Abstracts Archive - Page 1746 of 2425 - ACR Meeting Abstracts

Abstract Number: 849 • 2015 ACR/ARHP Annual Meeting
A Computational Tool for Individualized Prognosis of Percent of Predicted Forced Vital Capacity Trajectories in Systemic Sclerosis
Peter Schulam¹, Colin Ligon², Robert Wise³, Laura K. Hummers⁴, Fredrick M. Wigley⁵ and Suchi Saria^1,6, ¹Department of Computer Science, Johns Hopkins University, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Departments of Biostatistics, and Health Policy and Management, Bloomberg School of Public Health, Baltimore, MD
Background/Purpose: Interstitial lung disease (ILD) is a common cause of mortality in systemic sclerosis (Ssc). Decreased forced vital capacity (FVC) in Ssc-ILD is associated with…
Abstract Number: 850 • 2015 ACR/ARHP Annual Meeting
Incidence and Predictors of Severe Heart Disease in Systemic Sclerosis
Serena Vettori¹, Yannick Allanore², Laszlo Czirjak³, Francesco Del Galdo⁴, Christopher P. Denton⁵, Oliver Distler⁶, Ivan Foeldvari⁷, Marc Frerix⁸, Veronika K. Jaeger⁹, Brigitte Krummel-Lorenz¹⁰, Marco Matucci Cerinic¹¹, Carina Mihai¹², Ulf Müller-Ladner¹³, Gabriela Riemekasten¹⁴, Tim Schmeiser¹⁵, Ingo H. Tarner⁸, Ulrich A. Walker⁹, Gabriele Valentini¹⁶ and EUSTAR Group and DeSScipher Consortium, ¹Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ³Rheumatology and Immunology Medical School, University of Pécs, Pécs, Hungary, ⁴Division of Musculoskeletal Diseases, University of Leeds, Leeds, United Kingdom, ⁵Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁶Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany, ⁸Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ¹⁰Rheumatologist, Frankfurt, Germany, ¹¹Department of Internal Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹²Internal Medicine and Rheumatology Departement, Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Bucharest, Romania, ¹³Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁴Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Berlin, Germany, ¹⁵Internistic Rheumatology, Krankenhaus St. Josef, Wuppertal, Germany, ¹⁶Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy
Background/Purpose: Heart disease occurs in most patients with systemic sclerosis (SSc), as emerged by autopsy and imaging studies. It can cause cardiac blocks (CBs), ventricular…
Abstract Number: 851 • 2015 ACR/ARHP Annual Meeting
Does the Clinical Context Improve the Reliability of Rheumatologists Grading Digital Ulcers in Systemic Sclerosis?
Michael Hughes¹, Chris Roberts², Andrew Tracey¹, Graham Dinsdale¹, Andrea Murray¹ and Ariane L. Herrick¹, ¹Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester, United Kingdom
Background/Purpose: Digital ulcers (DUs) are often a primary end point in SSc clinical trials, although the reliability of rheumatologists grading DUs is poor to moderate…
Abstract Number: 852 • 2015 ACR/ARHP Annual Meeting
Health-Related Quality of Life in Early Systemic Sclerosis
Marie Hudson¹, Murray Baron², Mianbo Wang³, Candice Rabusa⁴, Susanna Proudman⁵, Mandana Nikpour⁶, Wendy Stevens⁴ and Canadian Scleroderma Research Group (CSRG), Australian Scleroderma Cohort Study (ASCS), ¹McGill University, Jewish General Hospital, Montreal, QC, Canada, ²Jewish General Hospital, Lady Davis Institute and McGill University, Montreal, QC, Canada, ³Lady Davis Institute for Medical Research, Montreal, QC, Canada, ⁴Rheumatology, St. Vincent’s Hospital, Melbourne, Australia, ⁵Rheumatology Unit, Royal Adelaide Hospital North Terrace, Adelaide, Australia, ⁶University of Melbourne Department of Medicine, Melbourne, Australia
Background/Purpose: Health-related quality of life (HRQoL) research is a priority in systemic sclerosis (SSc). Yet, much of the data comes from prevalent cohorts with established…
Abstract Number: 853 • 2015 ACR/ARHP Annual Meeting
Evaluation and Validation of Case-Finding Algorithms for the Identification of Patients with Granulomatosis with Polyangiitis in Large Healthcare Administrative Databases
Antoine G. Sreih¹, Narender Annapureddy², Kevin Byram³, George Casey⁴, Vince Frangiosa⁵, Michael George⁶, Sapna Sangani⁷, Rebecca Sharim⁵ and Peter A. Merkel⁸, ¹Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology and Immunology, Vanderbilt University, Nashville, TN, ³Internal Medicine, Vanderbilt University, Nashville, TN, ⁴The Vasculitis Foundation, Kansas City, MO, ⁵Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁶Department of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁷Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: To facilitate clinical care and research, validated algorithms are needed to accurately identify patients with granulomatosis with polyangiitis (GPA; Wegener's). This study, sought to…
Abstract Number: 854 • 2015 ACR/ARHP Annual Meeting
Nationwide Incidence of Anti Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis in Iceland
Þórunn Bjarnadóttir¹, Árni Jón Geirsson², Kristján Steinsson³, Jóhannes Björnsson⁴, Gunnar Tomasson⁵ and Björn Rúnar Lúdvíksson^6,7, ¹Landspitali University Hosptital, Reykjavík, Iceland, ²Rheumatology, Department of Rheumatology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, ³Rheumatology, Univ. Hospital, Reykjavik, Iceland, ⁴Department of Pathology, Akureyri Hospital, Akureyri, Iceland, ⁵Rheumatology Section, Boston University, Boston, MA, ⁶Department of Immunology, University of Iceland, Reykjavik, Iceland, ⁷Landspitali University Hosptital, Reykjavik, Iceland
Background/Purpose: The Icelandic population is geographically isolated, genetically homogenous and with distinct environmental exposures. Deviations in disease occurrence compared to other Western countries might provide…
Abstract Number: 855 • 2015 ACR/ARHP Annual Meeting
Seasonality in ANCA-Associated Vasculitis
Luciano Enrique Pompermayer¹, Marina Scolnik¹, Valeria Scaglioni², Maria de los Angeles Gallardo¹ and Enrique R. Soriano³, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Rheumatology, Hospital Italiano, Buenos Aires, Argentina, ³Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: pathogenesis of ANCA-associated vasculitis (AAV) is multifactorial and most likely involves the interaction of environmental and genetic factors. Environmental seasonal exposures may play a role in the manifestation…
Abstract Number: 856 • 2015 ACR/ARHP Annual Meeting
Elderly Versus Younger Patients with ANCA-Associated Vasculitis
Maria de los Angeles Gallardo¹, Marina Scolnik¹, Luciano Enrique Pompermayer¹, Valeria Scaglioni² and Enrique R. Soriano³, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Rheumatology, Hospital Italiano, Buenos Aires, Argentina, ³Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Clinical characteristics of elderly patients with ANCA- associated vasculitis (AAV) have not been fully elucidated. Advancing age is a risk factor for treatment-related side effects…
Abstract Number: 857 • 2015 ACR/ARHP Annual Meeting
Prognosis Value of Geriatric Assessment Scales in Older Adults with New Onset ANCA-Associated Vasculitis: A Pilot Retrospective Study
Antoine Néel¹, Josephine Thomazeau¹, Christelle Volteau², Laure De Decker³, Christian Agard¹, Marie Lino⁴, Julie Graveleau¹, Fadi Fakhouri⁴ and Mohamed Hamidou¹, ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²Clinical Research Department, Nantes University Hospital, Nantes, France, ³Department of Geriatrics, Nantes University Hospital, Nantes, France, ⁴Nephrology, Nantes University Hospital, Nantes, France
Background/Purpose: 1/to assess the prognostic value of comorbidities, frailty and dependency as measures by dedicated geriatric scales, in older adults with ANCA-associated vasculitis (AAV). 2/…
Abstract Number: 858 • 2015 ACR/ARHP Annual Meeting
Stimulated Renal Glomerular Endothelial Cells Were Damaged By Fiber-like NETs Released By Neutrophils in ANCA-Associated Vasculitis
Yoshinori Komagata¹, Kanako Murakami¹, Chimako Kida¹, Kazuhito Fukuoka¹, Miho Karube², Shinya Kaname¹ and Yoshihiro Arimura¹, ¹First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ²Kyorin University School of Medicine, Tokyo, Japan
Background/Purpose: NETosis, a unique form of cell death of neutrophils, is characterized by the active release of chromatin fibers called NETs, that trap and kill…
Abstract Number: 859 • 2015 ACR/ARHP Annual Meeting
Predictors of Renal Histopathology in Antineutrophil Cytoplasmic Antibody Associated Glomerulonephritis
Sophia Lionaki¹, Clio Mavragani², George Liapis³, George Somarakis⁴, John Boletis¹, Alexandros A. Drosos⁵, Athanasios G. Tzioufas⁶ and Haralampos M. Moutsopoulos⁶, ¹Nephrology, Laiko Hospital, Department of Nephrology, Athens, Greece, ²Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ³Pathology, Laiko Hospital, Department of Pathology, Athens, Greece, ⁴Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, University of Ioannina, Rheumatology Clinic, Ioannina, Greece, ⁵Dept of Internal Medicine, University of Ioannina, Rheumatology Clinic, Ioannina, Greece, ⁶Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece
Background/Purpose: Prompt, aggressive therapy is vital for anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). In this regard, we aimed to identify predictors of distinct renal histopathological…
Abstract Number: 860 • 2015 ACR/ARHP Annual Meeting
Neutrophil/Lymphocyte Ratio: Could It be a Prognostic Indicator for Renal Outcome in Patients with Granulomatosis with Polyangiitis?
Berna Goker¹, Seminur Haznedaroglu¹, Hamit Kucuk¹, Ozkan Varan¹, Berivan Bitik¹, Abdurrahman Tufan¹, Ridvan Mercan¹ and Yasemin Erten², ¹Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, ²Internal Medicine-Nephrology, Gazi University Medical School, Ankara, Turkey
Background/Purpose: Neutrophil/lymphocyte ratio (NLR) has recently been extensively studied as a prognostic indicator in various malignancies, as well as an indicator of severity in cardiovascular…
Abstract Number: 861 • 2015 ACR/ARHP Annual Meeting
ANCA-Associated Pauci-Immune Glomerulonephritis: ¿Always Pauci-Immune?
Valeria Scaglioni¹, Marina Scolnik¹, Luis J. Catoggio¹, Carlos Federico Varela², Gustavo Greloni², Silvia Christiansen³ and Enrique R. Soriano⁴, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Nephrology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³Pathology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Internal Medicine, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina
Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) is considered a “pauci-immune” disease, characterized by absent or mild glomerular tuft staining for immunoglobulin and/or complement. However,…
Abstract Number: 862 • 2015 ACR/ARHP Annual Meeting
Discriminative Performance of Nasal Endoscopic Findings and History Items in Patients with Granulomatosis with Polyangiitis
Erdem Eren¹, Toygar Kalkan², Secil Arslanoglu¹, Mustafa Ozmen³, Kazim Onal¹, Emine Figen Tarhan³ and Servet Akar⁴, ¹Head and Neck Surgery, Izmir Ataturk Research and Training Hospital, Izmir, Turkey, ²Internal Medicine, Izmir Ataturk Research and Training Hospital, Izmir, Turkey, ³Rheumatology, Izmir Ataturk Research and Training Hospital, Izmir, Turkey, ⁴Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey
Background/Purpose: Granulomatosis with polyangiitis (Wegener's granulomatosis, GPA) is a systemic vasculitis of unknown etiology. It is characterized by necrotizing granulomatous inflammation and affects predominantly small…
Abstract Number: 863 • 2015 ACR/ARHP Annual Meeting
Contribution of MPO-/PR3-ANCA Tests to the Diagnosis of ANCA-Associated Vasculitis in a Community Hospital: Evaluation of 2,782 Samples
Eishi Uechi, Chiai Nakata, Tomoo Murayama and Yoshiki Shiohira, Rheumatology, Tomishiro Central Hospital, Okinawa, Japan
Background/Purpose: The purpose of this study was to evaluate the contribution of MPO-/PR3-ANCA tests to the diagnosis of ANCA-associated vasculitis (AAV). Methods: We extracted patients…

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