ACR Meeting Abstracts

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  • Abstract Number: 2774 • 2015 ACR/ARHP Annual Meeting

    Longterm Outcome of Patients Switched from Iv to Sc Formulation of Abatacept: A Monocentric Study

    Rossella Reggia1, Ilaria Cavazzana1, Angela Tincani2 and Franco Franceschini1, 1Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 2Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Italy

    Background/Purpose: Abatacept is a selective T cell costimulation modulator indicated for  active Rheumatoid Arthritis (RA). Since August 2013, in Italy, the drug has also been…
  • Abstract Number: 2775 • 2015 ACR/ARHP Annual Meeting

    What Factors Are Associated with Starting an Intravenous Vs. Sub-Cutaneous Biologic in Patients with RA?

    Kaleb Michaud1,2, Sofia Pedro2 and Steven Peterson3, 1Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 2National Data Bank for Rheumatic Diseases, Wichita, KS, 3Janssen Global Services, LLC, Malvern, PA

    Background/Purpose: To characterize which factors are associated with RA patients' preferences for biologic administration: sub-cutaneous or intravenous.Methods: Using a large US observational cohort, the National…
  • Abstract Number: 2776 • 2015 ACR/ARHP Annual Meeting

    Profiling Compounds in Human Primary Cell-Based Disease Models Guide Indication Selection

    Jason Ptacek, Ellen L. Berg and Alison O'Mahony, BioSeek, a division of DiscoveRx Corp., South San Francisco, CA

    Background/Purpose: In vitro co-cultures of human primary cells, including immune cells, fibroblasts, smooth muscle, keratinocytes, epithelial or endothelial cells were developed to capture the complexity…
  • Abstract Number: 2777 • 2015 ACR/ARHP Annual Meeting

    Drug Retention Rates of Biologic Monotherapies for Patients with Rheumatoid Arthritis Receiving TNF Inhibiting Fusion Protein Agent and Antibody Agent; From Multicenter Registry in Japan

    Hiroyuki Matsubara1, Masatoshi Hayashi2, Nobunori Takahashi3, Toshihisa Kojima3, Koji Funahashi3 and Naoki Ishiguro4, 1Department of Orthopedic Surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, 2Department of Orhtopedic Surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, 3Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, 4Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan

    Background/Purpose: In general, drug retention rate reflects the effectiveness and tolerability of the drug. TNF inhibitors include fusion protein agent such as etanercept (ETN) and…
  • Abstract Number: 2778 • 2015 ACR/ARHP Annual Meeting

    Abatacept-Treated Rheumatoid Arthritis Patients Have Better Drug-Survival Rate When Abatacept Is the First or Second Line Biologic Agent with an Excellent Overall Safety Profile: A Single Center Experience

    Irini Flouri1, Argyro Repa2, Antonis Fanouriakis2, Nikolaos Kougkas2, Ioannis Papalopoulos2, Eleni Kampouraki2, Dimitrios Boumpas3, Nestor Avgoustidis2, George Bertsias2 and Prodromos Sidiropoulos2, 1Rheumatology, Clinical Immunology, Allergy, University of Crete, Medical School, University Hospital, Heraklion, Greece, 2Rheumatology, Clinical Immunology, and Allergy, University of Crete, Medical School, University Hospital, Heraklion, Greece, 3Biomedical Research Foundation, Academy of Athens, Athens, Greece

    Background/Purpose: Long-term prospective observational studies are complementary to controlled clinical trials in exploring the effectiveness and safety of biological therapies in rheumatoid arthritis (RA). We…
  • Abstract Number: 2779 • 2015 ACR/ARHP Annual Meeting

    Better Drug Survival of Non-TNFi Compared to TNFi Biologics after Non-TNFi Failure in RA Patients: A Single Center Experience

    Konstantinos Thomas, Christos Koutsianas, Argyro Lazarini, Christina Tsalapaki, Chrisoula Hatzara, Anna Kandili, Katerina Antonatou and Dimitrios Vassilopoulos, University of Athens Medical School, Clinical Immunology and Rheumatology Unit, 2nd Department of Medicine and Laboratory, Athens, Greece

    Background/Purpose: There are sparse data in the literature regarding the drug survival of TNFi vs. non-TNFi biologics in rheumatoid arthritis (RA) patients who have already…
  • Abstract Number: 2780 • 2015 ACR/ARHP Annual Meeting

    Relationship Between Immunogenicity, Hypersensitivity Reactions and Skin Tests Against Infliximab, Etanercept and Adalimumab in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Firas Doghanji1, Sebnem Ataman2, Ali Erhan Ozdemirel2, Recep Bülent Seckin1, Ayse Peyman Yalcin1 and Sevim Bavbek3, 1Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, 2Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, 3Immunology and Allergy, Ankara University Faculty of Medicine, Ankara, Turkey

    Relationship between immunogenicity, hypersensitivity reactions and skin tests against Infliximab, Etanercept and Adalimumab in patients with rheumatoid arthritis and ankylosing spondylitis Background/Purpose: Anti-TNF drugs can…
  • Abstract Number: 2781 • 2015 ACR/ARHP Annual Meeting

    Absence of Effects of Filgotinib on Erythrocytes, CD8+ and NK Cells in Rheumatoid Arthritis Patients Brings Further Evidence for the JAK1 Selectivity of Filgotinib

    René Galien1,2, Reginald Brys3, Annegret Van der Aa3, Pille Harrison3 and Chantal Tasset3, 1Galapagos SASU, Romainville, France, 2102 Avenue Gaston Roussel, Galapagos SASU, Romainville, France, 3Galapagos NV, Mechelen, Belgium

    Background/Purpose: The distinct role of JAK family members (JAK1, JAK2, JAK3 and TYK2) in signaling for cytokines and growth factors has established these kinases as…
  • Abstract Number: 2782 • 2015 ACR/ARHP Annual Meeting

    Not Only 5 but Also 6 Weeks Intervals of Tocilizumab Infusion Induce Clinical Remission in Patients with Active Rheumatoid Arthritis

    Hiroshi Uda1, Koji Shigematsu2, Yoshitaka Ishizaki2 and Osamu Saiki1,3, 1Rheumatology, Higashiosaka City General Hospital, Higashiosaka, Japan, 2Orthopedics, Higashiosaka City General Hospital, Higashiosaka, Japan, 3Rheumatology, Shiraishi Hospital, Imabari, Japan

    Background/Purpose: For active rheumatoid arthritis patients with inadequate response to synthetic disease modifying antirheumatic drugs (DMARDs), biologic agents are indicated. However, the cost of biologics,…
  • Abstract Number: 2783 • 2015 ACR/ARHP Annual Meeting

    What Is the Rate of Primary and Secondary Failure of Anti-TNF in RA Patients? Data from a Rheumatoid Arthritis Cohort

    Edward C. Keystone1, Mohammad Movahedi2,3, Angela Cesta2, Xiuying Li2, Sandra Couto2, Emmanouil Rampakakis3, John S. Sampalis3,4, Claire Bombardier2,5,6 and OBRI Investigators, 1The Rebecca MacDonald Centre For Arthritis, Mount Sinai Hospital, Toronto, ON, Canada, 2Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 3JSS Medical Research, St-Laurent, QC, Canada, 4McGill University, Montreal, QC, Canada, 5University of Toronto, Department of Medicine (DOM) and Institute of Health Policy Management, and Evaluation (IHPME), Toronto, ON, Canada, 6Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Although the majority of RA patients respond to treatment with anti-TNF agents, some patients present with refractory disease (1ry failure) while others show some…
  • Abstract Number: 2784 • 2015 ACR/ARHP Annual Meeting

    Faecal Levels of Calprotectin Are Increased in Patients with Primary Sjögren’s Syndrome and Correlates with Disease Activity

    Thomas Mandl1, Bodil Ohlsson2 and Kristofer Andreasson3, 1Dept of Rheumatology, Skåne University Hospital Malmö, Lund University, Malmo, Sweden, 2Dept of Internal Medicine, Skane University Hospital Malmo, Lund University, Sweden, Malmo, Sweden, 3Dept of Rheumatology, Skane University Hospital Lund, Lund University, Sweden, Lund, Sweden

    Background/Purpose: FC is a validated biomarker differentiating inflammatory bowel disease from irritable bowel syndrome. We have evaluated faecal levels of calprotectin (FC) in patients with…
  • Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting

    Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome

    Yoshiyuki Arinuma1,2, Yuko Sakuma3, Eisuke Ogawa2, Tatsuhiko Wada4, Tatsuo Nagai2, Sumiaki Tanaka2 and Shunsei Hirohata2, 1Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, 2Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 3Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 4Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…
  • Abstract Number: 2786 • 2015 ACR/ARHP Annual Meeting

    miR200b-5p: A Possible Predictor of Lymphoma Development in Sjögren’s Syndrome (SS)?

    Efstathia K. Kapsogeorgou1,2, Vasiliki C. Gourzi1 and Athanasios G. Tzioufas1, 1Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, 2Pathophysiology, School of Medicine, National University of Athens, Greece, Athens, Greece

    Background/Purpose: miR200b miRNAs (miR200b-3p and miR200b-5p) are critical regulators of the expression of oncogenes and tumour suppressor genes. Herein, we sought to investigate whether their…
  • Abstract Number: 2787 • 2015 ACR/ARHP Annual Meeting

    Expression of Interferons Lambda in Salivary Glands of Patients with Sjögren’s Syndrome

    Eirini Apostolou1, Efstathia K. Kapsogeorgou1, Orsia D. Konsta1, Maria Ioanna Saridaki2, Evangelos Andreakos2 and Athanasios G. Tzioufas1, 1Pathophysiology, Faculty of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece, 2Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece

    Background/Purpose: Type I and II interferons (IFNs) have been implicated in the pathophysiology of Sjögren’s Syndrome (SS). Recently a new family of IFNs, namely type…
  • Abstract Number: 2788 • 2015 ACR/ARHP Annual Meeting

    DNA Microarray Analysis of Labial Salivary Glands in Patients with Sjögren’s Syndrome: Comparison with IgG4-Related Disease

    Hiroyuki Takahashi1, Hiroto Tsuboi1, Mana Iizuka1, Hiromitsu Asashima1, Tomoya Hirota1, Yuya Kondo1, Isao Matsumoto1, Takayuki Sumida1, Seiji Nakamura2, Sachiko Furukawa2, Masafumi Moriyama3, Yuji Nakai4, Keiko Abe4 and Toshio Yoshihara5, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Faculty of Dental Science, Kyushu University, Fukuoka, Japan, 3Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, 4Functional Food Science and Nutrigenomics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan, 5Department of Otolaryngology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: The previous reports showed that DNA microarray in Sjögren’s syndrome (SS) identified the genes associated with mononuclear infiltrates such as immunoglobulin, human leukocyte antigen,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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