Abstracts Archive - Page 1636 of 2425 - ACR Meeting Abstracts

Abstract Number: 2459 • 2015 ACR/ARHP Annual Meeting
Personal and Environmental Factors Associated with Leisure Participation Among Children and Adolescents with Juvenile Idiopathic Arthritis
Sabrina Cavallo¹, Annette Majnemer², Ciarán M. Duffy³ and Debbie Ehrmann Feldman⁴, ¹École de Santé Publique, Université de Montréal, Montreal, QC, Canada, ²School of Physical and Occupational therapy, McGill University, Montreal, QC, Canada, ³Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁴School of Rehabilitation, Université de Montréal, Montreal, QC, Canada
Background/Purpose: To identify potential disease-related, personal and environmental factors associated with leisure in children and adolescents with juvenile idiopathic arthritis (JIA) according to the International…
Abstract Number: 2460 • 2015 ACR/ARHP Annual Meeting
B10 Cells May be Involved in Controlling Disease Activity in Polyarticular Juvenile Idiopathic Arthritis Patients
Qianzi Zhao¹ and Lawrence K. Jung², ¹Rheumatology, Children's National Medical Center, Washington, DC, ²Pediatric Rheumatology, Children's National Medical Center, Washington, DC
Background/Purpose: In addition to antibodies production, B cells have been shown to have down-regulatory function on immune response in both mouse and human. The down-regulatory…
Abstract Number: 2461 • 2015 ACR/ARHP Annual Meeting
Identification of Target Antigens for Anti-Endothelial Cell Antibodies in Patients with Pediatric Rheumatic Diseases Using Proteomics
Rie Karasawa¹, Mayumi Tamaki¹, Yanmin Chen², Kaiyu Jiang², Kazuo Yudoh¹ and James Jarvis², ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Pediatrics, The University at Buffalo, Buffalo, NY
Background/Purpose: Juvenile dermatomyositis (JDM), the most common inflammatory myopathy of childhood, is a rare systemic autoimmune vasculopathy. Juvenile idiopathic arthritis (JIA), the most common pediatric…
Abstract Number: 2462 • 2015 ACR/ARHP Annual Meeting
Altered Expression of IL-10 Family Cytokines in Chronic Recurrent Multifocal Osteomyelitis Result in Enhanced Inflammasome Activation
Sigrun Hofmann¹, Angela Rösen-Wolff¹, Hermann Girschick², Henner Morbach³ and Christian Hedrich⁴, ¹Children's Hospital Dresden, Dresden, Germany, ²Children's Hospital, Berlin, Germany, ³Children's Hospital Würzburg, Würzburg, Germany, ⁴Pediatric Rheumatology and Immunology, Children's Hospital Dresden, Dresden, Germany
Background/Purpose: Chronic recurrent multifocal osteomyelitis (CRMO) is the most severe presentation of the autoinflammatory bone disorder chronic nonbacterial osteomyelitis (CNO). The pathophysiology of CNO remains…
Abstract Number: 2463 • 2015 ACR/ARHP Annual Meeting
Soluble Low-Density Lipoprotein Receptor-Related Protein 1 in Juvenile Idiopathic Arthritis
Alan M. Rosenberg¹, Marianna Newkirk², Elham Rezaei¹, Zhenhong Li³ and Kiem Oen⁴, ¹Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Medicine, McGill University Health Centr, Montreal, QC, Canada, ³McGill University Health Centr, Montreal, QC, Canada, ⁴University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Low-density lipoprotein receptor–related protein 1 (LRP1), a transmembrane protein, mediates endocytosis of an array of extracellular ligands. LRP1 has intracellular and extracellular domains. With…
Abstract Number: 2464 • 2015 ACR/ARHP Annual Meeting
Characterization of the Serum Anti-Citrullinated Protein Antibody Profile in Juvenile Idiopathic Arthritis: Association with Oral Health
Sampath Prahalad¹, Lauren J. Lahey², Geoffrey M. Thiele³, Lori Ponder¹, Sheila T. Angeles-Han¹, Lauren Lange⁴, Aimee O. Hersh⁵, Mina Rohani-Pichavant¹, Se Ryeong Jang¹, Larry B. Vogler¹, Patricia Vega-Fernandez¹, Kelly A. Rouster-Stevens¹, John F. Bohnsack⁶, Ted R. Mikuls⁷ and Jeremy Sokolove⁸, ¹Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, ²Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, ³Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, ⁶Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT, ⁷Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁸Stanford University, Palo Alto, CA
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic childhood arthropathy. Most children with JIA phenotypically differ from adults with rheumatoid arthritis (RA) although…
Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting
Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE
Hanna Kim¹, Yin Liu², Adriana Almeida de Jesus¹, Robert Wesley³, Yan Huang¹, Gina A. Montealegre Sanchez¹, Dawn C. Chapelle¹, Wanxia L. Tsai⁴, Massimo G. Gadina⁴, Frederick W. Miller⁵, Sarfaraz Hasni⁶, Adeline Vanderver⁷, Lisa G Rider⁵ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, ²Scientific Review Branch, NIAMS, NIH, Bethesda, MD, ³Clinical Center, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁵Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁶National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁷Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis…
Abstract Number: 2466 • 2015 ACR/ARHP Annual Meeting
Epigenetic Traits Correlate with Clinical Activity in Juvenile Idiopathic Arthritis
Roberto Spreafico^1,2, Maura Rossetti^1,2, Carol A. Wallace³, Daniel Lovell^4,5 and Salvatore Albani^1,6, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Sanford-Burnham Medical Research Institute, La Jolla, CA, ³Seattle Children’s Hospital and Research Institute, Seattle, WA, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Duke-National University of Singapore Graduate Medical School, Singapore, Singapore
Background/Purpose: Epigenetic regulation of gene expression is increasingly under scrutiny to understand the pathogenesis of multifactorial human diseases, such as juvenile idiopathic arthritis (JIA). Indeed,…
Abstract Number: 2467 • 2015 ACR/ARHP Annual Meeting
Interaction Between Senescent T Cells and Fibrocyte-like Cells through CD31, TNFα, and IL-17 Create a Tissue Destructive Environment in the Synovium in Juvenile Idiopathic Arthritis
Ian D. Ferguson¹, Patricia Griffin², Hiroshi Yano³, Joshua J. Michel², Jeffrey A. Dvergsten⁴, Sarah L. Gaffen⁵, Margalit E. Rosenkranz¹, Daniel A. Kietz¹ and Abbe N. Vallejo¹, ¹Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Department of Pediatrics, Duke University Medical Center, Durham, NC, ⁵Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
Background/Purpose: T cells are considered effectors of immunopathology in JIA. In previous work, we reported dominance of senescent CD8T cells in synovial fluid of children…
Abstract Number: 2468 • 2015 ACR/ARHP Annual Meeting
Antibodies to Histocompatibility Antigens in Juvenile Systemic Lupus Erythematosus Patients
Ana L Rodríguez-Lozano¹, Anne M. Stevens², Jessica M Foster³, Marisa S. Klein-Gitelman⁴, Hermine I. Brunner⁵, Elizabeth Field⁶, Ann M Reed⁷ and Karen Onel⁸, ¹Immunology, Instituto Nacional de Pediatria, Mexico City, Mexico, ²Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, ³Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ⁴Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Internal Medicine, University of Iowa, Iowa City, IA, ⁷Department of Pediatrics, Duke University, Durham, NC, ⁸Pediatric Rheumatology, Univ of Chicago, Chicago, IL
Background/Purpose: Microchimerism with HLA mismatched maternal cells can be readily demonstrated in normal individuals and is now established as a normal biological phenomenon. Pediatric SLE…
Abstract Number: 2469 • 2015 ACR/ARHP Annual Meeting
The Lymphocyte Repertoire in Juvenile Dermatomyositis
Lauren A. Henderson¹, Edwin Anderson¹, Robert C. Fuhlbrigge^1,2, Luigi D. Notarangelo^1,3,4 and Susan Kim¹, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Department of Dermatology, Brigham and Women's Hospital, Boston, MA, ³The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, ⁴Harvard Stem Cell Institute, Boston, MA
Background/Purpose: In adult dermatomyositis, clonal populations of T lymphocytes with shared variable (V) gene usage have been identified, suggesting aberrant T cell responses to a…
Abstract Number: 2470 • 2015 ACR/ARHP Annual Meeting
Single Center Experience in Next Generation Sequencing for Genetic Diagnosis of Autoinflammatory Disorders
Antonella Insalaco¹, Elisa Pisaneschi², Francesca Romana Lepri², Daniele Minervino², Virginia Messia¹, Manuela Pardeo³ and Fabrizio De Benedetti¹, ¹Division of Rheumatology, Department of Pediatric Medicine, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ²Ospedale Pediatrico Bambino Gesù, IRCCS, Department of Cytogenetics, Roma, Italy, ³Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy
Background/Purpose: Autoinflammatory disorders (AIDs) represent an expanding group of complex diseases characterized by periodic or chronic systemic inflammations. Mutations in more than 15 genes have…
Abstract Number: 2471 • 2015 ACR/ARHP Annual Meeting
Increased Muscle Interferon-Gamma Expression Levels in Juvenile Dermatomyositis
Gian Marco Moneta¹, Adele D'Amico², Margherita Verardo³, Denise Pires Marafon⁴, Luisa Bracci Laudiero⁵, Fabrizio De Benedetti⁶ and Rebecca Nicolai⁷, ¹Department Pediatric Medicine, Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy, ²Department of Neuroscience,, Unit of Neuromuscular and Neurodegenrative Disease, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy, ³Department of Neuroscience, Unit of Neuromuscular and Neurodegenrative Disease, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy, ⁴Pediatric Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁵Rheumatology Laboratory, Bambino Gesú Children Hospital, Rome, Italy, ⁶Pediatric Rheumatology, Bambino Gesù Children's Hospital, Rome, Italy, ⁷Department of Pediatric Medicine, Division of Rheumatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Background/Purpose : Juvenile dermatomyositis (JDM) is a rare autoimmune disorder characterized by muscle weakness, skin rashes and other systemic features. The immunopathogenesis of JDM is…
Abstract Number: 2472 • 2015 ACR/ARHP Annual Meeting
Highly Elevated S100A8/A9 and S100A12 Levels May Distinguish Systemic Juvenile Idiopathic Arthritis Patients with New Onset Disease and Subclinical Macrophage Activation Syndrome
Jessica Turnier¹, Ndate Fall², Alexei A. Grom³, Sherry Thornton² and Hermine I. Brunner⁴, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ³PRCSG, Cincinnati, OH, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis remains a clinical diagnosis without a specific diagnostic test. Previous studies have demonstrated that extremely high levels of S100 proteins…
Abstract Number: 2473 • 2015 ACR/ARHP Annual Meeting
Psycho-Socio-Economic Burdens of Childhood Onset Rheumatic Diseases on Families
Sook Fun Hoh¹, Manasita Tanya², Justin Hung Tiong Tan², Lena Das^2,3 and Thaschawee Arkachaisri², ¹Nursing, KK Women's and Children's Hospital, Singapore, Singapore, ²Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, ³Dept of Rheumatology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH
Background/Purpose: Rheumatic diseases (RD) in children, being complex and chronic in nature, do not only pose physical insult to the affected child, but also psychological…

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