Abstract Number: 2100 • 2016 ACR/ARHP Annual Meeting
Pharmaceutical Disruption of B2GPI CXCL4 Complex Using Computationally Designed Oligopeptides
Background/Purpose: Antiphospholipid syndrome (APS) is an autoimmune thrombophilia characterized by recurrent thromboembolism and or pregnancy morbidity in the presence of antiphospholid antibodies (aPL). Major auto…Abstract Number: 2101 • 2016 ACR/ARHP Annual Meeting
the Association Between ABO Blood Types and Venous Thromboembolism in Individuals with a Positive Antiphospholipid Antibody Profile Is Varied By Sex
Background/Purpose: Venous thrombotic events (VTE) are the most common complications in patients with persistently positive aPL antibodies (aPL+)1 . The pathogenesis of VTE is multifactorial,…Abstract Number: 2102 • 2016 ACR/ARHP Annual Meeting
the Prevalence and Associations of IgG/a/M ANTI-β2GPI and ANTI-Domain I Antibodies in an Antiphospholipid Syndrome (APS) Cohort of Patients from Turkey
Background/Purpose: Methods: Results: Conclusion: All patients (n=75) Vascular Thrombosis only (n=15) P IgG anti-β2GPI 17% 19% 14% NS IgA anti-β2GPI 36%…Abstract Number: 2103 • 2016 ACR/ARHP Annual Meeting
Peripheral Blood B Cells Are Expanded and Their Cytokine Expression Is Dysregulated in Juvenile Dermatomyositis
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare form of childhood autoimmune myositis that presents with proximal muscle weakness and heliotrope rash. B cells are strongly…Abstract Number: 2104 • 2016 ACR/ARHP Annual Meeting
Treatment with Tocilizumab Decreases CXCL13 Expression in Cultured Temporal Arteries from Patients with Giant Cell Arteritis
Background/Purpose: IL-6 has been considered a biomarker of disease activity in GCA and a potential therapeutic target. However, the functional role of IL-6 in GCA…Abstract Number: 2105 • 2016 ACR/ARHP Annual Meeting
Autoimmune Pancreatitis-Associated Autoantigens Among 100 IgG4-Related Diseases Patients
Background/Purpose: IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder of uncertain etiology. Recognition of this disease as a distinct entity stemmed from investigation into autoimmune pancreatitis…Abstract Number: 2106 • 2016 ACR/ARHP Annual Meeting
Regulation of Marginal Zone B Cell Differentiation By microRNA-146a
Background/Purpose: B cell development in the bone marrow is followed by specification into several functional subsets in the spleen, including marginal zone B (MZB) cells…Abstract Number: 2107 • 2016 ACR/ARHP Annual Meeting
Targeting Mir-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production
Background/Purpose: Better understanding of epigenetic regulatory mechanisms in RA pathogenesis will facilitate the development of new biomarkers or therapeutic strategies. MicroRNAs are post-transcriptional regulators that…Abstract Number: 2108 • 2016 ACR/ARHP Annual Meeting
DNA Hypomethylation in Promoter Region of Zbtb38 Gene Ultimately Leads to Downregulated Expression of Anti-Inflammatory IL1r2 in Experiential Model of Rheumatoid Arthritis
Background/Purpose: Interleukin 1 beta (IL1B) is a multifunctional cytokine that is highly expressed in rheumatoid arthritis (RA) and drives pro-inflammatory pathways via interleukin 1 receptor…Abstract Number: 2109 • 2016 ACR/ARHP Annual Meeting
Immunoprofiling of Bruton’s Tyrosine Kinase (Btk)/Tec Family Kinase Inhibitors Indicate Activities Beyond Btk in Immunocyte Function
Background/Purpose: CC-292, CC-90008, and ibrutinib are covalent Btk/Tec family kinase inhibitors that block Btk activity by binding with high affinity to the adenosine triphosphate (ATP)…Abstract Number: 2110 • 2016 ACR/ARHP Annual Meeting
Synovial Fibroblasts Regulate B Cell Survival Via B Cell Activating Factor of the TNF Family (BAFF)
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) are one main contributor of joint destruction since they resist apoptosis and secrete pro-inflammatory cytokines and matrix…Abstract Number: 2111 • 2016 ACR/ARHP Annual Meeting
Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B-Cell Clones
Background/Purpose: Rheumatoid arthritis (RA) is the most frequent form of autoimmune arthritis with a prevalence of almost 1% worldwide. Anti-citrullinated protein antibodies (ACPA) are the…Abstract Number: 2112 • 2016 ACR/ARHP Annual Meeting
Disease-Activity Associated Autoantibodies to Malondialdehyde-Modified Proteins Can be Isolated from Synovial B Cells in RA
Background/Purpose: Malondialdehyde (MDA) is a naturally occurring reactive aldehyde that arises during apoptosis or as a consequence of elevated reactive oxygen species and lipid peroxidation.…Abstract Number: 2113 • 2016 ACR/ARHP Annual Meeting
Anti-Carbamylated Protein Antibody (cross)-Reactivity Against Multiple Carbamylated Protein Antigens
Background/Purpose: Antibodies that target carbamylated proteins (anti-CarP) have been implicated in rheumatoid arthritis and are known to associate with joint damage. Furthermore, these autoantibodies…Abstract Number: 2114 • 2016 ACR/ARHP Annual Meeting
Exposure to Carbamylated Self- and Non-Self-Proteins Can Lead to a Break-of -Tolerance and the Induction of Autoimmunity
Background/Purpose: Autoantibodies are an important hallmark of Rheumatoid Arthritis (RA). Approximately 50% of RA patients harbor anti-carbamylated protein (CarP) antibodies. These autoantibodies target proteins that…
ACR Meeting Abstracts