ACR Meeting Abstracts

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  • Abstract Number: 2714 • 2015 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Synovial Fibroblast Potentiates Mast Cell Degranulation and Migration Independent of Cell-to-Cell Contact

    Hee-suk Lim1, Jiyong Choi2,3, Yeong Wook Song4 and Kichul Shin1, 1Division of Rheumatology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Background/Purpose: A number of studies have shown that synovial mast cells (MCs) are activated, and elicit a pro-inflammatory role in rheumatoid arthritis (RA). Synovial MCs…
  • Abstract Number: 2715 • 2015 ACR/ARHP Annual Meeting

    Increased Frequency of Dysfunctional Hematopoietic Stem and Progenitor Cell Subpopulations in Treatment Naïve Rheumatoid Arthritis Patients

    Natalia Regine de Franca Shimabukuro1, Kelsey Ann O'Hagan Wong2, Marie Hudson3, Sabrina Fallavollita1 and Ines Colmegna2, 1Rheumatology, McGill University, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada, 3McGill University, Jewish General Hospital, Montreal, QC, Canada

    Background/Purpose: Hematopoietic stem and progenitor cells (HSPC) are responsible for the lifelong production of immune cells. Accumulation of DNA damage occurs in HSPC during normal…
  • Abstract Number: 2716 • 2015 ACR/ARHP Annual Meeting

    Dysregulated Osteoclastogenesis Is Related to Natural Killer T Cell Dysfunction in Rheumatoid Arthritis

    Seung-Jung Kee1, Hye Mi Jin2, Jeong-Hwa Kang2, Young-Nan Cho2, Ki-Jeong Park2, Hyun-Ju Jung2 and Yong-Wook Park2, 1Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 2Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea

    Background/Purpose: The aims of the present study were to investigate the role played by natural killer T (NKT) cells in osteoclastogenesis and their effects on…
  • Abstract Number: 2717 • 2015 ACR/ARHP Annual Meeting

    Stf-083010, the Inhibitor of ER Stress Transducer IRE1, Suppresses Rheumatoid Synovitis

    Soutarou Izumi1, Tomoyuki Nakasa2, Shigeru Miyaki3 and Mitsuo Ochi1, 1Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan, 2Orthopaedic Surgery, Matsuyama Redcross Hospital, Matsuyama, Japan, 3Translational Research Medical Center, Hiroshima, Japan

    Background/Purpose: Endoplasmic reticulum (ER) stress is a cellular signal, which is triggered by the failure to fold newly synthesized ER proteins. ER stress plays an…
  • Abstract Number: 2718 • 2015 ACR/ARHP Annual Meeting

    Along Those Lines: Synoviocyte Cell-to-Cell Communication Via Nanotubes

    Ruth Byrne1, Karolina von Dalwigk2, Isabel Olmos Calvo3,4, Felix Kartnig3, Mario Rothbauer4, Verena Charwat5, Thomas Karonitsch6, Peter Ertl4, Gunter Steiner7, Christian Schöfer8, Johannes Holinka9, Josef S. Smolen10, Clemens Scheinecker11 and Hans Peter Kiener12, 1Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, 2Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Inner Medicine III, Rheumathology, Medical University of Vienna, Vienna, Austria, 4Nanotechnology, Austrian Institute for Technology, Vienna, Austria, 5Department of Nanotechnology, Austrian Institute for Technology, Vienna, Austria, 6Internal Medicine III, Vienna Medical University, Vienna, Austria, 7Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 8Department of Cell and Developmental Biology, Medical University of Vienna, Vie, Austria, 9Department of Orthopedics, Medical University of Vienna, Vienna, Austria, 10Dept of Medicine 3, Division of Rheumatology, Medical Univ Vienna, Vienna, Austria, 11Divison of Rheumatology, Medical University of Vienna, Vienna, Austria, 12Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: The synovium is primarily formed by fibroblast-like synoviocytes (FLS). Its multicellularity requires precise coordination to generate a tissue that confers specialized functions critical to…
  • Abstract Number: 2719 • 2015 ACR/ARHP Annual Meeting

    Track Along: Monocytes Follow Fibroblast-like Synoviocyte Network for Movement and Rest within the Synovial Tissue

    Ruth Byrne1, Karolina von Dalwigk2, Gunter Steiner3, Johannes Holinka4, Reinhard Windhager4, Josef S. Smolen5, Hans Peter Kiener6 and Clemens Scheinecker7, 1Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, 2Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Orthopedics, Medical University of Vienna, Vienna, Austria, 5Dept of Medicine 3, Division of Rheumatology, Medical Univ Vienna, Vienna, Austria, 6Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 7Divison of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: The synovial lining tissue consists of fibroblast-like synoviocytes (FLS) and monocyte-derived macrophage-like synoviocytes (MLS) within a self-built meshwork of dense extracellular matrix (ECM) components.…
  • Abstract Number: 2720 • 2015 ACR/ARHP Annual Meeting

    Crucial Role of Nuclear Factor of Activated T Cell 5 (NFAT5), an Osmo-Protective Factor, in Migration and Invasion of Rheumatoid Synoviocytes

    Saseong Lee1, Seung-Ah Yoo1, Ki-Jo Kim2, Chong-Hyeon Yoon3, Wan-Uk Kim4 and Bong Ki Hong1, 1Institute of Bone and Joint Diseases, The Catholic University of Korea, Seoul, South Korea, 2St. Mary's Hospital, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 4Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: Fibroblast-like synoviocytes (FLS) play an important role in the progression of rheumatoid arthritis (RA). Particularly, FLS of RA patients (RA-FLS) exhibit pro-migratory and invasive…
  • Abstract Number: 2721 • 2015 ACR/ARHP Annual Meeting

    Elevated Subgingival Levels of Periodontal Pathogens in Rheumatoid Arthritis Patients, Particularly Leptotrichia species in New-Onset Disease

    Sheila Arvikar1, Hatice Hasturk2, Daniel Nguyen2, Klemen Strle3, Marcy B. Bolster4, Deborah Collier5, Allen C. Steere6 and Alpdogan Kantarci2, 1Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, 3Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 6Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures, shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. Most studies…
  • Abstract Number: 2722 • 2015 ACR/ARHP Annual Meeting

    Cyclic Phosphatidic Acid (CPA) Suppresses Expression of Cartilage Degrading Enzymes Such As MMP-3, MMP-13 and Adamts-4 in Inflammatory Synovial Fibroblasts and Articular Chondrocytes Induced By IL-1 Beta and/or TNF ALFA

    Ikuko Masuda1,2, Kodo Okada3, Hisashi Yamanaka1 and Shigeki Momohara1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, 3SANSHO, Co. Ltd., Tokyo, Japan

    Background/Purpose: Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including inhibitory effects of proliferation,…
  • Abstract Number: 2723 • 2015 ACR/ARHP Annual Meeting

    Basal STAT5 Signaling Is Elevated in Multiple Peripheral Blood Cell Subsets in Rheumatoid Arthritis and Is Markedly Downregulated By IFN-γ in T Lymphocytes

    Molly Boland1, Yanna Ding2, Surabhi Vinod3, S. Louis Bridges Jr.4 and Chander Raman1, 1Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The importance of type I interferons (IFN-α and others) as a driver of pathogenesis in autoimmunity, including rheumatoid arthritis (RA) is well recognized.  However,…
  • Abstract Number: 2724 • 2015 ACR/ARHP Annual Meeting

    Methotrexate Treatment Could Modulate the Abnormal CD4+T Lymphocyte Subset Distribution in NaÏve Rheumatoid Arthritis Patients

    Cristina Bohórquez Heras1, Lucía Ruiz Gutiérrez1, Carolina Garcia Torrijos2, Ana Turrión Nieves1, Ana Pérez Gómez1, Ana Sánchez Atrio1, Eduardo Cuende1, Atusa Movasat1, Fernando Albarrán Hernández1, Henry Moruno1, M José León1, David Diaz2, Jorge Monserrat2 and Melchor Álvarez de Mon1,2, 1University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, 2Laboratory of Immune System Diseases, Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain

    Background/Purpose: Mechanisms regulating the chronic autoimmune response in rheumatoid arthritis (RA) are not well understood. However, activated T CD4+ play a pivotal role initiating and…
  • Abstract Number: 2725 • 2015 ACR/ARHP Annual Meeting

    Secular Trends in Use of Disease Modifying Anti-Rheumatic Drugs for the Treatment of Rheumatoid Arthritis in the United States

    Rishi J. Desai1, Daniel H. Solomon2, Jun Liu3 and Seoyoung C. Kim4, 1PharmacoEpidemiology & PharmacoEconomics, Brigham and Women's Hospital, Boston, MA, 2Rheumatology, Brigham and Women's Hospital, Boston, MA, 3Division of Pharmacoepidemiology, Brigham and Women's Hospital, Boston, MA, 4Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Treatment of rheumatoid arthritis (RA) with disease modifying anti-rheumatic drugs (DMARDs) has undergone major advances in last two decades. More than 10 non-biologic DMARDs…
  • Abstract Number: 2726 • 2015 ACR/ARHP Annual Meeting

    The Effect of Prior Disease Duration and Prior DMARD Use on Treatment Outcomes in Patients with Early or Established Rheumatoid Arthritis

    Josef S. Smolen1, Daniel Aletaha2, Su Chen3 and Stefan Florentinus3, 1Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 3AbbVie Inc., North Chicago, IL

    Background/Purpose: A delay in effective treatment is known to negatively affect long term treatment outcomes in patients (pts) with rheumatoid arthritis (RA). The purpose of…
  • Abstract Number: 2727 • 2015 ACR/ARHP Annual Meeting

    BI 695501, a Proposed Biosimilar for Adalimumab, Shows Bioequivalence to Adalimumab Reference Products in a Randomized, Double-Blind Phase I Trial in Healthy Subjects

    Christopher Wynne1, Magdalena Petkova2, Ferdinand Rombout3, Niklas Czeloth3, Mario Altendorfer3, Benjamin Lang4, Francois-Xavier Frapaise3 and Rod Ellis-Pegler5, 1Christchurch Clinical Studies Trust, Christchurch, New Zealand, 2SGS, CPU Antwerpen, Antwerp, Belgium, 3Boehringer Ingelheim, Ingelheim, Germany, 4Boehringer Ingelheim, Biberach an der Riss, Germany, 5Auckland Clinical Studies Limited, Auckland, New Zealand

    Background/Purpose: BI 695501 is a proposed adalimumab biosimilar currently in development and was evaluated for pharmacokinetic (PK) similarity to both US-licensed and EU-approved reference products.…
  • Abstract Number: 2728 • 2015 ACR/ARHP Annual Meeting

    Baseline Characteristics and Changes in Disease Activity at 12 Months in Patients Treated with Abatacept Versus Other Biologic Disease-Modifying Antirheumatic Drugs in Clinical Practice Setting

    E Alemao1, S Joo2, M Frits3, C Iannaccone3, N Shadick3 and Michael Weinblatt3, 1Bristol-Myers Squibb, Princeton, NJ, 2Bristol-Myers Squibb, Hopewell, NJ, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Biologic (b)DMARDs have advanced the standard of care in RA, reducing unmet needs and increasing remission rates. Abatacept (ABA) is approved for the management…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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