Abstracts Archive - Page 1591 of 2607 - ACR Meeting Abstracts

Abstract Number: 115 • 2017 Pediatric Rheumatology Symposium
Anti-Phospholipid Antibodies in Children with Down Syndrome
Buthaina Al-Adba¹, Haitham El Bashir², Khalid ZahrAldin³, Ronald Thomas^4,5, Mohammad Al-Khalifa⁶, Asmaa Al-Marwani⁶, Dekra Al-Faridi⁶, Muhamad Al Dabbagh⁷ and Basil Fathalla³, ¹Pediatrics - Rheumatology, Hamad Medical Corporation, Doha, Qatar, ²Developmental Pediatrics & Children’s Rehabilitation - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar, ³Pediatrics, Hamad Medical Corporation, Doha, Qatar, ⁴Department of Research and Biostatistics, Children's Hospital of Michigan, Detroit, MI, ⁵Children's Research Center, Wayne State University, Detroit, MI, ⁶Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar, ⁷Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar
Background/Purpose: The prevalence of anti-phospholipid antibodies (APL) in children with Down syndrome (DS) is unknown. Furthermore, it is unknown if an intermittent or persistent presence…
Abstract Number: 123 • 2017 Pediatric Rheumatology Symposium
Acupuncture for Pediatric Chronic Pain Relief: A Review
Yujuan Zhang¹, Stephanie Hyon² and Chenchen Wang³, ¹Pediatric Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical School, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Acupuncture, a type of complementary and integrative therapy, has been widely used for pain relief in adults. However, evidence of the effect of acupuncture…
Abstract Number: 57 • 2017 Pediatric Rheumatology Symposium
Quantification of Dynamic MRI examinations in Juvenile Idiopathic Arthritis
Nikolay Tzaribachev¹, Romiesa Hagoug², Polymnia Louka³, Joyee Islam³, Mark Hinton³, Olga Kubassova⁴ and Mikael Boesen⁵, ¹PRI - Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, ²Imaging, Image Analysis Group, London, United Kingdom, ³Image Analysis Group, London, United Kingdom, ⁴Image Analysis Group, Image Analysis Group, London, England, ⁵Radiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiskberg, Denmark
Background/Purpose: In chronic inflammatory conditions, the need for a more objective measurement of disease activity has been identified, where dynamic contrast enhanced (DCE) MRI as…
Abstract Number: 111 • 2017 Pediatric Rheumatology Symposium
Eosinophilic Fasciitis in Children: Clinical Course and Response to Treatment from Two Large Academic Centers
Suhas Ganguli¹, Meiqian Ma², Christine Lauren³, Maria Garzon³, Cassyanne L. Aguiar⁴, Andrew Eichenfield⁵, Amy Starr⁶, Lisa F. Imundo^7,8, B. Anne Eberhard⁹ and Joyce Hui-Yuen¹⁰, ¹Pediatrics, Cohen Children's Medical Center of New York, Lake Success, NY, ²Pediatric Rheumatology, Cohen Children's Medical Center of New York, Lake Success, NY, ³Division of Pediatric Dermatology, Columbia University Medical Center, New York, NY, ⁴Pediatric Rheumatology, Children's Hospital of The King's Daughters, Norfolk, VA, ⁵Columbia University Medical Center, New York, NY, ⁶Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ⁷Pediatrics, Columbia University Medical Center, New York, NY, ⁸Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY, ⁹Cohen Children's Medical Center of New York, New Hyde Park, NY, ¹⁰Cohen Children's Medical Center of New York, Lake Success, NY
Background/Purpose: Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by a progressive inflammatory thickening of skin and soft tissues. The diagnosis is based…
Abstract Number: 149 • 2017 Pediatric Rheumatology Symposium
Deficiency of Complement C4A or Low Copy Number of Total C4 Genes, HLA-DRB1*15 and HLA-DRB1*03 Are Strong Genetic Risk Factors for Pediatric SLE of European Descent
Stacy Ardoin¹, Pinar Ozge Avar Aydin², Lai Hin Kimi Chan³, Katherine Lintner⁴, Yee Ling Wu^5,6, Rabheh Aziz¹, Anjali Patwardhan^7,8, Evan Mulvihill¹, Gakit Yu⁹, Bi Zhou¹⁰, Emeli Lundstrom¹¹, Leonid Padyukov¹², Kyla Driest¹³, Cagri Yildirim-Toruner¹³, Sharon Bout-Tabaku¹³, Charles Spencer¹⁴, Gloria Higgins¹, Sampath Prahalad¹⁵, Hermine Brunner¹⁶ and Chack-Yung Yu^10,17, ¹Pediatrics and Rheumatology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ²Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Pediatrics, Emory University School of Medicine, Atlanta, GA, ⁴Pediatrics, Nationwide Children's Hospital, Columbus, OH, ⁵The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁶Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁷Pediatric Rheumatology, Nationwide Childrens Hospital, Columbus, OH, ⁸Pediatric Rheumatology, Nationwide Children's Hospital, Columbia, MO, ⁹Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ¹⁰Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ¹¹Rheumatology, Karolinska Institute, Stockholm, Switzerland, ¹²Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden, ¹³Rheumatology, Nationwide Children's Hospital, Columbus, OH, ¹⁴Rheumatology, Nationwide Childrens Hospital/OSU, Columbus, OH, ¹⁵Pediatrics, Emory Children's Center, Atlanta, GA, ¹⁶Rheumatology, PRCSG, Cincinnati, OH, ¹⁷Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: A complete genetic deficiency of complement C4 almost always leads to the pathogenesis of systemic lupus erythematosus (SLE) with childhood onset, although its prevalence…
Abstract Number: 32 • 2017 Pediatric Rheumatology Symposium
High Mobility Group Box 1 Protein in Children with Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis
Hon Yan Ng¹, Stefan Slomp², Tracy Wilson-Gerwing³, Joan Dietz⁴, Abid Lodhi⁵, Tanya Holt⁶ and Alan Rosenberg³, ¹Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Pediatrics, Emergency Medicine, University of Alberta, Edmonton, AB, Canada, ³Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ⁴University of Saskatchewan, Saskatoon, SK, Canada, ⁵Regina Qu'appelle Health Region, Regina, SK, Canada, ⁶University of Saskatchewan, Sasktoon, SK, Canada
Background/Purpose: High Mobility Group Box 1 Protein (HMGB1) is a nuclear protein that stabilizes DNA and modulates gene expression. In sepsis and in certain other…
Abstract Number: 53 • 2017 Pediatric Rheumatology Symposium
A Prospective Study to Assess for Changes in Mood with Initiation of Anti-TNF therapy: A Pilot Study
Kader Cetin Gedik¹, Helen Papaioannou², Monica Marcus³, Clifford Deutschman⁴ and Beth Gottlieb⁵, ¹Pediatric Rheumatology, Cohen Children's Medical Center fo New York, New Hyde Park, NY, ²Developmental and Behavioral Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, ³Pediatric Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, TX, ⁴Center for Pediatric Research, Cohen Chilredn's Medical Center of New York, New Hyde Park, NY, ⁵Pediatric Rheumatology, Cohen Children's Medical Center of New York, New Hyde Park, NY
Background/Purpose: Anti- tumor necrosis factor (anti-TNF) agents have been widely studied in the treatment of juvenile idiopathic arthritis (JIA) and inflammatory bowel disease (IBD). Although there…
Abstract Number: 122 • 2017 Pediatric Rheumatology Symposium
Presenting Manifestations of Amplified Musculoskeletal Pain Syndrome in Males versus Females
Sabrina Gmuca¹, Jenna L. Tress², Jennifer Mosby³, Laura P. Richardson³ and David D. Sherry², ¹Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Seattle Children's Hospital, Seattle, WA
Background/Purpose: Amplified musculoskeletal pain syndrome (AMPS) is a chronic non-inflammatory musculoskeletal pain condition. AMPS has a predilection for females but males can be affected as…
Abstract Number: 78 • 2017 Pediatric Rheumatology Symposium
Predictors of Outcome Following Tonsillectomy in Periodic Fever, Aphthous Stomatitis Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome
Kalpana Manthiram¹, Daniel L. Kastner^2,3 and Kathryn Edwards⁴, ¹National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD, ⁴Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN
Background/Purpose: Tonsillectomy is considered curative in a majority of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Predictors of outcome following…
Abstract Number: 150 • 2017 Pediatric Rheumatology Symposium
Childhood-onset Takayasu Arteritis Associated with Mutations in CBL
Arturo Borzutzky^1,2, Charlotte Niemeyer³, Guillermo Pérez-Mateluna⁴, Cecilia Mellado⁵, Miriam Erlacher³, Marena Niewisch⁶, Mariana Aracena⁵ and Cristián García⁷, ¹Department of Pediatric Infectious Diseases and Immunology, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Millennium Institute on Immunology and Immunotherapy, Santiago, Chile, ³Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine,, University Medical Center Freiburg, Freiburg, Germany, ⁴Pediatric Infectious Diseases and Immunology, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁵Section of Genetics, Department of Pediatrics, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁶Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany, ⁷Department of Radiology, Pontificia Universidad Católica de Chile, Santiago, Chile
Background/Purpose: Takayasu arteritis (TA) is an inflammatory large-vessel vasculitis of unknown etiology that rarely presents in childhood. No monogenic etiologies of TA have been identified.…
Abstract Number: 27 • 2017 Pediatric Rheumatology Symposium
Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythmatosus Patients
Shreya Goyal¹, Daniel Ashton^2,3, Kamlesh Kukreja^3,4, Michael C. Braun^5,6 and Scott E. Wenderfer^5,7, ¹Pediatrics, Baylor College of Medicine, Houston, TX, ²Interventional Radiology, Texas Children's Hospital, Houston, TX, ³Radiology, Baylor College of Medicine, Houston, TX, ⁴Interventional RAdiology, Texas Children's Hospital, Houston, TX, ⁵Texas Children's Hospital, Houston, TX, ⁶Pediatrics-Renal, Baylor College of Medicine, Houston, TX, ⁷Pediatrics-Renal, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Title: Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythematosus Patients Background/Purpose: There is very little data in the literature on…
Abstract Number: 2 • 2017 Pediatric Rheumatology Symposium
Murine Model of Arthritis Flare Identifies CD8+ Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Nathan Nelson-Maney³, Robert Fuhlbrigge⁴ and Peter A. Nigrovic², ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁴Children's Hospital Colorado, Aurora, CO
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 109 • 2017 Pediatric Rheumatology Symposium
Clinical features of pediatric Behçet’s disease patients in Japan
Ken-ichi Yamaguchi¹ and Satoshi Fujikawa², ¹Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ²Immuno－Rheumatology Center, St.luke's International Hospital, Tokyo, Japan
Background/Purpose: To diagnose pediatric patients as Behçet’s disease (BD) is challenging. Sensitivity of four BD criteria, three BD criteria made for adult patients and Paediatric…
Abstract Number: 14 • 2017 Pediatric Rheumatology Symposium
Efficacy and Safety of Canakinumab in Patients with Periodic Fever Syndromes (Colchicine-Resistant FMF, HIDS/MKD and TRAPS): Results from a Phase 3, Pivotal, Umbrella Trial
Fabrizio De Benedetti¹, Jordi Anton², Eldad Ben-Chetrit³, Inmaculada Calvo⁴, Joost Frenkel⁵, Marco Gattorno⁶, Hal M. Hoffman⁷, Ozgur Kasapcopur⁸, Isabelle Koné-Paut⁹, Helen Lachmann¹⁰, Michel Moutschen¹¹, Seza Ozen¹², Pierre Quartier¹³, Anna Simon¹⁴, Andrew Zeft¹⁵, Karine Lheritier¹⁶, Antonio Speziale¹⁶ and Guido Junge¹⁶, ¹IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ²Unitat de Reumatologia Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain, ³Rheumatology Unit, Hadassah—Hebrew University Medical Center, Jerusalem, Israel, ⁴Hospital Universitario y Polytecnico La Fe, Valencia, Spain, ⁵University Medical Center,Utrecht, Utrecht, Netherlands, ⁶Pediatric Rheumatology, G. Gaslini Institute, Genoa, Italy, ⁷Division of Rheumatology, Allergy, and Immunology, University of California at San Deigo, La Jolla, CA, ⁸Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey, ⁹Hopital Kremlin Bicetre, University of Paris SUD, Paris, France, ¹⁰UK National Amyloidosis Centre, University College London Medical School, London, United Kingdom, ¹¹CHU de Liège/ University of Liège, Liège, Belgium, ¹²Department of Pediatrics, Hacettepe University, Ankara, Turkey, ¹³Necker-Enfants Malades Hospital, Paris, France, ¹⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ¹⁵Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ¹⁶Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Open-label studies have suggested the efficacy of canakinumab (CAN), a fully human, highly specific anti-IL-1β neutralizing monoclonal antibody, in colchicine-resistant-FMF (crFMF), hyper-immunoglobulin (Ig) D…
Abstract Number: 8 • 2017 Pediatric Rheumatology Symposium
Examination of Reported Risk Loci from Candidate Gene Studies of Systemic Juvenile Idiopathic Arthritis Identifies Link between IL1RN Variation and both Disease Susceptibility and Response to Interleukin-1 Directed Therapy
Victoria Arthur¹, Emily Shuldiner¹, Anne Hinks², The International Childhood Arthritis Genetics (INCHARGE) Consortium³, Patricia Woo⁴, Wendy Thomson², Elaine F. Remmers⁵ and Michael J. Ombrello¹, ¹Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ²Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, ³INCHARGE Consortium, Bethesda, MD, ⁴Paediatric Rheumatology Unit, University College London, London, United Kingdom, ⁵Inflammatory Disease Section, NHGRI, NIH, Bethesda, MD
Background/Purpose: Systemic JIA (sJIA) is a childhood inflammatory disease whose pathophysiology is poorly understood. sJIA is phenotypically heterogeneous with variable manifestations and responses to treatment.…

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