ACR Meeting Abstracts

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  • Abstract Number: 2699 • 2015 ACR/ARHP Annual Meeting

    Muscle Inflammation Relates to Disease Activity and Disability but Not Insulin Resistance in Rheumatoid Arthritis

    Ryan Jessee1, Rachel Narowski2, Monica Hubal3, Janet Huebner4, Virginia Kraus5, William Kraus6 and Kim Huffman2,7, 1Internal Medicine, Duke University Medical Center, Durham, NC, 2Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 3Research and Education, George Washington University School of Medicine and Health Sciences, Washington, DC, 4Duke Molecular Physiology Institute,, Duke University Medical Center, Durham, NC, 5Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 6Division of Cardiology, Duke University Medical Center, Durham, NC, 7Durham Veterans Affairs Medical Center, Durham, NC

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease, insulin resistance, and disability. Our objectives were to analyze levels of skeletal muscle inflammatory cytokines…
  • Abstract Number: 2700 • 2015 ACR/ARHP Annual Meeting

    Trabecular Thinning in Metacarpophalangeal Joints of Anticitrullinated Peptide Antibody Positive Patients with Arthralgia

    Kresten Krarup Keller1, Jesper Skovhus Thomsen2, Kristian Stengaard-Pedersen1, Andreas Wiggers Nielsen1, Berit Schiøtz-Christensen3, Lone Svendsen4, Merete Graakjær5, Peter Mosborg Pedersen6, Barbara Unger7, Bente Langdahl8 and Ellen-Margrethe Hauge1, 1Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 2Aarhus University, Aarhus, Denmark, 3Spine Centre of Southern Denmark, Middelfart, Denmark, 4Private Practice in Rheumatology, Skanderborg, Denmark, 5Clinic of Rheumatology Aarhus, Aarhus, Denmark, 6Randers Hospital, Randers, Denmark, 7Horsens Hospital, Horsens, Denmark, 8Endocrinology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by synovitis leading to bone erosions and joint destruction, but little is known about bone structure in the joints…
  • Abstract Number: 2701 • 2015 ACR/ARHP Annual Meeting

    An Expansion of Rare Lineage Intestinal Microbes Characterize Rheumatoid Arthritis

    Jun Chen1, John M. Davis III2, Eric L. Matteson3 and Veena Taneja4, 1Health Sciences Research, Mayo Clinic, Rochesert, MN, 2Division of Rheumatology, Mayo Clinic, Rochester, MN, 3Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 4Immunology, Mayo Clinic, Rochester, MN

    Background/Purpose: The adaptive immune response in Rheumatoid arthritis (RA) is influenced by an interaction between host genetics and environment, particularly the host microbiome. To define…
  • Abstract Number: 2702 • 2015 ACR/ARHP Annual Meeting

    Immunophenotyping of Rheumatoid Arthritis Reveals the Linkage Between HLA-DRB1 Genotype, CXCR4 Expressions on Memory CD4+ T Cells, and Disease Activity

    Yasuo Nagafuchi1, Hirofumi Shoda1, Shuji Sumitomo1, Shinichiro Nakachi1, Rika Kato2, Yumi Tsuchida2, Haruka Tsuchiya2, Keiichi Sakurai2, Norio Hanata2, Shoko Tateishi2, Hiroko Kanda2, Keishi Fujio1 and Kazuhiko Yamamoto1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Background/Purpose: The HLA-DRB1 is the strongest genetic risk factor for rheumatoid arthritis (RA). Although this fact suggests a pivotal role for adaptive immunity in RA,…
  • Abstract Number: 2703 • 2015 ACR/ARHP Annual Meeting

    Reduction in Matrix Metalloproteinase-1 and -2 Secretion from Fibroblast-like Synoviocytes after Induction of Adipogenesis By a Natural Peroxisome Proliferator-Activated Receptor Gamma Ligand, Arterpilin-C

    Eiji Sugiyama1, Satoshi Yamasaki1 and Je-Tae Woo2,3, 1Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, 2Department of Biological Chemistry, Chubu University, Aichi, Japan, 3JT WOO, Okinawa Research Center Co., Ltd, Okiawa, Japan

    Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles in rheumatoid arthritis (RA) by producing matrix metalloproteinase (MMP) and cytokines, and hence, these cells are a therapeutic…
  • Abstract Number: 2704 • 2015 ACR/ARHP Annual Meeting

    Neutrophil-Derived Lactoferrin Regulates the Activity of NFAT5 in Rheumatoid Arthritis Synovial Fibroblasts Via Toll-like Receptor 4

    Kunihiko Umekita, Shunichi Miyauchi, Kazuyoshi Kubo, Hajime Nomura, Kazumi Umeki, Koushou Iwao, Mao Komura and Akihiko Okayama, Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan

    Background/Purpose: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in the rheumatoid arthritis (RA) joints resulting in increased expression…
  • Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting

    AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis

    Masaru Kato1, Kerstin Klein2, Caroline Ospelt2, Christoph Kolling3, Michihito Kono1, Shinsuke Yasuda1, Renate E. Gay4, Steffen Gay5 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Schulthess Clinic, Zurich, Switzerland, 4Center of Experimental Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 5Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland

    Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…
  • Abstract Number: 2706 • 2015 ACR/ARHP Annual Meeting

    3D Location of Erosions in an Early Rheumatoid Arthritis Population: An MRI Study Using Statistical Shape Models with Implications for Pathogenesis

    Michael A. Bowes1, Gwenael Guillard1, Z. Xie2, Bethanie Wilkinson2 and Philip G. Conaghan3, 1Imorphics, Manchester, United Kingdom, 2Pfizer Inc, Groton, CT, 3University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom

    Background/Purpose: Concepts of erosion pathogenesis in rheumatoid arthritis (RA) have been based on radiographs, although MR images are much better able to visualise erosions. Statistical…
  • Abstract Number: 2707 • 2015 ACR/ARHP Annual Meeting

    An in Vitro Bovine Bone Chip Model with Micro-CT: A Model for the Assessment of Autoantibody Mediated Bone Resorption

    Manpreet Kaur Sethi1, Anand Dusad1, Andy Hollins2, Carlos D. Hunter3, Michael J. Duryee3, Ted R. Mikuls2, Geoffrey M. Thiele4 and Ellen M. Gravallese5, 1Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Omaha, NE, 3Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 5Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) are specific to rheumatoid arthritis (RA) and are associated with disease severity.  Although ACPAs are associated with disease progression, mechanisms…
  • Abstract Number: 2708 • 2015 ACR/ARHP Annual Meeting

    Correlation of Peripheral Blood Th-17 and Th-1 with Synovitis and Osteitis By MRI in Recent Onset Rheumatoid Arthritis

    Sukesh Edavalath1, Ankita Singh1, Namita Mohindra2, Sunil Kumar2 and Ramnath Misra1, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: An increased expansion of Th17 cells in the synovial membrane have shown to play a key role in causing persistent synovitis leading to cartilage…
  • Abstract Number: 2709 • 2015 ACR/ARHP Annual Meeting

    Immediate  Release of Peripheral Neutrophil Myeloperoxidase and Elastase and Formation of Extracellular Traps to Cigarette Smoking in Rheumatoid Arthritis

    Juliane Franz1, Stavros Giaglis1,2, Guenther Schaefer3, Erik Deman1, Andreas Thueler4, Sinuhe Hahn2 and Paul Hasler1, 1Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 2Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 4Rheumatology, Kantonsspital Baden, Baden, Switzerland

    Background/Purpose: Smoking represents an independent risk factor for rheumatoid arthritis (RA) (1). In response to infectious agents, neutrophil granulocytes can extrude their nuclear contents as…
  • Abstract Number: 2710 • 2015 ACR/ARHP Annual Meeting

    Necrox-7 Inhibits Cell Aggressiveness By Suppressing of NF-Kappa B Activation and Reactive Oxygen Species Generation in Human Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Hyun Jung Yoo1,2, Jin Kyun Park2, Eun Young Lee2, Eun Bong Lee2 and Yeong Wook Song2,3, 1Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component…
  • Abstract Number: 2711 • 2015 ACR/ARHP Annual Meeting

    The Lung Microbiome in Rheumatoid Arthritis and Associated Local/Systemic Autoimmunity

    Jose U. Scher1, Vijay Joshua2, Carles Ubeda3, Alejandro Artacho3, Leopoldo Segal4 and Anca I Catrina5, 1Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Cmm L8:04, Karolinska Institutet, Stockholm, Sweden, 3Institute for Research in Public Health, Valencia, Spain, 4Medicine, Pulmonay Division, NYU School of Medicine, New York City, NY, 5Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disorder in which several genetic and environmental factors play a role. Recent data suggest that the gut…
  • Abstract Number: 2712 • 2015 ACR/ARHP Annual Meeting

    Intracellular O-Glc-Nac Alterations in Mononuclear Blood Cell of Rheumatoid Arthritis Patients

    Jose Luis Montiel Hernandez1,2, Daniel Xibille-Friedmann3, Gerardo-Jossue Contis-Corrales1, Maritza-E. Castillo-Gregorio1, Carolina Bustos-Rivera Bahena4 and Donaji Domínguez-Zuñiga5, 1Faculty of Pharmacy, Universidad Autonoma del Estado de Morelos, Cuernavaca, Mexico, 2Cytokines and Autoimmunity Laboratory, Faculty of Pharmacy, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico, 3Rheumatology, Hospital General de Cuernavaca, Cuernavaca, Mexico, 4Universidad Autonoma del Estado de Morelos, Instituto de Dinamica Celular, Cuernavaca, Mexico, 5Faculty of Medicine, Universidad Autonoma del Estado de Morelos, Cuernavaca, Mexico

    Background/Purpose: Although it has been traditionally assumed that most glycosylation occurs on membrane or secreted proteins and lipids, it is well known that cytoplasmic or…
  • Abstract Number: 2713 • 2015 ACR/ARHP Annual Meeting

    A Novel Paradigm in the Clinical Context of Rheumatoid Arthritis: Role of Tfh and Th17 Cells in Autoimmunity

    Magdalena Budziakowska1, Arif Shahzad1, Jerry Pounds1, Shikha Singla1, Jerald M. Zakem1,2, Kismet Collins1, Tamika Webb-Detiege1, William E. Davis1,2, Zongbing You3, Robert Quinet1,2 and Xin Zhang4, 1Rheumatology, Ochsner Medical Center, New Orleans, LA, 2University of Queensland School of Medicine, Brisbane, Australia, 3Tulane University Health Science Center, New Orleans, LA, 4Laboratory of Cellular Immunology, Institution of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life…
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