Abstracts Archive - Page 1653 of 2425 - ACR Meeting Abstracts

Abstract Number: 2714 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Synovial Fibroblast Potentiates Mast Cell Degranulation and Migration Independent of Cell-to-Cell Contact
Hee-suk Lim¹, Jiyong Choi^2,3, Yeong Wook Song⁴ and Kichul Shin¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: A number of studies have shown that synovial mast cells (MCs) are activated, and elicit a pro-inflammatory role in rheumatoid arthritis (RA). Synovial MCs…
Abstract Number: 2715 • 2015 ACR/ARHP Annual Meeting
Increased Frequency of Dysfunctional Hematopoietic Stem and Progenitor Cell Subpopulations in Treatment Naïve Rheumatoid Arthritis Patients
Natalia Regine de Franca Shimabukuro¹, Kelsey Ann O'Hagan Wong², Marie Hudson³, Sabrina Fallavollita¹ and Ines Colmegna², ¹Rheumatology, McGill University, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³McGill University, Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Hematopoietic stem and progenitor cells (HSPC) are responsible for the lifelong production of immune cells. Accumulation of DNA damage occurs in HSPC during normal…
Abstract Number: 2716 • 2015 ACR/ARHP Annual Meeting
Dysregulated Osteoclastogenesis Is Related to Natural Killer T Cell Dysfunction in Rheumatoid Arthritis
Seung-Jung Kee¹, Hye Mi Jin², Jeong-Hwa Kang², Young-Nan Cho², Ki-Jeong Park², Hyun-Ju Jung² and Yong-Wook Park², ¹Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose: The aims of the present study were to investigate the role played by natural killer T (NKT) cells in osteoclastogenesis and their effects on…
Abstract Number: 2717 • 2015 ACR/ARHP Annual Meeting
Stf-083010, the Inhibitor of ER Stress Transducer IRE1, Suppresses Rheumatoid Synovitis
Soutarou Izumi¹, Tomoyuki Nakasa², Shigeru Miyaki³ and Mitsuo Ochi¹, ¹Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan, ²Orthopaedic Surgery, Matsuyama Redcross Hospital, Matsuyama, Japan, ³Translational Research Medical Center, Hiroshima, Japan
Background/Purpose: Endoplasmic reticulum (ER) stress is a cellular signal, which is triggered by the failure to fold newly synthesized ER proteins. ER stress plays an…
Abstract Number: 2718 • 2015 ACR/ARHP Annual Meeting
Along Those Lines: Synoviocyte Cell-to-Cell Communication Via Nanotubes
Ruth Byrne¹, Karolina von Dalwigk², Isabel Olmos Calvo^3,4, Felix Kartnig³, Mario Rothbauer⁴, Verena Charwat⁵, Thomas Karonitsch⁶, Peter Ertl⁴, Gunter Steiner⁷, Christian Schöfer⁸, Johannes Holinka⁹, Josef S. Smolen¹⁰, Clemens Scheinecker¹¹ and Hans Peter Kiener¹², ¹Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Inner Medicine III, Rheumathology, Medical University of Vienna, Vienna, Austria, ⁴Nanotechnology, Austrian Institute for Technology, Vienna, Austria, ⁵Department of Nanotechnology, Austrian Institute for Technology, Vienna, Austria, ⁶Internal Medicine III, Vienna Medical University, Vienna, Austria, ⁷Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁸Department of Cell and Developmental Biology, Medical University of Vienna, Vie, Austria, ⁹Department of Orthopedics, Medical University of Vienna, Vienna, Austria, ¹⁰Dept of Medicine 3, Division of Rheumatology, Medical Univ Vienna, Vienna, Austria, ¹¹Divison of Rheumatology, Medical University of Vienna, Vienna, Austria, ¹²Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: The synovium is primarily formed by fibroblast-like synoviocytes (FLS). Its multicellularity requires precise coordination to generate a tissue that confers specialized functions critical to…
Abstract Number: 2719 • 2015 ACR/ARHP Annual Meeting
Track Along: Monocytes Follow Fibroblast-like Synoviocyte Network for Movement and Rest within the Synovial Tissue
Ruth Byrne¹, Karolina von Dalwigk², Gunter Steiner³, Johannes Holinka⁴, Reinhard Windhager⁴, Josef S. Smolen⁵, Hans Peter Kiener⁶ and Clemens Scheinecker⁷, ¹Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Orthopedics, Medical University of Vienna, Vienna, Austria, ⁵Dept of Medicine 3, Division of Rheumatology, Medical Univ Vienna, Vienna, Austria, ⁶Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁷Divison of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: The synovial lining tissue consists of fibroblast-like synoviocytes (FLS) and monocyte-derived macrophage-like synoviocytes (MLS) within a self-built meshwork of dense extracellular matrix (ECM) components.…
Abstract Number: 2720 • 2015 ACR/ARHP Annual Meeting
Crucial Role of Nuclear Factor of Activated T Cell 5 (NFAT5), an Osmo-Protective Factor, in Migration and Invasion of Rheumatoid Synoviocytes
Saseong Lee¹, Seung-Ah Yoo¹, Ki-Jo Kim², Chong-Hyeon Yoon³, Wan-Uk Kim⁴ and Bong Ki Hong¹, ¹Institute of Bone and Joint Diseases, The Catholic University of Korea, Seoul, South Korea, ²St. Mary's Hospital, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁴Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Fibroblast-like synoviocytes (FLS) play an important role in the progression of rheumatoid arthritis (RA). Particularly, FLS of RA patients (RA-FLS) exhibit pro-migratory and invasive…
Abstract Number: 2721 • 2015 ACR/ARHP Annual Meeting
Elevated Subgingival Levels of Periodontal Pathogens in Rheumatoid Arthritis Patients, Particularly Leptotrichia species in New-Onset Disease
Sheila Arvikar¹, Hatice Hasturk², Daniel Nguyen², Klemen Strle³, Marcy B. Bolster⁴, Deborah Collier⁵, Allen C. Steere⁶ and Alpdogan Kantarci², ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, ³Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures, shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. Most studies…
Abstract Number: 2722 • 2015 ACR/ARHP Annual Meeting
Cyclic Phosphatidic Acid (CPA) Suppresses Expression of Cartilage Degrading Enzymes Such As MMP-3, MMP-13 and Adamts-4 in Inflammatory Synovial Fibroblasts and Articular Chondrocytes Induced By IL-1 Beta and/or TNF ALFA
Ikuko Masuda^1,2, Kodo Okada³, Hisashi Yamanaka¹ and Shigeki Momohara¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, ³SANSHO, Co. Ltd., Tokyo, Japan
Background/Purpose: Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including inhibitory effects of proliferation,…
Abstract Number: 2723 • 2015 ACR/ARHP Annual Meeting
Basal STAT5 Signaling Is Elevated in Multiple Peripheral Blood Cell Subsets in Rheumatoid Arthritis and Is Markedly Downregulated By IFN-Î³ in T Lymphocytes
Molly Boland¹, Yanna Ding², Surabhi Vinod³, S. Louis Bridges Jr.⁴ and Chander Raman¹, ¹Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The importance of type I interferons (IFN-α and others) as a driver of pathogenesis in autoimmunity, including rheumatoid arthritis (RA) is well recognized. However,…
Abstract Number: 2724 • 2015 ACR/ARHP Annual Meeting
Methotrexate Treatment Could Modulate the Abnormal CD4+T Lymphocyte Subset Distribution in NaÏve Rheumatoid Arthritis Patients
Cristina Bohórquez Heras¹, Lucía Ruiz Gutiérrez¹, Carolina Garcia Torrijos², Ana Turrión Nieves¹, Ana Pérez Gómez¹, Ana Sánchez Atrio¹, Eduardo Cuende¹, Atusa Movasat¹, Fernando Albarrán Hernández¹, Henry Moruno¹, M José León¹, David Diaz², Jorge Monserrat² and Melchor Álvarez de Mon^1,2, ¹University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, ²Laboratory of Immune System Diseases, Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain
Background/Purpose: Mechanisms regulating the chronic autoimmune response in rheumatoid arthritis (RA) are not well understood. However, activated T CD4+ play a pivotal role initiating and…
Abstract Number: 2725 • 2015 ACR/ARHP Annual Meeting
Secular Trends in Use of Disease Modifying Anti-Rheumatic Drugs for the Treatment of Rheumatoid Arthritis in the United States
Rishi J. Desai¹, Daniel H. Solomon², Jun Liu³ and Seoyoung C. Kim⁴, ¹PharmacoEpidemiology & PharmacoEconomics, Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Boston, MA, ³Division of Pharmacoepidemiology, Brigham and Women's Hospital, Boston, MA, ⁴Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Treatment of rheumatoid arthritis (RA) with disease modifying anti-rheumatic drugs (DMARDs) has undergone major advances in last two decades. More than 10 non-biologic DMARDs…
Abstract Number: 2726 • 2015 ACR/ARHP Annual Meeting
The Effect of Prior Disease Duration and Prior DMARD Use on Treatment Outcomes in Patients with Early or Established Rheumatoid Arthritis
Josef S. Smolen¹, Daniel Aletaha², Su Chen³ and Stefan Florentinus³, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ³AbbVie Inc., North Chicago, IL
Background/Purpose: A delay in effective treatment is known to negatively affect long term treatment outcomes in patients (pts) with rheumatoid arthritis (RA). The purpose of…
Abstract Number: 2727 • 2015 ACR/ARHP Annual Meeting
BI 695501, a Proposed Biosimilar for Adalimumab, Shows Bioequivalence to Adalimumab Reference Products in a Randomized, Double-Blind Phase I Trial in Healthy Subjects
Christopher Wynne¹, Magdalena Petkova², Ferdinand Rombout³, Niklas Czeloth³, Mario Altendorfer³, Benjamin Lang⁴, Francois-Xavier Frapaise³ and Rod Ellis-Pegler⁵, ¹Christchurch Clinical Studies Trust, Christchurch, New Zealand, ²SGS, CPU Antwerpen, Antwerp, Belgium, ³Boehringer Ingelheim, Ingelheim, Germany, ⁴Boehringer Ingelheim, Biberach an der Riss, Germany, ⁵Auckland Clinical Studies Limited, Auckland, New Zealand
Background/Purpose: BI 695501 is a proposed adalimumab biosimilar currently in development and was evaluated for pharmacokinetic (PK) similarity to both US-licensed and EU-approved reference products.…
Abstract Number: 2728 • 2015 ACR/ARHP Annual Meeting
Baseline Characteristics and Changes in Disease Activity at 12 Months in Patients Treated with Abatacept Versus Other Biologic Disease-Modifying Antirheumatic Drugs in Clinical Practice Setting
E Alemao¹, S Joo², M Frits³, C Iannaccone³, N Shadick³ and Michael Weinblatt³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Hopewell, NJ, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Biologic (b)DMARDs have advanced the standard of care in RA, reducing unmet needs and increasing remission rates. Abatacept (ABA) is approved for the management…

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