Abstracts Archive - Page 1591 of 2607 - ACR Meeting Abstracts

Abstract Number: 116 • 2017 Pediatric Rheumatology Symposium
Arthritis as First Presenting Symptom of Inflammatory Bowel Disease: A Case Control Study
Kathryn Phillippi¹, Thomas Sferra², Nora Singer³ and Elizabeth Brooks⁴, ¹Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children’s Hospital / Case Medical Center, Cleveland, OH, ²Pediatric Gastroenterology, Rainbow Babies and Children's Hospital/Case Medical Center, Cleveland, OH, ³MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio, Cleveland, OH, ⁴Division of Pediatric Infectious Diseases and Rheumatology, Rainbow Babies and Children’s Hospital / Case Medical Center, Cleveland, OH, Cleveland, OH
Background/Purpose: Inflammatory bowel disease (IBD) is associated with extra-intestinal manifestations, the most common of which is arthralgia/arthritis. 4.1- 15% of patients with inflammatory bowel disease…
Abstract Number: 115 • 2017 Pediatric Rheumatology Symposium
Anti-Phospholipid Antibodies in Children with Down Syndrome
Buthaina Al-Adba¹, Haitham El Bashir², Khalid ZahrAldin³, Ronald Thomas^4,5, Mohammad Al-Khalifa⁶, Asmaa Al-Marwani⁶, Dekra Al-Faridi⁶, Muhamad Al Dabbagh⁷ and Basil Fathalla³, ¹Pediatrics - Rheumatology, Hamad Medical Corporation, Doha, Qatar, ²Developmental Pediatrics & Children’s Rehabilitation - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar, ³Pediatrics, Hamad Medical Corporation, Doha, Qatar, ⁴Department of Research and Biostatistics, Children's Hospital of Michigan, Detroit, MI, ⁵Children's Research Center, Wayne State University, Detroit, MI, ⁶Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar, ⁷Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar
Background/Purpose: The prevalence of anti-phospholipid antibodies (APL) in children with Down syndrome (DS) is unknown. Furthermore, it is unknown if an intermittent or persistent presence…
Abstract Number: 123 • 2017 Pediatric Rheumatology Symposium
Acupuncture for Pediatric Chronic Pain Relief: A Review
Yujuan Zhang¹, Stephanie Hyon² and Chenchen Wang³, ¹Pediatric Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical School, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Acupuncture, a type of complementary and integrative therapy, has been widely used for pain relief in adults. However, evidence of the effect of acupuncture…
Abstract Number: 57 • 2017 Pediatric Rheumatology Symposium
Quantification of Dynamic MRI examinations in Juvenile Idiopathic Arthritis
Nikolay Tzaribachev¹, Romiesa Hagoug², Polymnia Louka³, Joyee Islam³, Mark Hinton³, Olga Kubassova⁴ and Mikael Boesen⁵, ¹PRI - Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, ²Imaging, Image Analysis Group, London, United Kingdom, ³Image Analysis Group, London, United Kingdom, ⁴Image Analysis Group, Image Analysis Group, London, England, ⁵Radiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiskberg, Denmark
Background/Purpose: In chronic inflammatory conditions, the need for a more objective measurement of disease activity has been identified, where dynamic contrast enhanced (DCE) MRI as…
Abstract Number: 111 • 2017 Pediatric Rheumatology Symposium
Eosinophilic Fasciitis in Children: Clinical Course and Response to Treatment from Two Large Academic Centers
Suhas Ganguli¹, Meiqian Ma², Christine Lauren³, Maria Garzon³, Cassyanne L. Aguiar⁴, Andrew Eichenfield⁵, Amy Starr⁶, Lisa F. Imundo^7,8, B. Anne Eberhard⁹ and Joyce Hui-Yuen¹⁰, ¹Pediatrics, Cohen Children's Medical Center of New York, Lake Success, NY, ²Pediatric Rheumatology, Cohen Children's Medical Center of New York, Lake Success, NY, ³Division of Pediatric Dermatology, Columbia University Medical Center, New York, NY, ⁴Pediatric Rheumatology, Children's Hospital of The King's Daughters, Norfolk, VA, ⁵Columbia University Medical Center, New York, NY, ⁶Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ⁷Pediatrics, Columbia University Medical Center, New York, NY, ⁸Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY, ⁹Cohen Children's Medical Center of New York, New Hyde Park, NY, ¹⁰Cohen Children's Medical Center of New York, Lake Success, NY
Background/Purpose: Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by a progressive inflammatory thickening of skin and soft tissues. The diagnosis is based…
Abstract Number: 149 • 2017 Pediatric Rheumatology Symposium
Deficiency of Complement C4A or Low Copy Number of Total C4 Genes, HLA-DRB1*15 and HLA-DRB1*03 Are Strong Genetic Risk Factors for Pediatric SLE of European Descent
Stacy Ardoin¹, Pinar Ozge Avar Aydin², Lai Hin Kimi Chan³, Katherine Lintner⁴, Yee Ling Wu^5,6, Rabheh Aziz¹, Anjali Patwardhan^7,8, Evan Mulvihill¹, Gakit Yu⁹, Bi Zhou¹⁰, Emeli Lundstrom¹¹, Leonid Padyukov¹², Kyla Driest¹³, Cagri Yildirim-Toruner¹³, Sharon Bout-Tabaku¹³, Charles Spencer¹⁴, Gloria Higgins¹, Sampath Prahalad¹⁵, Hermine Brunner¹⁶ and Chack-Yung Yu^10,17, ¹Pediatrics and Rheumatology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ²Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Pediatrics, Emory University School of Medicine, Atlanta, GA, ⁴Pediatrics, Nationwide Children's Hospital, Columbus, OH, ⁵The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁶Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁷Pediatric Rheumatology, Nationwide Childrens Hospital, Columbus, OH, ⁸Pediatric Rheumatology, Nationwide Children's Hospital, Columbia, MO, ⁹Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ¹⁰Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ¹¹Rheumatology, Karolinska Institute, Stockholm, Switzerland, ¹²Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden, ¹³Rheumatology, Nationwide Children's Hospital, Columbus, OH, ¹⁴Rheumatology, Nationwide Childrens Hospital/OSU, Columbus, OH, ¹⁵Pediatrics, Emory Children's Center, Atlanta, GA, ¹⁶Rheumatology, PRCSG, Cincinnati, OH, ¹⁷Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: A complete genetic deficiency of complement C4 almost always leads to the pathogenesis of systemic lupus erythematosus (SLE) with childhood onset, although its prevalence…
Abstract Number: 32 • 2017 Pediatric Rheumatology Symposium
High Mobility Group Box 1 Protein in Children with Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis
Hon Yan Ng¹, Stefan Slomp², Tracy Wilson-Gerwing³, Joan Dietz⁴, Abid Lodhi⁵, Tanya Holt⁶ and Alan Rosenberg³, ¹Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Pediatrics, Emergency Medicine, University of Alberta, Edmonton, AB, Canada, ³Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ⁴University of Saskatchewan, Saskatoon, SK, Canada, ⁵Regina Qu'appelle Health Region, Regina, SK, Canada, ⁶University of Saskatchewan, Sasktoon, SK, Canada
Background/Purpose: High Mobility Group Box 1 Protein (HMGB1) is a nuclear protein that stabilizes DNA and modulates gene expression. In sepsis and in certain other…
Abstract Number: 53 • 2017 Pediatric Rheumatology Symposium
A Prospective Study to Assess for Changes in Mood with Initiation of Anti-TNF therapy: A Pilot Study
Kader Cetin Gedik¹, Helen Papaioannou², Monica Marcus³, Clifford Deutschman⁴ and Beth Gottlieb⁵, ¹Pediatric Rheumatology, Cohen Children's Medical Center fo New York, New Hyde Park, NY, ²Developmental and Behavioral Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, ³Pediatric Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, TX, ⁴Center for Pediatric Research, Cohen Chilredn's Medical Center of New York, New Hyde Park, NY, ⁵Pediatric Rheumatology, Cohen Children's Medical Center of New York, New Hyde Park, NY
Background/Purpose: Anti- tumor necrosis factor (anti-TNF) agents have been widely studied in the treatment of juvenile idiopathic arthritis (JIA) and inflammatory bowel disease (IBD). Although there…
Abstract Number: 122 • 2017 Pediatric Rheumatology Symposium
Presenting Manifestations of Amplified Musculoskeletal Pain Syndrome in Males versus Females
Sabrina Gmuca¹, Jenna L. Tress², Jennifer Mosby³, Laura P. Richardson³ and David D. Sherry², ¹Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Seattle Children's Hospital, Seattle, WA
Background/Purpose: Amplified musculoskeletal pain syndrome (AMPS) is a chronic non-inflammatory musculoskeletal pain condition. AMPS has a predilection for females but males can be affected as…
Abstract Number: 78 • 2017 Pediatric Rheumatology Symposium
Predictors of Outcome Following Tonsillectomy in Periodic Fever, Aphthous Stomatitis Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome
Kalpana Manthiram¹, Daniel L. Kastner^2,3 and Kathryn Edwards⁴, ¹National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD, ⁴Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN
Background/Purpose: Tonsillectomy is considered curative in a majority of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Predictors of outcome following…
Abstract Number: 150 • 2017 Pediatric Rheumatology Symposium
Childhood-onset Takayasu Arteritis Associated with Mutations in CBL
Arturo Borzutzky^1,2, Charlotte Niemeyer³, Guillermo Pérez-Mateluna⁴, Cecilia Mellado⁵, Miriam Erlacher³, Marena Niewisch⁶, Mariana Aracena⁵ and Cristián García⁷, ¹Department of Pediatric Infectious Diseases and Immunology, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Millennium Institute on Immunology and Immunotherapy, Santiago, Chile, ³Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine,, University Medical Center Freiburg, Freiburg, Germany, ⁴Pediatric Infectious Diseases and Immunology, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁵Section of Genetics, Department of Pediatrics, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁶Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany, ⁷Department of Radiology, Pontificia Universidad Católica de Chile, Santiago, Chile
Background/Purpose: Takayasu arteritis (TA) is an inflammatory large-vessel vasculitis of unknown etiology that rarely presents in childhood. No monogenic etiologies of TA have been identified.…
Abstract Number: 27 • 2017 Pediatric Rheumatology Symposium
Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythmatosus Patients
Shreya Goyal¹, Daniel Ashton^2,3, Kamlesh Kukreja^3,4, Michael C. Braun^5,6 and Scott E. Wenderfer^5,7, ¹Pediatrics, Baylor College of Medicine, Houston, TX, ²Interventional Radiology, Texas Children's Hospital, Houston, TX, ³Radiology, Baylor College of Medicine, Houston, TX, ⁴Interventional RAdiology, Texas Children's Hospital, Houston, TX, ⁵Texas Children's Hospital, Houston, TX, ⁶Pediatrics-Renal, Baylor College of Medicine, Houston, TX, ⁷Pediatrics-Renal, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Title: Assessing the Safety of Kidney Biopsies Performed on Childhood-onset Systemic Lupus Erythematosus Patients Background/Purpose: There is very little data in the literature on…
Abstract Number: 2 • 2017 Pediatric Rheumatology Symposium
Murine Model of Arthritis Flare Identifies CD8+ Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Nathan Nelson-Maney³, Robert Fuhlbrigge⁴ and Peter A. Nigrovic², ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁴Children's Hospital Colorado, Aurora, CO
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 109 • 2017 Pediatric Rheumatology Symposium
Clinical features of pediatric Behçet’s disease patients in Japan
Ken-ichi Yamaguchi¹ and Satoshi Fujikawa², ¹Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ²Immuno－Rheumatology Center, St.luke's International Hospital, Tokyo, Japan
Background/Purpose: To diagnose pediatric patients as Behçet’s disease (BD) is challenging. Sensitivity of four BD criteria, three BD criteria made for adult patients and Paediatric…
Abstract Number: 14 • 2017 Pediatric Rheumatology Symposium
Efficacy and Safety of Canakinumab in Patients with Periodic Fever Syndromes (Colchicine-Resistant FMF, HIDS/MKD and TRAPS): Results from a Phase 3, Pivotal, Umbrella Trial
Fabrizio De Benedetti¹, Jordi Anton², Eldad Ben-Chetrit³, Inmaculada Calvo⁴, Joost Frenkel⁵, Marco Gattorno⁶, Hal M. Hoffman⁷, Ozgur Kasapcopur⁸, Isabelle Koné-Paut⁹, Helen Lachmann¹⁰, Michel Moutschen¹¹, Seza Ozen¹², Pierre Quartier¹³, Anna Simon¹⁴, Andrew Zeft¹⁵, Karine Lheritier¹⁶, Antonio Speziale¹⁶ and Guido Junge¹⁶, ¹IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ²Unitat de Reumatologia Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain, ³Rheumatology Unit, Hadassah—Hebrew University Medical Center, Jerusalem, Israel, ⁴Hospital Universitario y Polytecnico La Fe, Valencia, Spain, ⁵University Medical Center,Utrecht, Utrecht, Netherlands, ⁶Pediatric Rheumatology, G. Gaslini Institute, Genoa, Italy, ⁷Division of Rheumatology, Allergy, and Immunology, University of California at San Deigo, La Jolla, CA, ⁸Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey, ⁹Hopital Kremlin Bicetre, University of Paris SUD, Paris, France, ¹⁰UK National Amyloidosis Centre, University College London Medical School, London, United Kingdom, ¹¹CHU de Liège/ University of Liège, Liège, Belgium, ¹²Department of Pediatrics, Hacettepe University, Ankara, Turkey, ¹³Necker-Enfants Malades Hospital, Paris, France, ¹⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ¹⁵Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ¹⁶Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Open-label studies have suggested the efficacy of canakinumab (CAN), a fully human, highly specific anti-IL-1β neutralizing monoclonal antibody, in colchicine-resistant-FMF (crFMF), hyper-immunoglobulin (Ig) D…

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