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  • Abstract Number: 487 • 2016 ACR/ARHP Annual Meeting

    Limited Utility of Cytokine Profiles in Rheumatoid Arthritis Patients with Clinically Active Disease and Normal Inflammatory Indices

    Gail S. Kerr1, Asha Mariam Alex2, Harlan Sayles3 and Ted R Mikuls4, 1Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC, 2Rheumatology, Georgetown University Hospital, Washington, DC, 3University of Nebraska Medical Center, Omaha, NE, 4Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Methods: RA patients enrolled in a longitudinal observational registry (VARA) were studied and clinical and disease status characteristics documented. Patients with high joint counts (TJC +…
  • Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting

    Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis

    Asha Mariam Alex1,2, Gary A. Kunkel3, Jorge Flautero Arcos4, Richard Amdur5 and Gail S. Kerr6, 1Rheumatology, Veterans Affairs Medical Center, Washington, DC, 2Rheumatology, Georgetown University Hospital, Washington, DC, 3Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, 4Rheumatology, Howard University Hospital, Washington, DC, 5Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, 6Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC

    Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
  • Abstract Number: 489 • 2016 ACR/ARHP Annual Meeting

    Early Detection of Inflammatory Arthritis: The Role of Musculoskeletal Symptoms, Infections and Rheumatoid Arthritis-Related Comorbidities in Primary Care

    Marian van Beers-Tas1, Markus Nielen2, Joke C. Korevaar2 and Dirkjan van Schaardenburg3, 1Rheumatology, Amsterdam Rheumatology & Immunology Center, Reade, Amsterdam, Netherlands, 2NIVEL (Netherlands Institute for Health Services Research), Utrecht, Netherlands, 3Rheumatology, Amsterdam Rheumatology and immunology Center, location Academic Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands

    ACR ABSTRACT 2016   Early detection of inflammatory arthritis: the role of musculoskeletal symptoms, infections and rheumatoid arthritis-related comorbidities in primary care Background/Purpose: Rheumatoid arthritis…
  • Abstract Number: 490 • 2016 ACR/ARHP Annual Meeting

    First Report of Symptoms Using the Symptoms in Persons at Risk of Rheumatoid Arthritis (SPARRA) Questionnaire

    Marian van Beers-Tas1, Lilian van Tuyl2, Karim Raza3, Rebecca J Stack4, Axel Finckh5, Delphine Courvoisier6, Aase Hensvold7, Anca I Catrina7, Tanja A. Stamm8, Erika Mosor9 and Dirkjan van Schaardenburg10, 1Rheumatology, Amsterdam Rheumatology & Immunology Center, Reade, Amsterdam, Netherlands, 2Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, 3University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, 4Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, 5Rheumatology Division, University Hospital of Geneva, Geneva, Switzerland, 6University hospital of Geneva, Geneva, Switzerland, 7Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 8Internal Medicine III, Vienna Medical University, Vienna, Austria, 9Section for Outcomes Research, CeMSIIS, Medical University of Vienna, Vienna, Austria, 10Rheumatology, Amsterdam Rheumatology and immunology Center, location Academic Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands

    Background/Purpose: Persons at risk of rheumatoid arthritis (RA) may experience a variety of symptoms1,2. However, information on location, timing, severity and predictive value of these…
  • Abstract Number: 491 • 2016 ACR/ARHP Annual Meeting

    Anti-Citrullinated Peptide Antibodies Testing Rate over Time in Newly Diagnosed RA Patients – Data from Three Administrative Claims Databases (2007–2014)

    E Alemao, Z Guo and L Burns, Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Current clinical guidelines recommend testing for anti-citrullinated protein antibodies (ACPA) at the time of RA diagnosis.1 However, there is a lack of information about…
  • Abstract Number: 492 • 2016 ACR/ARHP Annual Meeting

    Calprotectin Levels Correlate with Inflammation in Early Rheumatoid Arthritis before Disease-Modifying Antirheumatic Drug Treatment and after 12 Months of Treatment

    Maria K. Jonsson1,2,3, Hilde B. Hammer4, Hilde H. Nordal1,3, Anna-Birgitte Aga2, Inge C Olsen2, Karl Albert Brokstad3, Tore K Kvien2, Bjørg-Tilde Fevang1,5, Siri Lillegraven2, Espen A. Haavardsholm2 and ARCTIC study group, 1Dept. of Rheumatology, Haukeland University Hospital, Bergen, Norway, 2Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Dept. of Clinical Sciences, University of Bergen, Bergen, Norway, 4Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, 5Department of Clinical Science, University of Bergen, Bergen, Norway

    Background/Purpose:  Calprotectin (MRP8/MRP14, S100A8/A9) is a major leukocyte protein previously shown to be associated with disease activity in patients with established rheumatoid arthritis (RA). Some…
  • Abstract Number: 493 • 2016 ACR/ARHP Annual Meeting

    The 2010 ACR/EULAR Criteria Are Not Sufficiently Accurate in the Early Identification of Autoantibody-Negative Rheumatoid Arthritis

    Debbie M. Boeters1, Cécile Gaujoux-Viala2, Arnaud Constantin3 and Annette H.M. van der Helm-van Mil1, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology Department, University Hospital of Nîmes and EA2415, Montpellier University, Nîmes, France, 3Rheumatology, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France

    Background/Purpose:  The 2010-ACR/EULAR criteria were derived to classify RA earlier in time. Previous studies indeed observed that the 2010-criteria were fulfilled earlier than the 1987-criteria.…
  • Abstract Number: 494 • 2016 ACR/ARHP Annual Meeting

    Sensitivity and Specificity of 14-3-3η, Anti-CEP-1 and Anti-Sa Antibodies in a Cohort of Seronegative and Suspected Rheumatoid Arthritis (RA) Patients from a Community Rheumatology Practice

    Dmitry Karayev1, Guoqiu Shen1, Yvonne Lam1, Andrew Rimmer1, Nayan Lal1, Eugene Karayev1, Kristine Azarraga1, Ronald A. Blum1, Allan L. Metzger1, Robert I. Morris1 and Arash A. Horizon2, 1Rheumatology Diagnostics Laboratory, Inc. (RDL), Los Angeles, CA, 2Center for Rheumatology Medical Group, Los Angeles, CA

    Background/Purpose: RA is the most common autoimmune inflammatory joint disease, affecting up to 1% of the world population. Detection of antibodies, specifically against IgM rheumatoid…
  • Abstract Number: 495 • 2016 ACR/ARHP Annual Meeting

    The Relative Performance of 28-Joint Disease Activity Score Based on C-Reactive Protein with Three Versus Four Components in Patients with Rheumatoid Arthritis

    Ferdinand Breedveld1, Xin Wang2, Anabela Cardoso3 and Edward Keystone4, 1Leiden Univ Medical Center, Leiden, Netherlands, 2AbbVie Inc., North Chicago, IL, 3Torre Oriente, AbbVie, Lisboa, Portugal, 4Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: The commonly used version of the 28-joint disease activity score based on C-reactive protein (DAS28-CRP4) includes swollen and tender joint counts (S/TJC), CRP and…
  • Abstract Number: 496 • 2016 ACR/ARHP Annual Meeting

    Impact of Anti-Citrullinated Protein Antibody and/or Rheumatoid Factor on Rheumatoid Arthritis Manifestations and Outcomes

    Ee Tzun Koh1, Angela Marie Chan1, Wei Qiang See2, Wenwei Xiang2, Khai Pang Leong1 and Tan Tock Seng Rheumatoid Arthritis Study Group, 1Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, 2Clinical Research and Innovation Office, Tan Tock Seng Hospital, Singapore, Singapore

    Background/Purpose: RA Patients with anti-citrullinated protein antibody (ACPA) or rheumatoid factor (RF) are known to have worse clinical outcomes compared to seronegative patients. To determine…
  • Abstract Number: 497 • 2016 ACR/ARHP Annual Meeting

    The Identification of an ACR Score with the Optimal Discriminatory Ability Between Treatments in Patients with Early and Established Rheumatoid Arthritis

    Josef Smolen1, Roy Fleischmann2, Daniel Aletaha3, Yihan Li4, Stefan Florentinus4 and Ivan Lagunes Galindo4, 1Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 2Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 3Medical University Vienna and Hietzing Hospital, Vienna, Austria, 4AbbVie Inc., North Chicago, IL

                                                                                                                           Background/Purpose: In patients (pts) with rheumatoid arthritis (RA), the American College of Rheumatology (ACR)20 score was developed to best discriminate effective from placebo…
  • Abstract Number: 498 • 2016 ACR/ARHP Annual Meeting

    Higher Serum Heavy Metals Concentrations Are Associated with Rheumatoid Arthritis : A Study of the Korean National Health and Nutrition Examination Survey (KNHANES)

    Sang Hyun Joo1, Dong Jin Go2,3, Eun Young Ahn3, Hyun Mi Kwon3, Joongyub Lee4 and Yeong Wook Song5,6, 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, The Republic of, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, 4Division of Clinical Epidemiology Medical Research Collaborating Center Biomedical Research Institution, Seoul National University Hospital, Seoul, Korea, The Republic of, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 61Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, The Republic of

    Background/Purpose: The heavy metal Cadmium (Cd) may contribute to the high risk of developing rheumatoid arthritis (RA) through the cigarette smoking and occupational exposure including…
  • Abstract Number: 499 • 2016 ACR/ARHP Annual Meeting

    High Levels of Mir-451a Differentiate Patients at Risk of Developing RA from Healthy Controls

    Klára Prajzlerová1, Veronika Hrušková2, Petra Hánová1, Heřman F Mann1, Karel Pavelka1, Jiří Vencovský3, Ladislav Šenolt1 and Mária Filková1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose:  Individuals with clinically suspect arthralgia (CSA) with positivity of antibodies to citrullinated protein antigens (ACPA) have articular symptoms without clinical signs of arthritis. CSA…
  • Abstract Number: 500 • 2016 ACR/ARHP Annual Meeting

    Can Thiol/Disulphide Is a Novel Marker in Rheumatoid Arthritis?

    Sema Haliloglu1, cemile bicer2, Murat Alisik3, Bilge Ekinci4, Mehmet Emin Budak5, Omur volkan6, Hulya Uzkeser7 and Ayse Carlioglu8, 1Physical Medicine and Rehabilitation, Maltepe Occupational Diseases Hospital, Istanbul, Turkey, 2Biochemistry, Yildirim Beyazit University Medical Faculty, Ankara, Turkey, 3Biochemistry, Ataturk Training and Research Hospital, Ankara, Turkey, 4Physical Medicine and Rehabilitation, Erzurum Region Training and Research Hospital, Erzurum, Turkey, 5Endocrinology, Erzurum Region Training and Research Hospital, erzurum, Turkey, 6Rheumatology, Erzurum Region Training and Research Hospital, Erzurum, Turkey, 7Physical Medicine and Rehabilitation, Ataturk University,Medical Faculty, Erzurum, Turkey, 8Endocrinology, Erzurum Region Training and Research Hospital, Erzurum, Turkey

    Background/Purpose:  Rheumatoid arthritis is a chronic, systemic, autoimmune disease about 5% -%1 of world population affected. Highly reactive oxygen free radicals are believed to be…
  • Abstract Number: 501 • 2016 ACR/ARHP Annual Meeting

    Use of Rheumatologic Testing By Primary Care Physicians in Patients with Inflammatory Arthritis

    Dilpreet Singh1, Jasdeep Badwal1, Ritika Vankina1, Santhi Gokaraju2, Jennifer Friderici3, Scott Halista4 and Tara Lagu1, 1Baystate Medical Center/Tufts University School of Medicine, Springfield, MA, 2Presbyterian Hospital of Dallas, Dallas, TX, 3Baystate Medical Center, Springfield, MA, 4Arthritis Treatment Center, Springfield, MA

    Background/Purpose: Anti-cyclic citrullinated peptide antibody (Anti-CCP) is a diagnostic tool that predicts the progression of undifferentiated polyarthritis and erosive disease in rheumatoid arthritis (RA). It…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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