Abstracts Archive - Page 1648 of 2607 - ACR Meeting Abstracts

Abstract Number: 728 • 2016 ACR/ARHP Annual Meeting
Correlation Between the Spinal MRI Findings and the Serum Level of DKK-1 in Patients with Spondyloarthritis Treated with TNF Antagonist
Zheng Zhao, Gang Wang, Yanyan Wang, Jinshui Yang, Jian Zhu and Feng Huang, Rheumatology, Chinese PLA General Hospital, Beijing, China
Background/Purpose : Recent prospective data suggest that spinal inflammatory damage in patients with ankylosing spondylitis will eventually convert into fat. In these complex inflammatory lesions,…
Abstract Number: 729 • 2016 ACR/ARHP Annual Meeting
Does the Presence of Multiple Spondyloarthritis-Features in Patients with Chronic Back Pain Always Lead to Diagnosis of Axial Spondyloarthritis?
Zineb Ez-Zaitouni¹, Pauline Bakker¹, Miranda van Lunteren¹, Inger Jorid Berg², Robert Landewé³, Maikel van Oosterhout⁴, Mariagrazia Lorenzin⁵, Désirée van der Heijde¹ and Floris van Gaalen¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ⁴Rheumatology, Groene Hart Hospital, Gouda, Netherlands, ⁵Rheumatology Unit, Department of Medicine DIMED, Rheumatology Unit,University of Padova, Padova, Italy
Background/Purpose: The number of clinical spondyloarthritis (SpA)-features plays an important role in the Assessment of SpondyloArthritis international Society (ASAS) modified Berlin algorithm for the diagnostic…
Abstract Number: 730 • 2016 ACR/ARHP Annual Meeting
Clinical and Quality of Life Improvements Observed with Golimumab and Infliximab in a Large Real-Life Ankylosing Spondylitis Population
Filip van Den Bosch¹, Rene-Marc Flipo², Jürgen Braun³, Shiva Sajjan⁴, N Vastesaeger⁵, Sumesh Kachroo⁶ and Marinella Govoni⁷, ¹Rheumatology, Ghent University Hospital, Ghent, Belgium, ²Rheumatology, University Hospital, Lille, France, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Merck & Co., Inc., Kenilworth, NJ, ⁵Merck Sharp & Dohme, Belgium, Brussels, Belgium, ⁶CORE, Merck & Co., Inc., Kenilworth, NJ, ⁷Via Tasso 14, Merck Sharp & Dohme, Italy, Cento, Italy
Background/Purpose : We assessed baseline parameters associated with health-related quality-of-life (HRQoL) improvement in AS patients with anti-TNF treatment (golimumab [GLM]; infliximab [IFX; originator]) in the…
Abstract Number: 731 • 2016 ACR/ARHP Annual Meeting
High Prevalence of Hip Arthritis in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors
Maria Konsta¹, Michael Nurmohamed², J.C. van Denderen³, Ingrid Visman⁴ and I.E. Van der Horst - Bruinsma⁵, ¹Amsterdam Rheumatology and Immunology Center,VUmc and Reade, Amsterdam, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ³Center for Rheumatology and Rehabilitation, Jan van Breemen Institute, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology and Immunology Center, VUmc and Reade, Amsterdam, Netherlands, ⁵GENRA Consortium, Amsterdam, Netherlands
Background/Purpose: Hip involvement is the most frequent extraspinal arthritic manifestation of Ankylosing Spondylitis (AS) and a common cause of disability. It is present in 24%…
Abstract Number: 732 • 2016 ACR/ARHP Annual Meeting
Long-Term Effect of TNF Inhibitors on Radiographic Progression in Ankylosing Spondylitis Is Associated with Syndesmophytes at Baseline and Time-Averaged CRP Levels
Maria Konsta^1,2, Grigorios Sakellariou³, Alexios Iliopoulos⁴, PETROS P SFIKAKIS⁵ and I.E. Van der Horst - Bruinsma⁶, ¹Amsterdam Rheumatology and Immunology Center,VUmc and Reade, Amsterdam, Netherlands, ²First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Greece, Athens, Greece, ³Rheumatology, Veterans Administration Hospital, Athens, Greece, ⁴Department of Rheumatology, Veterans Administration Hospital, Athens, Greece, ⁵First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ⁶GENRA Consortium, Amsterdam, Netherlands
Background/Purpose: Although the radiographic progression in AS is associated with both baseline and time-averaged level of CRP in TNF naïve patients, the effect of level…
Abstract Number: 733 • 2016 ACR/ARHP Annual Meeting
Efficacy and Safety of Non-Biological Therapy (Non-Biological Drugs and Non-Pharmacological Interventions): A Systematic Literature Review for the 2016 Update of the ASAS/EULAR Recommendations for the Management of Axial Spondyloarthritis
Andrea Regel¹, Alexandre Sepriano², Xenofon Baraliakos¹, Désirée van der Heijde², Juergen Braun¹, Robert Landewé³, Filip van Den Bosch⁴ and Sofia Ramiro², ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ⁴Rheumatology, Ghent University Hospital, Ghent, Belgium
Background/Purpose: As part of the 2016 update of the ASAS/EULAR recommendations for the management of axSpA, we performed a systematic literature review (SLR) to assess…
Abstract Number: 734 • 2016 ACR/ARHP Annual Meeting
Lateral Spine BMD Measurement and Trabecular Bone Score Can Represent a Bone Loss in Patients with Advanced Ankylosing Spondylitis
Min Kyung Chung¹, Seo Hwa Kim², Haneul Kim¹, Jung Hee Koh¹, Jennifer Lee³, Seung-Ki Kwok⁴, Sung-Hwan Park⁵ and Ji Hyeon Ju⁵, ¹Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ²Division of Rheumatology,, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁴[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: It is well known that osteoporosis is paradoxically common in patients with ankylosing spondylitis (AS) in spite of their new bone formation and extraosseous…
Abstract Number: 735 • 2016 ACR/ARHP Annual Meeting
Impact of Time Since Diagnosis, Age, and Number of Prior Non-Steroidal Anti-Inflammatory Drugs on Response to Adalimumab (HUMIRA) in Patients with Ankylosing Spondylitis
Joachim Sieper¹, Atul A. Deodhar², Maja Hojnik³, Ying Zhang⁴ and Maxime Dougados⁵, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Oregon Health and Science University, Portland, OR, ³AbbVie, Ljubljana, Slovenia, ⁴AbbVie, North Chicago, IL, ⁵René Descartes University and Hôpital Cochin, Paris, France
Background/Purpose: Ankylosing spondylitis (AS) patients (pts) were found to respond better to TNF inhibitors (TNFi) if treated early in the disease course. The objective of…
Abstract Number: 736 • 2016 ACR/ARHP Annual Meeting
A Multi-Center, Open Label, Randomized Clinical Tries of Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Ankylosing Spondylitis
Jieruo Gu¹, Liudan Tu², Minjing Zhao³, Zhiming Lin⁴, Zetao Liao⁵, Shuangyan Cao⁶, Qinghong Yu⁷ and Zhizhong Ye⁸, ¹Rheumatology, Third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ²The Third Hospital of Sun Yat-sen University, Guangzhou, China, ³The Third Affiliated Hospital of Sun Yat-sen University, guangzhou, China, ⁴Rheumatology, 3rd Affiliated Hospital of Sun Yat-Sen Uni, Guangzhou, China, ⁵Rheumatology, 3rd Affiliated Hoapital of Sun Yat-Sen Uni, Guangzhou, China, ⁶Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁷Department of Rheumatology, Fourth People’s Hospital of Shenzhen City, Xiangmi Lake branch, Guangzhou, China, ⁸Department of Rheumatology，ZhuJiang Hospital of Southern Medical University, Guangzhou, China
Background/Purpose: To compare the clinical、radiographic and magnatic resonance imaging change in active ankylosing spondylitis patients with etanercept and celecoxib alone/combined treatment，and to evaluate the effectiveness…
Abstract Number: 737 • 2016 ACR/ARHP Annual Meeting
Hydroxychloroquine Whole Blood Levels Do Not Associate with Hydroxychloroquine Retinopathy
Michelle Petri¹, Wei Fu² and Syed Mahmood Shah³, ¹Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The American Academy of Ophthalmology guidelines on hydroxychloroquine retinopathy were recently revised (Ophthalmology 2016;1-9). These guidelines recommend optical coherence tomography (OCT) with multifocal electroretinogram…
Abstract Number: 738 • 2016 ACR/ARHP Annual Meeting
Preventive Effect of Combined Treatment with Bisphosphonate and Vitamin D on Atherosclerosis in Patients with Systemic Lupus Erythematosus
Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Ryo Hisada, Masatoshi Kanda, Sanae Shimamura, Ikuma Nakagawa, Yuka Shimizu, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Shinsuke Yasuda and Tatsuya Atsumi, Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Background/Purpose: Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Preventing atherosclerosis is a key objective while monitoring patients with SLE.…
Abstract Number: 739 • 2016 ACR/ARHP Annual Meeting
Safety and Efficacy of Rituximab in the Treatment of Refractory Systemic Lupus Erythematosus: Results from a National Register
Stephanie Nesbit^1,2, John A. Reynolds³, Emily Sutton⁴, Eric F Morand², Ian N. Bruce³ and BILAG Biologics Register Consortium, ¹University of Manchester, Manchester, United Kingdom, ²Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁴University of Manchester, Manchester Academic Health Science Centre, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom
Background/Purpose: Response to the anti-CD20 agent rituximab (RTX) in SLE is variable but it is still widely used for refractory SLE. Our aim was to…
Abstract Number: 740 • 2016 ACR/ARHP Annual Meeting
Patient Adherence with Mycophenolate Mofetil Therapy in a Systemic Lupus Erythematosus Cohort: A Multi-Factorial Assessment
Maryam Ghaderi-Yeganeh¹, Ann Biehl², Zerai G. Manna³, Alice Fike⁴ and Sarfaraz Hasni³, ¹National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Department of Pharmacy, National Institutes of Health Clinical Center, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Lack of adherence to treatment recommendations is a serious confounder to assessment of treatment efficacy for systemic lupus erythematosus (SLE). Estimates of nonadherence with…
Abstract Number: 741 • 2016 ACR/ARHP Annual Meeting
Hydroxychloroquine Is Not Associated with Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase (G6PD) Deficient Patients
Samya Mohammad, Megan E. B. Clowse, Amanda Eudy and Lisa Criscione-Schreiber, Division of Rheumatology, Department of Medicine, Duke University, Durham, NC
Background/Purpose: Hydroxychloroquine (HCQ) is frequently used to treat autoimmune diseases. The HCQ package insert and online drug information resources report an increased risk of hemolytic…
Abstract Number: 742 • 2016 ACR/ARHP Annual Meeting
A Pivotal Phase III, Randomized, Placebo-Controlled Study of Belimumab in Patients with Systemic Lupus Erythematosus Located in China, Japan, and South Korea
Fengchun Zhang¹, Sang-Cheol Bae², Damon Bass³, Myron Chu³, Sally Egginton⁴, David Gordon³, David Roth³, Yoshiya Tanaka⁵ and Jie Zheng⁶, ¹Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, ³GSK, Philadelphia, PA, ⁴GSK, Stevenage, United Kingdom, ⁵University of Occupational and Environmental Health, Kitakyushu, Japan, ⁶Ruijin Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China
Background/Purpose: SLE is an autoimmune disease associated with elevated levels of B Lymphocyte Stimulator (BLyS). This study assessed the efficacy and safety of belimumab (BLyS-specific…

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