Abstracts Archive - Page 1567 of 2607 - ACR Meeting Abstracts

Abstract Number: 2696 • 2017 ACR/ARHP Annual Meeting
Things Left Unsaid: Important Topics That Are Not Discussed between Patients with Systemic Sclerosis, Their Carers and Their Healthcare Professionals
Christopher Denton¹, Bee Laird², Lizette Moros³ and José Luis Luna Flores⁴, ¹Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom, ²Reframe Research, East Sussex, United Kingdom, ³Boehringer-Ingelheim, Ingelheim, Germany, ⁴Boehringer Ingelheim, Ingelheim, Germany
Background/Purpose: Systemic sclerosis (SSc) is a serious rare condition that can be complicated by internal organ damage including interstitial lung fibrosis (SSc-ILD), which is a…
Abstract Number: 2697 • 2017 ACR/ARHP Annual Meeting
Systemic Sclerosis Quality of Life Questionnaire (SScQoL) Captures the Complex Problems Experienced By Patients with Scleroderma
Matylda Sierakowska¹, Stanislaw Sierakowski², Marzena Olesinska³, Marek Brzosko⁴, Piotr Leszczynski⁵, Katarzyna Pawlak-Bus⁵, Bogdan Batko⁶, Piotr Wiland⁷, Maria Majdan⁸, Malgorzata Bykowska-Sochacka⁹, Wojciech Romanowski¹⁰, Aleksandra Zon-Giebel¹¹, Slawomir Jeka¹² and Mwidimi Ndosi¹³, ¹Department of Integrated Medical Care, Medical University of Bialystok, Bialystok, Poland, ²Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Poland, Bialystok, Poland, ³Department of Connective Tissue Disease, National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, ⁴Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, ⁵Department of Rheumatology and Rehabilitation, Medical University in Poznan, Poznan, Poland, ⁶Center of Rheumatology, J. Dietl Hospital in Krakow, Krakow, Poland, ⁷Department and Clinic of Rheumatology and Internal Medicine, Medical University, Wroclaw, Poland, ⁸Department of Rheumatology and Connective Tissue Diseases, Medical University in Lublin, Lublin, Poland, ⁹Dr J. Titz-Kosko Regional Hospital for Rheumatic Diseases in Sopot, Sopot, Poland, ¹⁰Poznan Centre of Rheumatology in Srem, Srem, Poland, ¹¹Silesian Center of Rheumatology, Rehabilitation and Prevention of Disability, Ustron, Poland, ¹²2nd University Hospital, CM UMK, Department of Rheumatology and Connective Tissue Diseases,, Bydgoszcz, Poland, ¹³Department of Nursing and Midwifery, University of the West of England, Bristol, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is a chronic rheumatic disease that disturbs the patients’ biological, social, emotional spiritual, and physical functioning; resulting in reduced quality of…
Abstract Number: 2698 • 2017 ACR/ARHP Annual Meeting
IL-21-mTOR Axis Blocks the Differentiation and Function of SLE Tregs Via Suppression of Autophagy
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Mechanistic target of rapamycin (mTOR) activation has emerged as a prominent mediator of pro-inflammatory T-cell expansion and regulatory T (Treg) cell depletion in systemic…
Abstract Number: 2699 • 2017 ACR/ARHP Annual Meeting
Mosaic, a Novel Gene, Mediating Autoimmunity in Mice
Alice Chan¹, Mark Anderson², Hong-Erh Liang³ and Elizabeth Li², ¹Pediatrics, UCSF, San Francisco, CA, ²Diabetes Center, UCSF, San Francisco, CA, ³Department of Medicine, UCSF, San Francisco, CA
Background/Purpose: A novel candidate gene, Mosaic (Multi-Organ System Autoimmunity in Canines), was identified as the culprit causing an early and severe multiorgan autoimmunity in a…
Abstract Number: 2700 • 2017 ACR/ARHP Annual Meeting
Fra-2 Overexpression Leads to Systemic Autoimmunity By Affecting IL2 Dependent Treg Homeostasis
Florian Renoux¹, Mara Stellato¹, Daniela Impellizzieri², Alexander Vogetseder³, Przemyslaw Blyszczuk¹, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jörg Distler⁷, Gabriela Kania¹, Onur Boyman² and Oliver Distler⁸, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ³Department of Pathology, Cantonal Hospital Lucerne, Lucerne, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁸Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Fos-related antigen 2 (Fra-2) is a transcription factor belonging to the Fos family proteins which is part of the AP-1 transcription factor complex. We…
Abstract Number: 2701 • 2017 ACR/ARHP Annual Meeting
TNFR2+ Regulatory T Cellssubpopulations ARE Highly Suppressive and Are Increased on Anti-TNF Treatment
Francois Santinon¹, Maxime Batignes², Benoit Salomon³, Patrice Decker², Marie-Christophe Boissier⁴, Luca Semerano⁵ and Natacha Bessis², ¹INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, bobigny, France, ²INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ³Sorbonne Universités, UPMC Université Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France, ⁴Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, ⁵INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité and Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Rheumatology Department, France, Bobigny, France
Background/Purpose: In rheumatoid arthritis (RA), regulatory T cells (Tregs) are defective in their suppressive capacities and fail to control chronic inflammation. TNF-α is involved in…
Abstract Number: 2702 • 2017 ACR/ARHP Annual Meeting
Tissue-Invasive T Cells in Rheumatoid Arthritis
Cornelia M. Weyand¹, Yi Shen², Yinyin Li¹, Eric L. Matteson³, Stuart Goodman⁴ and Jorg Goronzy⁵, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁴Orthopaedic Surgery, Stanford Medical Center Outpatient Clinic, Redwood City, CA, ⁵Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: A key pathogenic event in rheumatoid arthritis (RA) is the formation of lasting lymphoid microstructures in the synovial tissue. It requires the transmigration of…
Abstract Number: 2703 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis of TCRs from CD8+ T Cells in Sjogren’s Syndrome
Michelle L. Joachims¹, Christina Lawrence¹, Richard C. Pelikan¹, Kerry M. Leehan¹, Lida Radfar², David M. Lewis³, Astrid Rasmussen¹, R. Hal Scofield¹, Kiely Grundahl¹, Kathy L. Sivils¹, Linda F. Thompson¹ and A. Darise Farris¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ³Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune exocrinopathy characterized by focal lymphocytic infiltration of the salivary and lacrimal glands, severe dry eyes and mouth, fatigue…
Abstract Number: 2704 • 2017 ACR/ARHP Annual Meeting
Skin Migratory Dendritic Cells Targeted and Tolerized By Calcitriol-Peptide Liposomes Supress Antigen-Specific Autoreactive T Cell Expansion and Memory Differentiation to Regulate Autoimmune Arthritis
Ryan Galea^1,2, Hendrik Nel^1,2, Meghna Talekar^1,2, Suzanne Cole³, Karyn Cochlin⁴, Shannon Hitchcock⁵, Bijun Zeng^1,2, Suman Yekollu^1,2, Jamie Rossjohn⁶, Hugh Reid⁷, Ravi Malaviya⁵, Dave Shealy⁸, Brendan O'Sullivan^1,2 and Ranjeny Thomas^1,2, ¹Dendright Pty Ltd, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, ³Immunology, Janssen Research and Development, Spring House, PA, ⁴Immunology, Janssen Research and Development, Springhouse, PA, ⁵Janssen Research and Development, Springhouse, PA, ⁶Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, ⁷Monash University, Melbourne, Australia, ⁸Janssen Research and Development, Spring House, PA
Background/Purpose: Current treatments to control autoimmune arthritis and vasculitis use broadly immunosuppressive drugs, associated with undesirable side effects. Antigen-specific immunological tolerance strategies are preferable to…
Abstract Number: 2705 • 2017 ACR/ARHP Annual Meeting
Aberrant Expression and Function of Human Circulating T Follicular Helper Cells and Its Subsets in IgG4 Related Disease
Yu Chen¹, Wen Zhang², Panpan Zhang³, Yanan Zhu¹ and Hongxian Yang³, ¹Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ²Rheuamtology, Peking Union Medical College Hospital, Beijing, China, ³rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
Background/Purpose: To study the expression and function of T follicular helper cells and its subsets in IgG4-related disease(IgG4-RD). Methods: Flow cytometry was performed to analyze…
Abstract Number: 2706 • 2017 ACR/ARHP Annual Meeting
T Follicular-Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren’s Syndrome Patients
Elena Pontarini¹, William Murray Brown², Cristina Croia², Elisa Corsiero³, Davide Lucchesi², Elisa Astorri², Nurhan Sutcliffe², Anwar Tappuni², Costantino Pitzalis⁴ and Michele Bombardieri⁵, ¹William Harvey Research Institute, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom, ³Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: Lymphocytic aggregates in the salivary glands (SG) of Sjögren’s syndrome (SS) can organize in ectopic lymphoid structures (ELS) forming functional germinal centers (GCs), which…
Abstract Number: 2707 • 2017 ACR/ARHP Annual Meeting
Estrogen Downregulates the Expression of Serine Arginine Splicing Factor 1 (SRSF1) in Human T Lymphocytes
Elena N. Cravens¹, Takayuki Katsuyama¹, Andrew R. Gillooly², George C. Tsokos¹ and Vaishali R. Moulton¹, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multifactorial etiopathogenesis that primarily afflicts women in the childbearing years. Hormones especially estrogen are…
Abstract Number: 2708 • 2017 ACR/ARHP Annual Meeting
Placental Growth Factor Regulates the Generation of T-Helper 17 Cells to Link Angiogenesis with Autoimmunity
Seung-Ah Yoo Sr.¹, Min-cheol Kang Sr.², Mingyo Kim Sr.³, Jin-Sun Kong Sr.¹, Ki-Myo Kim Sr.¹, junghee Koh Sr.¹, Chul-Soo Cho⁴, Seung-Hyo Lee Sr.⁵, Zae Young Ryoo Sr.⁶ and Wan-Uk Kim Sr.^1,7, ¹The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ²School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, seoul, Korea, Republic of (South), ³Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, seoul, Korea, Republic of (South), ⁴Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁵Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, SEOUL, Korea, Republic of (South), ⁶School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, SEOUL, Korea, Republic of (South), ⁷The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: T-helper (Th) cells actively communicate with adjacent cells by secreting soluble mediators, and yet crosstalk between Th cells and endothelial cells is poorly understood.…
Abstract Number: 2709 • 2017 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target for Patients with Rheumatoid Arthritis
Lisa Goschl^1,2, Michael Bonelli³, Victoria Saferding⁴, Teresa Peglej², Sylvia Knapp⁵, Johan Bäcklund⁶, Christoph Bock⁵, Patrick Matthias⁷, Kiyoshi Hirahara⁸, Clemens Scheinecker¹, Günter Steiner⁹, Josef S. Smolen¹ and Wilfried Ellmeier², ¹Medical University of Vienna, Devision of Rheumatology, Vienna, Austria, ²Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Austria, Vienna, Austria, ⁵CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ⁶Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁷Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ⁸Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan, ⁹Medical University of Vienna, Dvision of Rheumatology, Vienna, Austria
Background/Purpose: Autoreactive T cells drive the inflammatory process, which leads to an irreversible destruction of the joints. Gene transcription and regulation of proinflammatory cytokine production…
Abstract Number: 2710 • 2017 ACR/ARHP Annual Meeting
CXCR3+CCR6+CD4+ T Cells (Th1Th17) and RF As Novel Predictive Markers for Clinical Response to Abatacept Treatment in Patients with Rheumatoid Arthritis: The 52-Week Analysis
Koji Mishima¹, Shunichiro Ota², Kazuhiko Higashioka¹, Tsuyoshi Nakayama³, Masahiro Ayano¹, Yasutaka Kimoto⁴, Hiroki Mitoma¹, Mitsuteru Akahoshi¹, Yojiro Arinobu¹, Yasushi Inoue⁵, Kensuke Oryoji⁶, Takuya Sawabe⁷, Shuji Nagano⁸, Hiroaki Nishizaka⁹, Seiji Yoshizawa¹⁰, Shigeru Yoshizawa¹¹, Takeshi Otsuka¹², Akira Ueda¹³, Yoshifumi Tada¹⁴, Hitoshi Nakashima¹⁵, Takahiko Horiuchi¹⁶, Koichi Akashi¹ and Hiroaki Niro³, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Rheumatology, Shimonoseki City Hospital, Yamaguchi, Japan, ³Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ⁵Department of Rheumatology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan, ⁶The Center for Rheumatology, Matsuyama Red Cross Hospital, Ehime, Japan, ⁷Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan, ⁸Center for Rheumatology, Iizuka Hospital, Fukuoka, Japan, Iizuka City, Japan, ⁹Kitakyushu Municipal Medical Center, Kitakyushu, Japan, ¹⁰Hamanomachi Hospital, Fukuoka, Japan, ¹¹Department of Rheumatology, Fukuoka Hospital, National Hospital Organization, Fukuoka, Japan, ¹²Munakata Medical Association Hospital, Munakata, Japan, ¹³Department of Internal Medicine, Miyazaki Prefectural Hospital, Miyazaki, Japan, ¹⁴Rheumatology, Saga University, Saga, Japan, ¹⁵Div of Nephrol & Rheumatol, Dept of Int Med, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, ¹⁶Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: The advent of biological therapy has made a remarkable progress in the management of rheumatoid arthritis (RA). Abatacept (ABA), a non-TNF inhibitor, is a…

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