Abstract Number: 1104 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Chronic Tendinopathy
Background/Purpose: Chronic tendinopathy is an inflammatory and degenerative condition caused by injuries or overuse. Current therapeutic options focus on alleviating the symptoms and pain rather…Abstract Number: 1105 • 2016 ACR/ARHP Annual Meeting
Bone Metabolism in Rheumatic Diseases May be Affected By Free Fatty Acids
Background/Purpose: Obesity is associated with an increased risk of osteoarthritis also in non-weight bearing joints and increased amounts of visceral fat are associated with lower…Abstract Number: 1106 • 2016 ACR/ARHP Annual Meeting
Test of the Spleen Tyrosine Kinase Inhibitor Fostamatinib in a Translational Joint Tissue Model Show Significant Effect on Bone, but Not on Synovial Tissue
Background/Purpose: The Spleen tyrosine kinase (Syk) inhibitor fostamatinib was not approved as treatment for rheumatoid arthritis (RA) due to insufficient effect on joint structure in…Abstract Number: 1107 • 2016 ACR/ARHP Annual Meeting
Combining Scaffold-Free Cartilage Transplants to Controlled Gene Expression for Therapeutic Application in Rheumatic Disorders
Background/Purpose: Cartilage destruction is accompanied by a tremendous loss of life quality due to deprivation of agility, flexibility and pain. Additionally, increased catabolic mediators such…Abstract Number: 1108 • 2016 ACR/ARHP Annual Meeting
Protein Citrullinations By PAD Enzymes Promote Dendritic Cell Transdifferentiation into Osteoclast and Generate Targets for RA-Specific Antibodies
Background/Purpose: Immature dendritic cells (DCs) can develop into osteoclasts (OCs), however, the mechanisms regulating this differentiation switch are not yet understood. We have shown that…Abstract Number: 1109 • 2016 ACR/ARHP Annual Meeting
Targeting IL-8 and CXCR1/2 Abrogates RANKL- and ACPA-Mediated Osteoclastogenesis
Background/Purpose: Increased circulating levels of Interleukin-8 (IL-8) have been linked to the bone loss associated with breast cancer metastasis. Recently, we have shown that anti-citrullinated…Abstract Number: 1110 • 2016 ACR/ARHP Annual Meeting
Inactive Rhomboid Family Member 2/Tnfα Convertase/Tnfα Pathway Is Essential to the Pathogenesis of Haemophilic Arthropathy
Background/Purpose: A major manifestation of Hemophilia A, an X-linked bleeding disorder, is hemophilic arthropathy (HA), a debilitating degenerative joint disease that is caused by intraarticular…Abstract Number: 1111 • 2016 ACR/ARHP Annual Meeting
Huntingtin Interactin Protein 1 (HIP1) Regulates Receptor Tyrosine Kinases Mediated Activity and Cell Invasiness in Fibroblast-like Synoviocytes
Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is a new arthritis severity gene recently identified in the Pristane and Collagen-induced arthritis (PIA, CIA) quantitative trait locus Cia25/Pia42…Abstract Number: 1112 • 2016 ACR/ARHP Annual Meeting
Hypoxia Modulates Neutrophil Integrin Expression, Adhesion and Trans-Endothelial Migration
Background/Purpose: Dysregulation of neutrophil activation is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs), including RA, SLE and APS. Neutrophils are…Abstract Number: 1113 • 2016 ACR/ARHP Annual Meeting
Leptin Promotes Distribution of Mast Cells in Salivary Glands of Patients with Primary Sjogren’s Syndrome
Background/Purpose: Mast cells (MCs) are immune cells that produce and secrete a variety of mediators and cytokines, which influence various inflammatory and immune processes. It…Abstract Number: 1114 • 2016 ACR/ARHP Annual Meeting
Extracellular Vesicles in the Circulating of Rheumatoid Arthritis Patients Are Pro-Inflammatory
Background/Purpose: Rheumatoid arthritis (RA) is a progressive and degenerative joint disease with chronic synovial inflammation in multiple joints. Interestingly, the symmetry and spreading of the…Abstract Number: 1115 • 2016 ACR/ARHP Annual Meeting
Non-Esterified Fatty Acids Are Associated with Clinical Features and an Enhanced Th1 Response in Rheumatoid Arthritis: Towards Disease Profiling
Background/Purpose: Non-Esterified Fatty Acids (NEFA) are important lipid mediators which can play a role in a number of biological functions other than energy supply. NEFA…Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…Abstract Number: 1117 • 2016 ACR/ARHP Annual Meeting
EGCG Down-Regulates TNF-α-Induced Mcl-1 Expression By Modulating Mule/Huwe1, β-TrCP, and USP9X Ubiquitin/De-Ubiquitin Ligases in Rheumatoid Arthritis Synovial Fibroblasts
Background/Purpose: Myeloid cell leukemia (Mcl-1) phosphorylation at Ser64 position (p-Mcl-1Ser64) has been shown to enhance Mcl-1’s stability and resistance to proteasomal degradation. However, the…Abstract Number: 1118 • 2016 ACR/ARHP Annual Meeting
Increased Population of Myeloid Dendritic Cells and Upregulated Gene Expression of Tnfα Is Associated with Poor Response to Hydroxychloroquine
Background/Purpose: Cutaneous lupus erythematosus (CLE) is an autoimmune disease with various subsets and wide-ranging clinical manifestations. T lymphocytes are the predominant cell type found in…
ACR Meeting Abstracts