Abstract Number: 1828 • 2016 ACR/ARHP Annual Meeting
Metabolic Reprogramming in CD4+CD28-CXCR3intt-bethi cells and Its Relevance to Pathogenesis in Patients with SLE
Background/Purpose: CD4+ T cells play a crucial role in pathological process of Systemic Lupus Erythematosus (SLE). Recently, importance of metabolic reprograming in immunocompetent cells was…Abstract Number: 1829 • 2016 ACR/ARHP Annual Meeting
Hyper-Responsiveness to TLR-4 Stimulation in SLE: Association with High Levels of Serum IFN-Alpha and a Distinct Inflammatory Cytokine Profile
Background/Purpose: IFN-alpha is a pathogenic factor in SLE. High serum interferon activity (IFN-high) marks a subgroup of SLE patients strongly associated with double-stranded DNA (dsDNA) antibodies.…Abstract Number: 1830 • 2016 ACR/ARHP Annual Meeting
The Role of Tripartite Motif-Containing 21 in Interferon Signature of Systemic Lupus Erythematosus
Background/Purpose: Although the increased expression of type I interferon (IFN)-inducible genes, called “IFN signature”, has been suggested to have important roles in the pathogenesis of…Abstract Number: 1831 • 2016 ACR/ARHP Annual Meeting
A Novel Graph Theoretic Approach Applied to Modular Repertoire Analysis Identifies a Dual Molecular Progression in Adult SLE Patients, with Distinct Interferon and Neutrophil Transcription Patterns
Background/Purpose: Gene expression studies support a pivotal role for type I interferon (IFN) in SLE. Previous work using a modular repertoire analysis based on co-clustered…Abstract Number: 1832 • 2016 ACR/ARHP Annual Meeting
Increased Interferon b Expression in Bone Marrow Mediates a Senescent Phenotype and Impaired Production of Immunomodulatory Factors By SLE Mesenchymal Stromal Cells
Background/Purpose: Bone marrow mesenchymal stromal cells (MSCs) are multipotent stem cells that create a special microenvironment for hematopoiesis and immunity. MSCs display robust immunomodulatory properties…Abstract Number: 1833 • 2016 ACR/ARHP Annual Meeting
Autoantibody Response to TROVE2 in Systemic LUPUS Erythematosus Patients
Background/Purpose: Ro60/TROVE2 is a clinically important member of the nuclear antigen family. It binds synergistically YRNAs, allowing the formation of a stable complex with exoribonuclease…Abstract Number: 1834 • 2016 ACR/ARHP Annual Meeting
Commensal Ro60 Autoantigen Ortholog Cross-Reactivity in Human Lupus and Gnotobiotic Models
Background/Purpose: The earliest autoantibodies in lupus are directed against the autoantigen Ro60, an RNA binding protein with orthologs that we identified in a subset of…Abstract Number: 1835 • 2016 ACR/ARHP Annual Meeting
Study on the Expression of NOD2 in Lupus Nephritis and Its Potential Signaling Pathway
Background/Purpose: () - -the Immunohistochemistry was to observe the expression of NOD2 in renal biopsies eal-time uantitative olymerase hain eactionPCR was used to detect the level of…Abstract Number: 1836 • 2016 ACR/ARHP Annual Meeting
SLE Bone Marrow Contains Factors That Promote Type I Interferon Activation
Background/Purpose: SLE is characterized by the inappropriate activation of type I Interferon (IFN) and increases in apoptosis and NETosis by neutrophils, which in combination with…Abstract Number: 1837 • 2016 ACR/ARHP Annual Meeting
Genetic Susceptibility Loci for Systemic Lupus Erythematosus in the Dominican Republic Population
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with marked disparities in prevalence and disease characteristics among different populations. Those disparities are believed…Abstract Number: 1838 • 2016 ACR/ARHP Annual Meeting
Antibodies Against Bacterial Products Curli/DNA Are Found in Lupus Patients and Are Associated with Disease Flares
Background/Purpose: Bacterial infections are a major contributor to morbidity and mortality in SLE, a known trigger of flares and they are often difficult to distinguish…Abstract Number: 1839 • 2016 ACR/ARHP Annual Meeting
Elevated Plasma Cell-Free Mitochondrial DNA Defines a Subgroup of Lupus Patients with Membranous Lupus Nephritis
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations, characterized by production of antibodies against nucleic acids and upregulation of type I…Abstract Number: 1840 • 2016 ACR/ARHP Annual Meeting
A Dichotomy of Regulatory Immunome Is Related to Disease Activity in Juvenile Systemic Lupus Erythematosus
Background/Purpose: The pathogenesis of SLE involves disturbances to the homeostatic balance between the immune effector and regulatory system. The conventional mono-dimensional mechanistic interrogation of one…Abstract Number: 1841 • 2016 ACR/ARHP Annual Meeting
Dysregulation of the Splicing Machinery Components in Leukocytes from Patients with Systemic Lupus Erythematosus: Influence on Autoimmune and Atherothrombotic Mechanisms
Background/Purpose: The aim of this study was to evaluate whether alterations in the splicing-machinery could influence the development and activity of the disease and the…Abstract Number: 1842 • 2016 ACR/ARHP Annual Meeting
Pentraxin 3 Level Positively Correlated with Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus Patients
Background/Purpose: Systemic lupus erythematosus (SLE) is a kind of chronic and autoimmune disease with variable multi-system involvement of unknown causes, which is characterized by periods…
ACR Meeting Abstracts