Abstracts Archive - Page 1660 of 2425 - ACR Meeting Abstracts

Abstract Number: 2819 • 2015 ACR/ARHP Annual Meeting
Rorc Antagonism Inhibits IL-23-Dependent Aberrant Bone Formation in Vivo
Mark Panzenbeck¹, Kathleen Hoyt¹, Donald Souza², Gregg Davis¹, Elizabeth Glynn¹, Thomas Wieckowski¹, Michael Turner¹, Robert Hughes¹, Dustin Smith¹, Christian Harcken¹, Gerald Nabozny³ and Mark Labadia⁴, ¹Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Immunology & Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ³Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: RORγt is a nuclear hormone receptor expressed in Th17 cells and distinct subsets of lymphoid cells, including innate lymphoid cells (ILC), and γδ T-cells.…
Abstract Number: 2820 • 2015 ACR/ARHP Annual Meeting
Multi-Omics Studies of Gut Microbiota in Enthesitis-Related Arthritis Identify Diminished Microbial Diversity and Altered Typtophan Metabolism As Potential Factors in Disease Pathogenesis
Matthew L. Stoll¹, Landon S. Wilson², Stephen Barnes³, Ranjit Kumar⁴, Anna Genin⁵, Randy Q. Cron¹, Charles O. Elson⁶, Casey D Morrow⁷ and Elliot J. Lefkowitz⁸, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pharmicology / Toxicology, University of Alabama at Birmingham, Birmingham, AL, ³Pharmicology, University of Alabama at Birmingham, Birmingham, AL, ⁴Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ⁸Microbiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Children with enthesitis-related arthritis (ERA) and adults with spondyloarthritis are at risk for intestinal inflammation. We have previously shown altered microbiota in children with…
Abstract Number: 2821 • 2015 ACR/ARHP Annual Meeting
Increased CD4 T Cell GM-CSF Production in Spondyloarthritis
M Hussein Al-Mossawi¹, Jelle De Wit², Anna Ridley³ and Paul Bowness¹, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: Immunological, genetic and therapeutic studies have implicated the IL-17A/IL-23 inflammatory axis in SpA. GM-CSF is emerging as a cytokine that marks out a pathogenic…
Abstract Number: 2822 • 2015 ACR/ARHP Annual Meeting
Increased Peripheral Blood CCR6+/IL-23R+ Gamma Delta T Cells Are Associated with High Disease Activity in Patients with Axial Spondyloarthritis
Elizabeth Mainolfi¹, Susan M. Goodman², Shawn Anderson³, Jon Hill⁴, Thakker Paresh⁵, Meera Ramanujam⁶, Rivka Friedlander⁷, Elli Kim⁷, Dalit Ashany⁸, Ed Purdue⁹, Christine Averill⁹, Michael Nevid⁹, Allison Shaber⁹, Lisa Mandl¹⁰, Steven R. Goldring¹¹, Gerald Nabozny¹ and VP Bykerk², ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Transl. Medicine & Clin. Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Department of Medicine, Rheumatology Division, Hospital for Special Surgery, New York, NY, ⁸Rheumatic Disease, Hospital for Special Surgery, New York, NY, ⁹Osteolysis Research Laboratory, Hospital for Special Surgery, New York, NY, ¹⁰Department of Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Hospital for Special Surgery, New York, NY
Background/Purpose: The IL-23 axis and Th17 type immunity has been implicated in the pathogenesis of Ankylosing Spondylitis (AS) and an enrichment of gamma delta (gd)…
Abstract Number: 2823 • 2015 ACR/ARHP Annual Meeting
Gut Inflammation in HLA-B27 Transgenic Rats Alters the Monocyte Compartment and Its Osteoclastogenic Potential
C. Ansalone, L. Utriainen, S. W. F. Milling and C. S. Goodyear, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Human HLA-B27 and β2-microglobulin transgenic rats (B27 rats), an animal model for spondyloarthropathies, spontaneously develop inflammatory colitis and bone loss. We have previously demonstrated…
Abstract Number: 2824 • 2015 ACR/ARHP Annual Meeting
Autoantibodies Against CD74 – a New Diagnostic Marker for Spondyloarthritis (SpA)
Bruno Larida, AESKU.DIAGNOSTICS INC, Oakland, CA
Background/Purpose: Spondyloarthritis (SpA) is a common debilitating inflammatory disorder. The pathogenesis of axial spondyloarthritis (axSpA) including ankylosing spondylitis (AS), although known to be strongly associated…
Abstract Number: 2825 • 2015 ACR/ARHP Annual Meeting
Characterization of Mesenchymal Stem Cells Generated from Axial Spondyloarthritis Patient-Derived Induced Pluripotent Stem Cells
Gerlinde Layh-Schmitt¹, Shajia Lu¹, Emily Lazowick¹, Stephen Brooks¹, Massimo Gadina¹ and Robert A. Colbert², ¹NIAMS/NIH, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Ankylosing spondylitis (AS) is an immune-mediated inflammatory disease associated with trabecular bone loss and concomitant aberrant bone formation in the spine. Over 40 genes…
Abstract Number: 2826 • 2015 ACR/ARHP Annual Meeting
Stimulation of Autophagy Reduces Misfolded HLA-B27 in a Rat Model of Spondyloarthritis
Fatemeh Navid¹, Gerlinde Layh-Schmitt¹ and Robert A. Colbert², ¹NIAMS/NIH, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: HLA-B27/human β2microglobulin transgenic rats develop spondyloarthritis (SpA) characterized by inflammation in the gut and peripheral joints by mechanisms that remain poorly defined, but do…
Abstract Number: 2827 • 2015 ACR/ARHP Annual Meeting
Analysis of HLA-B27 Transgenic Rats Reveals Specific Gut Transcriptome and Microbiome Signatures Associated with Inflammation
Tejpal Gill¹, Mark Asquith², Stephen Brooks¹, James T. Rosenbaum³ and Robert A. Colbert⁴, ¹NIAMS/NIH, Bethesda, MD, ²OHSU, Portland, OR, ³Devers Eye Institute, Legacy Hospital system, Portland, OR, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: HLA-B27 and human beta 2-microglobulin expression in rats (transgenic; TG) induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA) with associated gastrointestinal inflammation. While…
Abstract Number: 2828 • 2015 ACR/ARHP Annual Meeting
Profiling Immunogenic Bacteria within the Microbiota of ZAP-70 Mutant SKG Mice Associated with Spondyloarthritis and Ileitis Using IgA-SEQ
Linda Rehaume¹, Alicia Kang¹, Olga Zbarskaya¹, Jane Mullaney¹, Matthew Kim¹, Paraic O Cuiv¹, Nicola Angel², Philip Hugenholtz², Mark Morrison¹ and Ranjeny Thomas¹, ¹Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ²Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia
Background/Purpose: IgA production is the main barrier mechanism of mucosal surfaces. High affinity IgA is generated through T cell-dependent mechanisms and preferentially binds to invasive…
Abstract Number: 2829 • 2015 ACR/ARHP Annual Meeting
Enhanced Expression of the Transcription Factor T-Bet Alters Pro-Inflammatory Cytokine Profile in Ankylosing Spondylitis
Max C. Lau¹, Patricia Keith¹, Mary-Ellen Costello¹, Linda A. Bradbury¹, Kelly A. Hollis¹, Gethin P. Thomas², Matthew A. Brown^1,3 and Tony J. Kenna¹, ¹The University of Queensland Diamantina Institute, Brisbane, Australia, ²Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Research Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16x10-10). T-bet is…
Abstract Number: 2830 • 2015 ACR/ARHP Annual Meeting
Synovial Fluid T Cells of Patients with Reactive Arthritis and Undifferentiated Spondyloarthropathy Respond to Salmonella Typhimurium Outer Membrane Protein a and Induces IL17 and IL23 Production By Synovial Fluid Mononuclear Cells
Ramnath Misra¹, Smriti Chaurasia¹, Ajit K Shashny² and Amita Aggarwal^3,4, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Central Institute of Medicinal and Aromatic Plants, Scientist, Lucknow, India, ³Clinical Immunology, Additional Professor Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁴Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: We have previously shown that synovial fluid mononuclear cells (SFMCs) of patients with Reactive arthritis (ReA) and undifferentiated Spondyloarthropathy (uSpA) proliferated to low molecular…
Abstract Number: 2831 • 2015 ACR/ARHP Annual Meeting
A Subset of Natural Killer Cells Are Expanded in Synovial Fluid of Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis
Abhra Chandra Chowdhury, Smriti Chaurasia, Amita Aggarwal and Ramnath Misra, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: We have previously shown that there is an increase in IL-17 in the synovial fluid of patients with Reactive arthritis(ReA) and undifferentiated spondyloarthropathy(uSpA). Besides…
Abstract Number: 2832 • 2015 ACR/ARHP Annual Meeting
Characterization of Leukocyte Subsets in Ankylosing Spondylitis Patients
Yolanda Jiménez Gómez, Chary Lopez-Pedrera, Pilar Font, Patricia Ruiz-Limon, Carlos Perez-Sanchez, Nuria Barbarroja, M. Carmen Castro Villegas, Jerusalem Calvo-Gutierrez, MariCarmen Abalos-Aguilera, Alejandro Escudero-Contreras and Eduardo Collantes-Estevez, IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain
Background/Purpose: AS is a chronic inflammatory disease, of unknown aetiology, characterized by pathological ossification. We aimed: 1) To analyze the profile of inflammation, oxidative status…
Abstract Number: 2833 • 2015 ACR/ARHP Annual Meeting
Negative Regulator, MiR-23a, Down-Regulated in Psoriatic Arthritis. Implications for Disease Pathogenesis
Sarah Wade¹, Michelle Trenkmann¹, Trudy McGarry¹, Douglas J. Veale² and Ursula Fearon¹, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ²St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: Psoriatic Arthritis (PsA) is a chronic immune-mediated inflammatory disease, characterised by proliferation of synovial tissue and progressive destruction of articular cartilage/bone associated with psoriasis.…

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