Abstract Number: 380 • 2016 ACR/ARHP Annual Meeting

Linear Discriminant Analysis of Cultured Fibroblast-like Synoviocytes Identifies 6 Candidate Genes Which Predict Extended Course in Juvenile Idiopathic Arthritis

AnneMarie Brescia¹, Megan Simonds², Suzanne McCahan³, Tim Bunnell³, Kathleen E. Sullivan⁴ and Carlos D. Rosé¹, ¹Pediatric Rheumatology, Thomas Jefferson University/ AI duPont Hospital for Children, Wilmington, DE, ²Nemours, Nemours Biomedical Research, Wilmington, DE, ³Nemours Biomedical Research, Wilmington, DE, ⁴Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA

Abstract Number: 381 • 2016 ACR/ARHP Annual Meeting

Calprotectin As a Multipotent Biomarker in Juvenile Idiopathic Arthritis

Celine La¹, Phu-Quoc Le², Bernard R. Lauwerys³, Laurence Goffin⁴, Alina Ferster⁵, Julie Smet⁶, Patrick Stordeur⁷, Cecile Boulanger⁸, Jean-Pierre Brasseur⁹, Benoit Brasseur¹⁰, David Tuerlincks¹¹, Delphine Spruyt¹², Paschalis Sidiras¹³, Joanne Rasschaert¹², Viviane de Maertelaer¹⁴, Sandra Kleimberg¹⁵, Tatiana Sokolova¹⁶, Patrick Durez^17,18 and Valérie Badot^1,19, ¹Rheumatology, Hôpital Erasme,Université Libre de Bruxelles, Brussels, Belgium, ²Service d'hemato-oncologie, Hopital Universitaire des enfants Reine Fabiola (HUDERF), 1020, Belgium, ³Service de rhumatologie, Pôle de pathologies rhumatismales inflammatoires et systémiques, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium, ⁴Service de pédiatrie, Hopital Universitaire des enfants Reine Fabiola (HUDERF), Brussels, Belgium, ⁵Service d'Onco-Hématologie, Hôpital Reine Fabiola, Brussels, Belgium, ⁶Laboratorire d'Immunologie, Hopital Erasme-Université Libre de Bruxelles, Brussels, Belgium, ⁷Laboratoire d'Immunologie, Hopital Erasme-Université Libre de Bruxelles, Brussels, Belgium, ⁸Service d'hématologie et Oncologie pédiatrique, Clinique universitaire Saint-Luc, Brussels, Belgium, ⁹Service de rhumatologie, Hopital Universitaire Mont-Godinne, Yvoir, Belgium, ¹⁰Service de Pédiatrie, Hopital Universitaire Mont-Godinne, Yvoir, Belgium, ¹¹Service de pédiatrie, Hopital Universitaire Mont-Godinne, Yvoir, Belgium, ¹²Laboratory of Bone and Metabolic Biochemistry, Université Libre de Bruxelles, Brussels, Belgium, ¹³Service de Rhumatologie, Hopital Erasme-Université Libre de Bruxelles, Brussels, Belgium, ¹⁴Service de Biostatistique et Informatique Médicale, Université Libre de Bruxelles, Brussels, Belgium, ¹⁵Service de Rhumatologie et de Médecine Physique, Hopital Erasme-Université Libre de Bruxelles, Brussels, Belgium, ¹⁶Project Coordinator, CAP 48 cohort, Brussels, Belgium, ¹⁷Service de Rhumatologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ¹⁸Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ¹⁹Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium

Abstract Number: 382 • 2016 ACR/ARHP Annual Meeting

Tumor Necrosis Factor-α -308 a/G Gene Polymorphism in Children with Juvenile Idiopathic Arthritis: Relation to Disease Activity, Damage and Disability

Tamer Gheita¹, Iman El Gazzar², Hanan Fathy³, Abeer Nour El-Din⁴, Enas Abdel Rasheed⁵, Rasha Bassyouni⁶ and Sanaa Kenawy⁷, ¹Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, ²Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, ³Rheumatology, Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁴Pediatric Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁵Clinical Pathology Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁶Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁷Pharmacology, Pharmacology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Abstract Number: 383 • 2016 ACR/ARHP Annual Meeting

Potential Biomarkers of Disease Activity in Juvenile Idiopathic Arthritis – Data from the Portuguese Register, Reuma.Pt

Ana Filipa Mourão^1,2,3, MJ Santos⁴, Mónica Eusébio⁵, Ana Lopes⁶, Filipa Ramos⁷, Manuel Salgado⁸, Paula Estanqueiro⁹, Jose Antonio Melo Gomes¹⁰, Fernando Magalhaes Martins¹¹, José Antonio Costa¹², Ana Carolina Furtado¹³, Ricardo Figueira¹⁴, Iva Brito^15,16,17, Jaime Branco^18,19, João E. Fonseca²⁰ and Helena Canhão²¹, ¹NOVA Medical School - Faculdade Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal, ²Centro Hospitalar Lisboa Ocidental (CHLO- E.P.E.), Lisbon, Portugal, ³Rheumatology, Instituto de Medicina Molecular, Lisbon, Portugal, ⁴Rheumatology Research Unit Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal, ⁵Sociedade Portuguesa de Reumatologia, LIsboa, Portugal, ⁶Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ⁷Rheumatology and Metabolic Bone Diseases Department, Santa Maria Hospital,CHLN, Lisbon, Portugal, ⁸Pediatrics, Centro Hospitalar de Coimbra, Coimbra, Portugal, ⁹Pediatrics, Centro Hospitalar da Universidade de Coimbra, Coimbra, Portugal, ¹⁰Instituto Português de Reumatologia, Lisbon, Portugal, ¹¹Portuguese Society of Rheumatology, Lisbon, Portugal, ¹²Rheumatology, Centro Hospitalar do Alto Minho, Hospital de Ponte de Lima, Ponte de Lima, Portugal, ¹³Rheumatology, Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Portugal, ¹⁴Rheumatology, Hospital Dr. Nélio Mendonça, Funchal, Portugal, ¹⁵Rheumatology, Centro Hospitalar do Pirto, Hospital de São João, Porto, Portugal, ¹⁶Rua Raul Caldevilla 126-2 Dto, Hospital Sao Joao, Porto, Portugal, ¹⁷Faculdade de Medicina da Universidade do Porto, Porto, Portugal, ¹⁸Rheumatology, CHLO, Hospital Egas Moniz, Lisbon, Portugal, ¹⁹CEDOC, Nova Medical School, Lisbon, Portugal, ²⁰Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Lisboa, Portugal, ²¹Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal

Abstract Number: 384 • 2016 ACR/ARHP Annual Meeting

WITHDRAWN

Abstract Number: 385 • 2016 ACR/ARHP Annual Meeting

Safety of Adalimumab in Pediatric Patients with Polyarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Psoriasis, and Crohn’s Disease

Gerd Horneff¹, Marieke M. B. Seyger², Dilek Arikan³, Jasmina Kalabic⁴, Jaclyn K. Anderson³, Andreas Lazar⁵, David A. Williams³, Chen Wang³, Rita Tarzynski-Potempa³ and Jeffrey S. Hyams⁶, ¹Asklepios Kliniken GmbH, Hamburg, Germany, ²Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³AbbVie Inc., North Chicago, IL, ⁴AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁵AbbVie Deutschland GmbH & Co. KG, North ChicagoLudwigshafen, IL, Germany, ⁶Connecticut Children’s Medical Center, Hartford, CT

Abstract Number: 386 • 2016 ACR/ARHP Annual Meeting

Long-Term Efficacy and Safety of Adalimumab in Pediatric Patients with Enthesitis Related Arthritis

Rubén Burgos-Vargas¹, Shirley M.L. Tse², Gerd Horneff³, Kristina Unnebrink⁴ and Jaclyn K. Anderson⁵, ¹Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, ²University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada, ³Asklepios Clinc Sankt Augustin, Sankt Augustin, Germany, ⁴AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁵AbbVie Inc., North Chicago, IL

Abstract Number: 387 • 2016 ACR/ARHP Annual Meeting

Rituximab Should be Considered in Rheumatoid Factor Negative Poly-Articular Juvenile Idiopathic Arthritis

Sunil Sampath^1,2, Liza J. McCann³, Michael W. Beresford^3,4, Eileen Baildam³, Jamie C Sergeant^1,5, Wendy Thomson², Helen Foster⁶, Sharon Douglas², Taunton Southwood⁷, Kimme L. Hyrich¹ and Biologics for Children with Rheumatic Diseases (BCRD) study Group¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, ³Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ⁴Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, ⁵NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁶Paediatric Rheumatology, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, ⁷School of Immunity and Infection,Institute of Clinical Sciences,University of Birmingham, Birmingham, United Kingdom

Abstract Number: 388 • 2016 ACR/ARHP Annual Meeting

Pharmacokinetics, Safety, and Tolerability of Tofacitinib in Pediatric Patients from Two to Less Than Eighteen Years of Age with Juvenile Idiopathic Arthritis

Hermine I. Brunner¹, Nicolino Ruperto², Anasuya Hazra³, Ronnie Wang⁴, Charles Mebus⁴, Christine Alvey⁴, Manisha Lamba⁴, Sriram Krishnaswami⁴, Thomas C Stock³, Umberto Conte⁵, Min Wang⁵, Nikolay Tzaribachev⁶, Ivan Foeldvari⁷, Gerd Horneff⁸, Daniel Kingsbury⁹, Elena Koskova¹⁰, Elzbieta Smolewska¹¹, Richard K Vehe¹², Zbigniew Zuber¹³, Daniel J Lovell¹ and Alberto Martini², ¹Pediatric Rheumatology Collaborative Study Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Istituto Giannina Gaslini, Genoa, Italy, ³Pfizer Inc, Collegeville, PA, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc, New York, NY, ⁶Pediatric Rheumatology Research Institute, Bad Bramstedt, Bad Bramstedt, Germany, ⁷Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, ⁸Asklepios Klinik, Sankt Augustin, Germany, ⁹Randall Children's Hospital, Portland, OR, ¹⁰National Institute of Rheumatic Diseases, Piestany, Piestany, Slovakia, ¹¹Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Lodz, Poland, ¹²University of Minnesota Masonic Children’s Hospital, Minneapolis, MN, ¹³St Louis Children’s Hospital ODS Rheumatology and Neurology, Krakow, Poland

Abstract Number: 389 • 2016 ACR/ARHP Annual Meeting

Long-Term Effectiveness and Safety of Abatacept in Juvenile Idiopathic Arthritis: Interim Results from the Abatacept in JIA Registry

DJ Lovell¹, N Ruperto², N Tzaribachev³, A Zeft⁴, R Cimaz⁵, V Stanevica⁶, G Horneff⁷, J Bohnsack⁸, TA Griffin⁹, R Carrasco¹⁰, M Trachana¹¹, JA Dare¹², I Foeldvari¹³, RK Vehe¹⁴, TA Simon¹⁵, N Baker¹⁵, Hermine I. Brunner¹⁶ and A Martini², ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Istituto G. Gaslini Pediatria II Reumatologia, Genova, Italy, ³University Medical Center Schleswig-Holstein, Bad Bramstedt, Germany, ⁴Pediatric Rheumatology, Cleveland Clinic, Cleveland, OH, ⁵Pediatrics, Ospedale Pediatrico Anna Meyer, Florence, Italy, ⁶Riga Stradins University, Riga, Latvia, ⁷Asklepios Klinik Zentrum für Allgemeine Paediatrie und Neonatologie, Sankt Augustin, Germany, ⁸University of Utah School of Medicine, Salt Lake City, UT, ⁹Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC, ¹⁰Pediatric Rheumatology, Specially For Children, Austin, TX, ¹¹Hippokration General Hospital, Thessaloniki, Greece, ¹²University of Arkansas Medical Center, Little Rock, AR, ¹³Hamburg Centre for Pediatric Rheumatology, Hamburg, Germany, ¹⁴University of Minnesota, Minneapolis, MN, ¹⁵Bristol-Myers Squibb, Princeton, NJ, ¹⁶Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Abstract Number: 390 • 2016 ACR/ARHP Annual Meeting

Use, Safety and Efficacy of Zrc 3197, a Biosimilar Candidate for Reference Adalimumab (Humira) from a Tertiary Pediatric Rheumatology Centre in India

Manjari Agarwal¹, Abhay Shivpuri², Sumidha Mittal³, Amit Khosla⁴ and Sujata Sawhney⁵, ¹Institute of Child Health, Attending Consultant, New Delhi, India, ²Division of Pediatric Rheumatology,Institute of Child Health, Post Doctoral Fellow, New Delhi, India, ³Post Doctoral Fellow, New Delhi, India, ⁴Department of Ophthalmology,Sir Ganga Ram Hospital, Senior Consultant, New Delhi, India, ⁵Paediatric rheumatology, Senior Consultant, New Delhi, India

Abstract Number: 391 • 2016 ACR/ARHP Annual Meeting

A Single Centre Experience from India on the Safety and Efficacy of Cipla Etanercept and Intas Etanercept and Its Comparison with Reference Etanercept(Enbrel) in Children with JIA

Abhay Shivpuri¹, Sumidha Mittal², Manjari Agarwal³ and Sujata Sawhney⁴, ¹Division of Pediatric Rheumatology,Institute of Child Health, Post Doctoral Fellow, New Delhi, India, ²Post Doctoral Fellow, New Delhi, India, ³Institute of Child Health, Attending Consultant, New Delhi, India, ⁴Paediatric rheumatology, Senior Consultant, New Delhi, India

Abstract Number: 392 • 2016 ACR/ARHP Annual Meeting

Safety and Clinical Response of Weekly Adalimumab in the Treatment of Juvenile Idiopathic Arthritis, Pediatric Chronic Uveitis and Other Childhood Rheumatic Diseases

Colleen K. Correll¹, Danielle R. Bullock¹, Rachel Cafferty¹ and Richard K Vehe², ¹Pediatrics, University of Minnesota, Minneapolis, MN, ²University of Minnesota Masonic Children’s Hospital, Minneapolis, MN

Abstract Number: 393 • 2016 ACR/ARHP Annual Meeting

Association of Sex, Race and Ethnicity on Disease Outcomes in Juvenile Idiopathic Arthritis Patients

Vivek Joseph¹, Tracy R. Andrews², Esi Morgan³, Ronald Laxer⁴, cagri Toruner⁵, Tzielan Lee^6,7, Beth S. Gottlieb⁸, C. April Bingham⁹, Sheetal S. Vora¹⁰, Jon M. Burnham¹¹, Judyann C. Olson¹², Murray H. Passo¹³, Michelle Batthish¹⁴, Meredith Riebschleger¹⁵ and Jennifer E. Weiss¹⁶, ¹Internal Medicine, Rutgers New Jersey Medical School, Bloomfield, NJ, ²Biostatistics, David & Alice Jurist Institute, Hackensack University Medical Center, hackensack, NJ, ³Pediatric Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁶Dept of Pediatric Rheumatology, Stanford Univ School of Med, Palo Alto, CA, ⁷Pediatric Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ⁸Pediatric Rheumatology, The Steven and Alexandra Cohen Children's Medical Center of New York, The Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, ⁹Penn State Health Children's Hospital, Hershey, PA, ¹⁰Pediatric Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ¹¹Pediatric Rheumatology, Children's Hospital Philadelphia, Philadelphia, PA, ¹²Ped/MACC Fund Research Ctr, Medical College of Wisconsin, Milwaukee, WI, ¹³Division of Rheumatology PTD, Medical University of South Carolina, Charleston, SC, ¹⁴Division of Pediatric Rheumatology, McMaster Children's Hospital, Hamilton, ON, Canada, ¹⁵Pediatric Rheumatology, University of Michigan, CS Mott Children's Hospiatl, Ann Arbor, MI, ¹⁶Hackensack Univ Med Ctr, Hackensack, NJ

Abstract Number: 394 • 2016 ACR/ARHP Annual Meeting

Effect of BMI on Symptoms and Outcomes in Juvenile Idiopathic Arthritis Patients

Jennifer E. Weiss¹, Tracy Andrews², Esi Morgan³, Ronald Laxer⁴, Cagri Yildirim-Toruner⁵, C. April Bingham⁶, Beth Gottlieb⁷, Tzielan Lee⁸, Sheetal S. Vora⁹, Jon M. Burnham¹⁰, Judyann C. Olson¹¹, Murray Passo¹², Michelle Batthish¹³ and Meredith Riebschleger¹⁴, ¹Hackensack Univ Med Ctr, Hackensack, NJ, ²Biostatistics, David & Alice Jurist Institute, Hackensack University Medical Center, hackensack, NJ, ³Pediatric Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Div of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁶Penn State Health Children's Hospital, Hershey, PA, ⁷Pediatric Rheumatology PTD, Cohen Children's Medical Center of New York, Lake Success, NY, ⁸Dept of Pediatric Rheumatology, Stanford Univ School of Med, Palo Alto, CA, ⁹Pediatric Rheumatology, Medical College of Wisconsin, Milwaukee, WI, ¹⁰Pediatric Rheumatology, Children's Hospital Philadelphia, Philadelphia, PA, ¹¹Ped/MACC Fund Research Ctr, Medical College of Wisconsin, Milwaukee, WI, ¹²Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ¹³Division of Pediatric Rheumatology, McMaster Children's Hospital, Hamilton, ON, Canada, ¹⁴Pediatric Rheumatology, University of Michigan, CS Mott Children's Hospiatl, Ann Arbor, MI