Abstract Number: 532 • 2015 ACR/ARHP Annual Meeting
Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression: Preliminary Results
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease that leads to bone erosion. Bone morphogenetic proteins (BMPs) have favourable effects in the recovery of bone…Abstract Number: 533 • 2015 ACR/ARHP Annual Meeting
The Interferon Gene Signature in Early Rheumatoid Arthritis Demonstrates No Significant Association with Disease Activity
Background/Purpose: An interferon-α gene signature (IGS) has been demonstrated in a number of rheumatological conditions, including rheumatoid arthritis (RA) where it is present in about…Abstract Number: 534 • 2015 ACR/ARHP Annual Meeting
Antibodies to Malondialdehyde-Acetaldehyde Adducts Are Highly Expressed in Rheumatoid Arthritis Synovial Fluid
Background/Purpose: Malondialdehyde-acetaldehyde (MAA) adducts are expressed in synovial tissues in rheumatoid arthritis (RA). Post-translational MAA modifications are pro-inflammatory, promoting robust anti-MAA antibody responses that…Abstract Number: 535 • 2015 ACR/ARHP Annual Meeting
Taurine As a Biomarker for Prediction of Response to Biologic Therapy in Rheumatoid Arthritis
Background/Purpose: To identify a serum biomarker for prediction of the response to biologics (Bio) in patients with rheumatoid arthritis (RA), we performed serum metabolomics analysis…Abstract Number: 536 • 2015 ACR/ARHP Annual Meeting
Increased Circulating CD14brightCD16+ Intermediate Monocytes Are Regulated By TNF-Alpha and IL-6 Axis in Accompany with Disease Activity in Rheumatoid Arthritis Patients
Background/Purpose: Recently, three different subsets of circulating monocytes: CD14brightCD16- (classical), CD14brightCD16+ (intermediate) and CD14dimCD16+ (nonclassical) monocytes have been defined. It has been reported that circulating…Abstract Number: 537 • 2015 ACR/ARHP Annual Meeting
The Course of Bone Marrow Edema in Early Undifferentiated and Rheumatoid Arthritis; A Longitudinal MRI Study on Bone Level
Background/Purpose: In rheumatoid arthritis (RA) patients, bone marrow edema (BME)-scores are associated with development of erosions. However, little is known on the course and outcome…Abstract Number: 538 • 2015 ACR/ARHP Annual Meeting
Multidrug Resistant Lymphocytes of Patients with Rheumatoid Arthritis Are Predictive for DMARD and Glucocorticoid Treatment Response
Background/Purpose: A large fraction of patients with RA does not respond to treatment with glucocorticoids (GCs) and disease-modifying anti-rheumatic drugs (DMARDs), or becomes resistant in…Abstract Number: 539 • 2015 ACR/ARHP Annual Meeting
Quantification of T-Cell Receptor Excision Circles (TREC) from Peripheral Blood in Patients with Inflammatory Polyarthritis of Recent Onset (EPA): Association with Radiographic Joint Damage
Background/Purpose: Patients with established Rheumatoid arthritis (RA) present evidence for an exhausted immune system. It is not known whether patients seen at the Early inflammatory…Abstract Number: 540 • 2015 ACR/ARHP Annual Meeting
Clinical Relevance of Etanercept Levels and Anti-Etanercept Antibodies in Long-Term Treatment of Rheumatoid Arthritis Patients
Background/Purpose: Biological compounds have belonged to the therapeutic options for the treatment of rheumatoid arthritis for about 15 years. The application of biological substances is…Abstract Number: 541 • 2015 ACR/ARHP Annual Meeting
Microrna-125b Expression in PBMCs Is Associated with Disease Activity in Patients with Early Rheumatoid Arthritis
Background/Purpose: MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression at posttranscription level and play a significant role in rheumatoid…Abstract Number: 542 • 2015 ACR/ARHP Annual Meeting
Reduced Expression of Mir-204 in Early RA Promotes Inflammatory Pathways in Synovial Fibroblasts
Background/Purpose: Synovial fibroblasts (SF) from the joints of RA patients display an activated and invasive phenotype. They produce a number of pro-inflammatory cytokines and proteolytic…Abstract Number: 543 • 2015 ACR/ARHP Annual Meeting
The IL-20 Receptor Axis in Early Rheumatoid Arthritis: Novel Inflammation-Independent Links Between Autoantibody Positivity and Radiographic Progression
Background/Purpose: Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs) and bone erosions. Successful treatment can compromise…Abstract Number: 544 • 2015 ACR/ARHP Annual Meeting
IL-6 May Have an Important Role in the Resistance to Anti-TNF Therapies of Human T-Lymphotropic Virus Type 1 (HTLV-1) Positive Rheumatoid Arthritis (RA) Patients; HTLV-1 Infected Cells Activate the Inflammatory Responses of RA Synovial Fibroblasts
Background/Purpose: We reported that human T-lymphotropic virus type 1 (HTLV-1) positive patients with rheumatoid arthritis (RA) had higher inflammation and greater resistance to anti-TNF treatment…Abstract Number: 545 • 2015 ACR/ARHP Annual Meeting
Baseline Serum Soluble Interleukin–2 Receptor Alpha (sIL–2Rα) Levels Increased as Intervals Decreased from Cohort Entry to Onset of Incident Rheumatoid Arthritis (pre–RA), not Observed in Matched Control (CN) Subjects
Background/Purpose: Baseline sIL-2Rα levels predicted total mortality in both pre-RA and matched CN subjects, in a preceding prospective cohort study (A&R 2010; 62:S19). Now, the…Abstract Number: 546 • 2015 ACR/ARHP Annual Meeting
Adipokines and Insulin-like Growth Factor 1 As Predictors of Clinical and Radiographic Outcomes in Early Rheumatoid Arthritis
Background/Purpose: Adipokines are cytokines/hormones primarily synthesized in white adipose tissue. In rheumatoid arthritis (RA), some adipokines have been associated with worse outcomes (1-3). The aim…
ACR Meeting Abstracts