Abstracts Archive - Page 1726 of 2607 - ACR Meeting Abstracts

Abstract Number: 1904 • 2016 ACR/ARHP Annual Meeting
Elevated GITRL Is Associated with Multi-Organ Involvement and Increased Disease Activity of Primarty Sjogren’s Syndrome and Promotes Pathogenic Th1/17 Differentiation
Xiaolin Sun¹, Yuzhou Gan Sr.², Jing He³ and Zhanguo Li⁴, ¹People's hospital,Peking University, Beijing, China, ²Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ³Peking Univerisity People's Hospital, Beijing, China, ⁴Peking University People's Hospital, Beijing, China
Background/Purpose: Accumulating data showed that Glucocorticoid-induced Tumor Necrosis Factor Receptor Family-related Protein (GITR), with its ligand (GITRL), plays an important role in promoting T-cell-mediated immunity…
Abstract Number: 1905 • 2016 ACR/ARHP Annual Meeting
Therapeutic Targeting of JAK/STAT Pathway Inhibits Follicular Helper T Cell Maturation and Function
Flora Sagez and Jacques-Eric Gottenberg, Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: T follicular helper (Tfh) cells represent a CD4+T cell subset specialized to provide help to B cells and to induce memory B cell and…
Abstract Number: 1906 • 2016 ACR/ARHP Annual Meeting
Impact of Environmental Factors and Inflammation on Alterations of the Total Peripheral T-Cell Compartment in Granulomatosis with Polyangiitis
Anja Kerstein¹, Silke Schueler¹, Otávio Cabral-Marques¹, Juliane Fazio², Robert Haesler³, Antje Mueller¹, Silke Pitann¹, Dietrich Kabelitz², Frank Moosig⁴, Sebastian Klapa⁵, Christian Haas⁶, Gabriela Riekemasten¹, Steffen Wolters¹ and Peter Lamprecht¹, ¹Department of Rheumatology, Vasculitis Center UKSH, University of Lübeck, Luebeck, Germany, ²Institute of Immunology, Christian-Albrechts-University of Kiel, Kiel, Germany, ³Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, ⁴Rheumatology Center Schleswig-Holstein Mitte, Neumuenster, Germany, ⁵Section Maritime Medicine, Institute of Experimental Medicine, Christian-Albrechs-University of Kiel c/o German Naval Medical Institute, Kronshagen, Germany, ⁶Division of Nephrology, Department of Internal Medicine 1, University of Lübeck, Luebeck, Germany
Background/Purpose: Autoimmune diseases are driven by a combination of predisposing genetic and environmental factors resulting in self-perpetuating chronic inflammation and tissue damage. In granulomatosis with…
Abstract Number: 1907 • 2016 ACR/ARHP Annual Meeting
T-Bet Regulates Ahr-Mediated Th-17 Differentiation Independently of IFNγ
Masahiro Yokosawa, Yuya Kondo, Shunta Kaneko, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Our previous reports showed that the development of collagen-induced arthritis was suppressed in T-bet transgenic (T-bet Tg) mice. The regulatory mechanism might relate to…
Abstract Number: 1908 • 2016 ACR/ARHP Annual Meeting
Identification of a Novel Pro-Inflammatory T Cell Epitope from His-tRNA-Synthetase Associated with Interstitial Lung Disease in Anti-Jo-1 Positive Patients
Angeles Shunashy Galindo-Feria¹, Inka Albrecht², Antonella Notarnicola², Maryam Dastmalchi², Anatoly Dubnovitsky³, Tatiana Sandalova³, Genadiy Kozhukh³, Lars Rönnblom⁴, Adnane Achour⁵, Vivianne Malmström⁶ and Ingrid E. Lundberg², ¹Department of Medicine., Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine Solna and Department of Infectious Diseases,, Science for Life Laboratory, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden, ⁴Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ⁵Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁶Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Previous studies have demonstrated that CD4+ T cells from peripheral blood of anti-histidyl-tRNA synthetase (anti-His-tRNA) also known as anti-Jo-1 positive patients proliferate in response…
Abstract Number: 1909 • 2016 ACR/ARHP Annual Meeting
The Transcription Factor Fra2 Is Playing a Key Role in Treg Development and Autoimmunity
Florian Renoux¹, Mara Stellato², Daniela Impellizzieri³, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jeorg HW Distler⁶, Gabriela Kania², Onur Boyman³ and Oliver Distler², ¹Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Decreased numbers or altered functions of regulatory T cells (Tregs) have been reported in many inflammatory rheumatic diseases, and Tregs are considered promising…
Abstract Number: 1910 • 2016 ACR/ARHP Annual Meeting
IL-21 Inhibits Treg Differentiation and Function in SLE By Modulating GATA-3 and CTLA-4
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Studies indicate quantitative and qualitative Treg insufficiencies underlying the dysregulated immune response in SLE. However, it is unknown what mechanisms drive the Treg dysfunction…
Abstract Number: 1911 • 2016 ACR/ARHP Annual Meeting
Potent and Selective Tyk2 Inhibitor Highly Efficacious in Rodent Models of Inflammatory Bowel Disease and Psoriasis
Wenyan Miao¹, Craig Masse¹, Jeremy Greenwood², Rosana Kapeller¹ and William Westlin¹, ¹Nimbus Therapeutics, Cambridge, MA, ²Schrodinger Inc., New York, NY
Background/Purpose: Tyk2 is a member of the JAK family kinases and is a key mediator of IL-12, IL-23, and type I interferon signaling. These cytokines…
Abstract Number: 1912 • 2016 ACR/ARHP Annual Meeting
A New Avenue of Immune Regulation Conferred By Self-Glycerophospholipids Via Mobilization and Migration of Myeloid-Derived Suppressor Cells
Ramesh Halder¹ and Ram R. Singh^1,2,3, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ³Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA
Background/Purpose: Lipids function as essential components of biological membranes, as signaling molecules, and as energy storage molecules. Glycerol-based phospholipids, called glycerophospholipids (GPL), are the most…
Abstract Number: 1913 • 2016 ACR/ARHP Annual Meeting
B Cell Depletion Therapy Impact CD8 T Cells in ANCA-Associated Vasculitis
Antoine Néel^1,2, Marie Bucchia³, Aurelie Caristan¹, Mélanie Néel², Marie Rimbert⁴, Christian Agard¹, Maryvonne Hourmant⁵, Gaelle Tilly², Michelle Yap², François Perrin¹, Pascal Godmer⁶, Julie Graveleau¹, Sophie Brouard², Celine Bressollette⁷, Fadi Fakhouri⁸, Mohamed Hamidou⁹ and Nicolas Degauque², ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²INSERM U1064, Nantes, France, ³Pediatrics, Nantes University Hospital, Nantes, France, ⁴Immunology Laboratory, Nantes University Hospital, Nantes, France, ⁵Nephrology, Nantes University Hospital, Nantes, France, ⁶CH Vannes, Vannes, France, ⁷Virology Laboratory, Nantes University Hospital, Nantes, France, ⁸Nephrology Department, Nantes University Hospital, Nantes, France, ⁹Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France
Background/Purpose: In anti-neutrophil cytoplasmic antibodies associated vasculitis (AAV), several clues suggest that the efficacy of B cell depletion therapy lies beyond the suppression of ANCA-producing…
Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting
Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis
Adrienn Markovics¹, Timea Ocsko¹, Robert S. Katz², Edit I Buzas³, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Semmelweis University, Budapest, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…
Abstract Number: 1915 • 2016 ACR/ARHP Annual Meeting
Partial Elimination of Intestinal Microbiota Dampens T Helper 17 Cell Differentiation and Established Collagen-Induced Arthritis in Mice
Rebecca Rogier¹, Heather Evans-Marin², Birgitte Walgreen¹, Monique M. Helsen¹, Liduine van den Bersselaar¹, Peter M. van der Kraan¹, Fons A.J. van de Loo³, Peter L. van Lent¹, Jose U. Scher⁴, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdolahi-Roodsaz¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Division of Rheumatology, New York University School of Medicine, New York, NY, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴New York University School of Medicine, New York, NY
Background/Purpose: High-throughput sequencing of intestinal microbiota recently revealed that the composition of intestinal microbiota is perturbed in patients with new onset untreated rheumatoid arthritis (RA).…
Abstract Number: 1916 • 2016 ACR/ARHP Annual Meeting
Heightened MAIT Cell Sensitivity to MR1 Ligands Could Impact Control of Dysbiosis in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Diahann Jansen¹, Elizabeth Klinken¹, Hendrik Nel², Soi Cheng Law², Helen Benham^3,4,5, Lisa Cummins⁶, Matthew Brown⁷, Tony Kenna², Ligong Liu⁸, David Fairlie⁸, Jamie Rossjohn^9,10,11, Mark Morrison³, Ranjeny Thomas³, Paraic O Cuiv¹, James McCluskey¹² and Alexandra Corbett¹², ¹The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, ²The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ³Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, ⁴University of Queensland School of Medicine, Brisbane, Australia, ⁵Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, ⁶Princess Alexandra Hospital, Woolloongabba, Australia, ⁷Queensland University of Technology, Brisbane, Australia, ⁸Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, ⁹Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, ¹⁰Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, ¹¹Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, ¹²Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia
Background/Purpose: Mucosal associated invariant T (MAIT) cells are an innate-like lymphocyte population predominant at mucosal sites, which express a semi-invariant T cell receptor restricted to…
Abstract Number: 1917 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Cells Produce Extracellular Vesicles That Incorporate PD-1 and microRNAs Targeting the PD-1 Pathway in Surrounding Cells
Stinne Greisen^1,2, Yan Yan³, Aida Hansen¹, Morten Venø³, Jens Randel Nyengaard⁴, Malene Hvid⁵, Arlene Sharpe⁶, Jørgen Kjems³ and Bent Deleuran^7,8, ¹Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Interdisciplinari Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark, ⁴Clinical Medicine, Electro Microscopy Laboratory, Aarhus University Hospital, Aarhus, Denmark, ⁵Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁶Microbiology and Immunobiology, Harvard Medical School, Boston, MA, ⁷Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁸Department of Biomedicine, Aarhus University, Aarhus, Denmark
Background/Purpose: Programmed death-1 (PD-1) is a central marker of T cell exhaustion. Exhausted T cells are present in inflammatory conditions, where they fail to eliminate…
Abstract Number: 1918 • 2016 ACR/ARHP Annual Meeting
Characterising the Specificity, Function and Behavior of CD4+ T Cells Initiating Inflammation in a Murine Model of Rheumatoid Arthritis
Robert Benson¹, Catriona Prendergast², Iain B McInnes², James Brewer³ and Paul Garside⁴, ¹nstitute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, United Kingdom, ³Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ⁴University of Glasgow, Glasgow, Great Britain
Background/Purpose: CD4+ T cells are important contributors to the pathogenesis of Rheumatoid Arthritis (RA). The presence of activated T cells in the inflamed synovium, strong…

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