Abstract Number: 2774 • 2015 ACR/ARHP Annual Meeting
Longterm Outcome of Patients Switched from Iv to Sc Formulation of Abatacept: A Monocentric Study
Background/Purpose: Abatacept is a selective T cell costimulation modulator indicated for active Rheumatoid Arthritis (RA). Since August 2013, in Italy, the drug has also been…Abstract Number: 2775 • 2015 ACR/ARHP Annual Meeting
What Factors Are Associated with Starting an Intravenous Vs. Sub-Cutaneous Biologic in Patients with RA?
Background/Purpose: To characterize which factors are associated with RA patients' preferences for biologic administration: sub-cutaneous or intravenous.Methods: Using a large US observational cohort, the National…Abstract Number: 2776 • 2015 ACR/ARHP Annual Meeting
Profiling Compounds in Human Primary Cell-Based Disease Models Guide Indication Selection
Background/Purpose: In vitro co-cultures of human primary cells, including immune cells, fibroblasts, smooth muscle, keratinocytes, epithelial or endothelial cells were developed to capture the complexity…Abstract Number: 2777 • 2015 ACR/ARHP Annual Meeting
Drug Retention Rates of Biologic Monotherapies for Patients with Rheumatoid Arthritis Receiving TNF Inhibiting Fusion Protein Agent and Antibody Agent; From Multicenter Registry in Japan
Background/Purpose: In general, drug retention rate reflects the effectiveness and tolerability of the drug. TNF inhibitors include fusion protein agent such as etanercept (ETN) and…Abstract Number: 2778 • 2015 ACR/ARHP Annual Meeting
Abatacept-Treated Rheumatoid Arthritis Patients Have Better Drug-Survival Rate When Abatacept Is the First or Second Line Biologic Agent with an Excellent Overall Safety Profile: A Single Center Experience
Background/Purpose: Long-term prospective observational studies are complementary to controlled clinical trials in exploring the effectiveness and safety of biological therapies in rheumatoid arthritis (RA). We…Abstract Number: 2779 • 2015 ACR/ARHP Annual Meeting
Better Drug Survival of Non-TNFi Compared to TNFi Biologics after Non-TNFi Failure in RA Patients: A Single Center Experience
Background/Purpose: There are sparse data in the literature regarding the drug survival of TNFi vs. non-TNFi biologics in rheumatoid arthritis (RA) patients who have already…Abstract Number: 2780 • 2015 ACR/ARHP Annual Meeting
Relationship Between Immunogenicity, Hypersensitivity Reactions and Skin Tests Against Infliximab, Etanercept and Adalimumab in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Relationship between immunogenicity, hypersensitivity reactions and skin tests against Infliximab, Etanercept and Adalimumab in patients with rheumatoid arthritis and ankylosing spondylitis Background/Purpose: Anti-TNF drugs can…Abstract Number: 2781 • 2015 ACR/ARHP Annual Meeting
Absence of Effects of Filgotinib on Erythrocytes, CD8+ and NK Cells in Rheumatoid Arthritis Patients Brings Further Evidence for the JAK1 Selectivity of Filgotinib
Background/Purpose: The distinct role of JAK family members (JAK1, JAK2, JAK3 and TYK2) in signaling for cytokines and growth factors has established these kinases as…Abstract Number: 2782 • 2015 ACR/ARHP Annual Meeting
Not Only 5 but Also 6 Weeks Intervals of Tocilizumab Infusion Induce Clinical Remission in Patients with Active Rheumatoid Arthritis
Background/Purpose: For active rheumatoid arthritis patients with inadequate response to synthetic disease modifying antirheumatic drugs (DMARDs), biologic agents are indicated. However, the cost of biologics,…Abstract Number: 2783 • 2015 ACR/ARHP Annual Meeting
What Is the Rate of Primary and Secondary Failure of Anti-TNF in RA Patients? Data from a Rheumatoid Arthritis Cohort
Background/Purpose: Although the majority of RA patients respond to treatment with anti-TNF agents, some patients present with refractory disease (1ry failure) while others show some…Abstract Number: 2784 • 2015 ACR/ARHP Annual Meeting
Faecal Levels of Calprotectin Are Increased in Patients with Primary Sjögren’s Syndrome and Correlates with Disease Activity
Background/Purpose: FC is a validated biomarker differentiating inflammatory bowel disease from irritable bowel syndrome. We have evaluated faecal levels of calprotectin (FC) in patients with…Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting
Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome
Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…Abstract Number: 2786 • 2015 ACR/ARHP Annual Meeting
miR200b-5p: A Possible Predictor of Lymphoma Development in Sjögren’s Syndrome (SS)?
Background/Purpose: miR200b miRNAs (miR200b-3p and miR200b-5p) are critical regulators of the expression of oncogenes and tumour suppressor genes. Herein, we sought to investigate whether their…Abstract Number: 2787 • 2015 ACR/ARHP Annual Meeting
Expression of Interferons Lambda in Salivary Glands of Patients with Sjögren’s Syndrome
Background/Purpose: Type I and II interferons (IFNs) have been implicated in the pathophysiology of Sjögren’s Syndrome (SS). Recently a new family of IFNs, namely type…Abstract Number: 2788 • 2015 ACR/ARHP Annual Meeting
DNA Microarray Analysis of Labial Salivary Glands in Patients with Sjögren’s Syndrome: Comparison with IgG4-Related Disease
Background/Purpose: The previous reports showed that DNA microarray in Sjögren’s syndrome (SS) identified the genes associated with mononuclear infiltrates such as immunoglobulin, human leukocyte antigen,…