Abstracts Archive - Page 1740 of 2607 - ACR Meeting Abstracts

Abstract Number: 2115 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Factors May Potentiate Immune Complex Formation of Anti-Citrullinated Protein Antibodies
Willem J.J. Falkenburg^1,2, Dirkjan van Schaardenburg^3,4, Jana Koers⁵, Pleuni Ooijevaar-de Heer⁵, Gertjan Wolbink^6,7, Arthur E.H. Bentlage⁸, Gestur Vidarsson⁸ and Theo Rispens⁵, ¹Rheumatology, Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ²Department of Immunopathology, Sanquin Research, Amsterdam, Netherlands, ³Rheumatology, Amsterdam Rheumatology and immunology Center, location Academic Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁴Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁵Immunopathology, Sanquin Research, Amsterdam, Netherlands, ⁶Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Center, Amsterdam, Netherlands, ⁷Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, ⁸Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a complex inflammatory disorder in which autoantibodies play a prominent role. Several types of autoantibodies, including rheumatoid factors (RFs) -…
Abstract Number: 2116 • 2016 ACR/ARHP Annual Meeting
Cytokines Inhibition Modulates Activation and Homing Receptor of Different Peripheral Memory B Cell Subsets in RA
Zafar Mahmood¹, Marc Schmalzing², Michael Gernert³, Thomas Dörner⁴ and Hans-Peter Tony³, ¹Department of Medicine II, Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, ²Rheumatology/Clinical Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, ³Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, ⁴Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: With the advent of B cell targeted therapies the modulation of memory B cells seems to be a prime target. Human peripheral memory B…
Abstract Number: 2117 • 2016 ACR/ARHP Annual Meeting
B Cell Phenotype and in Vitro Function in Patients with Rheumatoid Arthritis Developing Low Serum Immunoglobulins after Multiple Cycles of Rituximab
Geraldine Cambridge¹, Rita A. Moura², Venkat Reddy³ and Maria J. Leandro¹, ¹Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ²Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Lisbon, Portugal, ³Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Repeat treatment with rituximab (RTX) predisposes some patients with rheumatoid arthritis (RA) to develop low levels of serum immunoglobulins (Igs). Understanding B cell function…
Abstract Number: 2118 • 2016 ACR/ARHP Annual Meeting
Rituximab Treated Non Responder Rheumatoid Arthritis Patients Are Generating a New Autoantibody Repertoire
Zoltan Konthur¹, Melvin Michael Wiemkes², Thomas Häupl³, Gerd R. Burmester⁴ and Karl Skriner⁵, ¹Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Germany, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁴Charité – University Medicine Berlin, Berlin, Germany, ⁵Humboldt University of Berlin, Berlin, Germany
Background/Purpose: Rituximab (RTX) has shown clinical efficacy but up to 40 % of RTX treated rheumatoid arthritis (RA) patients are poor responders (Ann Rheum Dis.…
Abstract Number: 2119 • 2016 ACR/ARHP Annual Meeting
Wogonin, a Plant-Derived Flavonoid, Exert Anti-Inflammatory and Chondroprotective Effects through the Activation Nrf2/HO-1 Signaling in Human OA Chondrocytes
Mohammad N. Khan, Abdul Haseeb, Sara Haynie and Tariq M Haqqi, Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Methods: Primary human OA chondrocytes were isolated by enzymatic digestion of the cartilage obtained from OA patients who underwent total knee arthroplasty at…
Abstract Number: 2120 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04690) As a Potential Treatment for Degenerative Disc Disease
Charlene Barroga¹, Vishal Deshmukh¹, Luis Dellamary¹, Josh Stewart¹, Haide Hu², John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Degenerative Disc Disease (DDD), one of the main causes of low back pain, is characterized by degeneration of intervertebral disc, nucleus pulposus (NP), and…
Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 2122 • 2016 ACR/ARHP Annual Meeting
KiSS1 Is a Regulator of ADAMTS4 and ADAMTS5 Expression and Is Post-Transcriptionally Regulated By Micro-RNA N105 in Human OA Chondrocytes
Mohammad Shahidul Makki^1,2 and Tariq Haqqi³, ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Osteoarthritis (OA) is a chronic and debilitating disease of the articulating joints in every population. Micro-RNAs are ~22 nucleotides long non-coding single stranded RNAs…
Abstract Number: 2123 • 2016 ACR/ARHP Annual Meeting
Follistatin-like Protein 1 Is a Potent Regulator of Articular Chondrocytes in Osteoarthritis
Yury Chaly, Bruce Hostager, Sonja Smith and Raphael Hirsch, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Osteoarthritis (OA) is the most common degenerative disease of the joints, affecting nearly 30 million Americans. It is characterized by a change in chondrocyte…
Abstract Number: 2124 • 2016 ACR/ARHP Annual Meeting
Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity
Joanna Sherwood¹, Jessica Bertrand², Francesco Dell'Accio³ and Thomas Pap⁴, ¹Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Department of Orthopedic Surgery, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, ³William Harvey Research Institute,, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁴Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: The ELR+ CXC chemokine CXCL6 is produced by healthy articular chondrocytes and retained within the cartilage matrix via interactions with heparan sulphate proteoglycans. There,…
Abstract Number: 2125 • 2016 ACR/ARHP Annual Meeting
Aggrecan Degradation Is Not Just Aggrecan Degradation:a Study of the Neo-Epitopes Tege and Args Released from Cartilage upon Aggrecanase Activity
Anne Sofie Siebuhr¹, Yi He², Yunyun Lou², Sabine Hoielt³, Morten Asser Karsdal¹ and Anne C. Bay-Jensen¹, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Biomarkers and Research, 2730, Denmark
Background/Purpose: Cartilage degradation is a hallmark of arthritic disease. The main constituents of cartilage is aggrecan and type II collagen. Previous studies have shown that…
Abstract Number: 2126 • 2016 ACR/ARHP Annual Meeting
Cytokine Dependent Effects of Anti-Inflammatory Inhibitors Targeting JAK and p38 on Cartilage Turnover
Christian S. Thudium¹, Cecilie F. Kjelgaard-Petersen^1,2, Britt Christensen¹, Morten Asser Karsdal³ and Anne C. Bay-Jensen³, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) and inflammatory subtypes of osteoarthritis (iOA) are degenerative joint diseases with an inflammatory component allowing for potential anti-inflammatory treatment benefit. A…
Abstract Number: 2127 • 2016 ACR/ARHP Annual Meeting
Dicam Promotes Proliferation and Hypertrophic Differentiation of Chondrocyte through Indian Hedgehog Signaling of Primary Cilia
Seungwoo Han^1,2, Hye-Ri Park², Min-Su Han², Eun-Ju Lee², Ji-Ae Jang², Ji-Min Kim³, Gun-Woo Kim^2,4 and Younkwan Jung², ¹Internal Medicine, Daegu Fatima hospital, Daegu, Korea, The Republic of, ²Fatima Research Institute, Daegu, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, ⁴Rheumatology, Daegu Fatima hospital, Daegu, Korea, The Republic of
Background/Purpose: Chondrocytes in growth plate is known to respond to hydrostatic loading by increasing Indian hedgehog (Ihh) signaling, and that the primary cilium is required…
Abstract Number: 2128 • 2016 ACR/ARHP Annual Meeting
Autophagic Clearance of Dysfunctional Mitochondria Requires Parkin in Human Chondrocytes
Mohammad Y Ansari¹ and Tariq M. Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose:
Abstract Number: 2129 • 2016 ACR/ARHP Annual Meeting
Extracellular Adenosine Deficiency Plays a Role in the Pathogenesis of Osteoarthritis (OA) and Adenosine Replacement Prevents Post-Traumatic Osteoarthritis
Carmen Corciulo¹, Matin Lendhey², Tuere Wilder¹, Oran Kennedy² and Bruce Cronstein³, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Orthopaedic Surgery, NYU-School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Extracellular adenosine is highly regulated and plays an important homeostatic role via occupancy of cell surface receptors (A1R, A2AR, A2BR, A3R). Mice lacking A2AR…

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