Abstracts Archive - Page 1607 of 2425 - ACR Meeting Abstracts

Abstract Number: 2850 • 2016 ACR/ARHP Annual Meeting
Changes in Urinary Biomarker Levels Can Predict Treatment Responses in Lupus Nephritis
Joan Wither¹, Stephenie Prokopec², Babak Noamani¹, Dennisse Bonilla¹, Zahi Touma³, Carmen Avila-Casado⁴, Heather Reich⁵, James Scholey⁵, Paul R. Fortin⁶, Paul Boutros² and Carolina Landolt-Marticorena¹, ¹Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Ontario Institute for Cancer Research, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Pathology, University Health Network, Toronto, ON, Canada, ⁵Nephrology, University Health Network, Toronto, ON, Canada, ⁶Université Laval, CHU de Québec, Québec, QC, Canada
Background/Purpose: The relapsing and remitting nature of lupus nephritis (LN) poses a challenge to clinicians who must balance the risk of long term kidney damage…
Abstract Number: 2851 • 2016 ACR/ARHP Annual Meeting
An Antigen Microarray to Rule-out Systemic Lupus Erythematosus, the SLE-Key® Rule-out Test, Performs Well As an Aid in Clinical Practice
Donald Massenburg, Justine Oldenberg, Amanda Sell, Tristan Krause and Alvin F. Wells, Rheumatology and Immunotherapy Center, Franklin, WI
Background/Purpose: The SLE-key® test to Rule Out lupus was developed by ImmunArray Ltd using serum samples of 246 SLE patients and 252 self-declared healthy controls.…
Abstract Number: 2852 • 2016 ACR/ARHP Annual Meeting
Long Term Prognosis of Lupus Nephritis in the Afro-Caribbean Population of Martinique with Free Access to Healthcare
Aymeric Couturier¹, Vincent Molinie², Charles Cartou³, Serge ARFI⁴, Violaine Emal-Aglae⁵, Katlyne Polomat⁶, Florence MOINET⁶, Georges JEAN BAPTISTE⁷ and Christophe Deligny⁸, ¹nephrology, Pierre Zobda Quitman hospital, Fort de France, Martinique, ²Pathology, Pierre Zobda Quitman Hospital, Fort de France, Martinique, ³nephrology, Pierre Zobda Quitman Hospital, Fort de France, Martinique, ⁴University Hospital, CHU Fort de France, Fort de France, Martinique, ⁵Nephrology, Centre Hospitalier de Mangot-Vulcin, Le Lamentin, Martinique, ⁶Rheumatology and Internal Medicine, Zobda Quitman Hospital, Fort de France, Martinique, ⁷RHEUMATOLOGY, CHU MARTINIQUE, FWI, Fort-de-France, Martinique, ⁸Zobda Quitman Hospital, Rheumatology and Internal Medicine, Fort de France, Martinique
Background/Purpose: In African-descent patients, lupus nephritis (LN) lead to a worse outcome than in Caucasians. Long term data are rare in countries where black populations…
Abstract Number: 2853 • 2016 ACR/ARHP Annual Meeting
Neutrophilia in Systemic Lupus Erythematosus As a Potential Indicator of Disease Activity
Emily E. Lewis¹, W Joseph McCune² and Jason S Knight³, ¹University of Michigan, Ann Arbor, MI, ²Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Neutrophilia and elevated neutrophil-to-lymphocyte ratio are being increasingly recognized as reliable markers of inflammation (and usually negative prognostic outcome) in scenarios as diverse as…
Abstract Number: 2854 • 2016 ACR/ARHP Annual Meeting
Laboratory and Demographic Longitudinal Profile of a Large Cohort of Individuals Presenting with the ANA Nuclear Dense Fine Speckled Immunofluorescence Pattern
Andressa Mathias¹, Alessandra Dellavance², José Sá³, Felipe Muramoto⁴, Valdecir Marvulle⁵ and Luis Eduardo C. Andrade⁶, ¹Immunology Division, Fleury Medicine and Health Laboratories, SAO PAULO, Brazil, ²Research and Development Department, Fleury Medicine and Health Laboratories, São Paulo, Brazil, ³Infomation Technology Department, Fleury Medicine and Health Laboratories, SAO PAULO, Brazil, ⁴Information Technology Departmente, Fleury Medicine and Health Laboratories, SAO PAULO, Brazil, ⁵Statistics Department, Universidade Federal de São Paulo, SAO PAULO, Brazil, ⁶Rheumatology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: The nuclear dense fine speckled (DFS) pattern observed in the ANA assay on HEp-2 cells is strongly associated with autoantibodies to the 70/75kD lens…
Abstract Number: 2855 • 2016 ACR/ARHP Annual Meeting
The Long-Term Clinical Outcomes of Lupus Nephritis
Julie Davidson¹, Qinggong Fu², Beulah Ji³, Sapna Rao⁴, David Roth⁵, Laurence S Magder⁶ and Michelle Petri⁷, ¹Worldwide Epidemiology, GlaxoSmithKline R&D, Uxbridge, United Kingdom, ²Worldwide Epidemiology, GlaxoSmithKline, Collegeville, PA, ³Clinical Development, GlaxoSmithKline R&D, Uxbridge, United Kingdom, ⁴Real World Evidence, GlaxoSmithKline R&D, Research Triangle Park, NC, ⁵GSK, Philadelphia, PA, ⁶Epidemiology and Public Health, Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD, ⁷Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Clinical trials in lupus nephritis have often been designed to demonstrate renal response (or remission) following therapy based on categorical remission endpoints (often no…
Abstract Number: 2856 • 2016 ACR/ARHP Annual Meeting
Serum C5a Is Elevated in Lupus Nephritis and in Neuropsychiatric Systemic Lupus Erythematosus through Different Mechanisms
Yuko Sakuma¹, Tatsuo Nagai², Taku Yoshio³ and Shunsei Hirohata⁴, ¹Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ³Jichi Medical University, Tochigi, Japan, ⁴Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most serious complications of the disease. We have recently demonstrated that the breakdown…
Abstract Number: 2857 • 2016 ACR/ARHP Annual Meeting
Results from a Phase 0 Longitudinal Clinical Trial in Cutaneous Lupus Erythematosus: Analysis of the Type I IFN Signature in the Skin and Blood and Its Relationship with Disease Activity Scores and Autoantibody Profiles
Jessica Schreiter¹, Jarrat Jordan¹, Matteo Cesaroni¹, Marc Chevrier², Alexa Piantone³, Ian Gourley³, Jacqueline Benson¹ and Takahiro Sato¹, ¹Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ²Janssen Research and Development, LLC, Collegeville, PA, ³Immunology Translational Medicine, Janssen Pharmaceutical Research and Development, LLC, Spring House, PA
Background/Purpose: Type I IFN (IFN-I)-regulated gene expression is known to be elevated in blood and skin lesions of patients with two different forms of cutaneous…
Abstract Number: 2858 • 2016 ACR/ARHP Annual Meeting
Urinary PF4 and E-Selectin As Novel Biomarkers for Disease Activity and Renal Damage in Lupus Nephritis
Huihua Ding¹, Ling Qin¹, Samantha Stanley¹, Ramesh Saxena² and Chandra Mohan³, ¹Biomedical Engineering Department, University of Houston, Houston, TX, ²Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, ³Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is the leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). The objective of this study is to validate…
Abstract Number: 2859 • 2016 ACR/ARHP Annual Meeting
Health-Related Interference of Social Activities and Suicidal Ideation in Systemic Lupus Erythematosus: Georgians Organized Against Lupus Cohort
Charmayne M. Dunlop-Thomas¹, Gaobin Bao², S. Sam Lim² and Cristina Drenkard³, ¹Medicine/Rheumatology, Emory University, Atlanta, GA, ²Medicine, Emory University School of Medicine, Atlanta, GA, ³Emory University School of Medicine, Atlanta, GA
Background/Purpose: Social integration has been found to be a protective factor from suicide-related ideation even after adjusting for mental health predictors. This is especially…
Abstract Number: 2860 • 2016 ACR/ARHP Annual Meeting
Exercise Significantly Improves Cardiorespiratory Fitness and Reduces Disease-Related Fatigue without Adverse Effects on Disease Activity in Systemic Lupus Erythematosus: a Systematic Review with Meta-Analysis
Tom O'Dwyer¹, Laura Durcan² and Fiona Wilson³, ¹Physiotherapy, Trinity College Dublin, Dublin, Ireland, ²University of Washington, Seattle, WA, ³Physiotherapy, Trinity College, Dublin, Ireland
Background/Purpose: Systemic lupus erythematous (SLE) associates with accelerated mortality, frequently attributable to cardiovascular (CV) causes, which is not fully explained by traditional CV risk factors.…
Abstract Number: 2861 • 2016 ACR/ARHP Annual Meeting
Proportions of Circulating Follicular Helper T Cells and Complement Levels, White Blood Cell Counts, and Skin Manifestations in Patients with Active Systemic Lupus Erythematosus
Jun Kikuchi¹, Masaru Takeshita¹, Katsuya Suzuki², Yoshiaki Kassai³, Takahiro Miyazaki³ and Tsutomu Takeuchi², ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan
Background/Purpose: Although circulating B cells and T cells, including follicular helper T (Tfh) cells, are reported to be involved in systemic lupus erythematosus (SLE) 1,2),…
Abstract Number: 2862 • 2016 ACR/ARHP Annual Meeting
Whole Blood Phenotyping and Innate and Adaptive Stimulation Reveal Unique Differences in Granulocytes and Innate Pathways of African American SLE Patients with Variable Disease Activity
Samantha Slight-Webb¹, Krista M. Bean¹, Joseph Kheir¹, Bolanle Adebayo¹, Holden T. Maecker², Paul J. Utz³, Judith A. James⁴ and Joel M. Guthridge⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Medicine, Stanford University School of Medicine, Stanford, CA, ⁴Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by periods of heightened disease activity. Disease flares significantly affect quality of life and…
Abstract Number: 2863 • 2016 ACR/ARHP Annual Meeting
High Frequency of Terminally Differentiated CD8+ T Cells Characterize Systemic Lupus Erythematosus Patients with Renal Involvement
Nataly Manjarrez-Orduño¹, Laurence Menard¹, Julie Carman¹, Suzanne Suchard¹, Francesca Casano¹, Deborah Lee¹, Sium Habte¹, Sherif Daouti², Selena Kansal³, Dana Banas³, Can Jiang³, Dawn Stetsko³, Mark Cunningham³, Vivek Jayaswal⁴, Somnath Bandyopadhyay³, Sarah Hu³, Richard A. Furie⁵ and Steven G. Nadler⁶, ¹Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Princeton, NY, ³Bristol-Myers Squibb, Princeton, NJ, ⁴Biocon Bristol-Myers Squibb Research Center, Bangalore, India, ⁵Division of Rheumatology, Northwell Health, Great Neck, NY, ⁶Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: SLE is a highly heterogeneous disease. The identification of disease subtypes with different pathological mechanisms is crucial to identify subjects with different disease progression…
Abstract Number: 2864 • 2016 ACR/ARHP Annual Meeting
Identifying Dysregulated and Co-Dysregulated Markers in Systemic Lupus Erythematosus Using Multi-Modal Biomarker Data from a Large Pre-Clinical Study
Yanhua Sarah Hu¹, S Bandyopadhyay¹, Julie Carman², Nataly Manjarrez-Orduño², Can Jiang¹, Suzanne Suchard², Laurence Menard², sium habte¹, selena kansal¹, vivek jayaswal³, Richard A. Furie⁴ and Steven G. Nadler⁵, ¹Bristol-Myers Squibb, Princeton, NJ, ²Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ, ³Biocon Bristol-Myers Squibb Research Center, Bangalore, NJ, India, ⁴Division of Rheumatology, North Shore LIJ Health System, Great Neck, NY, ⁵Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, relapsing autoimmune disease affecting multiple organs and is a highly heterogeneous condition, with wide variations in the…

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