Abstract Number: 471 • 2016 ACR/ARHP Annual Meeting
Epstein-Barr Virus-Induced Expression of Receptor Activator Nuclear Factor-κb Ligand on B Cells Is Possibly Responsible for Erosive Arthritis in Epstein-Barr Virus-Infected Humanized Nonobese Diabetic/Shi-Scid/γcnull Mice
Background/Purpose: Humanized nonobese diabetic/Shi-scid/γcnull (NOG) mice, which are reconstituted with human hematoimmune system by transplantation with human CD34＋ hematopoietic stem cells (termed as humanization), have…Abstract Number: 472 • 2016 ACR/ARHP Annual Meeting
CCR6 Expression Regulates Arthritis in a T Cell Dependent Manner
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by synovial infiltration of various inflammatory cells. Chemokines are involved in controlling the recruitment…Abstract Number: 473 • 2016 ACR/ARHP Annual Meeting
Migration, Colonization and Distribution of Bone Marrow Mesenchymal Stem Cells Transplanted in CIA Rats Were Traced By Green Fluorescent Protein
Background/Purpose: To investigate the migration, colonization and distribution of bone marrow mesenchymal stem cells (BM-MSCs) traced by green fluorescent protein (GFP) in the immune organs and joints of…Abstract Number: 474 • 2016 ACR/ARHP Annual Meeting
Impaired Cognition Is Linked to Brain Depletion in Brain-Derived Neurotrophic Factor Levels in a Rat Model of Rheumatoid Arthritis
Background/Purpose: Cognitive dysfunction including depression-like symptoms is a frequent comorbidity of rheumatoid arthritis (RA)1. Mechanisms that have been linked to cognitive impairments in the general…Abstract Number: 475 • 2016 ACR/ARHP Annual Meeting
N-3 Polyunsaturated Fatty Acids in Fat-1 Mice Attenuate Collagen Antibody-Induced Arthritis
Background/Purpose: N-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and were considered useful for the treatment of rheumatoid arthritis (RA), however the mechanism is still…Abstract Number: 477 • 2016 ACR/ARHP Annual Meeting
Conventional Non-Steroidal Anti-Inflammatory Drugs, but Not COX2 Selective Inhibitors, Are Beneficial on Vascular Function in Arthritis: A Study in Adjuvant Induced Arthritis
Background/Purpose: (RA) is associated with an increase in cardiovascular (CV) risk explained in part by an accelerated atherosclerosis as a consequence of endothelial dysfunction. Non-steroidal…Abstract Number: 478 • 2016 ACR/ARHP Annual Meeting
Evaluation of the Relationship Between Methotrexate Polyglutamation and Efficacy in the Collagen-Induced Arthritis Mouse Model
Background/Purpose: Polyglutamate metabolites of methotrexate (MTX) are believed to represent the pharmacologically active form of the drug and have been proposed as a biomarker to…Abstract Number: 479 • 2016 ACR/ARHP Annual Meeting
Type II Collagen Secreted from Articular Chondrocytes Is Mainly Destroyed By Cathepsin S in RA Mice
Background/Purpose: Mast cells have long been recognized to increase strikingly in number in the synovial membrane of rheumatoid arthritis（RA），accounting for 5% of the surface synovial…Abstract Number: 480 • 2016 ACR/ARHP Annual Meeting
Local Cryotherapy Down-Regulates Local and Systemic IL-6/IL-17 Pathway with No Effect on TNF-α in Adjuvant-Induced Arthritis
Background/Purpose: Cryotherapy is widely and empirically used in an adjuvant and symptomatic setting in inflammatory rheumatic diseases, with a low level of evidence [1]. The aim…Abstract Number: 481 • 2016 ACR/ARHP Annual Meeting
Dual Effect of 3-Bromopyruvate on Both Th17 and Treg Cell Differentiation and Dendritic Cell Activation Ameliorates Autoimmune Arthritis in Mice
Background/Purpose: Recent studies have shown that cellular metabolism plays an important role in regulating immune cell function. In the process of cell differentiation, both interleukin-17-producing…Abstract Number: 482 • 2016 ACR/ARHP Annual Meeting
Comparison of Nonclinical Pharmacology, Pharmacodynamics and Efficacy Response of the Proposed Adalimumab Biosimilar GP2017 to Originator Adalimumab
Background/Purpose: Biosimilars are created to be essentially the same as their reference marketed biopharmaceuticals which have lost exclusivity, and they aim to offer more affordable…Abstract Number: 483 • 2016 ACR/ARHP Annual Meeting
Non-Steroidal Anti-Inflammatory Drugs Are More Beneficial Than Anti-Tnfα Drugs on the Radiographic Damage in Arthritis: A Study in Adjuvant Induced Arthritis
Background/Purpose: The management of the chronic inflammatory rheumatisms has dramatically evolved in the last decade with a concept of “treat to target”. The theory of…Abstract Number: 484 • 2016 ACR/ARHP Annual Meeting
Targeting the BTK-JAK Axis in Preclinical Models of Rat Collagen-Induced Arthritis with GS-4059 in Combination with a JAK Inhibitor
Background/Purpose: Bruton’s Tyrosine Kinase (BTK) mediates signaling in hematopoietic cells important for the initiation and progression of rheumatoid arthritis (RA). GS-4059 is an oral,…Abstract Number: 485 • 2016 ACR/ARHP Annual Meeting
Sexual Dimorphism of Popliteal Lymph Node Collapse As a Biomarker of Disease Progression in the Tumor Necrosis Factor Transgenic Mouse Model of Rheumatoid Arthritis
Background/Purpose: Although rheumatoid arthritis (RA) tends to occur earlier and with increased severity in females, the underling etiology of this sexual dimorphism is unknown. We…Abstract Number: 486 • 2016 ACR/ARHP Annual Meeting
IRF5 Promotes Arthritis but Restricts Virus Replication and Spread during Chikungunya Virus Infection
Background/Purpose: Chikungunya virus (CHIKV) is an arthritogenic alphavirus that invades the joints and causes chronic arthritis in up to 60% of infected individuals. Over the…
ACR Meeting Abstracts