Abstracts Archive - Page 1625 of 2425 - ACR Meeting Abstracts

Abstract Number: 3120 • 2016 ACR/ARHP Annual Meeting
RA Net: A Systems Biology Approach to Identify Genes Regulating Pathogenic Pathways in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Wei Wang¹, RIchard Ainsworth², Richard Stein², Rizi Ai³ and Gary Firestein⁴, ¹Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ²UC San Diego, La Jolla, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Medicine, UCSD, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) remains a significant unmet need despite improved therapy. Defining the interlaced nature of gene regulation and disease pathogenesis using integrative systems…
Abstract Number: 3121 • 2016 ACR/ARHP Annual Meeting
Specific Antibody Subphenotypes in Rheumatoid Arthritis Are Associated with Unique HLA-DRB1 Residues at Position 11
Chikashi Terao^1,2, Boel Brynedal³, Zuomei Chen⁴, Xia Jiang⁴, Helga Westerlind⁴, Monika Hansson⁵, Linda Mathsson-Alm^6,7, Per Johan Jakobsson⁸, Karl Skriner⁹, Guy Serre¹⁰, Johan Rönnelid⁷, Leonid Padyukov⁸, Jane Worthington¹¹, Lars Alfredsson⁴, Lars Klareskog⁸ and Soumya Raychaudhuri^1,2,11, ¹Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Program in Medical and Population Genetics, Broad Institute, Boston, MA, ³Section of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Karolinska, Sweden, ⁴Section of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁶Thermo Fisher Scientific, Uppsala, Sweden, ⁷Department of Immunology Genetics and Pathology,Uppsala University, Uppsala, Sweden, ⁸Unit of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ⁹Humboldt University of Berlin, Berlin, Germany, ¹⁰Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, ¹¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Antibody to citrullinated peptides/proteins (ACPA) is specific feature of rheumatoid arthritis (RA) and seen in 50 to 70% of RA patients. Amino acid (AA)…
Abstract Number: 3122 • 2016 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Association Study of Hand Osteoarthritis
Michelle S. Yau^1,2, Roby Joehanes³, Yi-Hsiang Hsu³, Douglas P. Kiel⁴ and David T. Felson⁵, ¹Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁴Institute for Aging Research, Institute for Aging Research, Hebrew Senior Life, Harvard Medical School, Boston, MA, USA, Boston, MA, ⁵Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose: Heritability of hand osteoarthritis (OA) has been estimated to be as high as 65%. Despite having a strong genetic component, genome-wide linkage and association…
Abstract Number: 3123 • 2016 ACR/ARHP Annual Meeting
Rare Mediterranean Fever (MEFV) Gene Polymorphisms Are Associated with Ankylosing Spondylitis in Turkish and Iranian Population
Zhixiu Li¹, Servet Akar², Handan Yarkan³, Pinar Cetin³, Gerçek Can³, Gökce Kenar³, Omer Nuri Pamuk⁴, Yavuz Pehlivan⁵, Katie Cremin⁶, Erika De Guzman¹, Jessica Harris¹, Ahmad Reza Jamshidi⁷, Mahdi Vojdanian⁷, Nooshin Ahmadzadeh⁷, Mahdi Mahmoudi⁷, Matthew A. Brown¹ and Nurullah Akkoc³, ¹Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ²Department of Rheumatology, İzmir Katip Çelebi University, School of Medicine, İzmir, Turkey, İzmir, Turkey, ³Department of Rheumatology, Dokuz Eylul University, Faculty of Medicine, İzmir, Turkey, İzmir, Turkey, ⁴Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, Edirne, Turkey, ⁵Department of Rheumatology, Uludag University Medical Faculty, Bursa, Turkey, Bursa, Turkey, ⁶The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁷Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of)
Background/Purpose: Ankylosing spondylitis (AS) is a highly heritable inflammatory arthritis common in both Turkish and Iranian populations. Familial Mediterranean Fever (FMF) is an autosomal recessive…
Abstract Number: 3124 • 2016 ACR/ARHP Annual Meeting
Huntingtin Interacting Protein 1 (Hip1) Is a New Arthritis Severity Gene
Teresina Laragione¹, Percio Gulko¹ and Max Brenner², ¹Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Cia25/Pia42 is an arthritis severity and joint damage quantitative trait locus on rat chromosome 12 previously identified in an intercross between MHC identical but…
Abstract Number: 3125 • 2016 ACR/ARHP Annual Meeting
Secular Trend of Premature Mortality in Gout: A Contrast from Rheumatoid Arthritis
Sharan K. Rai^1,2, Leo Lu³, Yuqing Zhang⁴ and Hyon K. Choi⁵, ¹Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Arthritis Research Canada, Vancouver, BC, Canada, ³Allergy, Immunology, and Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Gout and rheumatoid arthritis (RA), the two most common inflammatory arthritides, are both associated with premature mortality. General population-based studies have found substantially reduced…
Abstract Number: 3126 • 2016 ACR/ARHP Annual Meeting
Computational Polarizing Microscopy: A Novel Method to Detect Birefringent Crystals Using Lens-Free on-Chip Microscopy
Seung Yoon Lee¹, Yibo Zhang², Daniel E. Furst¹, Ann Rosenthal³, Ralph Schumacher⁴, John FitzGerald¹ and Aydogan Ozcan², ¹Division of Rheumatology, Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Electrical Engineering Department, University of California Los Angeles, School of Engineering, Los Angeles, CA, ³Division of Rheumatology, Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, ⁴Division of Rheumatology, Department of Internal Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
Background/Purpose: A compensated polarizing microscopy has been used for detecting monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals to confirm the diagnosis of gout…
Abstract Number: 3127 • 2016 ACR/ARHP Annual Meeting
Ultrasound Evaluation of the Achilles Tendon in Tophaceous Gout: A Case-Control Study
Matthew Carroll¹, Nicola Dalbeth², Mark Boocock¹ and Keith Rome¹, ¹School of Clinical Sceince, Health & Rehabilitation Research Institute, AUT University, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand
Ultrasound Evaluation of the Achilles Tendon in Tophaceous Gout: A Case-Control Study Background/Purpose: Tendon involvement in the lower limbs in gout is frequent. Tophus deposition…
Abstract Number: 3128 • 2016 ACR/ARHP Annual Meeting
A Longitudinal Dual Energy Computed Tomography Study on the Effect of Urate Lowering Therapies on the Reduction of Tophus Burden in Patients with Chronic Gout
Hanna Ellmann¹, Sara Bayat¹, Isabelle Oliveira¹, Matthias Englbrecht^2,3, Elizabeth Araujo⁴, Alexander Cavallaro⁵, Silvana Mendonca⁶, Michael Lell⁵, Bernhard Manger², Georg Schett⁷ and Juergen Rech⁷, ¹Medical Department 3, Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Medical Department 3; Rheumatology & Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Department of Radiology, University of Erlangen-Nuremberg, Department of Radiology, Erlangen, Germany, ⁶Americas Medical City, Rio de Janeiro, Brazil, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Dual energy computed tomography (DECT) allows reliably detecting and quantifying tophus burden in patients with chronic gout. Longitudinal studies on the effect of uric…
Abstract Number: 3129 • 2016 ACR/ARHP Annual Meeting
The Pharmacokinetics of Oxypurinol in Patients Treated with Hemodialysis and Allopurinol
Matthew Doogue¹, Dan Wright², Nick Cross³, John Irvine³, Peter T. Chapman⁴, Murray Barclay⁵ and Lisa K. Stamp¹, ¹University of Otago, Christchurch, New Zealand, ²School of Pharmacy, University of Otago, Dunedin, New Zealand, ³Nephrology, Christchurch Hospital, Christchurch, New Zealand, ⁴Christchurch Hospital, Christchurch, New Zealand, ⁵Medicine, University of Otago, Christchurch, New Zealand
Background/Purpose: Allopurinol is recommended as a first-line pharmacologic urate-lowering therapy in gout. Oxypurinol, the active metabolite of allopurinol, is entirely cleared by the kidneys. Oxypurinol…
Abstract Number: 3130 • 2016 ACR/ARHP Annual Meeting
Development and Pilot Testing of an Online Educational Tool for Gout Patients — Mygoutcare®
Puja Khanna¹, Aaron Rankin², Veronica Berrocal³, Larry An⁴ and Dinesh Khanna⁵, ¹Rheumatology, University of Michigan, Ann Arbor, MI, ²Medicine Rheumatology, University of Michigan, Ann Arbor, MI, ³Biostatistics, University of Michigan, Ann Arbor, MI, ⁴Medicine, University of Michigan, Ann Arbor, MI, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: Recent management guidelines for gout have identified several unmet educational needs in gout patients. Qualitative studies have documented the paucity of patient-focused materials which…
Abstract Number: 3131 • 2016 ACR/ARHP Annual Meeting
Pregabalin Is More Effective in Treating Hand Osteoarthritis Pain Than Duloxetine or Placebo: A Double-Blind Randomized Controlled Trial
Nidhi Sofat¹, Abiola Harrison², Salma Ayis³, Patrick Kiely⁴, Thomas Richard Barrick⁵ and Franklyn Howe⁶, ¹Basic Medical Sciences, St. George's, University of London, London, United Kingdom, ²Rheumatology, Mailpoint J1A, St George's, University of London, London, United Kingdom, ³Department if Statistics, Division of Health & Social Care Research, Guy's Campus, King's College London, London, United Kingdom, ⁴Rheumatology Dept, St Georges Hospital, London, Great Britain, ⁵Clinical Sciences, St George's, University of London, London, United Kingdom, ⁶Cardiovascular and Cell Sciences, St George's, University of London, London, United Kingdom
Background/Purpose: A prospective, randomized, double-blind, placebo-controlled trial from 42 primary care and rheumatology clinics in the UK. We recruited 85 participants: 65 with hand OA…
Abstract Number: 3132 • 2016 ACR/ARHP Annual Meeting
Protective Effects of Replacing Sedentary Time with Light and Moderate to Vigorous Physical Activity on Functional Limitation in Knee OA
Daniel White, Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Physical activity protects the development of functional limitation in knee osteoarthritis (OA). But little is known about the protective effects of physical activity intensity,…
Abstract Number: 3133 • 2016 ACR/ARHP Annual Meeting
Association Between Quantitatively Measured Infrapatellar Fat Pad High Signal Intensity Alteration and Knee Structural and Symptomatic Abnormalities in Patients with Symptomatic Knee Osteoarthritis
WEIYU HAN¹, Graeme Jones² and Changhai Ding², ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Background/Purpose: Infrapatellar fat pad (IPFP), a local adipose tissue, may have important contributions to knee osteoarthritis (OA). IPFP signal intensity alterations on MRI may represent…
Abstract Number: 3134 • 2016 ACR/ARHP Annual Meeting
Hydroxychloroquine Is Not Effective in Reducing Symptoms of Hand Osteoarthritis: Results from a Placebo-Controlled Randomised Trial
Sarah R. Kingsbury¹, Puvan Tharmanathan², Ada Keding³, Sarah Ronaldson³, Andrew Grainger⁴, Richard J. Wakefield⁵, Catherine Arundel³, Fraser Birrell⁶, Michael Doherty⁷, Tonia Vincent⁸, Fiona E Watt⁹, Krysia Dziedzic¹⁰, Terence W. O'Neill¹¹, Nigel K Arden¹², David L Scott¹³, John Dickson¹⁴, Toby Garrood¹⁵, Michael Green^16,17, Ajit Menon¹⁸, Tom Sheeran¹⁹, David Torgerson³ and Philip G. Conaghan⁴, ¹Section of Musculoskeletal Disease, Chapel Allerton Hospital, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, Leeds, United Kingdom, ²University of York, York, United Kingdom, ³Health Sciences, University of York, York, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵University of Leeds, Leeds, United Kingdom, ⁶Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁷Academic Rheumatology, University of Nottingham, Nottingham, Great Britain, ⁸University of Oxford, London, Great Britain, ⁹Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ¹⁰Institute for Primary Care and Health Sciences, Keele University, Staffordshire, United Kingdom, ¹¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ¹²Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ¹³Department of Rheumatology, King's College London, London, United Kingdom, ¹⁴South Tees Hospitals NHS Foundation Trust, Middlesbrough, United Kingdom, ¹⁵Rheumatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ¹⁶York Teaching Hospital NHS Foundation Trust, York, United Kingdom, ¹⁷Harrogate and District NHS Foundation Trust, Harrogate, United Kingdom, ¹⁸Haywood Hospital, Stoke-On-Trent, United Kingdom, ¹⁹Cannock Chase Hospital, Cannock, United Kingdom
Background/Purpose: Synovitis is prevalent in OA and associated with pain. Hydroxychloroquine (HCQ) is used routinely for treating synovitis in inflammatory arthritis. The primary aim of…

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