Abstracts Archive - Page 1620 of 2425 - ACR Meeting Abstracts

Abstract Number: 3045 • 2016 ACR/ARHP Annual Meeting
Immunometabolism in ANCA-Associated Glomerulonephritis
Peter C. Grayson¹, Sean Eddy², Viji Nair², Hemang Parikh³, Maja Lindenmeyer⁴, Laura Mariani², Huateng Huang², Wenjun Ju³, Casey Greene⁵, Clemens Cohen⁴, Jeffrey Krischer³, Matthias Kretzler², Peter A. Merkel⁶ and Felix H. Eichinger², ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Division of Nephrology, University of Michigan, Ann Arbor, MI, ³University of South Florida, Tampa, FL, ⁴University of Munich, Munich, Germany, ⁵Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Mounting an inflammatory response requires immune cells to undergo major changes in metabolism. Mediators such as cytokines can specifically alter the metabolism of different…
Abstract Number: 3046 • 2016 ACR/ARHP Annual Meeting
Inflammatory Pathways As Shared Molecular Targets Across ANCA-Associated Vasculitis and Nephrotic Syndrome
Sean Eddy¹, Viji Nair¹, Hemang Parikh², Maja Lindenmeyer³, Laura Mariani¹, Felix H. Eichinger¹, Huateng Huang¹, Wenjun Ju², Casey Greene⁴, Peter C. Grayson⁵, Clemens Cohen³, Jeffrey Krischer², Peter A. Merkel⁶ and Matthias Kretzler¹, ¹Division of Nephrology, University of Michigan, Ann Arbor, MI, ²University of South Florida, Tampa, FL, ³University of Munich, Munich, Germany, ⁴Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Clinical trials in rare diseases typically test therapeutic efficacy in one disease defined by a particular clinical phenotype. Improved understanding of the molecular mechanisms…
Abstract Number: 3047 • 2016 ACR/ARHP Annual Meeting
Diabetes and BMI Modify the Association Between Painful Hip OA and All-Cause Mortality
Rebecca Cleveland¹, Todd A. Schwartz², Jordan B. Renner³, Leigh F. Callahan¹ and Joanne M. Jordan¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Individuals with specific comorbid conditions have increased risk of having hip osteoarthritis (OA). Some of these conditions are also associated with increased risk of…
Abstract Number: 3048 • 2016 ACR/ARHP Annual Meeting
Pain Severity As a Mediator of the Effect of Depressive Symptoms on Physical Performance in Knee Osteoarthritis
Alan Rathbun¹, Michelle Shardell², Michelle S. Yau³, Mona Baumgarten⁴, Elizabeth Stuart⁵ and Marc Hochberg⁶, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Depression is a significant comorbidity of knee osteoarthritis (OA) that occurs in approximately 20% of OA patients. Depressive symptoms are associated with both subsequent…
Abstract Number: 3049 • 2016 ACR/ARHP Annual Meeting
Prevalence of Doctor-Diagnosed Arthritis Among Adults with Clinically Measured Pre-Diabetes— United States, 2009–2014
Kamil E. Barbour¹, Michael Boring¹, Charles Hemlick², Jennifer M. Hootman³, Louise Murphy¹ and Giuseppina Imperatore⁴, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Centers for Disease Control and Prevention, Atlanta, GA, ³Centers for Disease Control and Prevention, Kennesaw, GA, ⁴Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA
Background/Purpose: In the US, over 86 million adults have pre-diabetes; physical activity is recommended to reduce the high risk of developing diabetes. Arthritis is…
Abstract Number: 3050 • 2016 ACR/ARHP Annual Meeting
Post-Partum Complications and Depression in New Mothers with Juvenile Arthritis
Debbie Ehrmann Feldman¹, Evelyne Vinet², Marie-Pierre Sylvestre³, Elizabeth Hazel^4,5, Ciarán M. Duffy⁶, Anick Bérard⁷, Garbis Meshefedjian⁸ and Sasha Bernatsky⁹, ¹School of Rehabilitation, Université de Montréal, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Université de Montréal, Montreal, QC, Canada, ⁴Rhematology, McGill University Health Centre, Montreal, QC, Canada, ⁵Rheumatology, McGill University Health Centre, Pointe-Claire, QC, Canada, ⁶Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁷Université de Montréal, Montréal, QC, Canada, ⁸Public Health Department of Montreal, Montreal, QC, Canada, ⁹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: There is little information regarding maternal post-partum complications in women with inflammatory arthritis conditions and none on persons with juvenile arthritis. Our objective was…
Abstract Number: 3051 • 2016 ACR/ARHP Annual Meeting
Is Frailty a Relevant Concept in Systemic Lupus Erythematosus (SLE)?
Patricia P. Katz¹, James Andrews², Edward H. Yelin¹ and Jinoos Yazdany¹, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Frailty, a syndrome of weight loss, weakness, slowness, exhaustion, and inactivity, has been examined primarily in geriatric cohorts and is associated with poor health…
Abstract Number: 3052 • 2016 ACR/ARHP Annual Meeting
Causes of Death for Patients with Rheumatoid Arthritis
Jessica Widdifield¹, Michael Paterson², Anjie Huang³, Bindee Kuriya⁴, Carter Thorne⁵, Janet E. Pope⁶, Claire Bombardier⁷ and Sasha Bernatsky⁸, ¹McGill University, Toronto, ON, Canada, ²Institute of Clinical Evaluative Sciences, Toronto, ON, Canada, ³Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁴Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵University of Toronto and Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ⁷University of Toronto, Toronto, ON, Canada, ⁸Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Information on causes of death can assist in monitoring health trends and discovering health gaps. Our aim was to determine the primary causes of…
Abstract Number: 3053 • 2016 ACR/ARHP Annual Meeting
Cartilage Loss Primarily Occurs in the Most Affected Tibiofemoral Compartment with No Evidence of a Ceiling Effect Among Advanced-Stage Disease: A Two-Year Longitudinal Study of Data from the Osteoarthritis
Ming Zhang¹, Lori Lyn Price², Amanda R. Canavatchel¹, Jeffrey B. Driban³, Puwei Yuan⁴, Grace H. Lo⁵ and Timothy E. McAlindon⁶, ¹Tufts Medical Center, Boston, MA, ²Clinical Care Research, Tufts Medical Center, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴the Fourth OA Department, Shaanxi University of Chinese Medicine, Xian Yang, China, ⁵Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Cartilage morphometry on magnetic resonance images (MRIs) is an important outcome measure for clinical trials among individuals with knee osteoarthritis (KOA). However, it remains…
Abstract Number: 3054 • 2016 ACR/ARHP Annual Meeting
The Impact of Obesity on Knee Osteoarthritis Symptoms and Related Biomarker Profiles in a Bariatric Surgery Cohort
Thayer Mukherjee¹, Fernando Bomfim², Evan Wilder¹, Lauren Browne³, Kayleigh Toth⁴, Shira Aharon⁴, Janice Lin⁴, Renata La Rocca Vieira⁵, Christine Ren-Fielding⁶, Manish Parikh⁷, Steven B. Abramson⁸, Mukundan Attur⁹ and Jonathan Samuels², ¹NYU Langone Medical Center, New York, NY, ²Rheumatology, NYU Langone Medical Center, New York, NY, ³NYU Langone Medical Center, Rheumat, New York, NY, ⁴NYU Langone Medical Center, Rheumatology, New York, NY, ⁵Department of Radiology, NYU Langone Medical Center, New York, NY, ⁶Department of Surgery, New York University School of Medicine, New York, NY, ⁷Department of Surgery, NYU Langone Medical Center, New York, NY, ⁸Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Obesity is a common risk factor for knee osteoarthritis (KOA). While it is intuitive that bariatric weight loss improves knee pain, it is not…
Abstract Number: 3055 • 2016 ACR/ARHP Annual Meeting
Ultrasound Features of the First Metatarsophalangeal Joint in Gout and Asymptomatic Hyperuricaemia: Comparison with Normouricaemic Individuals
Sarah Stewart¹, Nicola Dalbeth^2,3, Alain Vandal⁴, Bruce Allen⁵, Rhian Miranda⁶ and Keith Rome⁷, ¹School of Podiatry, Auckland University of Technology, Auckland, New Zealand, ²Auckland District Health Board, Auckland, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand, ⁴Counties Manukau District Health Board, Auckland, New Zealand, ⁵Horizon Radiology, Auckland, New Zealand, ⁶Auckland City Hospital Radiology, Auckland, New Zealand, ⁷School of Clinical Sceince, Health & Rehabilitation Research Institute, AUT University, Auckland, New Zealand
Background/Purpose: The first metatarsophalangeal joint (1MTPJ) is frequently affected in gout. This study aimed to identity ultrasound features of the 1MTPJ in people with gout…
Abstract Number: 3056 • 2016 ACR/ARHP Annual Meeting
Efficacy of a Work Disability Prevention Program for People with Rheumatic and Musculoskeletal Conditions: A Randomized Controlled Trial
Julie J. Keysor^1,2, Michael P. LaValley³, Carrie Brown⁴, David T. Felson⁵, Rawan AlHeresh⁶, Molly Vaughan⁷, Robert A. Yood⁸, John Reed⁹ and Saralynn Allaire¹⁰, ¹Physical Therapy, Boston University, Boston, MA, ²Clinical Epidemiology Research and Training, Boston University School of Medicine, Boston, MA, ³Biostatistics, Boston University School of Public Health, Boston, MA, ⁴Boston University School of Public Health, Boston, MA, ⁵Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁶Rheumatology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, ⁷635 Commonwealth Avenue, Room 651, Boston University College of Health & Rehabilitation Sciences, Boston, MA, ⁸Fallon Clinic, Worcester, MA, ⁹Rheumatology, Reliant Medical Group, Worcester, MA, ¹⁰Clinical Epidemiology Research and Training Unit, Clinical Epidemiology, BUSM, Boston, MA
Background/Purpose: Rheumatic and musculoskeletal conditions are leading causes of work disability. A previous trial showed a preventive work disability intervention delivered by vocational rehabilitation counselors…
Abstract Number: 3057 • 2016 ACR/ARHP Annual Meeting
Objectively Measured Physical Activity and Risk of Knee Osteoarthritis: The Osteoarthritis Initiative
Jin Qin¹, Kamil E. Barbour¹, Michael C. Nevitt², Charles Hemlick³, Jennifer M. Hootman³, Louise Murphy⁴, Jane A. Cauley⁵ and Dorothy D. Dunlop⁶, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ³Centers for Disease Control and Prevention, Atlanta, GA, ⁴Division of Populatio Health, Centers for Disease Control and Prevention, Atlanta, GA, ⁵Department of Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, ⁶Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Regular physical activity (PA) reduces risk of cardiovascular disease, cancer, diabetes, and premature death. Moreover, PA can counteract the reduction in fitness, muscular strength,…
Abstract Number: 3058 • 2016 ACR/ARHP Annual Meeting
Varus Thrust and Incident and Progressive Knee Osteoarthritis
Leena Sharma¹, Alison H. Chang², Charles Eaton³, Marc Hochberg⁴, Rebecca D. Jackson⁵, C. Kent Kwoh⁶, Michael C. Nevitt⁷, Orit Almagor⁸, Kirsten C. Moisio⁸ and Joan S. Chmiel⁹, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²PT & Human Movement Sciences, Northwestern University, Chicago, IL, ³Brown University, Providence, RI, ⁴Department of Medicine, University of Maryland, Baltimore, MD, ⁵Ohio State University, Columbus, OH, ⁶Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁷Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁸Northwestern University, Chicago, IL, ⁹Preventive Medicine, Northwestern University, Chicago, IL
Background/Purpose: Varus thrust, bowing-out of the knee during gait, i.e., appearance (or worsening) of varus during stance improving in late stance or swing, was associated…
Abstract Number: 3059 • 2016 ACR/ARHP Annual Meeting
Impact of a Musculoskeletal Training Program on Residents’ Evaluation, Diagnosis, and Treatment of Osteoporosis
Michael J. Battistone¹, Richard Nelson², Junjie Ma^3,4, Karla L. Miller⁵, Phillip Lawrence^6,7, Joanne Lafleur⁸, Marissa Grotzke⁹, Andrea M. Barker¹ and Grant W. Cannon⁵, ¹Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ²Epidemiology, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ³Veterans Affairs Salt Lake City Health Care System and University of Utah College of Pharmacy, Salt Lake City, UT, ⁴University of Utah College of Pharmacy, Salt Lake City, UT, ⁵Internal Medicine, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ⁶Salt Lake City VA Medical Center and Roseman University of Health Sciences, Salt Lake City, UT, ⁷Roseman University of Health Sciences, Salt Lake City, UT, ⁸University of Utah Department of Pharmacotherapy and Salt Lake City VA Medical Center, Salt Lake City, UT, ⁹Division of Endocrinology, Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT
Background/Purpose: The Center of Excellence (COE) in Musculoskeletal (MSK) Care and Education was established at the Salt Lake City Veterans Affairs Medical Center (SLCVAMC) in…

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