Abstracts Archive - Page 1658 of 2425 - ACR Meeting Abstracts

Abstract Number: 2789 • 2015 ACR/ARHP Annual Meeting
Blood and Salivary Gland BAFF-Driven B-Cell Hyperactivity in Rituximab Non-Responder Patients with Primary Sjögren’s Syndrome
Divi Cornec¹, Sebastian Costa², Valerie Devauchelle³, Sandrine Jousse-Joulin⁴, Pascale Marcorelles⁵, Jean-Marie Berthelot⁶, laurent chiche⁷, Eric Hachulla⁸, Pierre-Yves Hatron⁹, Vincent Goeb¹⁰, O Vittecoq¹¹, Alain Saraux¹² and Jacques-Olivier Pers¹³, ¹Department of rheumatology, Brest Occidentale University, Brest, France, ²anatomopathological department, Brest university hospital, Brest, France, ³Service de Rhumatologie, CHU Brest, Brest, France, ⁴Rheumatology, CHu La cavle Blanche, Brest, France, ⁵anatomopathological department, Brest university hospital, CHU Morvan, Brest, France, ⁶Rhumatologie, CHU Nantes, Nantes, France, ⁷internal medicine, Hopital Europeen, Marseille, France, ⁸Department of Internal Medicine, University Lille Nord-de-France, Lille, France, ⁹Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, ¹⁰Rhumatologie, CHU Amiens, Amiens, France, ¹¹University Hospital, Rouen, France, ¹²Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹³EA2216/ERI29 UBO, Brest, France
Background/Purpose: To determine whether B-cell markers (blood and minor salivary gland (SG) B-cell depletion (BCD), autoantibodies, BAFF) are associated with clinical response to rituximab in…
Abstract Number: 2790 • 2015 ACR/ARHP Annual Meeting
Leflunomide/Hydroxychoroquine Combination Treatment Additively Inhibits T Cell Receptor/Toll-like Receptor 9-Triggered Th1 and Th17 Cytokine Secretion
E.H.M. van der Heijden^1,2, S.A.Y. Hartgring¹, S. Hiddingh¹, A.A. Kruize², T.R.D.J. Radstake^1,3 and J.A.G. van Roon¹, ¹Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is a systemic auto-immune disease, leading to an exocrinopathy of mainly salivary and lachrymal glands. T- and B-cell-driven immunity is…
Abstract Number: 2791 • 2015 ACR/ARHP Annual Meeting
TREX-1 Variants in Sjögren’s Syndrome Related Lymphomagenesis
Panagiota Makri¹, Adrianos Nezos², Michael Voulgarelis³, Haralampos M. Moutsopoulos⁴ and Clio Mavragani⁵, ¹Physiology, Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ³Pathophysiology, Department of Pathophysiology, Medical School of Athens, Athens, Greece, ⁴Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece, ⁵Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Three prime Repair Exonuclease 1 (TREX-1) is an exonuclease involved in DNA repair preventing genomic instability. TREX-1 variants have been previously associated with activation of type…
Abstract Number: 2792 • 2015 ACR/ARHP Annual Meeting
Not Only Sjögren’s Syndrome. EBV Infection Reactivation As a Risk Factor of the Dryness Symptome Development
Maria Maslinska¹ and Anna Zuk-Wasek², ¹Clinic of Early Arthritis, Institute of Rheumatology, Warsaw, Poland, ²2. National Institute of Public Health – National Institute of Hygiene (NIPH – NIH, Warsaw, Poland
Background/Purpose: The glandular cell apoptosis in Epstein-Barr virus (EBV) infection may play role in primary Sjögren’s Syndorme (pSS) development, possibly causing progressive gland damage and…
Abstract Number: 2793 • 2015 ACR/ARHP Annual Meeting
IL35 Serum Level Is Decreased in Patients with Primary Sjogren Syndrome, Essentially in Patients with the More Active Disease Data from the French Prospective Assess Cohort
Olivier Fogel¹, Raphaèle Seror², Gaetane Nocturne³, Elodie Rivière⁴, Saida Boudaoud⁵, Jacques Gottenberg⁶, Véronique Le Guern⁷, Xavier Mariette⁸, Jean-Jacques Dubost⁹ and Corinne Miceli-Richard¹⁰, ¹INSERM U1012, Paris Sud University, Le Kremlin Bicêtre, France, ²Rheumatology, AP-HP Bicêtre Hospital / Paris-Sud University, Le Kremlin-Bicêtre, France, ³INSERM U1012, Université Paris Sud, Le Kremlin Bicêtre, France, ⁴Unité INSERM 1184 Université Paris Sud, le Kremlin Bicetre, France, ⁵INSERM U1012 - Université Paris XI, Le Kremlin Bicêtre, France, ⁶Hautepierre, Strasbourg, France, ⁷National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ⁹Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ¹⁰Rheumatology, Hôpitaux Paris Sud & INSERM U1184, Le Kremlin Bicêtre, France
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is an autoimmune disease mediated by B-cells as evidenced by the occurrence of non-Hodgkin lymphoma and increased B-cell markers in…
Abstract Number: 2794 • 2015 ACR/ARHP Annual Meeting
A New Scoring System for Ultrasonographic Evaluation of Salivary Gland in Sjogren: Multireader Reliability
Sandrine Jousse-Joulin¹, Malin V. Jonsson², Nicoletta Luciano³, Elke Theander⁴, Vera Milic⁵, Alojzija Hocevar⁶, Jacqueline Brown⁷, Andrew Carr⁸, Divi Cornec⁹, Marina Carotti¹⁰, Benjamin A. Fisher¹¹, Joel Fradin¹², John Rout¹³, Alain Saraux¹⁴, Alja Stel¹⁵, Arjan Vissink¹⁶, Simon Bowman¹⁷, Alan N. Baer¹⁸, Matija Tomšič⁶, Wan-Fai Ng¹⁹, Chiara Baldini³ and Valerie Devauchelle²⁰, ¹Rheumatology, CHu La cavle Blanche, Brest, France, ²Department of Clinical Dentistry, Section for Oral and Maxillofacial Radiology,, University of Bergen, Bergen, Norway, ³Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ⁴Skåne University Hospital Malmö, Lund University, Malmo, Sweden, ⁵rheumatology, belgrade university, belgrade, Serbia, ⁶Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁷dental division, Tower Wing Guy's hospital, london, United Kingdom, ⁸departement of radiology, University of Newcastle, New castle, United Kingdom, ⁹Department of rheumatology, Brest Occidentale University, Brest, France, ¹⁰Istituto di Radiologia, Ospedali Riuniti di Ancona, Ancona, Italy, ¹¹Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom, ¹²Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ¹³Birmingham Dental Hospital, Birmingham, United Kingdom, ¹⁴Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹⁵Hanzeplein 1, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ¹⁶Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ¹⁷Rheumatology Dept, University Hospital Birmingham, Birmingham, United Kingdom, ¹⁸Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²⁰Service de Rhumatologie, CHU Brest, Brest, France
Background/Purpose: A new consensual scoring system for Ultrasonography (US) of the salivary gland in pSS is required and endorsed by an international group of experts…
Abstract Number: 2795 • 2015 ACR/ARHP Annual Meeting
Fatigue in Primary Sjögren’s Syndrome: Clinical, Laboratory, Psychometric and Biological Associations
Theofanis Karageorgas¹, Sofia Fragkioudaki², Adrianos Nezos³, Dimitris Karaiskos⁴, Clio Mavragani⁵ and Haralampos M. Moutsopoulos⁶, ¹Clinical Immunology and Rheumatology, "Attikon" University Hospital of Athens, Athens, Greece, ²Physiology, Medical School of Athens, Department of Physiology, Athens, Greece, ³Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ⁴Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ⁵Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ⁶Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece
Background/Purpose: To identify independent predictors of fatigue in primary Sjogren’s Syndrome (pSS) patients taking into account clinical, laboratory and psychological features and to explore the…
Abstract Number: 2796 • 2015 ACR/ARHP Annual Meeting
Elevated Serum Immunoglobulin G Is a Prognostic Factor for Progression of Interstitial Lung Disease in Primary Sjögren’s Syndrome
Eriko Ishioka¹, Katsuya Suzuki², Naoshi Nishina², Hidekata Yasuoka³, Kunihiro Yamaoka² and Tsutomu Takeuchi², ¹Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Lung involvement is a systemic manifestation of primary Sjögren's syndrome (pSS), however, the prevalence in pSS is various (9-75 %) and details are still…
Abstract Number: 2797 • 2015 ACR/ARHP Annual Meeting
Identification of Serum Biomarker for the Glandular Dysfunction of Primary Sjögren’s Syndrome
Ayumi Nishikawa¹, Katsuya Suzuki¹, Yoshiaki Kassai², Yuumi Gotou³, Takahiro Miyazaki⁴, Maiko Takiguchi⁴, Rimpei Morita⁵, Akihiko Yoshimura⁵ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Takeda Pharmaceutical Company, Fujisawa, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, ⁴Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, ⁵Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dry eye and mouth. Measurements of un-stimulated salivary flow and Schirmer’s test are…
Abstract Number: 2798 • 2015 ACR/ARHP Annual Meeting
Increased Frequency of the PTPN22W* Variant in Primary Sjögren’s Syndrome-Association with Low Type I IFN Scores in Peripheral Blood
Nikolaos Vlachogiannis¹, Eliona Gkioka², Adrianos Nezos³ and Clio Mavragani⁴, ¹Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ²Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ³Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ⁴Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Protein tyrosine phosphatase non-receptor 22 (PTPN22) gene encodes a protein tyrosine phosphatase previously shown to inhibit antigen-receptor signaling in T cells and promoting type…
Abstract Number: 2799 • 2015 ACR/ARHP Annual Meeting
Varicella Zoster Reactivation in Patients with Primary Sjögren’s Syndrome and SLE
Eliza F. Chakarvarty¹, Jacy Odell², Astrid Rasmussen³, Kathy L. Sivils², Joel M. Guthridge² and Judith A. James⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Increasing data has suggested that individuals with systemic lupus (SLE) are at increased risk of herpes zoster (HZ) reactivation compared to healthy controls and…
Abstract Number: 2800 • 2015 ACR/ARHP Annual Meeting
Bone Microarchitecture and Bone Strength in Patients with Primary Sjögren’s Syndrome: A Case-Control Study Using HR-pQCT
Sandra Gofinet Pasoto¹, Kristopherson Lustosa Augusto¹, Jackeline Couto Alvarenga², Liliam Takayama¹, Valéria Caparbo³, Ricardo M. Oliveira⁴, Eloisa Bonfá¹ and Rosa M R Pereira¹, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴RDO Diagnósticos Médicos, São Paulo, Brazil
Background/Purpose: To evaluate bone mineral density (BMD), microarchitecture, strength and prevalence of vertebral fractures (VF) in primary Sjögren's syndrome (pSS).Methods: We evaluated 71 female pSS…
Abstract Number: 2801 • 2015 ACR/ARHP Annual Meeting
Tofacitinib Suppresses Lymphocytic Infiltration in the Salivary Gland of Non-Obese Diabetic Mice; The Animal Model of Sjögren’s Syndrome
Jennifer Lee¹, Ji Yeon Lee², Jung Hee Koh³, Min Kyung Chung⁴, Ji Hun Kim¹, Seung-Ki Kwok⁵, Ji Hyeon Ju² and Sung-Hwan Park⁶, ¹Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, South Korea, ⁵[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: Interferon signatures are upregulated in patients with primary Sjogren’s syndrome (pSS) and interferons are considered to have a pathogenic role in pSS. As Janus…
Abstract Number: 2802 • 2015 ACR/ARHP Annual Meeting
Co-Occurence of Anti-Ro52/TRIM21 and Anti-TRIM38 Autoantibodies Is Associated with Higher Severity of Dry Eye in Sjögren’s Syndrome
Nina Wolska¹, Paulina Rybakowska¹, Arkadiusz Klopocki¹, Michael Brown¹, Courtney G. Montgomery², Kiely Grundahl¹, Astrid Rasmussen¹, Robert Hal Scofield³, Lida Radfar⁴, Donald U Stone⁵, Juan-Manuel Anaya^6,7, John Ice², Christopher Lessard³, David M. Lewis⁸, Nelson L. Rhodus⁹, Raj Gopalakrishnan¹⁰, Andrew Huang¹¹, Pamela J Hughes¹², Michael D. Rohrer¹³, Michael Weismann¹⁴, Swamy Venuturupalli¹⁵, Joel M. Guthridge³, Judith A. James¹⁶, Kathy L. Sivils³, Harini Bagavant¹⁷, Umesh S Deshmukh¹⁷ and , ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Dean McGee Eye Institute, Oklahoma City, OK, ⁶Rheumatology, Center for Autoimmune Diseases Research (CREA), Rosario University, Bogotá, Colombia, ⁷Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, ⁸College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁰Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota, Minneapolis, MN, ¹¹Washington University,, St Louis, MO, ¹²Division of Oral and Maxillofacial Surgery, University of Minnesota, Minneapolis, MN, ¹³Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁴Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁵Cedars-Sinai Medical Center, West Hollywood, CA, ¹⁶Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁷Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Autoantibodies reactive with Ro52/TRIM21 are detected in almost 70% of primary Sjögren’s syndrome (pSjS) patients and their presence is associated with higher severity of…
Abstract Number: 2803 • 2015 ACR/ARHP Annual Meeting
Systemic Interferon Type I and Type II Signatures Present in Distinct Subsets of Primary Sjögren’s Syndrome: En Route Towards More Selective Targeting
Naomi I Maria¹, Cornelia G. van Helden-Meeuwsen¹, Eline C. Steenwijk¹, Arne S. IJpma², Zana Brkic¹, Paul L. van Daele^1,3, P. Martin van Hagen^1,3, Peter J. van der Spek², Hemmo A. Drexhage¹, Wan-Fai Ng⁴ and Marjan A. Versnel¹, ¹Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ²Bioinformatics, Erasmus Medical Center, Rotterdam, Netherlands, ³Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease with a large heterogeneity in clinical phenotype. The IFN type I signature is present in…

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