Abstract Number: 2636 • 2017 ACR/ARHP Annual Meeting
EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion through Junctional Adhesion Molecule-a in Lupus Patients
Background/Purpose: EZH2 is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and modulates DNA methylation patterns. We have previously suggested that EZH2…Abstract Number: 2637 • 2017 ACR/ARHP Annual Meeting
A Novel Regulatory Antigen Presenting B Cell and Memory Regulatory T Cell Subsets Are Enriched during the Quiescent Phase of Childhood Onset Systemic Lupus Erythematosus
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multi-factorial disease and the conventional oligo-dimensional investigative approach involving one or a few cell subsets at a time…Abstract Number: 2638 • 2017 ACR/ARHP Annual Meeting
Inducible cAMP Early Repressor Promotes Glycolysis By Inhibiting the Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 in Th17 Cells
Background/Purpose: Th17 cells are key players in SLE. Because Th17 cells use mainly glycolysis, blocking glycolysis can inhibit Th17 cell differentiation and treatment of lupus-prone…Abstract Number: 2639 • 2017 ACR/ARHP Annual Meeting
Pathological Relevance of T Follicular Helper Cell and Plasmablast in Patients with Systemic Lupus Erythematosus
Background/Purpose: Increasing evidence points to immunological heterogeneity in the pathogenesis of SLE. Indeed, targeted therapy for SLE showed considerable variability of efficacy. Thus, it seems…Abstract Number: 2640 • 2017 ACR/ARHP Annual Meeting
Response Gene to Complement-32 Expression Is Upregulated in Lupus T Cells and Promotes IL-17A Expression
Background/Purpose: RGC (Response Gene to Complement)-32 is a cell cycle regulator widely expressed in normal tissues including brain, kidney, spleen, thymus, multiple tumors and in…Abstract Number: 2641 • 2017 ACR/ARHP Annual Meeting
Immune Complex-Driven Neutrophil Activation in Systemic Lupus Erythematosus – Novel Biomarkers of Disease Activity and Severity
Background/Purpose: Neutrophil activation is linked to inflammation and autoimmune diseases, including systemic lupus erythematosus (SLE) where nucleic acid-containing immune complexes (ICs) drive inflammation through engagement…Abstract Number: 2642 • 2017 ACR/ARHP Annual Meeting
Lupus Serum Induces Glomerular Endothelial Cell Neutrophil Adhesion in Association with Soluble Mediators of Chemotaxis and Adhesion
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with endothelial dysfunction, which can accelerated inflammation. Ingress of neutrophils into tissue requires chemotaxis and adhesion to endothelial…Abstract Number: 2643 • 2017 ACR/ARHP Annual Meeting
HO-1 Expression in Monocytes Might Regulate Kidney Damage in Lupus Nephritis Patients
Background/Purpose: It is well established that up to 70% of systemic lupus erythematosus (SLE) patients will develop Lupus Nephritis (LN). Recent studies have revealed that…Abstract Number: 2644 • 2017 ACR/ARHP Annual Meeting
Increased Toll-like Receptor 7 Expression Promotes B Cell Abnormalities and Skewing of Cytokine and Autoantibody Profiles in SLE Patients
Background/Purpose: Toll-like receptor 7 (TLR7) is implicated in the production of type I IFNs and the activation of B cells in systemic lupus erythematosus (SLE).…Abstract Number: 2645 • 2017 ACR/ARHP Annual Meeting
The Internalization of DNA-Antibodies By Podocytes during Lupus Nephritis
Background/Purpose: Podocytes are postmitotic visceral epithelial cells, located at the Bowmans capsule of the kidney building up the slit diaphragm with their foot processes to…Abstract Number: 2646 • 2017 ACR/ARHP Annual Meeting
Premature Senescence of Naive CD4+ T-Cells in Systemic Lupus Erythematosus
Background/Purpose: The pool of naïve CD4+ T-cells is reduced in patients suffering from systemic lupus erythematosus (SLE). We aimed to study if the occurrence of…Abstract Number: 2647 • 2017 ACR/ARHP Annual Meeting
Epstein Barr Virus Interluekin-10 (vIL10) in Systemic Lupus Erythematosus
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibody production and periods of elevated and suppressed disease activity. Various genetic and…Abstract Number: 2648 • 2017 ACR/ARHP Annual Meeting
The SLE Risk Variant, Reference Single Nucleotide Polymorphism (rs)10499197, Upstream of Tumor Necrosis Factor Alpha-Induced Protein 3 (TNFAIP3) Modulates Enhancer Function and TNFAIP3 Gene Expression
Background/Purpose: Genome Wide Association studies (GWAS) have identified several variants in the tumor necrosis factor alpha-induced protein 3 (TNFAIP3) gene associated with autoimmune disease. TNFAIP3…Abstract Number: 2649 • 2017 ACR/ARHP Annual Meeting
Anti-Suprabasin Antibody; A Novel Autoantibody May Contribute to the Pathogenesis of Neuropsychiatric Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE), an autoimmune disorder characterized by the production of pathogenic autoantibodies and inflammatory mediators, involves multiple organ systems. Neuropsychiatric systemic lupus…Abstract Number: 2650 • 2017 ACR/ARHP Annual Meeting
Analysis of C9Orf72 Expansions in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: Preliminary Data
Background/Purpose: The most frequent genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Dementia (FTLD) is a large hexanucleotide expansion (>30, mostly hundred/thousand repeats)…
ACR Meeting Abstracts