Abstracts Archive - Page 1670 of 2425 - ACR Meeting Abstracts

Abstract Number: 2970 • 2015 ACR/ARHP Annual Meeting
Primary Care Assessment of Capillaroscopy Abnormalities in Patients with Raynaud’s Phenomenon
Rebecca Overbury¹, Maureen Murtaugh², Aryeh Fischer³ and Tracy M. Frech⁴, ¹Internal Medicine and Pediatrics, University of Utah, Salt Lake City, UT, ²Internal Medicine-Division of Epidemiology, University of Utah School of Medicine, SLC, UT, ³University of Colorado School of Medicine, Aurora, CO, ⁴Div of Rheumatology, University of Utah Medical Ctr, Salt Lake City, UT
Background/Purpose: Raynaud’s phenomenon is a clinical symptom that can commonly present to a primary care provider or generalist. Proper identification of an underlying connective tissue…
Abstract Number: 2971 • 2015 ACR/ARHP Annual Meeting
Raynaud Phenomenon Subjects with Abnormal Capillary Dilations Show a Risk Threshold Diameter Value for the Transition to the Capillaroscopic Early� Scleroderma Pattern: A Case Control Study
Maurizio Cutolo¹, Carmen Pizzorni², Marianna Meroni², Vanessa Smith³, Sabrina Paolino², Barbara Ruaro², Alberto Sulli², Bruno Seriolo² and Amelia Chiara Trombetta², ¹Department of Internal Medicine, University of Genova, Genova, Italy, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Nailfold Video Capillaroscopy (NVC) is a reliable method to qualitatively differentiate Primary (PRP) from Secondary Raynaud Phenomenon (SRP) through diagnosis of the “early scleroderma…
Abstract Number: 2972 • 2015 ACR/ARHP Annual Meeting
Cardiopulmonary Exercise Testing in Patients with Systemic Sclerosis: Unexplored Mechanisms of Dyspnea
Sara R. Schoenfeld¹, George Alba², Josanna Rodriguez-Lopez³, Richard N. Channick³, Flavia V. Castelino⁴ and Marcy B. Bolster⁴, ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Pulmonary and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Pulmonary and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Patients with systemic sclerosis (SSc) experience dyspnea for multiple reasons. Cardiopulmonary exercise testing (CPET), an important tool in the evaluation of undifferentiated dyspnea, provides…
Abstract Number: 2973 • 2015 ACR/ARHP Annual Meeting
Exercise Intolerance Evaluated By Invasive Cardiopulmonary Exercise Testing in Connective Tissue Disease: Beyond Pulmonary Hypertension
Rudolf Oliveira^1,2, David Systrom², Julie Tracy², Abbey Karin², Aaron Waxman², Paul Dellaripa³ and Paul Hoover³, ¹Medicine, Division of Respiratory Disease, Federal University Of São Paulo, São Paulo, Brazil, ²Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Exercise intolerance is common in patients with connective tissue disease (CTD) and may be related to pulmonary hypertension (PH). However, determining the exact etiology…
Abstract Number: 2974 • 2015 ACR/ARHP Annual Meeting
Insulin Resistance Is Associated with the Digital Ulcer in Patients with Systemic Sclerosis
Seung-Geun Lee¹, Eun-Kyoung Park², Dong-Wan Koo², Geun-Tae Kim³, Hee-Sang Tag³ and Joung-Wook Lee⁴, ¹Division of Rheumatology, Department of Internal Medicine, Busan National University School of Medicine, Busan, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, ⁴Divsion of Rheumatology, Department of Internal Medicine, Busan St. Marys center, Busan, South Korea
Background/Purpose: Growing evidence supports the view that systemic sclerosis (SSc) is a vascular disease mediated by autoimmunity and evolving into progressive tissue fibrosis. Several vascular…
Abstract Number: 2975 • 2015 ACR/ARHP Annual Meeting
Induced Sputum Analysis in Systemic Sclerosis Patients
Irena Litinsky¹, Elizabeth Fireman², Ari Polachek¹, Adi Broyde¹, Amir Sharabi¹, Marina Anouk¹, Daphna Paran¹ and Ori Elkayam¹, ¹Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ²Institute of Pulmonary and Allergic Diseases, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Background/Purpose: Induced sputum (IS) is a noninvasive tool, aimed at collecting cellular and soluble materials from lung airways. IS is well accepted by patients, safer…
Abstract Number: 2976 • 2015 ACR/ARHP Annual Meeting
Ambrisentan Dose Migration over 3 Years in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension (CTD-PAH)
James Tislow¹, Chris Blair² and Hunter Gillies³, ¹Medical Affairs, Gilead Sciences, Inc., Foster City, CA, ²Biostatistics, Gilead Sciences, Inc., Foster City, CA, ³Clinical Research - Cardiovascular, Gilead Sciences, Inc., Foster City, CA
Background/Purpose: Pulmonary arterial hypertension (PAH) is an important complication in patients with connective tissue disease and may lead to increased morbidity and early mortality. …
Abstract Number: 2977 • 2015 ACR/ARHP Annual Meeting
A Meta-Analysis of Phosphodiesterase 5 Inhibitors for the Treatment of Raynaud’s Phenomenon
Janet E. Pope¹, Fadumo Rirash², Paul Tingey³, Sarah Harding⁴, Lara J. Maxwell⁵, Jordi Pardo⁶, Elizabeth Ghogomu⁷, Peter Tugwell⁸ and George A. Wells⁹, ¹University of Western Ontario, London, ON, Canada, ²Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, ³Faculty of Medicine, University of Queensland, Brisbane, Australia, ⁴ERLanger, ERLanger, KY, ⁵Centre for Global Health, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada, ⁶University of Ottawa, Ottawa, ON, Canada, ⁷University of Ottawa, Cochrane Musculoskeletal Group, Ottawa, ON, Canada, ⁸Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, ⁹Cardiovascular Research Reference Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada
Background/Purpose: To assess the benefits and harms of phosphodiesterase 5 inhibitors (PDE5) for the treatment of Raynaud's phenomenon (RP).Methods: The Cochrane library, MEDLINE, EMBASE and Clinicaltrials.gov…
Abstract Number: 2978 • 2015 ACR/ARHP Annual Meeting
Longitudinal Assessment of Gastrointestinal Symptoms in the Prospective Registry of Early Systemic Sclerosis Cohort
Tracy M. Frech¹, Maureen Murtaugh², Jessica K. Gordon³, Robyn T. Domsic⁴, Ami A. Shah⁵, Faye N. Hant⁶, Shervin Assassi⁷, Monique E. Hinchcliff⁸, Elana J. Bernstein⁹, Virginia D. Steen¹⁰, Victoria K. Shanmugam^11,12 and Dinesh Khanna¹³, ¹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah, Salt Lake, UT, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁸Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Columbia University, New Yory, NY, ¹⁰Rheumatology, Georgetown University Medical Center, Washington, DC, ¹¹Director, Division of Rheumatology, The George Washington University, Washington, DC, ¹²Division of Rheumatology, The George Washington University, Washington, DC, ¹³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS) is a multicenter incident cohort study of patients with early diffuse cutaneous systemic sclerosis (dcSSc; <…
Abstract Number: 2979 • 2015 ACR/ARHP Annual Meeting
Laser Speckled Imaging and Videomicroscopy Assessment of Sublingual Perfusion in Systemic Sclerosis and Healthy Controls
Mark Sievert¹, Daniel R. Machin², Anthony J. Donato², Maureen Murtaugh³, John D. Pauling⁴, Robyn T. Domsic⁵, Lee S. Shapiro⁶ and Tracy M. Frech⁷, ¹University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, ³University of Utah, Salt Lake, UT, ⁴Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Steffens Scleroderma Center, Albany, NY, ⁷Div of Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: Our group has previously described the sublingual frenulum abnormalities in systemic sclerosis (SSc, scleroderma). The goal of this project was to assess microvascular abnormalities…
Abstract Number: 2980 • 2015 ACR/ARHP Annual Meeting
Assessment of Sublingual Frenulum Perfusion in Systemic Sclerosis
Tracy M. Frech¹, Daniel R. Machin², Phillip E. Gates², Robyn T. Domsic³, Lee S. Shapiro⁴, John D. Pauling⁵ and Anthony J. Donato², ¹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, ³Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Steffens Scleroderma Center, Albany, NY, ⁵Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom
Background/Purpose: SSc is characterized by vasculopathy that precedes fibrosis and progresses to end-stage vascular manifestations such as malnutrition due to gastro-intestinal tract (GIT) involvement. Clinical…
Abstract Number: 2981 • 2015 ACR/ARHP Annual Meeting
Measurement of Tissue Damage in Scleroderma Using Digital Mammographic Xrays: A Proof of Concept Study
John Highton¹, Terence Doyle² and Simon Stebbings³, ¹Dept of Medicine, University of Otago, Dunedin, New Zealand, ²Medicine, University of Otago, Dunedin, New Zealand, ³Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Background/Purpose: We have used digital mammographic soft tissue Xrays of the fingers from patients with Scleroderma and related conditons to show damage related to the…
Abstract Number: 2982 • 2015 ACR/ARHP Annual Meeting
Blood Perfusion in Different Skin Areas of Hands in Primary Raynaud’s Phenomenon and Systemic Sclerosis Patients
Alberto Sulli¹, Barbara Ruaro¹, Amelia Chiara Trombetta¹, Vanessa Smith², Carmen Pizzorni¹, Sabrina Paolino¹ and Maurizio Cutolo¹, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genoa, Italy, ²Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Peripheral blood perfusion is reduced in patients affected by both primary (PRP) or secondary Raynaud’s phenomenon (SRP) (1-2). The objective of this study was…
Abstract Number: 2984 • 2015 ACR/ARHP Annual Meeting
Scleroderma Bronchoalveolar Lavage Fluid Thrombin Activity: Correlation with Pulmonary Function
Merrideth Ashley Morris¹, Tanjina Akter², Paul Nietert³, Galina S. Bogatkevich² and Richard Silver⁴, ¹Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Division of Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Multiple lines of evidence identify thrombin as an important mediator of lung fibrosis in systemic sclerosis (SSc). In addition to demonstrating dramatically high levels…
Abstract Number: 2985 • 2015 ACR/ARHP Annual Meeting
Mycophenolate Mofetil (MMF) Use in Systemic Sclerosis (SSc) Patients with a Designation of Elevated Systolic Pulmonary Artery Pressure (sPAP): Forced Vital Capacity (FVC), Outcomes and Survival from the European Scleroderma Trials and Research (EUSTAR) Database
Lesley Ann Saketkoo¹, Dörte Huscher², Christopher P. Denton³, Gabriela Riemekasten⁴, Virginia D. Steen⁵, Oliver Distler⁶ and EUSTAR member centres, ¹Tulane University Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ²Charité-University Hospital and German Rheumatism Research Centre, Berlin, Germany, ³Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁴Clinic of Rheumatology, University of Luebeck, Lübeck, Germany, ⁵Rheumatology, Georgetown University Medical Center, Washington, DC, ⁶Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland
Background/Purpose : SSc related PH carries a high mortality; with SSc-PH related to restrictive lung disease (RLD) having worse prognosis and more rapid time to…

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