Abstracts Archive - Page 1583 of 2607 - ACR Meeting Abstracts

Abstract Number: 2936 • 2017 ACR/ARHP Annual Meeting
B-Cell Depletion By Rituximab Affects the Distribution of Effector Th-Cell Subsets in Patients with ANCA Associated Vasculitis
Wayel H. Abdulahad¹, Ulrich Specks², Theo Bijma³, Deborah J. Phippard⁴, Fredrick Karnell⁵, Noha Lim⁵, John H. Stone⁶ and Cees G.M. Kallenberg¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Mayo Clinic College of Medicine, Rochester, MN, ³UMCG, Groningen, Netherlands, ⁴3 Bethesda Metro Center,, Suite 400, Bethesda, MD, ⁵Immune Tolerance Network, Bethesda, MD, ⁶Rheumatology Unit, Massachusetts General Hospital, Boston, MA
Background/Purpose: The current study is aimed to assess the effect of B-cell depletion on the distribution of effector T-cell subsets in AAV-patients. Alterations in CD4+…
Abstract Number: 2937 • 2017 ACR/ARHP Annual Meeting
Genetic Variants in HLA-C and Class I Pathway Genes Influence Susceptibility to Kawasaki Disease
Chisato Shimizu¹, Jihoon Kim², Hariklia Eleftherohorinou³, Victoria Wright³, Long Hoang⁴, Adriana Tremoulet⁵, Alessandra Franco⁶, Martin Hibberd⁴, Atsushi Takahashi^7,8, Michiaki Kubo⁹, Kaoru Ito¹⁰, Toshihiro Tanaka^10,11, Yoshihiro Onouchi^10,12, Lachlan Coin³, Michael Levin³, Jane Burns¹³ and Hiroko Shike¹⁴, ¹Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, ²Medicine, University California San Diego, School of Medicine, Division of Biomedical Informatics, La Jolla, CA, ³Imperial College London, London, United Kingdom, ⁴Genome Institute of Singapore, Singapore, Singapore, ⁵Pediatrics, University California San Diego, School of Medicine, La Jolla, CA, ⁶Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, ⁷Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ⁸Department of Genomic Medicine, National Cerebral And Cardiovascular Center, Suita, Japan, ⁹RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ¹⁰Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ¹¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo, Japan, ¹²Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan, ¹³Pediatrics, University California San DIego, School of Medicine, San Diego, CA, ¹⁴Penn State Hershey Medical Center, Hershey, PA
Background/Purpose: Host genetics influence susceptibility to Kawasaki disease (KD), an acute pediatric vasculitis, and genome wide association studies (GWAS) have detected variants with modest effects…
Abstract Number: 2938 • 2017 ACR/ARHP Annual Meeting
Is Synovial Hypertrophy without Doppler Activity in Rheumatoid Arthritis Joints Sensitive to Change ? – Results of a Longitudinal Ultrasound Study
Lene Terslev¹, Mikkel Østergaard¹, Joseph Sexton² and Hilde B Hammer², ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Ultrasound (US) is used to assess diseases activity in rheumatoid arthritis (RA). Gray scale (GS) US shows the synovial hypertrophy (SH) and Doppler the…
Abstract Number: 2939 • 2017 ACR/ARHP Annual Meeting
Clinical Correlate of Synovial Proliferation in Early Rheumatoid Arthritis
Fan XIAO¹, JIANG YUE², Queenie Mak³, Lai-Shan Tam⁴ and James F Griffith⁵, ¹Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, HONG KONG, Hong Kong, ³Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, HONGKONG, Hong Kong
Clinical Correlate of Synovial Proliferation in Early Rheumatoid Arthritis Background/Purpose: To determine whether semi-quantitative, quantitative assessment of synovitis severity or synovial perfusion data correlates best…
Abstract Number: 2940 • 2017 ACR/ARHP Annual Meeting
Outcome of Power Doppler Ultrasound-Detected Residual Synovitis in Rheumatoid Arthritis Patients with Clinical Remission: A 1 Year Longitudinal Study with Consecutive Ultrasound Examinations
Gaël Mouterde¹, Cédric Lukas², Nathalie Filippi¹, Gregory Marin³, Nicolas Molinari³, Jacques Morel¹ and Bernard Combe¹, ¹Rheumatology, Montpellier University, Lapeyronie Hospital, Montpellier, France, ²Rheumatology, Lapeyronie Hospital and EA2415 Montpellier University, Montpellier, France, ³Statistics, Montpellier University, Lapeyronie Hospital, Montpellier, France
Background/Purpose: Some studies revealed an association of Power Doppler (PD) ultrasound (US)-detected residual synovitis (PDUSS) and risk of relapse and radiographic progression (RP), in rheumatoid…
Abstract Number: 2941 • 2017 ACR/ARHP Annual Meeting
Effect of Achieving Sustained SDAI Remission on Erosion Repair in Patients with Early RA: A Prospective HR-pQCT Study
Jiang Yue¹, James F Griffith², Fan XIAO³, Ling Qin⁴ and Lai-Shan Tam⁵, ¹Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, HONGKONG, Hong Kong, ³Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Bone Quality and Health Centre of the Department of Orthopaedics and Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, hongkong, Hong Kong, ⁵Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: To assess whether achieving sustained SDAI remission in patients with early rheumatoid arthritis (ERA) facilitates repair of existing bone erosions as measured by high-resolution…
Abstract Number: 2942 • 2017 ACR/ARHP Annual Meeting
One Year Changes in Ultrasound Findings in the Feet Are Associated with Patient Reported Outcomes but Not Clinical Examination: a Prospective Observational Study of Patients with Early Rheumatoid Arthritis
Hanyan Zou¹, Karen A. Beattie², George Ioannidis³ and Maggie Larche², ¹McMaster University, Hamilton, ON, Canada, ²Medicine, McMaster University, Hamilton, ON, Canada, ³St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: Despite extensive involvement of the feet in early RA, few studies report clinical and imaging changes in the feet over time. In this observational…
Abstract Number: 2943 • 2017 ACR/ARHP Annual Meeting
Ultrasound Scoring of One Parotid and One Submandibular Gland in Primary Sjogren’s Syndrome – Further Increasing Feasibility in Outpatient Clinics
Esther Mossel¹, Suzanne Arends², Jolien F. van Nimwegen², Konstantina Delli³, Alja J. Stel¹, Frans G.M. Kroese², Fred K.L. Spijkervet⁴, Arjan Vissink⁵ and Hendrika Bootsma², ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: To assess whether ultrasonographic scoring of (i) both parotid and submandibular salivary glands and (ii) all components of the Hocevar scoring system1, is needed…
Abstract Number: 2944 • 2017 ACR/ARHP Annual Meeting
Patterns and Characteristics of Accelerated Hand Osteoarthritis: Data from the Osteoarthritis Initiative
Julie Davis¹, Lena Franziska Schaefer², Timothy E. McAlindon³, Charles B. Eaton⁴, Mary Roberts⁵, Ida K. Haugen⁶, Stacy Smith⁷, Jeffrey Duryea², Bing Lu⁸ and Jeffrey B. Driban¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁵Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, ⁶Diakonhjemmet Hospital, Oslo, Norway, ⁷Radiology/Division of Musculoskeletal Imaging & Intervention, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁸Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Epidemiology for hand osteoarthritis (OA) incidence is lacking and few large cohorts have sufficient size to explore subsets. We previously characterized a subset of…
Abstract Number: 2945 • 2017 ACR/ARHP Annual Meeting
Incident Hand OA Is Strongly Associated with Reduced Peripheral Blood Leukocyte Telomere Length
Timothy E. McAlindon¹, Mary Roberts², Lena Franziska Schaefer³, Jeffrey B. Driban⁴, Jeffrey Duryea³, Francisco J Blanco⁵, Jose-Luis Fernandez-Garcia⁶ and Charles Eaton⁷, ¹Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, ³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ⁶Genetic Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁷Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI
Background/Purpose: Hand OA (HOA) is a painful, destructive and deforming polyarticular disorder that impairs an individual’s ability to perform manipulative activities of daily life and…
Abstract Number: 2946 • 2017 ACR/ARHP Annual Meeting
Identifying Rapid Structural Disease Progression in Knee Osteoarthritis
Jamie E. Collins^1,2, Jeffrey N. Katz^2,3 and Elena Losina^1,2, ¹Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA
Background/Purpose: Knee OA is a heterogeneous disease, with some patients experiencing rapid deterioration and others experiencing slow disease progression. Identifying patients likely to experience rapid…
Abstract Number: 2947 • 2017 ACR/ARHP Annual Meeting
Do Bone Marrow Lesions Reactivate Endochondral Ossification Leading to Osteophyte Genesis? Data from the Osteoarthritis Initiative
Leticia Deveza¹, Laurence Teoh², Elena Ochoa-Albiztegui³, Ali Guermazi⁴, Frank Roemer^4,5 and David Hunter¹, ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ²Department of General Medicine, Middlemore Hospital, Auckland, New Zealand, Auckland, New Zealand, ³Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, New York, NY, ⁴Department of Radiology, Boston University School of Medicine, Boston, MA, USA, Boston, MA, ⁵Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Osteophytes are formed through reactivation of endochondral ossification. In adults, reactivation of endochondral ossification may occur in the context of fracture repair. As yet,…
Abstract Number: 2948 • 2017 ACR/ARHP Annual Meeting
Distinct Trajectories of Medial Fixed Joint Space Width Loss over Four Years of Follow-up Among Knees with and at Risk for Knee Osteoarthritis
C. Kent Kwoh^1,2, Di Ran^2,3, Erin L. Ashbeck² and Jeffrey Duryea⁴, ¹Division of Rheumatology, Department of Medicine, The University of Arizona, Tucson, AZ, ²The University of Arizona Arthritis Center, Tucson, AZ, ³Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, Tucson, AZ, ⁴Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA
Background/Purpose: Knee OA (KOA) is typically described as a slowly progressive disease, though it is recognized that some patients experience rapid structural deterioration. Identification of…
Abstract Number: 2949 • 2017 ACR/ARHP Annual Meeting
The Relation of Cumulative Load to Prevalent Cartilage Damage in the Knee
Dana Mathews¹, Tuhina Neogi², Joshua Stefanik², Ali Guermazi³, Frank Roemer³, Louise Thoma⁴, Hiral Master⁴, Meredith Christiansen⁴, Cora E. Lewis⁵, Michael C. Nevitt⁶, James Torner⁷ and Daniel White⁸, ¹Physical Therapy, Biomechanics and Movement Science, University of Delaware, Newark, DE, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Department of Radiology, Boston University School of Medicine, Boston, MA, USA, Boston, MA, ⁴Physical Therapy and Biomechanics and Movement Science, University of Delaware, Newark, DE, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷University of Iowa, Iowa City, IA, ⁸Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Cartilage damage, which is a precursor and feature of knee osteoarthritis (OA), has been linked to both obesity and excessive joint loading. Assessment of…
Abstract Number: 2950 • 2017 ACR/ARHP Annual Meeting
Validation of a Definition for Flare in Patients with Established Gout
Angelo L. Gaffo¹, Nicola Dalbeth², Kenneth Saag³, Jasvinder A. Singh⁴, Elizabeth J. Rahn¹, Amy S. Mudano⁵, Yi-Hsing Chen⁶, Ching-Tsai Lin⁷, Sandra Bourke², Worawit Louthrenoo⁸, Janitzia Vazquez-Mellado⁹, Hansel Hernández-Llinas¹⁰, Tuhina Neogi¹¹, Ana Beatriz Vargas-Santos¹², Geraldo Castelar-Pinheiro¹³, Rodrigo B. Chaves-Amorim¹³, Till Uhlig¹⁴, Hilde B Hammer¹⁴, Maxim Eliseev¹⁵, Fernando Perez-Ruiz¹⁶, Lorenzo Cavagna¹⁷, Geraldine M. McCarthy¹⁸, Lisa K. Stamp¹⁹, Martijin Gerritsen²⁰, Viktoria Fana²¹, Francisca Sivera²² and William J. Taylor²³, ¹Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Auckland, Auckland, New Zealand, ³Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Taichung Veterans General Hospital, Taichung, Taiwan, ⁷Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan, ⁸Div of Rheumatology, Dept of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁹Rheumatology, Hospital General de Mexico, Mexico City, Mexico, ¹⁰Hospital General de Mexico, Mexico City, Mexico, ¹¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ¹²Internal Medicine Department, Division of Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ¹³Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, Brazil, ¹⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ¹⁵V. A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation, ¹⁶Servicio de Reumatología, Vizcaya, Spain, ¹⁷Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ¹⁸Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ¹⁹University of Otago, Christchurch, New Zealand, ²⁰Westfries Gasthuis, Hoorn, Netherlands, ²¹Center for Rheumatology and Spine Diseases, Rigshospitalet , Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ²²Sección de Reumatología, Hospital General Universitario de Elda., Elda, Spain, ²³University of Otago, Wellington, New Zealand
Background/Purpose: A standardized validated definition for gout flares (or attacks) is not available. Two provisional definitions published in 2012 were based on patient-reported elements (patient-defined…

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