Abstracts Archive - Page 1642 of 2425 - ACR Meeting Abstracts

Abstract Number: 2549 • 2015 ACR/ARHP Annual Meeting
Characterizing the RPTPσ Mediated Proteoglycan Switch As a Target for Rheumatoid Arthritis Therapy
Karen M. Doody¹, Stephanie M. Stanford¹, Mattias N. D. Svensson¹, Cristiano Sacchetti¹, Gary S. Firestein², A. Radu Aricescu³ and Nunzio Bottini^1,4, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ³Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, ⁴Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA
Background/Purpose: RPTPσ (gene PTPRS) is a protein tyrosine phosphatase that binds heparan sulfate- and chondroitin sulfate-containing proteoglycans with its extracellular immunoglobulin domains 1 and…
Abstract Number: 2550 • 2015 ACR/ARHP Annual Meeting
Metabolomic Profiling of Joints in Murine Models of Inflammatory Arthritis
Ilya gertsman¹, Jesus Rivera-Nieves², Maripat Corr², Bruce Barshop¹ and Monica Guma³, ¹pediatrics, University of California, San Diego, La Jolla, CA, ²Medicine, University of California, San Diego, La Jolla, CA, ³Pharmacology, University of California, San Diego, La Jolla, CA
Background/Purpose: Given the complexity and heterogeneous nature of rheumatoid arthritis (RA), it is unlikely that a single biomarker may provide sufficient discrimination; therefore biomarker signatures…
Abstract Number: 2551 • 2015 ACR/ARHP Annual Meeting
Antibodies to Malondialdehyde-Acetaldhyde Adducts Are Increased in the Serum of Mice Following Infection with P. Gingivalis and/or Injection of Citrullinated Mouse Type II Collagen: a Model of Human Disease Response
Geoffrey M. Thiele⁴, Einstein Juma¹, Roxanne Haslam¹, Michael J. Duryee², Anand Dusad³, Carlos D. Hunter², James R. O'Dell⁴, Lynell W. Klassen⁴, Ted R. Mikuls⁴ and Geoffrey M. Thiele⁴, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with RA complicated by periodontal disease (PD) have been shown to have higher anti-citrullinated protein antibody (ACPA) levels, which have also become predictive…
Abstract Number: 2552 • 2015 ACR/ARHP Annual Meeting
Alterations in the Colonic Microbiome Precede the Development of Murine Inflammatory Arthritis
Jason Hendrickson¹, Gaurav Mehta², NIRMAL BANDA¹ and Kristine A. Kuhn¹, ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Alterations in resident bacteria, termed dysbiosis, is present in patients in early stages of rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis. However, it remains unclear…
Abstract Number: 2553 • 2015 ACR/ARHP Annual Meeting
Involvement of M2 Macrophages in the Pathogenesis of Arthritis in a Mouse Model
Shinjiro Kaieda¹, Naomi Yoshida², Yukiko Kunitake³, Daisuke Wakasugi⁴, Yukio Fujiwara⁵, Yoshihiro Komahara⁶, Hiroaki Ida⁷ and Tomoaki Hoshino², ¹Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, ²Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ³Kurume University School of Medicine, Kurume, Japan, ⁴Medecine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ⁵Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan, ⁶Cell Pathology, Graduate School of Medical Sciences, Kurume University, Kumamoto, Japan, ⁷Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan
Background/Purpose: Synovial lining macrophages play an important role in initiating and maintaining joint inflammation in arthritis. Classically activated pro-inflammatory macrophages and alternatively activated anti-inflammatory macrophages…
Abstract Number: 2554 • 2015 ACR/ARHP Annual Meeting
Inhibition of IL6 Receptor Improves Arthritis and Atherosclerosis in a Mouse Model of Rheumatoid Arthritis
Amy Archer¹, Carla Cuda², Alexander Shaffer², Emily Alex Waters³, Chad Haney⁴, Rana Saber², George Kenneth Haines III⁵, Jason Low⁶ and Harris R. Perlman⁷, ¹Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, ⁴Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, ⁵Mount Sinai, New York, NY, ⁶Genentech, San Francisco, CA, ⁷Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Rheumatoid arthritis is a chronic, systemic, autoimmune disease associated with an increased risk of cardiovascular disease. However, it is unclear what role patients’ dyslipidemia…
Abstract Number: 2555 • 2015 ACR/ARHP Annual Meeting
14-3-3η As a Novel RA Drug Target: Anti-14-3-3η Monoclonal Antibody Delays the Onset and Mitigates the Severity of Arthritis in CIA Mice
Abedelnasser Abulrob¹, Mario Mercier¹, Slavisa Corluka¹, Roger MacKenzie¹, Shalini Raphael¹, Sara Michienzi², Jane Savill², Yuan Gui², Walter Maksymowych³ and Anthony Marotta², ¹National Research Council of Canada, Ottawa, ON, Canada, ²Augurex Life Sciences Corp., Vancouver, BC, Canada, ³Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: As an extracellular ligand, 14-3-3η potently and concentration-dependently upregulates the expression of multiple factors including TNFα, IL-6, and RANKL and its clinical detection is…
Abstract Number: 2556 • 2015 ACR/ARHP Annual Meeting
Functional Genetics of PTPN2 in Rheumatoid Arthritis: Haploinsufficiency of PTPN2 Promotes Severity of CD4+ T-Cell Mediated Autoimmune Arthritis
Mattias N.D Svensson¹, Karen M. Doody¹, Cristiano Sacchetti¹, Dennis J. Wu¹, Gisen Kim², Annelie Hellvard³, Brith Bergum³, Piotr Mydel³, Mitchell Kronenberg², Michel L. Tremblay⁴ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁴Goodman Cancer Centre, McGill University, Montréal, QC, Canada
Background/Purpose: Several genome-wide associations studies have in recent years linked polymorphisms in the PTPN2 locus to rheumatoid arthritis (RA) and other autoimmune diseases. PTPN2 encodes…
Abstract Number: 2557 • 2015 ACR/ARHP Annual Meeting
Comparable Therapeutic Potential of Umbilical Cord Mesenchymal Stem Cells in Collagen Induced Arthritis with Anti-Tumor Necrosis Factor or Anti-CD20
Yue Sun, Wei Kong, Weiwei Chen, Genhong Yao, Xuebing Feng and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Tremendous progress has been made in the development of non-conventional therapies for rheumatoid arthritis (RA). Mesenchymal stem cells (MSC) present multiple immunosuppressive capacities and…
Abstract Number: 2558 • 2015 ACR/ARHP Annual Meeting
The Role of Leukocyte Associated Immunoglobulin-like Receptor-1 (LAIR-1) in Collagen-Induced Arthritis
Seunghyun Kim¹, John E. Coligan², Jeoung-Eun Park³, John M. Stuart⁴, Andrew Kang⁵ and Linda Myers⁵, ¹Rheumatology, University of Tennessee Health Science Center, Memphis, TN, ²NIH, Bethesda, MD, ³University of Tennessee, Memphis, TN, ⁴University of Tennessee/Veterans Affairs, Memphis, TN, ⁵University of Tennessee Health Science Center, Memphis, TN
Background/Purpose: Several observations implicate a critical role for T cell dysregulation as a central problem in RA. We present a method for suppressing T cell…
Abstract Number: 2559 • 2015 ACR/ARHP Annual Meeting
PRO-Resolving Mediators Issued from Apoptotic CELL Efferocytosis (SUPERMAPO) Modulate Antigen Presenting CELL Properties Toward a Tolerogenic Profile: Efficacy in the Treatment of Collagen- Induced Arthritis
Francis Bonnefoy¹, Romain Vallion², Mélanie Couturier³, Anna Daoui³, Eric Toussirot⁴ and Sylvain Perruche¹, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²INSERM UMR 1098, EFS Bourgogne Franche Comté, Besançon, France, ³INSERM UMR1098, EFS Bourgogne Franche Comté, Besançon, France, ⁴Service de Rhumatologie, CHU J Minjoz, Besancon, France
Background/Purpose: Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and…
Abstract Number: 2560 • 2015 ACR/ARHP Annual Meeting
The Mer Tyrosine Kinase Receptor Plays a Protective Role in Joint Inflammation By Mediating Efferocytosis
Claire E.J. Waterborg¹, Silke Beermann¹, Miranda B. Bennink¹, Carla V. Rothlin², Greg Lemke³ and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a hyper-inflammatory response in synovial joints. In joints of patients with active RA, few…
Abstract Number: 2561 • 2015 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase (BTK) Inhibitor, Demonstrates Potent Efficacy in an Animal Model of Rheumatoid Arthritis
Fumihito Hosoi, Youhei Yoshiga, Satoru Iguchi, Ryuusuke Kaneko, Yoshinori Nakachi, Daichi Akasaka, Kazuhiko Yonekura, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., TSUKUBA, Japan
Background/Purpose: Bruton’s tyrosine kinase (BTK) is a member of the Tec family kinases, and is expressed in B cells, monocytes/macrophages, mast cells, basophils and osteoclast1,2.…
Abstract Number: 2562 • 2015 ACR/ARHP Annual Meeting
The Inhibition of Wnt/Beta-Catenin Signaling Pathway Via Paricalcitol and Pyrvinium Ameliorates Experimental Arthritis
Suleyman Serdar Koca¹, Servet Yolbas², Ahmet Yildirim², Ahmet Tektemur³, Zulfinaz Betul Celik³, Ebru Etem Onalan³, Ibrahim Hanifi Ozercan⁴ and Mustafa Akin⁴, ¹İnternal Medicine Division of Rheumatology, Firat University, Faculty of Medicine, Elazig, Turkey, ²Rheumatology, Department of Rheumatology, Firat University, Elazig, Turkey, ³Department of Medical Biology Faculty of Medicine, Firat University, Elazig, Turkey, ⁴Department of Pathology, Faculty of Medicine, Firat University, Elazig, Turkey
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progression of which leads to the destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) display…
Abstract Number: 2563 • 2015 ACR/ARHP Annual Meeting
Immune Regulation By Migrating Mesenchymal Stem Cells Ameliorate Inflammatory Arthritis in Mice
Seung Min Jung, Yoojun Nam and Ji Hyeon Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Mesenchymal stem cells (MSCs) function as immune regulators in inflammatory conditions. However, it is unclear how to control local inflammation by systemically administered MSCs. We…

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