Abstracts Archive - Page 1673 of 2425 - ACR Meeting Abstracts

Abstract Number: 3016 • 2015 ACR/ARHP Annual Meeting
Bromodomain Inhibitor JQ1 Modulates Smooth Muscle Cell Switching and Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension in Mice
Sarah L. Trinder¹, Adrian Gilbane², Robert Good², Emma C. Derrett-Smith³, Christopher P. Denton⁴, David Abraham⁵ and Alan M. Holmes², ¹Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases,, UCL Division of Medicine, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁵Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: Pulmonary arterial hypertension (PAH) represents a serious co-morbidity affecting up to 10% of systemic sclerosis (SSc) patients. Cardinal features of PAH include inflammation and…
Abstract Number: 3017 • 2015 ACR/ARHP Annual Meeting
TYK2 and Systemic Sclerosis Susceptibility: a New Associated Locus in the IL-12 Pathway
Elena Lopez-Isac¹, Lara Bossini-Castillo², Sandra G Guerra³, Shervin Assassi⁴, Carmen P. Simeón⁵, Patricia E. Carreira⁶, Norberto Ortego-Centeno⁷, Paloma García de la Peña⁵, Lorenzo Beretta⁸, Alessandro Santaniello⁹, Chiara Bellocchi¹⁰, Claudio Lunardi¹¹, Gianluca Moroncini¹², Armando Gabrielli¹³, Gabriela Riemekasten¹⁴, Torsten Witte¹⁵, Nicolas Hunzelmann¹⁶, Alexander Kreuter¹⁷, Jorg HW. Distler¹⁸, Alexandre E. Voskuyl¹⁹, J.K. de Vries-Bouwstra²⁰, Ariane L. Herrick²¹, Jane Worthington²², Christopher P. Denton²³, Carmen Fonseca³, T.R.D.J. Radstake²⁴, Maureen D Mayes²⁵ and Javier Martín¹, ¹Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain, ³Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁴Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁵Rheumatologist, Granada, Spain, ⁶Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁷Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, ⁸Rheumatology, Milan, Italy, ⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena and University of Milan, Italy, Milan, Italy, ¹⁰Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹¹Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹²Dipartimento di Scienze mediche e Chirurgiche, Università politecnica delle Marche, Ancona, Italy, ¹³Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ¹⁴Clinic of Rheumatology and Clinical Immunology, Berlin, Germany, ¹⁵Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹⁶Department of Dermatology, University of Cologne, Cologne, Germany, ¹⁷Department of Dermatology, Venereology, and Allergologie, HELIOS St. Elisabeth Hospital, Oberhausen, Germany, ¹⁸Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁹Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, ²⁰Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²¹Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²³Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²⁴Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²⁵University of Texas - Houston Medical School, Houston, TX
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease. The aetiology of the disease is largely unknown, although both environmental and a genetic factors are…
Abstract Number: 3018 • 2015 ACR/ARHP Annual Meeting
Paracrine Effect of Proteins Secreted By Normal Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition on the Expression of Genes Associated with Tissue Fibrosis in Normal Human Lung Fibroblasts
Sonsoles Piera-Velazquez¹, Kerri Fasino² and Sergio A. Jimenez³, ¹Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, ³Div Connective Tissue Diseases, Thomas Jefferson Univ, Philadelphia, PA
Background/Purpose: Progressive tissue fibrosis and microvascular alterations are the hallmarks of Systemic Sclerosis (SSc). The mechanisms involved in SSc pathogenesis are complex and have not…
Abstract Number: 3019 • 2015 ACR/ARHP Annual Meeting
The CD4+CD52low T Cell Contributes to Disease Activity and Autoantybody Production in Systemic Lupus Erythematosus
Masataka Umeda¹, Tomohiro Koga¹, Kunihiro Ichinose², Toru Michitsuji¹, Toshimasa Shimizu², Shoichi Fukui³, Ayako Nishino³, Yoshikazu Nakashima⁴, Yoshiro Horai¹, Takahisa Suzuki¹, Shin-ya Kawashiri³, Naoki Iwamoto¹, Toshiyuki Aramaki⁵, Mami Tamai¹, Yasuko Hirai¹, Hideki Nakamura¹, Kazuo Yamamoto⁶, Tomoki Origuchi^7,8, Yukitaka Ueki⁹ and Atsushi Kawakami¹, ¹Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁴Department of Rheumatology, Nagasaki University, Nagasaki, Japan, ⁵Department of Rheumatology, Sasebo Chuo Hospital, Sasebo, Japan, ⁶Biomedical Research Support Center, Nagasaki University School of Medicine, Nagasaki, Japan, ⁷Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, ⁸Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁹Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan
Background/Purpose: CD52 is a cell-surface glycoprotein that is widely expressed in lymphocytes, monocytes and eosinophils. The anti-CD52 antibody has been used to treat multiple autoimmune…
Abstract Number: 3020 • 2015 ACR/ARHP Annual Meeting
IL-21 Abrogates CD4+CD25+FOXP3+ Treg Differentiation in Part By Suppressing Treg GATA-3 Expression in SLE
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Previous studies point to qualitative and quantitative Treg insufficiencies underlying aberrant T-cell activation in SLE. GATA-3 is critical in lineage commitment and functions of…
Abstract Number: 3021 • 2015 ACR/ARHP Annual Meeting
The Adaptor Protein Crkii Regulates Rap1 Activation in the Immunological Synapse
Adam Mor¹ and Inbar Alfaguter², ¹Rheumatology and Pathology, NYU Langone Medical Center, New York, NY, ²NYU, New York, NY
Background/Purpose: Crk proteins are a family of adaptors that play an important role in regulating multiple T cell functions. The two main Crk isoforms are…
Abstract Number: 3022 • 2015 ACR/ARHP Annual Meeting
Characterizing a Novel Gene, Mosaic, and Its Role in Mediating a Multisystem Autoimmunity
Alice Chan¹, Emily Brown², Oded Foreman³, Anita Oberbauer⁴, Angela Hughes⁵, Shelly Burton⁶, Hong-Erh Liang⁷, Mark Anderson⁸ and Danika Bannasch⁹, ¹Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, ²Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, ³Genentech, Inc, South San Francisco, CA, ⁴Department of Animal Science, School of Veterinary Medicine, University of California Davis, Davis, CA, ⁵Mars Veterinary, Gaithersburg, MD, ⁶Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada, ⁷Medicine, University of California San Francisco, San Francisco, CA, ⁸Diabetes Center, University of California San Francisco, San Francisco, CA, ⁹Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA
Background/Purpose: A novel candidate gene, Mosaic (Multi-Organ System Autoimmunity in Canines), was identified as the culprit causing an early and severe multiorgan autoimmunity in a…
Abstract Number: 3023 • 2015 ACR/ARHP Annual Meeting
Decreased Intracellular Calcium Flux in Follicular Helper T Cells after T Cell Receptor Stimulation
Abhinav Seth¹, Edward I. Herman², Jason S. Weinstein¹, Jin Young Choi³ and Joseph E. Craft⁴, ¹Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT, ⁴Dept of Internal Med/Rheum, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T (Tfh) cells are a specialized subset of CD4+ helper T cells that are required for B cell maturation in germinal centers…
Abstract Number: 3024 • 2015 ACR/ARHP Annual Meeting
FcÎ³riiia Mediated Signal Cause Epigenetic Changes in Human Naive CD4+ T-Cells
Ye Bi¹, Chen Chen², Terry Moore³ and Anil K. Chauhan⁴, ¹Internal Medicine, Saint Louis University, St. Louis, MO, ²Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO, ⁴Internal Medicine-Rheumatology, Saint Louis University, St Louis, MO
Background/Purpose: Signals that trigger epigenetic changes in CD4+ T-cells are unknown. To examine a role for FcγRIIIa mediated co-signal in causing epigenetic changes in human…
Abstract Number: 3025 • 2015 ACR/ARHP Annual Meeting
FcγRIIIa-Psyk Signaling up-Regulates TLR3 and TLR5 in Human Naïve CD4+ T-Cells
Chen Chen¹, Ye Bi², Terry Moore³ and Anil K. Chauhan⁴, ¹Rheumatology/Internal Medicine, Saint Louis University, St. Louis, MO, ²Internal Medicine, Saint Louis University, St. Louis, MO, ³Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO, ⁴Internal Medicine-Rheumatology, Saint Louis University, St Louis, MO
Background/Purpose: To delineate mechanism of FcγRIIIa-pSyk signal in TH17 and IFN-γhigh subset development. To examine whether Toll-like receptor signaling play a role in CD4+ T-cell…
Abstract Number: 3026 • 2015 ACR/ARHP Annual Meeting
The Effects of Lrg on the Differentiation of Naïve T Cells
Hayato Urushima¹, Minoru Fujimoto², Chiharu Iwahashi¹, Tomoharu Ohkawara², Hiromi Honda², Satoshi Serada¹ and Tetsuji Naka², ¹Laboratory for Immune Signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, ²Laboratry of immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan
Background/Purpose: Previously, we have identified leucine-rich alpha 2 glycoprotein (LRG) as a disease marker of Rheumatoid arthritis(RA). Although LRG is produced in site of inflammation…
Abstract Number: 3027 • 2015 ACR/ARHP Annual Meeting
Hyperactivated State of Mucosal Associated Invariant T Cells Due to Activation Potency of Monocytes in Systemic Lupus Erythematous
Goh Murayama¹, Asako Chiba², Ken Yamaji³, Naoto Tamura³, Yoshinari Takasaki³ and Sachiko Miyake², ¹Department of Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, ²Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 3028 • 2015 ACR/ARHP Annual Meeting
CD1d Regulates iNKT Cell Autoreactivity
Meng Zhao^1,2 and Mitchell Kronenberg², ¹Medicine, UC-San Diego, La Jolla, CA, ²Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA
Background/Purpose: Invariant Natural Killer T (iNKT) cells are a unique population of lymphocytes that express an invariant TCR alpha chain, and react to lipid antigens…
Abstract Number: 3029 • 2015 ACR/ARHP Annual Meeting
Increased Plasticity of Non-Classic Th1 Cells Towards the Th17 Phenotype
Antonia Klose¹, Fausto Pirronello¹, Hendrik Schulze-Koops¹, Jan Leipe² and Alla Skapenko¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology, University of Munich, Munich, Germany
Background/Purpose: Mechanisms underlying the predominance of Th17 cells observed in RA are not fully understood. Th cell plasticity is a potential mechanism leading to enrichment…
Abstract Number: 3030 • 2015 ACR/ARHP Annual Meeting
Increased Localization of Spleen Tyrosine Kinase (Syk) in Lipid Rafts of in Vitro TCR/CD3-CD28 Activated Lupus T Cells
Noymar Luque¹, Nursamaa Abdoel¹, Héctor Rojas², Martín Rodríguez¹, Gloria Vásquez³ and Ana Blasini¹, ¹Centro Nacional de Enfermedades Reumáticas. Hospital Universitario de Caracas, Caracas, Venezuela, ²Instituto de Inmunología, Escuela de Medicina, Universidad Central de Venezuela, Caracas, Venezuela, ³Grupo de Inmunología Celular e Inmunogenética. Universidad de Antioquia, Medellin, Colombia
Background/Purpose: Numerous alterations in signal transduction in SLE T cells have been previously reported. Diminished expression of the ζ chain of the TCR/CD3 complex has been…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].