Abstracts Archive - Page 1653 of 2607 - ACR Meeting Abstracts

Abstract Number: 803 • 2016 ACR/ARHP Annual Meeting
Multi-Organ RNA-Sequencing of Systemic Sclerosis (SSc) Patients Shows Reproducible Gene Expression Profiles Across Organ Systems
Bhaven K. Mehta¹, Michael E. Johnson¹, Kimberly A. Archambault¹, Tammara A. Wood², Antonia Valenzuela³, Amanda Crawford⁴, David Fiorentino⁵, Nielsen Fernandez-Becker⁶, Laren Becker⁶, Linda Nguyen⁶, Francesco Boin⁷, Paul Wolters⁸, Lorinda Chung⁹ and Michael Whitfield², ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Stanford University School of Medicine, Stanford, CA, ⁴Dermatology, Stanford University, Redwood City, CA, ⁵Dermatology, Stanford University, Stanford, CA, ⁶Gastroenterology & Hepatology, Stanford University School of Medicine, Palo Alto, CA, ⁷Rheumatology, University California San Francisco, San Francisco, CA, ⁸Pulmonary Division, Department of Medicine, University of California, San Francisco, San Francisco, CA, ⁹Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: While a hallmark of systemic sclerosis (SSc) is skin fibrosis, internal organ involvement is the primary cause of mortality. Pulmonary Arterial Hypertension (PAH), Interstitial…
Abstract Number: 804 • 2016 ACR/ARHP Annual Meeting
Combined-Phenotype Meta-GWAS in Systemic Sclerosis and Rheumatoid Arthritis Identifies IRF4 As a New Common Susceptibility Locus
Elena Lopez-Isac¹, Shervin Assassi², Carmen Pilar Simeón³, Patricia Carreira⁴, Norberto Ortego Centeno⁵, Benjamin Fernandez Gutierrez⁶, Alejandro Balsa⁷, Miguel Angel González-Gay⁸, Lorenzo Beretta⁹, Claudio Lunardi¹⁰, Gianluca Moroncini¹¹, Torsten Witte¹², Nicolas Hunzelmann¹³, Joerg HW Distler¹⁴, Gabriela Riekemasten¹⁵, Annette HM van der Helm-van Mil¹⁶, Jeska K. de Vries-Bouwstra¹⁷, Cesar Magro-Checa¹⁸, Alexandre E. Voskuyl¹⁹, Madelon C. Vonk²⁰, Øyvind Molberg²¹, Tony Merriman²², Roger Hesselstrand²³, Annika Nordin²⁴, Leonid Padyukov²⁵, Ariane L. Herrick²⁶, Stephen Eyre²⁷, Christopher Denton²⁸, Carmen Fonseca²⁹, Timothy R.D.J. Radstake³⁰, Jane Worthington³¹, Maureen D Mayes² and Javier Martín¹, ¹Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ²Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ³Internal Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ⁴Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁵Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ⁶Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁷Department of Rheumatology, Hospital La Paz, Madrid, Spain, ⁸School of Medicine, University of Cantabria, Santander, Spain, ⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁰Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹¹Dipartimento di Scienze mediche e Chirurgiche, Università politecnica delle Marche and Ospedali Riuniti, Ancona, Italy, ¹²Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹³Department of Dermatology, University of Cologne, Cologne, Germany, ¹⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ¹⁵Department of Rheumatology, University of Lübeck, Luebeck, Germany, ¹⁶Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁷Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Spain, ¹⁹Rheumatology, Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, ²⁰Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²¹Rheumatology, Oslo University Hospital, Oslo, Norway, ²²Department of Biochemistry, University of Otago, Otago, New Zealand, ²³Department of Rheumatology, Lund University, Lund, Sweden, ²⁴Department of Rheumatology, Karolinska Institute, Stockholm, Sweden, ²⁵Unit of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ²⁶Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, ²⁷The University of Manchester, Manchester, United Kingdom, ²⁸Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ²⁹Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ³⁰Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ³¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Genome-wide association studies (GWASs) have revolutionized our understanding of the genetic component of complex autoimmune diseases (ADs) by the identification of thousands of susceptibility…
Abstract Number: 805 • 2016 ACR/ARHP Annual Meeting
HLA Class II Functional Motifs Associated with Severe Systemic Sclerosis (SSc) and Sclerotic Graft Versus Host Disease (sclGVHD): The Shared Epitopes of Fibrosis
Jelena Blagojevic^1,2, David Venzon³, Lorenzo Beretta⁴, Edward W Cowen⁵, Laurin M Curtis⁶, Marco Matucci-Cerinic⁷, Steven Z Pavletic⁸ and Francesco Del Galdo⁹, ¹Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, Bethesda, MD, ⁴Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁵Dermatology Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, ⁶Experimental Transplantation and Immunology Branch, National Cancer institute (NCI), National Institutes of Health (NIH), Bethesda,, Bethesda, MD, ⁷Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ⁸Experimental Transplantation and Immunology Branch, National Cancer institute (NCI), National Institutes of Health (NIH), Bethesda, Bethesda, MD, ⁹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Single Nucleotide polymorphisms within the HLA region have been strongly associated with the occurrence of SSc and sclGVHD. However, specific studies on the amino…
Abstract Number: 806 • 2016 ACR/ARHP Annual Meeting
Single Cell Rnaseq Defines a Unique Transcriptome Profile for Myofibroblasts in the Skin of Patients with Systemic Sclerosis
Robert A. Lafyatis¹, Lisa Rice², Giuseppina Stifano², Jeff Browning^2,3 and Robert W. Simms⁴, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Boston University School of Medicine, Boston, MA, ³Boston university, Cambridge, MA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA
Background/Purpose: Fibrosis in systemic sclerosis (SSc), as well as a wide variety of other fibrotic diseases, is largely driven by myofibroblasts. Myofibroblasts are known to…
Abstract Number: 807 • 2016 ACR/ARHP Annual Meeting
A Novel Multi-Network Approach Reveals Tissue-Specific Cellular Modulators of Fibrosis in Systemic Sclerosis, Pulmonary Fibrosis and Pulmonary Arterial Hypertension
Jaclyn N. Taroni¹, Casey S. Greene², Tammara A. Wood³, Romy B. Christmann⁴, Harrison W. Farber⁵, Robert A. Lafyatis⁶, Christopher Denton⁷, Monique Hinchcliff⁸, Patricia A. Pioli⁹, Michael L. Whitfield¹⁰ and J. Matthew Mahoney¹¹, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Division of Rheumatology, Boston University Medical School, Boston, MA, ⁵Pulmonary Center, Boston University Medical Center, Boston, MA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁷Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁸Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹⁰Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ¹¹Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, VT
Background/Purpose: Systemic sclerosis (SSc) is characterized by multi-organ involvement and clinical heterogeneity. “Big data” approaches have yielded powerful tools to infer tissue-specific pathobiology. Large amounts of…
Abstract Number: 808 • 2016 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells (MVECs) Is Associated with Impaired Responses to Vascular Endothelial Growth Factor (VEGF) and Defective Angiogenesis
bashar kahaleh¹, Nezam Altorok², Yongqing Wang³, Shadia Nada², Mohammed Madkhali³ and John Sun³, ¹Rheumatology, University of Toledo, Toledo, OH, ²Medicine/Rheumatology, University of Toledo, Toledo, OH, ³University of Toledo, Toledo, OH
Background/Purpose: Impaired angiogenesis in SSc is a crucial component of disease pathology that occurs in spite of upregulation of VEGF and other proangiogenic factors. MicroRNA-126…
Abstract Number: 809 • 2016 ACR/ARHP Annual Meeting
Micrornas Targeting the Wnt Signalling Pathway in Black African Patients with Diffuse Cutaneous Systemic Sclerosis
Mohammed Tikly¹, Jacqueline Frost², Michèle Ramsay³, Eulalia Marti Puig⁴, Raquel Rabionet⁴, Xavier Estivill⁴ and Marc Friedländer⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ²University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, Sydney Brenner Institute for Molecular Biosciences, University of the Witwatersrand, Johannesburg, South Africa, ⁴Center for Genomic Regulation, Barcelona, Spain, ⁵Department of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm, Sweden
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system, vasculature and extracellular matrix [1]. Dysregulation of the Wnt pathway has been implicated in…
Abstract Number: 810 • 2016 ACR/ARHP Annual Meeting
Microrna-125b As a Potential Anti-Fibrotic and Anti-Apoptotic Regulator in Systemic Sclerosis
Anastasiia Kozlova¹, Elena Pachera¹, Florian Renoux², Michal Rudnik¹, Britta Maurer¹, Astrid Jüngel³, Joerg H.W Distler⁴, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Ctr Exp Rheum, Univ Hosp Zurich / Zurich Ctr Integr Hum Physiol (ZIHP), Zurich, Switzerland, ⁴Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: MicroRNAs (miRs) are a class of small, noncoding RNAs that regulate many biological processes. Some microRNAs are involved in skin fibrosis. Here, we aimed…
Abstract Number: 811 • 2016 ACR/ARHP Annual Meeting
Basophils Are Activated and Stimulate Both B Cells and Fibroblasts in Systemic Sclerosis
Benjamin Chaigne¹, Nicolas Dumoitier², Alexis Regent¹, Benjamin Terrier³, Jonathan London², Matthieu Groh¹, Nathalie Thieblemont⁴ and Luc Mouthon⁵, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, ³Internal Medicine, Cochin Hospital, Paris, France, ⁴Inserm U1016, Paris, France, ⁵Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Systemic sclerosis (SSc) is a rare multisystem connective tissue disease characterized by skin and internal organs fibrosis and vascular abnormalities, along with the presence…
Abstract Number: 812 • 2016 ACR/ARHP Annual Meeting
Monocytes/Neurotrophins/Myofibroblasts As a Novel Axis in Systemic Sclerosis
Michal Rudnik¹, Mara Stellato¹, Elena Pachera¹, Rucsandra Dobrota¹, Britta Maurer¹, Joerg C. Henes², Karin Klingel³, Karl Sotlar⁴, Przemyslaw Blyszczuk⁵, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ³Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁴Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁵Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease, which is characterized by inflammation, fibrosis and vasculopathy in multiple organs, mainly in the lung, heart and…
Abstract Number: 813 • 2016 ACR/ARHP Annual Meeting
Identifying and Assessing Subgroups in Systemic Sclerosis Patients Based on Comprehensive Autoantibody Profiling
Petra Budde¹, Hans-Dieter Zucht¹, Heike Göhler¹, Klaus Marquart¹, Peter Schulz-Knappe¹, Matthias Schneider² and Nicolas Hunzelmann³, ¹Protagen AG, Dortmund, Germany, ²Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ³Department of Dermatology, University of Cologne, Cologne, Germany
Background/Purpose: Systemic sclerosis (SSc) is a remarkably heterogeneous autoimmune disease, for which effective disease-modifying therapies are still lacking. The most widely used classification divides SSc…
Abstract Number: 814 • 2016 ACR/ARHP Annual Meeting
The Regulatory B Cells Ameliorate Skin Sclerosis, Lung Fibrosis, and Autoimmunity Via an Anti-Oxidative Effect in Systemic Sclerosis Model Mice
Ayumi Yoshizaki, Takemichi Fukasawa, Satoshi Ebata, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Asano Yoshihide and Shinichi Sato, Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular damage, excessive deposition of extracellular matrix, and fibrosis in the several organs, including…
Abstract Number: 815 • 2016 ACR/ARHP Annual Meeting
The Novel Anti-BICD2 Autoantibody Potentially Predicts a Favorable Disease Course in SSc
Johannes Schulte-Pelkum¹, Daniel Wirtz¹, Petra Budde¹, Hans-Dieter Zucht¹, Peter Schulz-Knappe¹, Prof. Dr. Matthias Schneider², Suzana Jordan³, Oliver Distler³, Britta Maurer³ and Nicolas Hunzelmann⁴, ¹Protagen AG, Dortmund, Germany, ²Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Dermatology, University of Cologne, Cologne, Germany
Background/Purpose: To evaluate clinical associations of our recently discovered systemic sclerosis-specific auto-antigen BICD2 in clinically well characterized systemic sclerosis (SSc) cohorts from two tertiary referral…
Abstract Number: 816 • 2016 ACR/ARHP Annual Meeting
Clinical Response to Treatment with Belimumab and Mycophenolate Mofetil Is Associated with Decrease in B Cell, TGF-β and PDGF Signaling in Systemic Sclerosis
Viktor Martyanov¹, Jessica K. Gordon², Tammara A. Wood¹, Robert F. Spiera² and Michael L. Whitfield¹, ¹Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: While B cell signaling is thought to be important in the pathogenesis of systemic sclerosis (SSc), the experience with B cell targeting therapies in…
Abstract Number: 817 • 2016 ACR/ARHP Annual Meeting
RNA and Protein Cargo of Exosomes Isolated from Serum of Systemic Sclerosis Patients Induce a Profibrotic Phenotype in Cultured Normal Human Dermal Fibroblasts: A Potential Mechanism for the Initiation and Progression of a Profibrotic Phenotype in SSc
Peter J. Wermuth, Kellan R. Carney, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Exosomes are lipid bilayer-bound microvesicles that contain various macromolecules including numerous microRNA (miRNA) and proteins. Exosomes mediate intercellular communication by fusing and releasing their…

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