Abstract Number: 2804 • 2015 ACR/ARHP Annual Meeting
The Global miRNA Whole Blood Profile of Ankylosing Spondylitis
Background/Purpose: MicroRNA (miRNA) are small non-coding RNAs that play an important role in posttranscriptional gene regulation and their involvement in the pathophysiology of several autoimmune…Abstract Number: 2805 • 2015 ACR/ARHP Annual Meeting
Enteric Flora in Newly Diagnosed Spondyloarthritis: A Collaborative Study
Matthew L Stoll, Pamela F Weiss, Jennifer E Weiss, Peter A Nigrovic, Lynn Punaro, Charles Spencer, Ken Schikler, Casey Morrow, Elliot Lefkowitz Enteric flora in…Abstract Number: 2806 • 2015 ACR/ARHP Annual Meeting
Bacterial Skin Microbiome in Psoriatic Arthritis – Pilot Data from Psoriatic Plaques on Dry Skin Sites from Patients with Psoriasis (PsC) and Psoriatic Arthritis (PsA)
Background/Purpose: In complex traits like psoriasis (PsC) and psoriatic arthritis (PsA) interactions between genetics and environmental factors are thought to result in the development of…Abstract Number: 2807 • 2015 ACR/ARHP Annual Meeting
Transcriptome Profiling of Synovium from Patients with Psoriatic Arthritis or Osteoarthritis Using RNA Sequencing Provides Insights into Disease Mechanisms Involved in Heterotopic Ossification with Potential Therapeutic Implications
Background/Purpose: Up to 44% of patients undergoing total hip arthroplasty (THA) show radiographic evidence of heterotopic ossification (HO). Patients with psoriatic arthritis (PsA) and a…Abstract Number: 2808 • 2015 ACR/ARHP Annual Meeting
Genetic Variants at Chromosome 5q15 Associated with Immune-Mediated Diseases Influence Gene Expression and Isoform Profile of the Endoplasmic Reticulum Aminopeptidase
Background/Purpose: Polymorphisms in the endoplasmic reticulum aminopeptidase genes ERAP1 and/or ERAP2 are strongly associated with the diseases AS, psoriasis, IBD and Behcet’s disease. Robust genetic…Abstract Number: 2809 • 2015 ACR/ARHP Annual Meeting
Increased Frequencies of IL-23R Positive T Cells and IL-22 and IL-17 Producing MAIT Cells in the Peripheral Blood of Patients with Ankylosing Spondylitis: Preliminary Results.
Background/Purpose: Ankylosing spondylitis (AS) is the prototypic and most common form of spondyloarthritis (SpA). It was recently suggested that IL-23 could play a pivotal role…Abstract Number: 2810 • 2015 ACR/ARHP Annual Meeting
The Presence of HLA-B27 Increases Severity of Arthritis but Does Not Appear to Influence New Bone Formation in Different in Vitro and in Vivo Models
Background/Purpose: The strong genetic association between the HLA-B27 gene and ankylosing spondylitis (AS) has been known for over 40 years. Among AS patients, HLA-B27 positivity…Abstract Number: 2811 • 2015 ACR/ARHP Annual Meeting
Higher Serum Level of Leptin Protects from Radiographic Spinal Progression in Patients with Ankylosing Spondylitis
Background/Purpose: Fat tissue synthesizes and releases a series of biologically active substances (adipokines), which are involved in bone metabolism through effects on bone formation and…Abstract Number: 2812 • 2015 ACR/ARHP Annual Meeting
Cytokine Secretion By Peripheral Blood Mononuclear Cells in Patients with Axial Spondyloarthritis and the Effect of Thymoquinone on Cytokine Profile
Background/Purpose: Axial spondyloarthritis (axSpA) defines a group of chronic inflammatory diseases which includes non-radiographic axSpA (nr-axSpA) who do not have definite sacroiliitis on pelvic X-rays.…Abstract Number: 2813 • 2015 ACR/ARHP Annual Meeting
IL-17 Induces Skin Inflammation Independently of IL-23R+ T Cells and Is Protected By Conditional Deletion of Wdfy3 in Neutrophils
Background/Purpose: IL-17 is elevated in both the lesional skin and arthritic joints of psoriatic arthritis (PsA) patients, however, the direct effect of IL-17 on myeloid…Abstract Number: 2814 • 2015 ACR/ARHP Annual Meeting
IL-10 May Mitigate Cardiovascular Risk in Psoriatic Arthritis Via an Anti-Atherosclerotic Effect on Cellular Cholesterol Transport
Background/Purpose: The increased risk of major adverse cardiovascular events (MACE) in patients who suffer from systemic inflammatory conditions such as Rheumatoid Arthritis (RA), Systemic Lupus…Abstract Number: 2815 • 2015 ACR/ARHP Annual Meeting
A Comparison of Th17 Gene Expression in Psoriatic Arthritis Synovial Fluid and Peripheral Blood
Background/Purpose: Psoriatic arthritis (PsA) is a destructive inflammatory arthritis that develops in approximately 30% of patients with cutaneous psoriasis. Th17 cells infiltrate psoriatic skin and…Abstract Number: 2816 • 2015 ACR/ARHP Annual Meeting
Is the Gender Difference in As Linked to IL-23?
Background/Purpose: Ankylosing Spondylitis (AS) has traditionally been portrayed as a disease where male patients outnumber female patients by a factor 3 to 4. It has…Abstract Number: 2817 • 2015 ACR/ARHP Annual Meeting
The Microbiome of Reactive Arthritis in a Guatemalan Cohort
Background/Purpose: Reactive arthritis (ReA) is an inflammatory arthritis that typically follows infection. Several agents microbial agents have been implicated, particularly Shigella, Salmonella, Campylobacter in the…Abstract Number: 2818 • 2015 ACR/ARHP Annual Meeting
Associations of IL23R, BMP6 and PTGS1 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease affecting spine which may lead to new bone formation and disability. However, the radiographic severity of AS…
ACR Meeting Abstracts