Abstracts Archive - Page 169 of 2425 - ACR Meeting Abstracts

Abstract Number: 0228 • ACR Convergence 2024
Do Imaging Tests Have a Role in Predicting Progression to Rheumatoid Arthritis in People with Clinically Suspect Arthralgia? A Systematic Review & Meta-Analysis
Ankita Gupta¹, Sulaiman Anis² and Paola de Pablo², ¹Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, ²University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Clinically suspect arthralgia (CSA) has been associated with an increased risk of developing inflammatory arthritis (IA). Subclinical inflammation on imaging tests may help to…
Abstract Number: 0773 • ACR Convergence 2024
Anti-Citrullinated Histone Antibody CIT-013 Targets NETs in Inflamed Joints and Halts NET-mediated Joint Deterioration
Leonie Middelink¹, Annemarie Kip², Maarten van der Linden³, Sangeeta Kumari², Stephanie van Dalen², Josephine Stein⁴, Tirza Bruurmijn², Martyn Foster⁵, Peter van Zandvoort², Patrick Round², Eric Meldrum², Helmuth van Es² and Renato Chirivi², ¹Citryll, Oss, Noord-Brabant, Netherlands, ²Citryll BV, Oss, Noord-Brabant, Netherlands, ³Citryll BV, Oss, Netherlands, ⁴Citryll BV, Oss, Noord-Holland, Netherlands, ⁵Experimental Pathology Consultancy, Benfleet, United Kingdom
Background/Purpose: Neutrophil extracellular traps (NETs) contribute to the pathophysiology of many immune-mediated inflammatory diseases (IMIDs). Though NETosis-targeting therapeutics have shown potential as effective treatments, currently…
Abstract Number: 0978 • ACR Convergence 2024
Associations of Fire Smoke and Other Pollutants with Incident Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease
Vanessa Kronzer¹, Yangyuna Yang², Punyasha Roul³, James Crooks⁴, Cynthia Crowson¹, John Davis¹, Jeffrey Sparks⁵, Jeffrey Pierce⁶, Katelyn O'Dell⁷, Sauer brian⁸, grant Cannon⁹, Joshua Baker¹⁰, Ted Mikuls² and Bryant England², ¹Mayo Clinic, Rochester, MN, ²University of Nebraska Medical Center, Omaha, NE, ³UNMC, Omaha, NE, ⁴National Jewish Health, Denver, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, ⁶Colorado State University, Fort Collins, ⁷George Washington University, Washington DC, ⁸Salt Lake City VA/University of Utah, Salt Lake City, UT, ⁹University of Utah and Salt Lake City VA, Salt Lake City, UT, ¹⁰Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA

Background/Purpose: Wildfires have burned increasing acreage in the United States (US) since the 1980s, releasing record and alarming levels of particulate matter smaller than 2.5…
Abstract Number: 0499 • ACR Convergence 2024
PD-1hiCXCR5-CD4+T Peripheral Helper Cells Enrich in Rheumatoid Arthritis and Predict Clinical Response to Anti-TNF Treatment
Wanki Ho¹, Huaqun Zhu¹, Hua Ye¹, Dongdong Fu² and Xi Xu¹, ¹Peking University People's Hospital, Beijing, China, ²Xinxiang Central Hospital, Xinxiang, Henan, China (People's Republic)
Background/Purpose: PD-1hiCXCR5-CD4+T peripheral helper cells (Tph) are newly identified pathogenic CD4+T helper cells and participate in rheumatoid arthritis (RA) pathogenesis. However, the clinical significance of…
Abstract Number: 0787 • ACR Convergence 2024
Efficacy of Intra-Articular Hyaluronic Acid Injection for Nonsurgical Management of Carpometacarpal Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Mohamed Abdelsalam¹, omnia Samy² and Asmaa al-Najjar³, ¹Rheumatology, Rehabilitation and Physical medicine department - faculty of medicine -Misr University for science and technology, 6th of October, Al Jizah, Egypt, ²Faculty of medicine - Zagazig university, Al Zagazig, Egypt, ³Faculty of medicine - Al-Azhar university in Gaza, Gaza, Palestinian Territories
Background/Purpose: Carpometacarpal osteoarthritis (CMC OA) is a painful condition affecting 21% of hand OA patients. Various treatment modalities have been explored to reduce pain and…
Abstract Number: 0931 • ACR Convergence 2024
Salivary Granular Convoluted Tubules Contribute to Maintain Tissue-specific Tolerance – Implications for the Development of Murine Sjögren´s Syndrome
Xiaomei Shan¹, Clara Reichardt¹, Marco Munoz Becerra¹, Aleix Rigau², Lena Müller³, Anne Zeitler¹, Jasmin Knopf⁴, Gerhard Grossmayer¹, Martin Herrmann¹, Christine Schauer¹, Markus Eckstein⁵, Georg Schett⁶ and Luis Munoz⁷, ¹Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany, ²Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, ³Medizin Universität Wien, Vienna, Austria, ⁴Universitätsklinikum Mannheim, Mannheim, Germany, ⁵Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ⁶Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ⁷Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen
Background/Purpose: Primary Sjögren's syndrome (PSS) is a chronic inflammatory disease affecting exocrine glands with an important systemic autoimmune reaction against some nuclear and membrane bound…
Abstract Number: 1028 • ACR Convergence 2024
Assessment of Patient-Reported Outcomes in Juvenile Idiopathic Arthritis by Race, Ethnicity, and Insurance Type in the Pediatric Rheumatology Care and Outcomes Improvement Network Registry
Julia Harris¹, Nancy Pan², Catherine Bingham³, Sheetal Vora⁴, Cagri Yildirim-Toruner⁵, Kerry Ferraro⁶, Erik Friedrichsen⁷, Michelle Batthish⁸, Jon Burnham⁹, Danielle Fair¹⁰, Suhas Ganguli¹¹, Mileka Gilbert¹², Beth Gottlieb¹³, Olha Halyabar¹⁴, Melissa Hazen¹⁵, Tzielan Lee¹⁶, Daniel Lovell¹⁷, Melissa Mannion¹⁸, Edward Oberle¹⁹, Linda Ray²⁰, Michael Shishov²¹, Mary Toth²² and Esi Morgan²³, ¹Children's Mercy Kansas City, Overland Park, KS, ²Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ³Penn State Children’s Hospital, Hershey, ⁴Atrium Health Levine Children's Hospital, Charlotte, NC, ⁵Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁶JIA parent and CHOP volunteer, Lower Gwynedd, PA, ⁷Seattle Children's Hospital, Seattle, ⁸McMaster Children's Hospital, Hamilton, ON, Canada, ⁹Children's Hospital of Philadelphia, Philadelphia, PA, ¹⁰Medical College of Wisconsin/Children's Wisconsin, Wauwatosa, WI, ¹¹Hackensack University Medical Center, Hackensack, ¹²Medical University of South Carolina, Charleston, SC, ¹³Cohen Children's Medical Center, Lake Success, NY, ¹⁴Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ¹⁵Boston Children's Hospital, Boston, MA, ¹⁶Stanford University School of Medicine, Palo Alto, CA, ¹⁷Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁸University of Alabama at Birmingham, Birmingham, AL, ¹⁹Nationwide Children's Hospital, Columbus, OH, ²⁰University of Mississippi Medical Center, Jackson, MS, ²¹Phoenix Children's Hospital, Phoenix, AZ, ²²Nemours Foundation, Orlando, FL, ²³Seattle Children's Hospital, Seattle, WA
Background/Purpose: As healthcare moves towards more patient-centered care, it is increasingly important to integrate patients’ opinions into clinical assessments and decision-making. The Pediatric Rheumatology Care…
Abstract Number: 1015 • ACR Convergence 2024
Performance of a Molecular Signal Response Classifier Predicting Inadequate Response to Tumor Necrosis Factor Inhibitors in Hispanic Patients with Rheumatoid Arthritis
Viet Bui¹, Miguel Rodriguez² and Sarah Ormseth³, ¹Harbor UCLA Medical Center and The Lundquist Institute, Torrance, CA, ²Texas Arthritis Center, El Paso, TX, ³The Lundquist Institute, Torrance, CA
Background/Purpose: Tumor necrosis factor inhibitors (TNFi) are generally the first class of biologic disease modifying anti-rheumatic drugs (DMARDs) prescribed for rheumatoid arthritis (RA) patients with…
Abstract Number: 0510 • ACR Convergence 2024
Applying Machine Learning Tools for Personalized Healthcare: Predicting Responses to Biologics in Rheumatoid Patients Through Comorbidity and Blood Test Analysis
Ahmad Alsaber¹, Adeeba Alherz², Huda Khraiss³, Ghaydaa Aldabie⁴, balqees alawadhi⁵, Jiazhu Pan⁶, Adel Alawadhi⁷, KHULOUD MOHAMMED⁸, Hoda Tarakmeh⁹, Aqeel Muhanna¹⁰, Yaser Ali¹¹ and mohammad Khudadah¹², and Kuwait Registry for Rheumatic Diseases (KRRD), ¹American University of Kuwait, Kuwait, Kuwait, ²Al-Amiri Hospital, Kuwait, Kuwait, ³Monash University, Melbourne, Queensland, Australia, ⁴ministry of health kuwait, kuwait, Kuwait, ⁵The Public Authority for Applied Education and Training (PAAET), Kuwait, Al Asimah, Kuwait, ⁶University of Strathclyde, Glasgow, Scotland, United Kingdom, ⁷Kuwait University, Kuwait, Kuwait, ⁸Farwaniya Hospital, Kuwait, Kuwait, ⁹MOH Kuwait, Kuwait, Kuwait, ¹⁰Ministry of Health, Kuwait, Al Farwaniyah, Kuwait, ¹¹Mubarek Al Kabeer Hospital, Kuwait city, Kuwait, ¹²ministery of health, kuwait, Kuwait
Background/Purpose: This study aims to employ various machine learning tools to predict the responses of rheumatoid arthritis (RA) patients to biologic treatments, using data from…
Abstract Number: 0034 • ACR Convergence 2024
Arthritogenic Subdoligranulum (S. Dido 7) Is Increased in Individuals At-Risk for and with Early RA and Decreases over Time During Development of Inflammatory Arthritis
Lyndsey Cole¹, Sucai Liu², Brendan Allen², Marie Feser³, Kristen Demoruelle⁴, Kevin Deane⁵, Michael Holers³ and Kristine Kuhn⁶, ¹University of Colorado School of Medicine, Centennial, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴University of Colorado Anschutz Medical Campus, Golden, CO, ⁵University of Colorado Denver Anschutz Medical Campus, Aurora, CO, ⁶University of Colorado, Aurora, CO
Background/Purpose: Subdoligranulum didolesgii, S. dido 7, is present in a subset of individuals who are at-risk for RA (termed ‘ARI’) and who have clinical RA,…
Abstract Number: 0942 • ACR Convergence 2024
An Aged K/BxA Arthritis Mouse Model Develops Features of Interstitial Lung Disease with Pulmonary Fibrosis and Bronchus-Associated T-Cell Aggregates Without a Pulmonary Insult, and Correlates with Worsening Arthritis Scores
Amir Razmjou¹, Richard Watson², Ani Shahbazian³, Jennifer Wang¹ and christina Charles-Schoeman⁴, ¹UCLA, Los Angeles, CA, ²UCLA Medical Center, Los Angeles, CA, ³UCLA, Los Angeles, ⁴UCLA Medical Center, Santa Monica, CA
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a significant extra-articular manifestation of RA with high morbidity/mortality, but the underlying pathogenesis remains poorly understood.…
Abstract Number: 1047 • ACR Convergence 2024
Impact of Treatment Switching on Adherence in Members with Rheumatoid Arthritis, Psoriatic Arthritis, or Systemic Lupus Erythematosus
Jean Park¹, Cliff Rutter², Elisea Avalos-Reyes³, Mary Anderson⁴, Will Cavers⁵, Dorothea Verbrugge⁶ and Kjel Johnson⁷, ¹CVS Health, Hartford, CT, ²CVS Health, Fair Oaks Ranch, TX, ³CVS Health, Highland Village, TX, ⁴CVS Health, Irving, TX, ⁵CVS Health, Palm Beach Gardens, ⁶CVS Health, Salt Lake City, ⁷CVS Health, Tampa
Background/Purpose: Switching treatment from conventional to biologic disease-modifying antirheumatic drugs (DMARDs) is a common practice for managing autoimmune diseases such as rheumatoid arthritis (RA), psoriatic…
Abstract Number: 0016 • ACR Convergence 2024
Establishment of a Human 3D In-Vitro Lymphoid Model to Evaluate Germinal Center Biology
Lichchavi Rajasinghe¹, Govinda Rocky Thomas,², Jee Ho Lee¹, Gary Sims¹ and Tatiana Ort¹, ¹Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, ²AstraZeneca Pharmaceuticals, Gaithersburg, MD
Background/Purpose: Germinal centers (GC) are specialized lymphoid structures found within the B cell follicles of secondary lymphoid tissue formed following infection or immunization. They are…
Abstract Number: 0803 • ACR Convergence 2024
Serum Adipokines and Interstitial Lung Disease in a Prospective Rheumatoid Arthritis Cohort
Anna Haggart¹, Joshua Baker², Tate Johnson³, Yangyuna Yang³, Punyasha Roul⁴, Katherine Wysham⁵, grant Cannon⁶, Gary Kunkel⁷, Dana Ascherman⁸, Paul Monach⁹, Gail Kerr¹⁰, Andreas Reimold¹¹, Michael Duryee³, Geoffrey Thiele³, Ted Mikuls³ and Bryant England³, ¹University of Nebraska Medical Center, Omaha, ²University of Pennsylvania, Philadelphia, PA, ³University of Nebraska Medical Center, Omaha, NE, ⁴UNMC, Omaha, NE, ⁵VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁶University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁷University of Utah and George E Wahlen VAMC, Salt Lake City, UT, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁹VA Boston Healthcare System, Boston, MA, ¹⁰Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, ¹¹Dallas VA Medical Center, Dallas, TX
Background/Purpose: Adipokines are metabolic cytokines shown to be dysregulated in RA and prognostic of RA-related complications such as cardiovascular disease. Similarly, aberrations in adipokines have…
Abstract Number: 1025 • ACR Convergence 2024
Gender Disparities in Disease Impact and Treatment Access for Spondyloarthropathies in Latin America: Insights from a Web Survey
Sebastián Ibáñez¹, María Dominga García¹ and Natalia González², ¹Clínica Alemana de Santiago, Santiago, Region Metropolitana, Chile, ²Fundación Espondilitis Chile, Santiago, Region Metropolitana, Chile
Background/Purpose: Previous studies have shown that female patients with spondyloarthritis (SpA) tend to experience a greater impact on their functionality, especially among women in Latin…

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