoui19, Bertrand Godeau20, Xavier Mariette21, Jacques Cadranel22, Pascal Cohen23, Xavier Puéchal23, Claire Le Jeunne24, Luc Mouthon25, Loïc Guillevin26 and Benjamin Terrier23, 1Internal Medicine, Cochin Hospital, Paris, France, 2Hôpital Pellegrin, Pessac, France, 3Hôpital Haut-Lévêque, Pessac, France, 4Internal Medicine, Foch Hospital, Suresnes, France, 5Internal Medicine Dpt 2, Pitié-Salpêtrière Hospital, APHP, Paris, France, 6Cnrs UPR9021, IBMC, Strasbourg, France, 7Hôpital Gabriel Montpied, Clermont-Ferrand, France, 8Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, 9Hôpital Ambroise Paré, Boulogne Billancourt, France, 10Internal Medicine, Centre Hospitalier, Niort, France, 11CHU, Brest, France, 12Internal Medicine department, Clermont-Ferrand, France, 13Hôpital Erasme, Bruxelles, Belgium, 14HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 15Pneumology, Bichat Claude-bernard, Universitary Hospital, APHP, Paris, France, 16Internal Medicine, Hospital Avicenne, Bobigny, France, 17CHU Caen, caen, France, 18Hôpital Cote de Nacre, Caen, France, 19Hôpital Eure Seine, Evreux, France, 20Henri Mondor, Créteil, France, 21Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, 22Hôpital Tenon, Paris, France, 23Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, 24Department of Internal Medicine, Hotel-Dieu Hospital, AP-HP, Paris, Paris, France, 25Department of Internal Medicine, Department of Internal Medicine, Cochin Hospital, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Paris-Descartes University, AP-HP, Paris, France, 26Internal Medicine, Hopital Cochin, Paris, France

    Background/Purpose: Despite recent therapeutic advances in treating ANCA-associated vasculitides (AAVs), some patients relapse or require long-term immunosuppression, leading to significant morbidity and mortality. IVIg represents…
  • Abstract Number: 888 • 2015 ACR/ARHP Annual Meeting

    Plasma Exchanges to Treat Primary Systemic Necrotizing Vasculitides: Data from a French Nationwide Study

    Gonzalo De Luna1, Dominique Chauveau2, Julien Aniort3, Pierre-Louis Carron4, Pierre Gobert5, Alexandre Karras6, Sylvain Adam-Marchand7, Francois Maurier8, Pierre-Yves Hatron9, Alexandre Mania10, Guillaume Le Guenno11, Stéphane Ballly12, Boris Bienvenu13, Eric Cardineau14, Tiphaine Goulenok15, Noémie Jourde-Chiche Sr.16, Maxime Samson17, Antoine Huart18, Jacques Pourrat19, Aurelien Tiple20, Olivier Aumaître21, Xavier Puéchal22, Farhad Heshmati23, Claire Le Jeunne24, Luc Mouthon25, Loïc Guillevin26 and Benjamin Terrier22, 1Medecine Interne, Cochin University Hospital, Paris, France, 2CH Toulouse, Toulouse, France, 3CHU, Clermont-Ferrand, France, 4Internal Medicine, Centre Hospitalier de Grenoble, Grenoble, France, 5Nephrology, Centre Hospitalier d'Avignon, Avignon, France, 6George Pompidou European Hospital, Paris, France, 7Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, 8HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 9Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, 10Hôpital Gabriel Montpied, Clermont-Ferrand, France, 11Internal Medicine department, Clermont-Ferrand, France, 12CH, Chambéry, France, 13Internal Medicine, Hospital Caen, Caen, France, 14CH, Alencon, France, 15University Paris Diderot - APHP - Bichat Hospital, aris, France, 16Nephrology, Aix-Marseille Université - APHM, Marseille, France, 17Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 18CHU, Toulouse, France, 19Nephrology, Rangeuil Hospital, Paris, France, 20Nephrology, CHU, Clermont-Ferrand, France, 21Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, 22Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, 23Cochin Hospital, Paris, France, 24Department of Internal Medicine, Hotel-Dieu Hospital, AP-HP, Paris, Paris, France, 25Department of Internal Medicine, Department of Internal Medicine, Cochin Hospital, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Paris-Descartes University, AP-HP, Paris, France, 26Internal Medicine, Hopital Cochin, Paris, France

    Background/Purpose: Plasma exchange (PE) is usually used to treat severe primary systemic necrotizing vasculitides (SNVs) and/or virus-induced vasculitides. Only severe renal insufficiency (serum creatinine (SCR)…
  • Abstract Number: 889 • 2015 ACR/ARHP Annual Meeting

    Central Nervous System Involvement of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss): Retrospective Analysis of 26 Cases and Review of the Literature

    Raphael André1, Chahéra Khouatra2, Jean-Luc Saraux3, Francois Maurier4, Gilles Blaison5, Boris Bienvenu6, Pascal Cathebras7, Nathalie Costedoat-Chalumeau8, Robin Dhote9, Aurélie Foucher10, Helder Gil11, Joelle Lapouarie12, David Launay13, Edouard Pertuiset14, Valentine Loustau15, Thierry Zenone16, Claire Le Jeunne17, Luc Mouthon18, Loïc Guillevin19 and Benjamin Terrier20, 1Cochin Hospital, Paris, France, 2CHU Lyon, Lyon, France, 3CH Eaubonne, Eaubonne, France, 4HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 5Internal medicine, CHR, Colmar, France, 6Internal Medicine, Hospital Caen, Caen, France, 7Internal Medicine, University Hospital St Etienne, St Etienne, France, 8Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, 9Internal Medicine, Hospital Avicenne, Bobigny, France, 10CHU, Saint Pierre de la Réunion, France, 11CHU, Besancon, France, 12CHU, Pau, France, 13Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, 14CH René Dubos, Pontoise, France, 15Hôpital Henri Mondor, Créteil, France, 16CH de Valence, Valence, France, 17Department of Internal Medicine, Hotel-Dieu Hospital, AP-HP, Paris, Paris, France, 18Department of Internal Medicine, Department of Internal Medicine, Cochin Hospital, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Paris-Descartes University, AP-HP, Paris, France, 19Internal Medicine, Hopital Cochin, Paris, France, 20Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by asthma, blood and tissue eosinophilia, vasculitis-related peripheral neuropathy, glomerulonephritis or skin symptoms. Although peripheral nervous system…
  • Abstract Number: 890 • 2015 ACR/ARHP Annual Meeting

    Anti-IgE Monoclonal Antibody in Refractory and/or Relapsing Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss): Data from 17 Patients

    Marie Jachiet1, Maxime Samson2, Vincent Cottin3, Jean-Emmanuel Kahn4, Guillaume Le Guenno5, Philippe Bonniaud6, Laurence Bouillet7, Anne Gondouin8, Fatma Makhlouf7, Nadine Meaux Ruault9, Helder Gil8, Hervé Devilliers10, Boris Bienvenu11, André Coste12, Violaine Giraud13, Stephane Dominique14, Bertrand Godeau15, Xavier Puéchal16, Chahéra Khouatra17, Marc Ruivard18, Claire Le Jeunne19, Luc Mouthon20, Loïc Guillevin21 and Benjamin Terrier16, 1Dermatology, Cochin Hospital, Paris, France, 2Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 3Division of Pneumology, Hôpital Louis-Pradel, Hospices Civils de Lyon, Lyon 1, Lyon, France, 4Internal Medicine, Foch Hospital, Suresnes, France, 5Internal Medicine department, Clermont-Ferrand, France, 6CHU, Dijon, France, 7CHU, Grenoble, France, 8CHU, Besancon, France, 9Internal Medicine and Clinical Immunology, CHU de Besançon, Besançon, France, 10Department of Internal Medicine and Systemic Diseases, Dijon University Hospital, Dijon, France, 11Internal Medicine, Hospital Caen, Caen, France, 12CHI, Créteil, France, 13Hôpital Ambroise Paré, Boulogne Billancourt, France, 14Pneumology, Rouen University Hospital, Rouen, France, 15Henri Mondor, Créteil, France, 16Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, 17CHU Lyon, Lyon, France, 18CHU Clermont-Ferrand, Clermont–Ferrand, France, 19Department of Internal Medicine, Hotel-Dieu Hospital, AP-HP, Paris, Paris, France, 20Department of Internal Medicine, Department of Internal Medicine, Cochin Hospital, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Paris-Descartes University, AP-HP, Paris, France, 21Internal Medicine, Hopital Cochin, Paris, France

    Background/Purpose: Omalizumab, an anti-IgE monoclonal antibody, has proven efficacy for the treatment of moderate-to-severe and severe-persistent allergic asthma and allergic rhinitis, with a favorable safety…
  • Abstract Number: 891 • 2015 ACR/ARHP Annual Meeting

    Long-Term Use of Rituximab for Eosinophilic Granulomatosis with Polyangiitis

    David Theis1, Carol A. Langford2, Gary S. Hoffman3 and Alexandra Villa-Forte4, 1Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, 2Rheumatology, Cleveland Clinic, Cleveland, OH, 3Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, 4Rheumatology, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) often presents with persistently active disease requiring chronic glucocorticoid therapy or it may have a relapsing course with partial…
  • Abstract Number: 892 • 2015 ACR/ARHP Annual Meeting

    Autoimmune Associated Orbital Inflammatory Masses and Response to Immunosuppressive Therapy

    Alina Casian1, Shirish Sangle (joint first author)2, Ritu Malaiya3, Pamela Lutalo4, Louise Nel5, Bina Menon6, Hema Varma7, Miles Stanford8 and David P. D'Cruz5, 1Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, UK, London, United Kingdom, 2Louise Coote Lupus Unit, Guy's and St. Thomas' Hospital, London, United Kingdom, 3Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, 4Rheumatology, St. George's Hospital, London, United Kingdom, 5Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom, 6Rheumatology, Guy's Hospital, London, United Kingdom, 7Radiology, Guy's and St. Thomas' Hospital, London, United Kingdom, 8Ophthalmology, Guy's and St. Thomas' Hospital, London, United Kingdom

    Background/Purpose: To characterize a single centre retrospective case series of patients with orbital inflammatory masses associated with autoimmune diseases including granulomatosis with polyangiitis(GPA)(formerly Wegener’s granulomatosis),…
  • Abstract Number: 893 • 2015 ACR/ARHP Annual Meeting

    Epidemiological Features of Childhood IgA Vasculitis (Henoch-Schönlein) in a French County: A Population-Based Survey

    Maryam Piram1, Carla Maldini2, Sandra Biscardi3, Nathalie De Suremain4, Christine Orzechowski5, Emilie Georget6, Delphine Regnard7, Isabelle Koné-Paut1 and Alfred Mahr2, 1Pediatric Rheumatology, CHU Bicêtre, Le Kremlin Bicêtre, France, 2Internal Medicine, Hospital Saint-Louis, Paris, France, 3Pediatrics, Centre Hospitalier Intercommunal Créteil, Créteil, France, 4Pediatrics, CHU Trousseau, Paris, France, 5Pediatrics, CH Sainte Camille, Bry-sur-Marne, France, 6Pediatrics, Centre hospitalier de Villeneuve-Saint-Georges, Villeneuve Saint Georges, France, 7Pediatrics, CHU Bicêtre, Le Kremlin Bicêtre, France

    Background/Purpose: IgA vasculitis (IgAV, Henoch–Schönlein) is the most common childhood vasculitis in western countries. Population-based studies mainly carried out in Europe over the last 4…
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