Abstracts Archive - Page 1709 of 2425 - ACR Meeting Abstracts

Abstract Number: 292 • 2015 ACR/ARHP Annual Meeting
Neoepitope Biomarkers As Biomarkers of Polymyositis and Dermatomyositis and Functional Status
Anders Nedergaard¹, Kim Henriksen², Morten Asser Karsdal³, Wendy White⁴ and Xiang Guo⁴, ¹Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Copenhagen NW, Denmark, ²Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁴Translational Sciences, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: Polymyositis (PM) and Dermatomyositis (DM) are inflammatory conditions characterized by persistent inflammation of muscle tissue (and for DM also skin). Myositis has been shown…
Abstract Number: 293 • 2015 ACR/ARHP Annual Meeting
Measurement of Advanced Glycation Endproducts in the Skin of Patients with Idiopathic Inflammatory Myopathies
Simone Barsotti¹, Chiara Saponaro², Rosaria Talarico³, Alessandra Tripoli⁴, Claudia Ferrari⁵, Elisabetta Bianchini⁶, Nicole Di Lascio⁶, Melania Gaggini², Amalia Gastaldelli², Marta Mosca⁷, Maria Aurora Morales⁶ and Rossella Neri⁵, ¹Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ²National Research Council, Institute of Clinical Physiology, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ⁴University of Pisa, Rheumatology Unit, Pisa, Italy, ⁵Internal Medicine, University of Pisa, Pisa, Italy, ⁶Institute of Clinical Physiology, CNR, Pisa, Italy, ⁷University of Pisa, Pisa, Italy
Background/Purpose: Many data suggest that advanced glycation endproducts (AGEs) play an important role the development of atherosclerosis and cardiovascular (CV) disease. AGEs are produced and…
Abstract Number: 294 • 2015 ACR/ARHP Annual Meeting
A Decline in Pulmonary Function over One Year Predicts Outcome in Myositis-Associated Interstitial Lung Disease
Melissa B. Blom¹, Chester V. Oddis², Diane Koontz³ and Rohit Aggarwal⁴, ¹Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine / Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Interstitial lung disease (ILD) is a leading cause of mortality in myositis. Clinical trials in myositis-associated ILD (MA-ILD) are lacking due to the absence…
Abstract Number: 295 • 2015 ACR/ARHP Annual Meeting
Reliability of the Cutaneous Dermatomyositis Disease Area and Severity Index Among Dermatologists, Rheumatologists, and Neurologists
Neelam Khan^1,2, Janice Tiao^1,2, Rui Feng³, Shawn Bird⁴, Juliana Choi¹, Michael George⁵, Tania Gonzalez-Rivera⁵, Jacob L. Kaufman⁴, Jin Jun Luo⁶, Robert Micheletti¹, Aimee S. Payne¹, Raymond Price⁴, Adam I. Rubin⁷, Antoine G. Sreih⁸, Preethi Thomas⁵, Joyce Okawa⁷ and Victoria P. Werth^1,9, ¹Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Philadelphia V.A. Medical Center, Philadelphia, PA, ³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, ⁴Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁵Department of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁶Department of Neurology, Temple University School of Medicine, Philadelphia, PA, ⁷Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁸Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Philadelphia V.A. Medical Center, Philidelphia, PA
Background/Purpose: Previous studies have shown that skin lesions in dermatomyositis (DM) are best assessed using the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI). Although…
Abstract Number: 296 • 2015 ACR/ARHP Annual Meeting
Different Patterns of Involvement of Thigh Muscles in Dermatomyositis and Polymyositis Using Fat-Suppressed Magnetic Resonance Sequences
Nicolo Pipitone¹, Antonella Notarnicola², Lucia Spaggiari³, Gabriele Levrini⁴, Arnaldo Scardapane⁵, Florenzo Iannone⁶, Giovanni Lapadula⁶, Giulio Zuccoli⁷ and Carlo Salvarani⁸, ¹Unità di Reumatologia, Reggio Emilia, Arcispedale Santa Maria Nuova, Bari, Italy, ²Karolinska Hospital, Rheumatology Unit, Stockholm, Sweden, ³Radiology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Radiology, University of Bari, Bari, Italy, ⁶Bari University, Rheumatology, Bari, Italy, ⁷Children's Hospital of Pittsburgh, Pittsburgh, PA, ⁸Rheumatology, Arcispedale S.Maria Nuova, Reggio Emilia, Italy
Background/Purpose: MRI is often used to evaluate muscle inflammation in myositis. Muscle edema on fat-suppressed (short tau inversion recovery, STIR) sequences is thought to represent…
Abstract Number: 297 • 2015 ACR/ARHP Annual Meeting
How Useful Is Magnetic Resonance Imaging (MRI) in Monitoring Patients with Myositis?
Nicolo Pipitone¹, Antonella Notarnicola², Arnaldo Scardapane³, Gabriele Levrini⁴, Lucia Spaggiari⁵, Florenzo Iannone⁶, Giovanni Lapadula⁶, Giulio Zuccoli⁷ and Carlo Salvarani⁸, ¹Unità di Reumatologia, Reggio Emilia, Arcispedale Santa Maria Nuova, Bari, Italy, ²Karolinska Hospital, Rheumatology Unit, Stockholm, Sweden, ³Radiology, University of Bari, Bari, Italy, ⁴Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Radiology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁶Bari University, Rheumatology, Bari, Italy, ⁷Children's Hospital of Pittsburgh, Pittsburgh, PA, ⁸Rheumatology, Arcispedale S.Maria Nuova, Reggio Emilia, Italy
Background/Purpose: MRI is commonly used to assess muscle inflammation in myositis. Muscle edema on fat-suppressed sequences is thought to reflect active inflammation. However, it is…
Abstract Number: 298 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathway Activation in the Idiopathic Inflammatory Myopathies (IIM): Skeletal Muscle Cells As a Source of Cytokines (Myokines)
Adam P. Lightfoot¹, Katarzyna Goljanek-Whysall², Kate E. Earl², Caroline V. Cotton², Anne McArdle¹ and Robert G. Cooper³, ¹Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Rheumatic Diseaes Center, Salford Royal Foundation Trust, University of Manchester, Salford, United Kingdom
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are a collection of autoimmune disorders, characterised by the development of debilitating symmetrical skeletal muscle weakness. IIM Patients also…
Abstract Number: 299 • 2015 ACR/ARHP Annual Meeting
Subcutaneous Edema, Distal Weakness and Dysphagia Associated with the NXP2 Antibody
Jemima Albayda¹, Iago Pinal-Fernandez², Lisa Christopher-Stine³, Sonye K. Danoff⁴, Cheilonda Johnson⁵, Christopher Mecoli⁶, Julie J. Paik⁷, Alim Ramji⁸ and Andrew Mammen⁹, ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Autoimmune Systemic Diseases Unit, Vall D’Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain, ³Ste 4100 Rm 409, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Medicine/Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, ⁵Medicine/Pulmonology, Johns Hopkins University, Baltimore, MD, ⁶Rheumatology, Johns Hopkins University, Baltimore, MD, ⁷Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁸School of Medicine, Johns Hopkins University, Baltimore, MD, ⁹Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Myositis specific antibodies are known to be associated with specific phenotypes. The unusual presentation of subcutaneous edema, distal weakness and dysphagia was seen in…
Abstract Number: 300 • 2015 ACR/ARHP Annual Meeting
Causes of Creatine Kinase Levels Greater Than 1,000 IU/L in Patients Referred to Rheumatology
David Leverenz¹, Oana Zaha², Leslie J. Crofford¹ and Cecilia P. Chung³, ¹Medicine, Vanderbilt University, Nashville, TN, ²Medicine, Div of Rheumatology and Immunology, Vanderbilt University, Nashville, TN, ³Medicine, Div of Rheumatology & Immunology, Vanderbilt University, Nashville, TN
Background/Purpose: Patients with significantly elevated creatine kinase (CK) levels are commonly referred to rheumatologists to evaluate for the presence of an idiopathic inflammatory myopathy (IIM).…
Abstract Number: 301 • 2015 ACR/ARHP Annual Meeting
Economic Burden of Sporadic Inclusion Body Myositis in the United States of America: A Retrospective Cohort Study
Haijun Tian¹, Changgeng Zhao¹, Victoria Barghout², Zhongyuan Wei³, Neetu Agashivala¹, Aoife Callan⁴ and Gorana capkun-Niggli⁵, ¹Novartis Pharmaceuticals Corporation, East Hanover, NJ, ²VEB HealthCare LLC, Morristown, NJ, ³KMK Consulting Inc, Morristown, NJ, ⁴Novartis Pharmaceuticals Corporation, Dublin, Ireland, ⁵Novartis Pharmaceuticals Corporation, Basel, Switzerland
Background/Purpose: Sporadic inclusion body myositis (sIBM) is a rare & debilitating muscle disease characterized by the slow progressive asymmetric weakness, atrophy of proximal & distal…
Abstract Number: 302 • 2015 ACR/ARHP Annual Meeting
Resource Utilization in a US Sample of Patients with Sporadic Inclusion Body Myositis
Victoria Barghout¹, Carla DeMuro², Bob Goldberg³, Mark A Price², Linda Lowes⁴, Gorana capkun-Niggli⁵, Valerie Williams⁶ and Brian Tseng⁷, ¹VEB HealthCare LLC, Morristown, NJ, ²RTI Health Solutions, North Carolina, NC, ³The Myositis Association, Alexandria, VA, ⁴Nationwide Children’s Hospital, Columbus, OH, ⁵Novartis Pharmaceuticals Corporation, Basel, Switzerland, ⁶Psychometrics, RTI Health Solutions, North Carolina, NC, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Sporadic Inclusion Body Myositis (sIBM) is a progressive, idiopathic inflammatory myopathy characterized by dysphagia, weakness of proximal and distal muscles and atrophy. This cross-sectional…
Abstract Number: 303 • 2015 ACR/ARHP Annual Meeting
Mining RNA-Seq of Peripheral Blood Mononuclear Cells from JDM Alone Compared with JDM Plus Psoriasis for Biomarkers of Disease Activity
Elisha D.O. Roberson¹, Li Cao², Gabrielle A. Morgan^3,4,5, Adam Ostrower^3,4,5, Chiang-Ching Huang⁶ and Lauren M. Pachman^3,4,5, ¹John T. Milliken Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO, ²John T. Milliken Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, ³Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology/Immunology, Ann & Robert H. Lurie Children's Hosptial of Chicago, Chicago, IL, ⁶Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI
Background/Purpose: Our CureJM JDM Registry/Repository contains sequential samples of peripheral blood mononuclear cells (PBMCs) and sera obtained every 6 months from over 467 children with…
Abstract Number: 304 • 2015 ACR/ARHP Annual Meeting
Abnormal Pulmonary Function Tests, Interstitial Lung Disease, and Lung Function Decline in Patients with Classic and Clinically Amyopathic Dermatomyositis
Michael George¹, Maryl Kreider², Rupal Shah², Wallace Miller Jr.³, Peter A. Merkel⁴ and Victoria Werth^5,6, ¹Department of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Pulmonary, Allergy & Critical Care, University of Pennsylvania, Philadelphia, PA, ³Radiology, University of Pennsylvania, Philadelphia, PA, ⁴Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Dermatology, Veterans Affairs Medical Center, Philadelphia, PA, ⁶Dermatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Interstitial lung disease (ILD) is common in classic dermatomyositis (DM) and clinically amyopathic dermatomyositis (CADM), in which rash is present without weakness. Previous studies…
Abstract Number: 305 • 2015 ACR/ARHP Annual Meeting
The “Sleeve Sign”� in Dermatomyositis
Arash Lahoutiharahdashti¹, Julie J. Paik², Jemima Albayda¹, Andrew Mammen^3,4 and Lisa Christopher-Stine⁵, ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴NIAMS, NIH, Bethesda, MD, ⁵Ste 4100 Rm 409, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Dermatomyositis (DM) is a subset of idiopathic inflammatory myopathies, characterized by proximal skeletal muscle weakness and skin manifestations. Several skin eruptions have been described…
Abstract Number: 306 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathways in the Idiopathic Inflammatory Myopathies (IIM): Interrogating the Role of Micro-RNA 133a As an Important Regulator of ER Stress Activation
Adam P. Lightfoot¹, Katarzyna Goljanek-Whysall², Anne McArdle¹ and Robert G. Cooper^3,4, ¹Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Rheumatic Diseaes Center, Salford Royal Foundation Trust, University of Manchester, Salford, United Kingdom, ⁴MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom
Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) is a heterogeneous group of acquired autoimmune disorders, characterised by symmetrical muscle weakness. Whilst immune cells clearly play a…

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