Abstract Number: 2880 • 2016 ACR/ARHP Annual Meeting
Distinct Metabolic Pathways Regulate Lipid Antigen Presentation By Monocytes and B Cells: Implications for SLE Patients with Pre-Clinical Atherosclerotic Plaque
Background/Purpose: Systemic lupus erythematosus (SLE) patients have an increased risk of developing clinically apparent cardiovascular disease (CVD) and subclinical atherosclerotic plaque, detectable by vascular ultrasound…Abstract Number: 2881 • 2016 ACR/ARHP Annual Meeting
Reduced Hippocampal-Thalamic Fiber Tracts in Systemic Lupus Erythematosus
Background/Purpose: SLE patients experience deterioration in cognitive function over time but attribution to disease-related mechanisms is confounded by medication effects, psychiatric disease, hormonal influences and…Abstract Number: 2882 • 2016 ACR/ARHP Annual Meeting
CD4+ T Helper Cells and Regulatory T Cells in Active Lupus Nephritis – an Imbalance Towards a Predominant Th1 Response?
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the involvement of multiple organs and systems with aberrations in T cell response,…Abstract Number: 2883 • 2016 ACR/ARHP Annual Meeting
The CD4+CD52low T Cell Contributes to the Development of Systemic Lupus Erythematosus through the CCR8/TARC Pathway
Background/Purpose: CD52 is a cell-surface glycoprotein that is widely expressed in lymphocytes, monocytes and eosinophils. CD4+CD52high T cells inhibit the activation of CD4+CD52low T cells…Abstract Number: 2884 • 2016 ACR/ARHP Annual Meeting
Cell-Type Specific Epigenetic Features of Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that involves multiple organ systems and periods of variable disease activity. Although SLE, especially in…Abstract Number: 2885 • 2016 ACR/ARHP Annual Meeting
Expression Levels and Function of the Inhibitory Molecule, Immunoglobulin like Transcript 7 (ILT7), Are Decreased on Circulating Plasmacytoid Dendritic Cells in SLE Patients with High ANA Titers
Background/Purpose: Systemic lupus erythematous (SLE) is a complex autoimmune disease often involving multiple organs. In SLE, immune complexes containing autoreactive antibody and nuclear material activate…Abstract Number: 2886 • 2016 ACR/ARHP Annual Meeting
Associations Between Type I Interferon and Antiphospholipid Antibody Status Differ Between Ancestral Backgrounds
Background/Purpose: Autoantibodies in SLE that bind to double-stranded DNA or RNA-binding proteins are strongly associated with high levels of type I interferon (IFN), likely via…Abstract Number: 2887 • 2016 ACR/ARHP Annual Meeting
Clinical Predictors for Development of Interstitial Lung Disease in Mixed Connective Tissue Disease
Methods: We performed a retrospective case control study utilizing data from patients evaluated at a single tertiary care center from 2007-2014. Twenty-eight patients who met…Abstract Number: 2888 • 2016 ACR/ARHP Annual Meeting
Usefulness of Bosentan in the Prevention of Pulmonary Hypertension in Patients with Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease in which the damage of microcirculation is critical to develop the disease. In SSc, vascular complications…Abstract Number: 2889 • 2016 ACR/ARHP Annual Meeting
Therapeutic Plasma Exchange for the Treatment of Raynaud’s and Digital Ulcers in Systemic Sclerosis: A Systematic Review
Background/Purpose: Raynaud's phenomenon (RP) is an early marker of microvascular damage in systemic sclerosis (SSc) and digital ulcers (DU) are a serious complication of vascular…Abstract Number: 2890 • 2016 ACR/ARHP Annual Meeting
Feasibility of Same Day Adipose Tissue Harvest, Cell Processing and Subcutaneous Delivery of Adipose Derived Regenerative Cells into Fingers of Scleroderma Patients within a Randomized Double Blind Clinical Trial
Background/Purpose: Current medical therapy to improve hand function has had very limited benefit in patients with systemic sclerosis (SSc). Cells present within a person’s own…Abstract Number: 2891 • 2016 ACR/ARHP Annual Meeting
Prognostic Significance of Autoantibody Positivity in Interstitial Lung Disease: A Retrospective Case-Control Study
Background/Purpose: Routine screening for circulating autoantibodies (AAbs) on the initial evaluation of interstitial lung disease (ILD) contributes to the diagnosis of underlying autoimmune disease. However,…Abstract Number: 2892 • 2016 ACR/ARHP Annual Meeting
Serum Level of KL-6, a Biomarker of Interstitial Lung Disease (ILD), Is Higher in Diffuse SSc Than in Limited SSc and RA Even When the Activity of ILD Is Low
Background/Purpose: KL-6 is a glycoprotein expressed on and released from type 2 alveolar cells and the measurement of KL-6 in serum was developed by Kohno…Abstract Number: 2893 • 2016 ACR/ARHP Annual Meeting
Usefulness of the Eustar Preliminary Criteria for Vey Early Systemic Sclerosis and Le Roy Criteria for Early-Systemic Sclerosis in Identifying Patients at Risk of Development of Systemic Sclerosis
Background/Purpose: In our study, over the half of the patients initially classified as Early-SSc progressed to SSc during follow-up. EUSTAR preliminary criteria were more frequent…Abstract Number: 2894 • 2016 ACR/ARHP Annual Meeting
Efficacy of Rituximab in Systemic Sclerosis with Interstitial Lung Disease
Background/Purpose: Systemic sclerosis (SSc) is a progressive fibrotic and autoimmune disease, which results to severe systemic complications. Rituximab (Rtx), an anti CD-20 antibody, has recently…
ACR Meeting Abstracts