Abstracts Archive - Page 1600 of 2607 - ACR Meeting Abstracts

Abstract Number: 53 • 2016 ACR/ARHP Annual Meeting
Efficacy of Cannabis Flos in Patients with Fibromyalgia: A Monocentric Observational Study
Maria Chiara Gerardi¹, Alberto Batticciotto², Rossella Talotta¹, Maria Chiara Ditto¹, Fabiola Atzeni² and Piercarlo Sarzi-Puttini¹, ¹Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milan, Italy, ²Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy
Efficacy of Cannabis flos in patients with fibromyalgia: a monocentric observational study Background/Purpose: Fibromyalgia (FM) is a syndrome characterized by chronic widespread pain, fatigue,…
Abstract Number: 54 • 2016 ACR/ARHP Annual Meeting
Patients with Fibromyalgia in General Have Higher Self-Report Questionnaire Scores Than Patients with Rheumatoid Arthritis: Implications for Clinical Trials and Clinical Research
Theodore Pincus¹, Isabel Castrejón¹, Joel Block² and Nathaniel Cook¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Patients with rheumatoid arthritis (RA) who are included in clinical trials generally are selected for measures indicating high disease activity, such as more than…
Abstract Number: 55 • 2016 ACR/ARHP Annual Meeting
Identification of Endogenous Autoantigens Bound to Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis: A Key Role for Citrulline Residues in Histone 4
Xiaobo Meng¹, Peyman Ezzati¹, Irene Smolik², Carol Hitchon³ and Hani El-Gabalawy⁴, ¹UNIVERSITY OF MANITOBA, WINNIPEG, MB, Canada, ²Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Manitoba Arthritis Center, Winnipeg, MB, Canada
Background/Purpose: Anti-Citrullinated Peptides Antibodies (ACPA) aid in rheumatoid arthritis (RA) diagnosis. The nature of autoantigens specifically bound to ACPA immune complex in vivoremains unclear. We…
Abstract Number: 56 • 2016 ACR/ARHP Annual Meeting
A Systems Biology Approach to Investigating Beneficial Effects of Endurance Exercise in Myositis Patients
Jessica Boehler^1,2, Marshall Hogarth³, Matthew Barberio³, Svetlana Ghimbovschi², Kristy Brown^1,2, Li Alemo Munters⁴, Ingela Loell⁴, Yi-Wen Chen^2,5, Helene Alexanderson⁶, Ingrid E. Lundberg⁷ and Kanneboyina Nagaraju^5,8, ¹Department of Integrative Systems Biology, The George Washington University, Washingtion, DC, ²Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, ³Research Center for Genetic Medicine, Children's National Medical Center, Washingtion, DC, ⁴Karolinska University Hospital, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Sweden, Stockholm, Sweden, ⁵Department of Integrative Systems Biology, The George Washington University, Washington, DC, ⁶Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Research Center for Genetic Medicine, Children’s National Medical Center, Washington, DC
Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) are skeletal muscle disorders characterized by proximal muscle weakness and inflammation. Recent studies have suggested that endurance exercise improves…
Abstract Number: 57 • 2016 ACR/ARHP Annual Meeting
Genetic Polymorphism of IL-1RN Encoding the IL-1 Receptor Antagonist Predicts Radiographic Severity of Symptomatic Knee OA
Mukundan Attur¹, Sisi Ma², Jonathan Samuels³, Svetlana Krasnokutsky Samuels⁴, Hua Zhou², Jenny Bencardino⁵, Marc C. Hochberg⁶, Braxton Mitchell⁷, Virginia B. Kraus⁸, Joanne M. Jordan⁹ and Steven B. Abramson¹⁰, ¹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Rheumatology, NYU - Hospital for Joint Diseases, New York, NY, ⁴Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁵Radiology, NYU Langone Medical Center, New York, NY, ⁶University of Maryland School of Medicine, Baltimore, MD, USA, Baltimore, MD, ⁷Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, ⁸Department of Medicine, Duke University Medical Center, Durham, NC, ⁹Thurston Arthritis Research Center, University of North CArolina at Chapel Hill, Chapel Hill, NC, ¹⁰Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY
Background/Purpose: Growing numbers of studies show increased expression in Osteoarthritis (OA) of inflammatory cytokines, such as IL-1β and TNFα, in joint tissues and peripheral blood…
Abstract Number: 58 • 2016 ACR/ARHP Annual Meeting
Detecting Novel Candidate Risk Genes in Rheumatoid Arthritis with Gene-Based Association Testing
Aleksander Lenert¹ and David Fardo², ¹Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, ²Biostatistics, College of Public Health, University of Kentucky, Lexington, KY
Background/Purpose: Rheumatoid arthritis (RA) is driven by immune-system dysfunction with contribution from genetic risk factors. Emerging data from genomewide association studies (GWAS) of single nucleotide…
Abstract Number: 59 • 2016 ACR/ARHP Annual Meeting
Novel Agents for Blocking the Interaction of Immune Complexes with the Activatory FcγRIIIa Receptor
James Robinson¹, Euan Baxter¹, Darren Tomlinson², Richard Foster³, Robin Owen⁴, Stephanie Win¹, Joanne Nettleship⁵, Christian Tiede², Jayakanth Kankanala², Raymond Owens⁵, Colin Fishwick³, Michael McPherson² and Ann Morgan⁶, ¹NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ²Astbury Centre, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom, ³School of Chemistry, University of Leeds, Leeds, United Kingdom, ⁴Harwell Science and Innovation Campus, Diamond Light Source, Didcot, United Kingdom, ⁵Research Complex at Harwell, Oxford Protein Production Facility - UK, Oxford, United Kingdom, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, Great Britain
Background/Purpose: Protein-protein interactions are essential for the control of cellular functions and critical for regulation of the immune system. One example is the binding of…
Abstract Number: 60 • 2016 ACR/ARHP Annual Meeting
A Single Nucleotide Polymorphism of IL6-Receptor Is Associated with Response to Tocilizumab in Rheumatoid Arthritis: Results from Toci and ROC Studies
Cécile Luxembourger¹, Adeline Ruyssen-Witrand², Yannick Degboé³, Alain G. Cantagrel¹, Arnaud CONSTANTIN⁴, Philippe Gaudin⁵, Christian Jorgensen⁶, Jean-Francis Maillefert⁷, Hubert Marotte Sr.⁸, Delphine Nigon⁹, Daniel Wendling¹⁰, Jacques-Eric Gottenberg¹¹ and Yves-marie Pers¹², ¹Rheumatology, Centre Hospitalier Universitaire, Toulouse Purpan, Toulouse, France, ²Rheumatology Center, Purpan University Hospital, Toulouse, France, ³Rheumatology, Rheumatology Center, Purpan University Hospital, Toulouse, France, ⁴Rheumatology, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France, ⁵Rheumatology, Grenoble University Hospital, France, Grenoble, France, ⁶Inserm u844, Unite ImmunoRhumatologie Therapeutique, Montpellier, France, ⁷Rheumatology, University Hospital, Dijon, France, ⁸CHU de St Etienne, Service de rhumatologie, St Etienne, France, ⁹CHU Purpan, Toulouse, France, ¹⁰Rheumatology, Besançon university hospital, Besançon, France, ¹¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹²coordination RIC SUD, Montpellier, France
Background/Purpose: Biological agents (boDMARDs) have modified the therapeutic management of patients with rheumatoid arthritis (RA). However, boDMARDs can induce sustained remission in only 30% of…
Abstract Number: 61 • 2016 ACR/ARHP Annual Meeting
Killer Immunoglobulin-like Receptors Are Associated with Ankylosing Spondylitis
Aimee Hanson¹, International Genetics of Ankylosing Spondylitis Consortium (IGAS)², Kim-Anh Lê Cao³, Tony J. Kenna⁴ and Matthew A. Brown², ¹The University of Queensland Diamantina Institute, Translational Research Instiute, Brisbane, Australia, Brisbane, Australia, ²Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ³Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Background/Purpose: Killer immunoglobulin-like receptors (KIRs) are expressed predominantly on the surface of natural killer (NK) cells and some T-cells and are important in regulating the…
Abstract Number: 1 • 2016 ACR/ARHP Annual Meeting
Factors Predicting Likelihood of Remaining Positive for Rheumatoid Arthritis-Related Autoantibodies Following Autoantibody Screening
Jill M. Norris¹, Elizabeth A. Bemis¹, M. Kristen Demoruelle², Michael Weisman³, Jane H. Buckner⁴, Peter K. Gregersen⁵, Ted R Mikuls⁶, James R. O'Dell⁶, Richard M. Keating⁷, Kevin D. Deane⁸ and V. Michael Holers⁸, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁵Feinstein Insititute for Medical Research, Manhasset, NY, ⁶Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁷Division of Rheumatology, Scripps Health, La Jolla, CA, ⁸Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: RA-related autoantibodies are typically elevated prior to the onset of RA. Screening for autoantibody (aAb) positive individuals is a means to assemble a cohort…
Abstract Number: 2 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA)-Related Autoimmunity and Lumbar Bone Mineral Density in a Multi-Ethnic Community-Dwelling Population
Jan M. Hughes-Austin¹, Joachim H. Ix², Michael H. Criqui³, Ronit Katz⁴, Matthew Budoff⁵, Jon T. Giles⁶, Kiang Liu⁷ and Darcy S. Majka⁸, ¹Orthopaedic Surgery, University of California, San Diego, La Jolla, CA, ²University of California, San Diego, La Jolla, CA, ³Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ⁴University of Washington, Seattle, WA, ⁵Cardiology, Harbor-UCLA Medical Center, Torrance, CA, ⁶Rheumatology, Columbia University Medical Center, NY, NY, ⁷Department of Preventive Medicine, Northwestern University, Chicago, IL, ⁸Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Previous studies suggest that antibodies to citrullinated protein antigens (ACPA) contribute to decreased hand bone mineral density (BMD) in RA-free individuals. No evidence exists…
Abstract Number: 3 • 2016 ACR/ARHP Annual Meeting
The Presence of Rheumatoid Factor Is Associated with Lower Bone Mass in Korean Health Screening Male Subjects without Clinically Apparent Arthritis
Jiwon Hwang¹, Joong Kyong Ahn², Yeonghee Eun³, Hyemin Jeong³, Eun-Jung Park⁴, Hyungjin Kim³, Jaejoon Lee³, Eun-Mi Koh³ and Hoon-Suk Cha⁵, ¹Department of Medicine, National Police Hospital, Seoul, Korea, The Republic of, ²Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Division of Rheumatology, Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Jeju, South Korea, ⁵Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Close relationship between the immune and skeletal systems has been recognized through the bone loss in rheumatoid arthritis (RA). Rheumatoid factor (RF) is present…
Abstract Number: 4 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA)-Related Joint Symptoms and Thoracic Bone Mineral Density in an RA-Free Community Dwelling Population
Jan M. Hughes-Austin¹, Joachim H. Ix², Samuel R. Ward³, M. Kristen Demoruelle⁴, V. Michael Holers⁵, Jill M. Norris⁶ and Kevin D. Deane⁷, ¹Orthopaedic Surgery, University of California, San Diego, La Jolla, CA, ²University of California, San Diego, La Jolla, CA, ³Radiology, Orthopaedic Surgery, and Bioengineering, University of California, San Diego, La Jolla, CA, ⁴1775 Aurora Ct, 1775 Aurora Ct, Aurora, CO, ⁵Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁶University of Colorado Denver, Aurora, CO, ⁷Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Osteoporosis, defined by Tscore < -2.5, is one of the main consequences of RA and it appears early in the disease. It is twice…
Abstract Number: 5 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Periodontitis: Association and Characteristics of Chronic Periodontitis
BEATRIZ RODRIGUEZ-LOZANO¹, Jerián González Febles², Jorge Luis Garnier Rodríguez³, Shashi Dadlani⁴, Elisa Trujillo-Martin¹, Vanesa Hernández Hernández¹, Sagrario Bustabad⁵, Mariano Sanz Alonso² and Federico Díaz-González¹, ¹Rheumatology, Hospital Universitario de Canarias, S/C Tenerife, Spain, ²Periodontology, Universidad Complutense de Madrid, Madrid, Spain, ³Odontology, Dental Clinic Garnier, S/C Tenerife, Spain, ⁴Periodontology, Dental Clinic Garnier, S/C Tenerife, Spain, ⁵Rheumatology, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain
Background/Purpose: Recent clinical-epidemiological data suggest that periodontitis (P) shows higher prevalence in rheumatoid arthritis (RA) patients. However, due to the scarcity of epidemiological studies, the…
Abstract Number: 6 • 2016 ACR/ARHP Annual Meeting
Lower Omega-3 Fatty Acid Biomarkers Are Associated with Inflammatory Arthritis in a Population Positive for Anti-Citrullinated Protein Antibodies
Ryan W. Gan¹, Elizabeth A. Bemis¹, M. Kristen Demoruelle², Kevin D. Deane², Christopher C. Striebich³, James H. Goddard⁴, Stacey A. Brake⁴, Michael J. Clare-Salzler⁵, V. Michael Holers⁶ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Rhuematology, University of Colorado School of Medicine, Aurora, CO, ⁴Nine Health Services, Inc., Denver, CO, ⁵Experimental Pathology, University of Florida, College of Medicine, Gainesville, FL, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) can be elevated prior to onset of inflammatory arthritis (IA) and RA. However, understanding of factors related to…

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