Abstracts Archive - Page 1650 of 2607 - ACR Meeting Abstracts

Abstract Number: 758 • 2016 ACR/ARHP Annual Meeting
Relationship Between Corticosteroids and Adverse Events in SLE –Data from the Clinical Trial Belimumab in Subjects with Systemic Lupus Erythematosus
Sharzad Emamikia¹, Cidem Gentline², Magnus Backheden³, Katerina Chatzidionysiou², Laurent Arnaud⁴ and Ronald F. van Vollenhoven^2,5, ¹Department of Medicine, Karolinska Institute, Stockholm, Sweden, ²Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ³Department of Learning, Informatics, Management and Ethics, Unit for Medical Statistics, Stockholm, Sweden, ⁴Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Dept. of Medicine, Karolinska institutet, Stockholm, Sweden, ⁵Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands
Background/Purpose: Corticosteroids (CSs) are widely used in Systemic Lupus Erythematosus (SLE) patients, but have side-effects when used for prolonged periods of time. Our aim was…
Abstract Number: 759 • 2016 ACR/ARHP Annual Meeting
Gene Signature for Glucocorticoid, from in Vitro to In Vivo
Yanhua Sarah Hu¹, Somnath Bandyopadhyay¹, Deborah Furst¹, A Johnsen¹, Robert Latek¹, Steven G. Nadler² and Julie Carman³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ, ³Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Steroids are widely used in clinical practice for treating systemic lupus erythematosus (SLE), and can have a strong effect on immune cells in Whole…
Abstract Number: 760 • 2016 ACR/ARHP Annual Meeting
Effects of Type I Interferon Inhibition on Blood Leukocyte Subsets in Patients Treated in a Phase IIb Clinical Study of Anifrolumab in SLE
Geoffrey Stephens¹, Rong Zeng², Xiang Guo², Steve Eck³, Yuling Wu³, Liangwei Wang³, Gabor Illei³ and Wendy White², ¹Cellcion, Clarksburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³MedImmune, LLC, Gaithersburg, MD
Background/Purpose: A Phase IIb randomized controlled study (NCT01753193) was conducted with anifrolumab, a fully human, anti-interferon (IFN)–α receptor (IFNAR1) specific antibody in adults with moderate…
Abstract Number: 761 • 2016 ACR/ARHP Annual Meeting
Exposure-Response Analysis for Selection of Optimal Dosage Regimen of Anifrolumab in Patients with Systemic Lupus Erythematosus
L Santiago¹, B Wang², P Brohawn², L Wang², G Illei² and L Roskos², ¹MedImmune, Mountain View, CA, ²MedImmune, Gaithersburg, MD
Background/Purpose: Anifrolumab is a fully human IgG1 monoclonal antibody directed against subunit 1 of the type I interferon–α receptor (IFNAR1) currently in development for the…
Abstract Number: 762 • 2016 ACR/ARHP Annual Meeting
Pragmatic Treatment of Patients with Systemic Lupus Erythematosus with Rituximab: Long-Term Effects on Serum Immunoglobulins
Venkat Reddy¹, Lina Martínez-Estupiñán², David A. Isenberg³, Maria J. Leandro³ and Geraldine Cambridge³, ¹Rheumatology, University College Hospital, London, United Kingdom, ²Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ³Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: B cell depletion therapy based on rituximab is a therapeutic option for refractory disease in patients with Systemic Lupus Erythematosus (SLE). Hypogammaglobulinemia can be…
Abstract Number: 763 • 2016 ACR/ARHP Annual Meeting
Rituximab As a Corticosteroid-Sparing Agent in Patients with Systemic Lupus Erythematosus
Na Ri Kim¹, Jung Su Eun¹, Jong Wan Kang¹, Eon Jeong Nam¹ and Young Mo Kang², ¹Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, Republic of
Background/Purpose : The treatment of active systemic lupus erythematosus (SLE) remains problematic because the current treatment regimen based on corticosteroids and immunosuppressive agents have significant…
Abstract Number: 764 • 2016 ACR/ARHP Annual Meeting
Atacicept: Integrated Safety Profile from Phase II Randomized Placebo-Controlled Studies in Autoimmune Diseases
Patricia Fraser, Wai Chin and Amy Kao, EMD Serono, Billerica, MA
Background/Purpose: Atacicept, a recombinant fusion protein, targets both BLyS (B lymphocyte stimulator) and APRIL (a proliferation-inducing ligand), B cell activating factors involved in the pathogenesis…
Abstract Number: 765 • 2016 ACR/ARHP Annual Meeting
High Baseline B Lymphocyte Stimulator (BLyS) Levels Predict Response While Smoking and Organ Damage at Baseline Predict Failure to Belimumab in Three Swedish Clinical Practice Settings
Ioannis Parodis¹, Christopher Sjöwall², Andreas Jönsen³, Agneta Zickert¹, Daniel Ramsköld¹, Martina Frodlund², Laurent Arnaud¹, Vivianne Malmström¹, Anders A. Bengtsson³ and Iva Gunnarsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology/AIR, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ³Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden
Background/Purpose: Belimumab is a biologic drug approved to treat Systemic Lupus Erythematosus (SLE). The efficacy of belimumab has been demonstrated in phase III clinical trials.…
Abstract Number: 766 • 2016 ACR/ARHP Annual Meeting
Withdrawal of Mycophenolate Mofetil after Maintenance Treatment of SLE Nephritis Associated with Renal Relapse
H. Michael Belmont¹ and Adey Berhanu², ¹New York University School of Medicine, New York, NY, ²Rheumatology Fellowship Program, NYU Langone Medical Center/NYU School of Medicine, New York, NY
Background/Purpose: Current ACR and EULAR evidence based guidelines provide recommendations for therapeutic choices to induce and maintain remission of lupus nephritis, however, the appropriate duration…
Abstract Number: 767 • 2016 ACR/ARHP Annual Meeting
Hydroxychloroquine Induced Retinopathy in SLE
Michelle Petri¹ and Wei Fu², ¹Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Retinal toxicity from hydroxychloroquine (HCQ), has been recognized for many years. But poor compliance of HCQ might confound results of previous studies. Therefore, we…
Abstract Number: 768 • 2016 ACR/ARHP Annual Meeting
7-Year Safety and Efficacy of Belimumab in Patients with Systemic Lupus Erythematosus
Richard A. Furie¹, Daniel J. Wallace², Cynthia Aranow³, James Fettiplace⁴, Barbara Wilson⁵, Prafull Mistry⁶, David A Roth⁷ and David Gordon⁷, ¹Northwell Health, Great Neck, NY, ²Cedars-Sinai Medical Center, UCLA, Los Angeles, CA, ³The Feinstein Institute for Medical Research, Manhasset, NY, ⁴GSK, Uxbridge, Middlesex, United Kingdom, ⁵GSK, Research Triangle Park, NC, ⁶GSK, Stevenage, Hertfordshire, United Kingdom, ⁷GSK, Philadelphia, PA
Background/Purpose: The availability of published long-term data from systemic lupus erythematosus (SLE) clinical trials is limited [1]. To complement existing belimumab data, we examined the…
Abstract Number: 769 • 2016 ACR/ARHP Annual Meeting
Response to Belimumab in SLE Patients with High Disease Activity: Data from a Multicentric Clinical-Practice Based Study Cohort
Luca Iaccarino¹, Silvano Bettio², Rossella Reggia³, Giacomo Emmi⁴, Fulvia Ceccarelli⁵, Chiara Tani⁶, Maria Gerosa⁷, Marcello Govoni⁸, Alesandra Bortoluzzi⁹, Salvatore De Vita¹⁰, Ginevra De Marchi¹¹, Rossella De Angelis¹², Andrea Di Matteo¹², Carlo Salvarani¹³, Giulia Pazzola¹³, Elena Bartoloni-Bocci¹⁴, Laura Andreoli¹⁵, Margherita Zen¹⁶, Fabrizio Conti¹⁷, Marta Mosca⁶, Pier Luigi Meroni¹⁸, Roberto Gerli¹⁴, Angela Tincani¹⁹, Andrea Doria²⁰ and Lorenzo Emmi²¹, ¹Department of Medicine-DIMED, University of Padova, Padova, Italy, ²Rheumatology Unit, Univeristy of Padova, Padova, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ⁴Medical Pathology, Careggi University Hospital, Firenze, Italy, ⁵Sapienza University of Rome, Rome, Italy, ⁶Rheumatology Unit, University of Pisa, Pisa, Italy, ⁷University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ⁸Medical Sciences, UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, ⁹UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, ¹⁰Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital "Santa Maria della Misericordia", Udine, Italy, Udine, Italy, ¹¹Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, ¹²Polytechnic university of Marche, Rheumatologic Clinic, Iesi, Italy, ¹³Rheumatology Unit, Internal Medicine Department, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, ¹⁴Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ¹⁵University of Brescia, Spedali Civili, Brescia, Italy, ¹⁶Division of Rheumatology, University of Padova, Padova, Italy, ¹⁷Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, ¹⁸Rheumatology Department, University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ¹⁹Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Italy, ²⁰Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy, ²¹Internal Interdisciplinary Medicine Center for Autoimmune Systemic Diseases, Lupus Clinic,, Internal Interdisciplinary Medicine Center for Autoimmune Systemic Diseases, Lupus Clinic, AOU Careggi, Florence, Italy
Background/Purpose: To investigate effectiveness and identify predictors of response to belimumab in patients with active SLE in clinical practice setting. Methods: One hundred eighty eight…
Abstract Number: 770 • 2016 ACR/ARHP Annual Meeting
Introducing a Novel SLE-Specific IFN-I Inhibitor CNTO 6358: Laying the Groundwork for Precision Medicine in Lupus
Jarrat Jordan¹, Matteo Cesaroni¹, Jessica Schreiter¹, Chichi Huang², Tanesha Cash-Mason³, Marc Chevrier¹ and Jacqueline Benson¹, ¹Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ²Biologics Research, Janssen Research and Development, LLC., Spring House, PA, ³Cardiovascular and Metabolism Research, Janssen Research and Development, LLC., Spring House, PA
Background/Purpose: The type I interferon (IFN-I) family of cytokines signal through a ubiquitously expressed heterodimeric receptor (IFNAR) composed of IFNAR1 and the high-affinity binding chain…
Abstract Number: 771 • 2016 ACR/ARHP Annual Meeting
Preventive Effects of Glucocorticoids on Progression of Atherosclerosis in Japanese Patients with SLE
Hisaji Oshima¹, Masaki Iwasaki¹, Ikuko Tanaka², Misako Higashida³, Mari Ushikubo⁴, Eriko Takei⁵, Kumiko Akiya³ and Keisuke Izumi⁶, ¹Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ²NAGOYA Rheumatology Clinic, Nagoya, Japan, ³Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ⁴Department of Connective Tissue Disease, National Tokyo Medical Center, Tokyo, Japan, ⁵Connective tissue disease, National Tokyo Medical Center, Tokyo, Japan, ⁶Connective Tissue Dseases, National Tokyo Medical Center, Tokyo, Japan
Background/Purpose: Several cross-sectional studies have shown a progression of atherosclerosis in SLE was associated with activities of SLE but not with glucocorticoid therapy. However, a…
Abstract Number: 772 • 2016 ACR/ARHP Annual Meeting
Effect of HMG-CoA Reductase Inhibitor Drugs (Statins) on Systemic Lupus Erythematosus Disease Activity: A Systematic Review and Meta-Analysis
Givenchy Maree Garcia, Annalyn Urbano and Evelyn Salido, Section of Rheumatology, University of the Philippines - Philippine General Hospital, Manila, Philippines
Background/Purpose: Statins have been shown to have anti-inflammatory and immunomodulatory effects. In vitro studies show that these drugs inhibit inflammatory cells, decrease the expression of…

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