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  • Abstract Number: 1059 • 2016 ACR/ARHP Annual Meeting

    Quality of Life in Patients with Antiphospholipid Syndrome Is Related to Disease Burden and Anticoagulant Therapy

    Gabriela Hernandez-Molina1, Itzel Gonzalez-Pérez2, Carlos Pacheco2 and Antonio R. Cabral3, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 3Department of Medicine. Division of Rheumatology, The Ottawa Hospital.University of Ottawa, Ottawa, ON, Canada

    Background/Purpose:  Few studies have reported impaired health related quality of life (HRQoL) in patients with primary antiphospholipid syndrome (APS); however the causes of this outcome…
  • Abstract Number: 1060 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Antibodies and Related Clinical Events Following Infection in Children: A Systematic Review of Case Reports

    Noha Abdel-Wahab1, Maria A. Lopez-Olivo2 and Maria Suarez-Almazor3, 1Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Rheumatology and Rehabilitation Department, Assiut University Hospitals, Assiut, Egypt, Houston, TX, 2Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine,The University of Texas MD Anderson Cancer Center, Houston, Texas, USA,, Houston, TX, 3Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX

    Background/Purpose: A systematic review of case reports to summarize existing evidence in the literature regarding the association of APS and infection during childhood. Our aims…
  • Abstract Number: 1061 • 2016 ACR/ARHP Annual Meeting

    Identifying Clinical and Epidemiological Risk Factors Associated with Thrombosis and Pregnancy Morbidity in a Large Cohort of Chinese APS Patients

    Yu Zuo1, Chun Li2, David Karp3 and Zhanguo Li2, 1Rheumatology, UT Southwestern Medical Center, Dallas, TX, 2Peking University People's Hospital, Beijing, China, 3Rheumatic Diseases Division, UT Southwestern Med Ctr, Dallas, TX

    Background/Purpose: It is well known that anti-phospholipid antibodies (aPL) are associated with an increased risk of arterial and venous thrombosis and pregnancy loss/morbidity. However, assessment…
  • Abstract Number: 1062 • 2016 ACR/ARHP Annual Meeting

    Non-Conventional Antiphospholipid Antibodies in Patients with Clinical Obstetrical APS: Prevalence and Pregnancies Treatment Efficacy

    ARSENE MEKINIAN1, Marie Charlotte Bourrienne2, LIONEL CARBILLON3, AMELIE BENBARA4, SYLVIE CHOLLET MARTIN5, AHMED TIGAIZIN3, Francois Montestruc6, Olivier Fain7 and Pascale Nicaise-Roland8, 1SAINT ANTOINE HOSPITAL, PARIS, France, 2Unité Fonctionnelles d'Immunologie « Autoimmunité et Hypersensibilités », AP-HP, Hôpital Bichat-Claude Bernard, Paris, paris, France, 3JEAN VERDIER HOSPITAL, BONDY, France, 4JEAN VERDIER HOSPITAL, PARIS, France, 5UNITE HYPERSENSIBILITE, PARIS, France, 6exystat, PARis, France, 7Internal Medicine Department, Saint Antoine Hospital, Paris, France, 8Immunology Department, Bichat Claude-bernard, Universitary Hospital, APHP, Paris, France

    Background/Purpose: To describe the prevalence of non-conventional APL in patients with obstetrical APS pregnancy adverse outcome without conventional APL and the impact of treatment on…
  • Abstract Number: 1063 • 2016 ACR/ARHP Annual Meeting

    A Systematic Review of Direct Oral Anticoagulant Use in Antiphospholipid Syndrome

    Ayten Yazici1,2, OZAN UNLU3 and Doruk Erkan4, 1Hospital for Special Surgery, Cornell Weill Cornell Medicine, NEW YORK CITY, NY, Turkey, 2Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, 3Rheumatology Department, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 4Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY

    Background/Purpose: Oral direct oral anticoagulants (DOACs) are approved for the treatment of venous thrombosis and the prevention of venous/arterial thrombosis. There is growing information from…
  • Abstract Number: 1064 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking Registry Analysis: Direct Oral Anticoagulant Use Among Antiphospholipid Syndrome Patients

    Ozan Unlu1, Hannah Cohen2, Maria Jose Cuadrado3, Paul R. Fortin4, Guilherme Ramires de Jesus5, Maria Gerosa6, Jason K Knight7, Vittorio Pengo8, Michelle Petri9, Esther Rodriguez-Almaraz10, Stephane Zuily11,12, Doruk Erkan13 and On Behalf of APS ACTION .14, 1Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 2University College London, London, United Kingdom, 3Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, 4Medicine, CHU de Québec - Université Laval, Québec, QC, Canada, 5Department of Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, 6University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, 7University of Michigan, Ann Arbor, MI, 8Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, 9Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, 10Servicio De Reumatología, Hospital 12 De Octubre,, Madrid, Spain, 11CHU de Nancy, Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases, Vascular Medicine Division, NANCY, France, 12Inserm, UMR_S 1116, Nancy, France, 13Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 14., New York, NY

    Background/Purpose:  Direct oral anticoagulants (DOACs) are approved for the treatment of venous, and prevention of venous/arterial thrombosis. There have been case reports/ series where DOACs…
  • Abstract Number: 1065 • 2016 ACR/ARHP Annual Meeting

    A Practical Application of Antiphospholipid Antibodies Profiles in the Diagnosis and Managements of Antiphospholipid Syndrome: The Modified Antiphospholipid Score

    Kenji Oku1, Olga Amengual2, Kazumasa Ohmura1, Masaru Kato3, Toshiyuki Bohgaki1, Tetsuya Horita1, Shinsuke Yasuda1, Eriko Morishita4, Masahiro Ieko5 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Hokkaido University,Medicine II, Sapporo, Japan, 3Hokkaido University Graduate School of Medicine, Sapporo, Japan, 4College of Medical, Pharmaceutical and Health Science Kanazawa University, Kanazawa, Japan, 5Health Science University of Hokkaido, Toubetsu, Japan

    Background/Purpose: The clinical scoring systems to quantify the probability for the diagnosis of antiphospholipid syndrome (APS) or future thrombosis, have been proposed as to reflect…
  • Abstract Number: 1066 • 2016 ACR/ARHP Annual Meeting

    History of Lupus Nephritis Is an Independent Risk Factor for Thrombosis in Systemic Lupus Erythematosus Patients with Antiphospholipid Antibodies

    Vinicius Domingues1, Janet Nwaukoni2, Jill P. Buyon3 and H. Michael Belmont4, 1Rheumatology, NYU Langone Medical Center, New York, NY, 2Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Medicine, New York University School of Medicine, New York, NY, 4New York University School of Medicine, New York, NY

    Background/Purpose: Few studies have analyzed the risk factors for thrombosis in Systemic Lupus Erythematosus (SLE) patients with antiphospholipid antibodies (aPL) and most had small sample…
  • Abstract Number: 1067 • 2016 ACR/ARHP Annual Meeting

    History of Thrombocytopenia Is Associated with Lower Prevalence of Thrombotic Events in Systemic Lupus Erythematosus Patients with Antiphospholipid Antibodies

    Vinicius Domingues1, Janet Nwaukoni2, Jill P. Buyon3 and H. Michael Belmont4, 1Rheumatology, NYU Langone Medical Center, New York, NY, 2Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Medicine, New York University School of Medicine, New York, NY, 4New York University School of Medicine, New York, NY

    Background/Purpose: Thrombocytopenia is a common feature of both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and in the former most frequently results from antiplatelet…
  • Abstract Number: 1068 • 2016 ACR/ARHP Annual Meeting

    Recurrence of  Thrombosis Despite Negativization of Antiphospholipid Antibodies in Primary Antiphospholipid Syndrome. a Follow-up to 5 Years

    Gabriela Medina1, Eduardo Briones-Garcia2, Pilar Cruz-Dominguez3, Oscar I Florez-Durante4, Olga-Lidia Vera-Lastra5, Miguel A. Saavedra6 and Luis J. Jara7, 1Clinical research unit, Hospital de Especialidades Centro Medico La Raza,IMSS, Mexico City, Mexico, 2Direction of Education and Research, Clinical Research Unit, Mexico, Mexico, 3Research Division, Hospital de Especialidades, Centro Médico La Raza, IMSS, Mexico, Mexico, 4Clinical researh Unit, Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional, Mexico, Mexico, 5Rheumatology, Inst Mexicano Seguro Social, Mexico City, Mexico, 6Rheumatology, Centro Médico Nacional La Raza IMSS, México, Mexico, 7Direction of education and research, Hospital de Especialidades Centro Medico La Raza, Mexico City, Mexico

    Background/Purpose: In some antiphospholipid syndrome (APS) patients, the antiphospholipid antibodies (aPL) becomes persistently negative. Discontinuation of anticoagulation has been proposed, however the long term follow-up…
  • Abstract Number: 1069 • 2016 ACR/ARHP Annual Meeting

    The Predictive Value of Acl and Anti-β2GPI in Patients with Acute Deep Vein Thrombosis

    Katja Perdan-Pirkmajer1, Anja Boc2, Sašša Čučnik1, Alenka Mavri3, Polona Žigon1, Monika Štalc4, Nina Vene5 and Ales Ambrozic6, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Faculty of Medicine, Institute of Anatomy, University of Ljubljana, Ljubljana, Slovenia, 3Deparment of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia, 4Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia, 5Department of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia, 6Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia

    Background/Purpose:  Acute deep vein thrombosis (DVT) is generally treated with anticoagulants for 3 to 6 months. Antiphospholipid syndrome (APS) is an important cause of DVT.…
  • Abstract Number: 1070 • 2016 ACR/ARHP Annual Meeting

    Performance and External Validation of the Damage Index in Antiphospholipid Syndrome in Primary and Secondary APS Patients

    Mariana Moreno Ramirez1, Luis M. Amezcua-Guerra2, Victor Alejandro Escamilla Gomez3, Daniel Hernandez3, Luis Fernando Perez1, Javier Loaiza Felix1 and Angelica Vargas Guerrero1, 1Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 2Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 3Rheumatology, InstitutoNacional de Cardiología Ignacio Chavez, Mexico City, Mexico

    Background/Purpose: In APS, irreversible organ damage may result of disease activity, medications, or comorbid illnesses. To assess it, different methods have been used including the…
  • Abstract Number: 1071 • 2016 ACR/ARHP Annual Meeting

    Anti-β2GP-I-Domain 3 and Aps/PT-IgG Antibodies Identify Primary APS Patients with Both Thrombotic and Hematological Manifestations

    Diego Hernández-Ramírez1, Gabriela Hernandez-Molina2, Carlos Núñez-Álvarez3, Miguel Astudillo-Angel4, Carlos Pacheco1, Elizabeth Olivares-Martínez1 and Antonio R. Cabral5, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 3Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Mexico city, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 5Department of Medicine. Division of Rheumatology, The Ottawa Hospital.University of Ottawa, Ottawa, ON, Canada

    Background/Purpose: Thrombocytopenia and hemolytic anemia (HA) are considered non-criteria clinical manifestations by the Sydney revised criteria for APS. These features can precede, follow a thrombotic…
  • Abstract Number: 1072 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking Registry Analysis: Cardiovascular Risk Factors Among Different Groups of Antiphospholipid Antibody-Positive Patients

    Ozan Unlu1, Doruk Erkan2, Maria Tektonidou3 and On Behalf of APS ACTION .4, 1Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 2Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 3First Department of Internal Medicine, School of Medicine, National University of Athens, Athens, Greece, 4., New York, NY

    Background/Purpose: Traditional cardiovascular disease (CVD) risk factors increase the risk of thrombotic clinical manifestations in antiphospholipid antibody (aPL)-positive patients.  The prevalence of CVD risk factors…
  • Abstract Number: 1073 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking (APS ACTION) Clinical Database and Repository Analysis: The Comparison of Real World and Core Laboratory Antiphospholipid Antibody ELISA Results

    Savino Sciascia1, Rohan Willis2, Vittorio Pengo3, Steven Krilis4, Danieli Andrade5, Doruk Erkan6, Maria Laura Bertolaccini7 and On Behalf of APS ACTION .8, 1Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, 2Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, 3Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, 4Department of Immunology, Allergy and Infectious Diseases, University of New South Wales, Sydney, Australia, 5Rheumatology, University of Sao Paulo, Sao Paulo, Brazil, 6Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 7Academic Department of Vascular Surgery, King’s College London, London, United Kingdom, 8., New York, NY

    Background/Purpose: The APS ACTION International Clinical Database and Repository (“Registry”) was created to study the natural course of disease over 10 years in persistently aPL-positive…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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