Abstracts Archive - Page 1554 of 2425 - ACR Meeting Abstracts

Abstract Number: 2051 • 2016 ACR/ARHP Annual Meeting
Risk Factors for Cardiovascular Disease Predate the Onset of Symptoms of Rheumatoid Arthritis
Heidi Kokkonen¹, Lisbeth Ärlestig² and Solbritt Rantapää-Dahlqvist^3,4, ¹Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, ²Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ³Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, ⁴Rheumatology, Umeå University, Umeå, Sweden
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of developing cardiovascular (CV) comorbidity compared with the general population. Contradictory results concerning CV disease…
Abstract Number: 2052 • 2016 ACR/ARHP Annual Meeting
Preoperative Timing of Infliximab and Risk of Post-Operative Infection in a Medicare Cohort
Michael D. George¹, Joshua F. Baker¹, Jesse Yenchih Hsu², Qufei Wu³, Fenglong Xie⁴, Lang Chen⁴, Huifeng Yun⁵ and Jeffrey Curtis⁶, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Biostatistics, University of Pennsylvania, Philadelphia, PA, ³Biostatistics and Analysis Center, University of Pennsylvania, Philadelphia, PA, ⁴Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ⁶Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Patients taking biologic DMARDs often undergo elective surgery, but data to guide if and when to hold biologics before surgery is limited. This study…
Abstract Number: 2053 • 2016 ACR/ARHP Annual Meeting
Prosthetic Joint Infection with Staphylococcus Aureus: Recurrence after Surgical Treatment in U.S. Veterans with and without Rheumatoid Arthritis
Namrata Singh¹, Rajeshwari Nair², Michihiko Goto³, Elizabeth Field^4,5, Petar Lenert⁶, Ryan Carnahan⁷, Marin Schweizer² and Eli Perencevich², ¹Internal Medicine, University of Iowa Hospitals and Clinics and Iowa City VA, Iowa City, IA, ²Internal Medicine, Iowa City VA, Iowa City, IA, ³Iowa city VA and UIHC, Iowa City, IA, ⁴10e-01 Building 1 Vamc, University of Iowa, Iowa City, IA, ⁵Iowa City VA, Iowa City, IA, ⁶333 MRC Dept of Internal Med, University of Iowa, Iowa City, IA, ⁷Epidemiology, College of public health, UI, Iowa City, IA
Background/Purpose: Studies have shown rheumatoid arthritis (RA) to be a risk factor for development of prosthetic joint infections (PJI) and for worse outcome from PJI…
Abstract Number: 2054 • 2016 ACR/ARHP Annual Meeting
Effect of Temporary Methotrexate Discontinuation on Efficacy of Seasonal Influenza Vaccination in Patients with Rheumatoid Arthritis: A Randomized Clinical Trial
Jin Kyun Park¹, Min Ah Lee Lee², Kyung Hee Lee², Eun Young Lee¹, Yeong Wook Song³, Yunhee Choi⁴, Kevin L. Winthrop⁵ and Eun Bong Lee⁶, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ²Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, The Republic of, ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea, ⁴Division of Medical Statistics, Medical Research Collaborating Center, Seoul National University College of Medicine, Seoul, Korea, The Republic of, ⁵Oregon Health and Sciences University, Portland, OR, ⁶Seoul National University, Seoul, Korea, Republic of
Background/Purpose: Patients with rheumatoid arthritis (RA) are at a higher risk of infection due to the underlying immune dysfunction and immune suppression associated with treatment.…
Abstract Number: 2055 • 2016 ACR/ARHP Annual Meeting
Myocardial Abnormalities Are Associated with Corrected QT Interval in Patients with Rheumatoid Arthritis without Cardiac Symptoms Assessed Using Cardiac Magnetic Resonance Imaging
Yasuyuki Kobayashi¹, Hitomi Kobayashi², Atsuma Nishiwaki³, Kaita Sugiyama³, Yosuke Nagasawa⁴, Takamasa Nozaki², Noboru Kitamura⁵, Masami Takei⁴, Natsumi Ikumi⁶ and Hirotake Inomata³, ¹Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, ²Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ³Nihon University School of Medicine, Tokyo, Japan, ⁴Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ⁵Hematology and Rheumatology, NIhon University School of Medicine, Tokyo, Japan, ⁶Nihon University School of Medicine, Shinjuku, Japan
Background/Purpose: Individuals with rheumatoid arthritis (RA) have two-fold higher risk of sudden death than age- and sex-matched controls without RA. We hypothesized that myocardial abnormalities…
Abstract Number: 2056 • 2016 ACR/ARHP Annual Meeting
Choroid Plexus Infiltrates in Lupus Model (MRL/lpr) Mice Represent Tertiary Lymphoid Structures, Shedding Light on the Immunological Mechanisms of Neuropsychiatric Lupus
Ariel Stock¹, Sivan Gelb², Ayal Ben-Zvi² and Chaim Putterman³, ¹Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Hebrew University, Jerusalem, Israel, ³Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: MRL/lpr mice develop an overt neuropsychiatric phenotype including depression and cognitive dysfunction, similar to diffuse neuropsychiatric manifestations of human lupus. Additionally, MRL/lpr mice display…
Abstract Number: 2057 • 2016 ACR/ARHP Annual Meeting
TLR-7-Mediated Lupus Nephritis Flares Are Independent of Type I Interferon Signaling
Sonya Wolf¹, Tamra J. Reed², Chaim O. Jacob³ and J. Michelle Kahlenberg⁴, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ³Medicine/Div of Rheumatology, USC School of Medicine, Los Angeles, CA, ⁴Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the formation of autoantibodies, immune complex deposition, elevated production of type I interferons (IFNs),…
Abstract Number: 2058 • 2016 ACR/ARHP Annual Meeting
Ectonucleotidase-Mediated Protection of Lupus Mice from Exaggerated Immune Responses and Arterial Vasculopathy
Jason S Knight¹, Levi F Mazza¹, Srilakshmi Yalavarthi¹, Yogen Kanthi² and David J Pinsky², ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD39 and CD73 are so-called ectonucleotidases, surface enzymes expressed by leukocytes and endothelial cells that jut into the extracellular space. There, they mediate the…
Abstract Number: 2059 • 2016 ACR/ARHP Annual Meeting
Serine/Arginine-Rich Splicing Factor 1 (SRSF1) Is a Novel Factor in T Cell Homeostasis and Its Selective Loss in T Cells Causes Autoimmunity and Lupus-like Nephritis
Vaishali R. Moulton¹, Hao Li², Michael W. Mosho², Andrew R. Gillooly², Meghan L. Keane³ and George C. Tsokos⁴, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) express reduced amounts of the critical CD3 zeta signaling chain, and produce low levels of…
Abstract Number: 2060 • 2016 ACR/ARHP Annual Meeting
Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses
FuNien Tsai¹, Carla Cuda², Harris R. Perlman³, Philip J. Homan⁴, Salina Dominguez², Alexander Shaffer³, George Kenneth Haines III⁵ and Jack Hutcheson⁶, ¹Medicine-Rheumatology, Northwestern University-Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, IL, ³Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Medicine-Rheumatology, Northwestern University, Chicago, IL, ⁵Mount Sinai, New York, NY, ⁶UT Southwestern, Dallas, TX
Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…
Abstract Number: 2061 • 2016 ACR/ARHP Annual Meeting
Successful Treatment of Murine Lupus Nephritis with Helminths Related Tuftsin-Phosphorylcholine Compound and Its Effect on the Microbiota
Yehuda Shoenfeld¹, Tomer Bashi², Hadar Gershon³, Or Givol⁴, Alexander Volkov⁵, Iris Barshack⁵, Mati Fridkin⁶, Miri Blank² and Omry Koren⁷, ¹Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, ²Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ³Sefat Medical School, Bar-Ilan University, Sefat, Israel, ⁴Zabludowicz Center for Autoimmune Diseases, Ramat Gan, Israel, ⁵Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ⁶Organic chemistry, Weizmann Institute for Sciences, Rehovot, Israel, ⁷Sefat medical school, Bar-Ilan university, Sefat, Israel
Background/Purpose: , In areas where helminths infections are common, autoimmune diseases are rare. Treatment with helminthes and their ova, improved clinical findings of inflammatory bowel…
Abstract Number: 2062 • 2016 ACR/ARHP Annual Meeting
Increased Expression of Response Gene to Complement-32 in Kidney Biopsies from Patients with Lupus Nephritis
Julie Yip¹, Vinh Nguyen², Alexandru Tatomir^3,4, Armugam Mekala^4,5, Dallas Boodhou⁴, Horea Rus^3,4, Cinthia Drachenberg⁶ and Violeta Rus^5,7, ¹Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD, ²Medicine, University of Maryland School of Medicine, Baltimore, MD, ³Neurology, Research Service, VAMHCS, Baltimore, MD, ⁴Neurology, University of Maryland School of Medicine, Baltimore, MD, ⁵Research Service, VAMHCS, Baltimore, MD, ⁶Pathology, University of Maryland School of Medicine, Baltimore, MD, ⁷Medicine/Rheum & Clinc Immun, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: RGC (Response Gene to Complement)-32 is a cell cycle regulator widely expressed in normal tissues including brain, kidney, spleen, thymus, multiple tumors and in…
Abstract Number: 2063 • 2016 ACR/ARHP Annual Meeting
Identification of Microrna Predictive of Outcome in Lupus Nephritis
Mohammad Hadavand¹, Nada Binmadi², Hua Zhou³, Mayank Tandon⁴, Sarfaraz Hasni⁵ and Illias Alevizos⁶, ¹National Institute of Dental and Craniofacial Research, Bethesda, MD, ²Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, ³Molecular Physiology and Therapeutics Branch,, National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/NIH, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
Background/Purpose: High dose corticosteroids such as cyclophosphamide are commonly used to treat lupus nephritis (LN). Although effective in preventing end stage renal disease (ESRD)…
Abstract Number: 2064 • 2016 ACR/ARHP Annual Meeting
Blood and Kidney Molecular Profiles Distinguish Subjects with Lupus Nephritis from Other Kidney Disorders
Matteo Cesaroni¹, Jarrat Jordan¹, Marc Chevrier², Alan Perlman³, James M. Chevalier⁴, Thomas Parker³, Daniel Levine³, Surya V. Seshan⁵, Anna Gong⁶, Takahiro Sato¹ and Jacqueline Benson¹, ¹Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ²Janssen Research and Development, LLC, Collegeville, PA, ³The Rogosin Institute,New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY, ⁴Nephrology, The Rogosin Institute New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, ⁵Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁶The Rogosin Institute,New York Presbyterian Hospital-Weill Medical College of Cornell University, new york, NY
Background/Purpose: Kidney biopsy remains the gold standard for diagnosis and staging of Lupus Nephritis (LN). Although kidney biopsies are commonly performed in the clinical setting,…
Abstract Number: 2065 • 2016 ACR/ARHP Annual Meeting
Platelet FcγRIIa Polymorphism H131R Associates with Subclinical Atherosclerosis and Increased Platelet Activity in SLE
Sara Rasmussen¹, Harmony Reynolds², Jill P. Buyon³, Sokha Nhek⁴, Jonathan Newman³, Jeffrey Berger⁵ and Robert M Clancy¹, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Cardiology, New York University School of Medicine, New York, NY, ³Medicine, New York University School of Medicine, New York, NY, ⁴New York University School of Medicine, New York, NY, ⁵Medicine, Division of Cardiology, New York University School of Medicine, New York, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by heterogeneity of presentation, an undulating course, and elevated risk for premature cardiovascular disease.…

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