ACR Meeting Abstracts

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  • Abstract Number: 1960 • 2016 ACR/ARHP Annual Meeting

    2015 ACR/ARHP Workforce Study in the U.S.: The Role of Graduate Medical Education (GME) in Adult Rheumatology

    Marcy Bolster1, Anne R. Bass2, Jonathan S. Hausmann3, Marcia Ditmyer4, Seetha Monrad5 and Daniel Battafarano6, 1Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 2Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, 3Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, 4Academy for Academic Research, Las Vegas, NV, 5Internal Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, 6Medicine, San Antonio Military Medical Center, San Antonio, TX

    2015 ACR/ARHP Workforce Study in the U.S.: The Role of Graduate Medical Education (GME) in Adult Rheumatology  Background/Purpose: The 2015 ACR/ARHP Workforce Study provides a…
  • Abstract Number: 1961 • 2016 ACR/ARHP Annual Meeting

    Identification of Novel Genetic Susceptibility Loci in Primary Antiphospholipid Syndrome

    Elizabeth Gensterblum1, Travis Hughes2, Manuel Martínez-Bueno3, Maria Orietta Borghi4, Guillermo J. Pons-Estel5, Gerard Espinosa6, Alexandra Zhernakova7, Cisca Wijmenga8, Ricard Cervera5, Pier Luigi Meroni9, Marta Alarcón-Riquelme3,10 and Amr Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, 3Center for Genomics and Oncological Research (GENYO), Pfizer-University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain, 4University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, 5Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, 6Autoimmune Diseases Department. Hospital Clínic de Barcelona, Barcelona, Spain, 7Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, Netherlands, 8Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, 9Hospital G.Pini, University of Milano, IRCSS Instute Auxologico Italiano, Milan, Italy, 10Unit for Chronic Inflammatory Diseases, Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose:  Antiphospholipid syndrome (APS) is an autoimmune disease with incompletely understood etiology, characterized by recurrent thrombosis and pregnancy complications. We conducted this study to understand…
  • Abstract Number: 1962 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Neutrophils Are Characterized By Overexpression of P-Selectin Glycoprotein Ligand 1, a Potential Therapeutic Target

    Jason S Knight1, Patrick S. Coit1, He Meng1, Srilakshmi Yalavarthi1, Paul Renauer1, Robert C Grenn1, Levi F Mazza1, Hui Wang2, Daniel T Eitzman2 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI

    Background/Purpose:  Treatment of the thrombotic manifestations of antiphospholipid syndrome (APS) primarily focuses on inhibiting clotting pathways. In an effort to identify upstream inflammatory targets that…
  • Abstract Number: 1963 • 2016 ACR/ARHP Annual Meeting

    Thrombospondin-1 Is Elevated in the Plasma of Patients with Antiphospholipid Syndrome and Is Correlated with Free Active TGF-b1 Levels, IL-1b and IL-17A

    Markos Patsouras, Athanasios G. Tzioufas and Panayiotis G Vlachoyiannopoulos, School of Medicine, Pathophysiology Department, National and Kapodistrian University of Athens, Athens, Greece

    Background/Purpose: Antiphospholipid syndrome (APS) is an acquired thombophillia characterized by recurrent thromboembolism and pregnancy morbidity. Thrombospondin (TSP-1) is a matricellular glycoprotein secreted by platelets upon…
  • Abstract Number: 1964 • 2016 ACR/ARHP Annual Meeting

    The Frequency and Clinical Significance of IgA Anticardiolipin and Anti-β2-Glycoprotein-I Antibodies in Antiphospholipid Antibody Patients with and without Lupus

    Ayten Yazici1,2, OZAN UNLU3, Cecilia B. Chighizola4, Doruk Erkan5, Michelle Petri6 and On Behalf of APS ACTION .7, 1Hospital for Special Surgery, Cornell Weill Cornell Medicine, NEW YORK CITY, NY, Turkey, 2Rheumatology, Kocaeli University School of Medicine, Kocaeli, Turkey, 3Rheumatology Department, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 4Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, 5Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 6Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, 7., New York, NY

    Background/Purpose: APS ACTION International Clinical Database and Repository was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive…
  • Abstract Number: 1965 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Alliance for Clinical Trials & International Networking Registry Analysis: First and Recurrent Thrombosis Risk after 720 Patient-Years of Follow-up

    Ozan Unlu1, W. David Branch2, Paul R. Fortin3, Maria Gerosa4, Guillermo J. Pons-Estel5, Maria Tektonidou6, Amaia Ugarte7, Doruk Erkan8 and On Behalf of APS ACTION .9, 1Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 2Obstetrics and Gynecology, University of Utah and Intermountain Healthcare, Salt Lake City, UT, 3Medicine, CHU de Québec - Université Laval, Québec, QC, Canada, 4University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, 5Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, 6First Department of Internal Medicine, School of Medicine, National University of Athens, Athens, Greece, 7Hospital Universitario Cruces, Biscay, Spain, 8Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 9., New York, NY

    Background/Purpose: APS ACTION Registry was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients. Previously, based on…
  • Abstract Number: 1966 • 2016 ACR/ARHP Annual Meeting

    Antibodies Against Domain 1 and Domain 4/5 of β2 Glycoprotein I: Clinical Relevance in Obstetric Anti-Phospholipid Syndrome

    Cecilia B. Chighizola1, Laura Andreoli2,3, Marta Tonello4, Maria Gabriella Raimondo5, Francesca Pregnolato6, Cecilia Nalli7, Elena Mattia8, Laura Cesana9, Rajesh Kumar7, Chiara Comerio10, Claudia Grossi9, Francesco Mombelli11, Maria Gerosa12, Maria Orietta Borghi13, Amelia Ruffatti14, Angela Tincani15 and Pier Luigi Meroni16, 1Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, 2Rheumatology & Clinical Immunology, University of Brescia/Spedali Civili, Brescia, Italy, 3University of Brescia, Spedali Civili, Brescia, Italy, 4Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padova, Italy, 5University of Milan, Istituto Ortopedico Gaetano Pini, Milan, Italy, 6IRCCS Istituto Auxologico Italiano, Milano, Italy, 7Spedali Civili, Brescia, Italy, 8Azienda Ospedaliera of Padova, Padua, Italy, 9IRCCS Istituto Auxologico Italiano, Milan, Italy, 10University of Milan, Milan, Italy, 11University of Brescia, Brescia, Italy, 12University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, 13University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, 14Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, 15Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 16Rheumatology Department, University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy

    Background/Purpose: The domain reactivity of antibodies against b2 glycoprotein I (anti-b2GPI) has been investigated in patients with thrombotic anti-phospholipid syndrome (APS), leading to the identification…
  • Abstract Number: 1967 • 2016 ACR/ARHP Annual Meeting

    Depression Is a Risk Factor for Low Treatment Adherence in African American People with Systemic Lupus Erythematosus

    Cristina Drenkard1, Sonia Mathew2, Gaobin Bao3 and S. Sam Lim3, 1Emory University School of Medicine, Atlanta, GA, 2Mercer School of Medicine, Macon, GA, 3Medicine, Emory University School of Medicine, Atlanta, GA

    Background/Purpose: African American (AA) people with Systemic Lupus Erythematosus (SLE) are at high risk for severe disease and depression, and often require complex medication regimes.…
  • Abstract Number: 1968 • 2016 ACR/ARHP Annual Meeting

    Adverse Childhood Experiences and Outcomes of Systemic Lupus Erythematosus

    Laura Trupin1, Patricia P. Katz1, Cristina Lanata1, Edward H. Yelin1, Lindsey A. Criswell1, Charles G. Helmick2, Jinoos Yazdany1 and Maria Dall'Era1, 1Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 2National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: Adverse childhood experiences such as extreme deprivation, neglect, abuse, parental separation or incarceration, have been associated with adult health status, including onset of rheumatic…
  • Abstract Number: 1969 • 2016 ACR/ARHP Annual Meeting

    Peer Approaches to Lupus Self-Management (PALS): A Novel Lupus Peer Mentorship Intervention

    Edith M. Williams1, Leonard Egede2, Jim Oates3, Delia Voronca2 and Mulugeta Gebregziabher2, 1Public Health Sciences, Medical University of South Carolina, Charleston, SC, 2Medical University of South Carolina, Charleston, SC, 3Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that is associated with increased morbidity, mortality, health care costs and decreased quality of life.…
  • Abstract Number: 1970 • 2016 ACR/ARHP Annual Meeting

    Disparities in Access to Specialist Care at the Time of Diagnosis of Systemic Lupus Erythematosus

    Lisa Gaynon1, Patricia P. Katz2, Maria Dall'Era3, Laura Trupin2, Lindsey A. Criswell4, Cristina Lanata4, Charles Hemlick5 and Jinoos Yazdany2, 1Internal Medicine, California Pacific Medical Center, San Francisco, CA, 2Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 3Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 4Division of Rheumatology, UCSF, San Francisco, CA, 5Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: Disparities in outcomes among racial/ethnic minorities and individuals with low socioeconomic status with systemic lupus erythematosus (SLE) have been well reported. The degree to…
  • Abstract Number: 1971 • 2016 ACR/ARHP Annual Meeting

    Predictors of Delays to Care and Associated Outcomes in Pediatric Lupus Patients from the Childhood Arthritis and Rheumatology Research Alliance Registry

    Tamar Rubinstein1,2, Norman Ilowite3,4 and Dawn Wahezi5,6, 1Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, 2Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, 3Division of Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, 4Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 5Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 6Pediatric Rheumatology, The Children's Hospital at Montefiore, Bronx, NY

    Background/Purpose:  CARRA registry data for participants meeting ACR classification criteria for lupus were analyzed. Delays of one month, 3 months, and one year from symptom…
  • Abstract Number: 1972 • 2016 ACR/ARHP Annual Meeting

    Creatine Kinase in the United States Population: Impact of Demographics, Comorbidities and Body Composition on the Normal Range

    Neilia-Kay McGill, Joshua F. Baker and Michael D. George, Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The accurate interpretation of creatine kinase (CK) values is critical as this laboratory measure guides the workup of suspected myopathies. Incidentally discovered CK elevation…
  • Abstract Number: 1973 • 2016 ACR/ARHP Annual Meeting

    Intramuscular Versus Ultrasound Guided Peritendinous Glucocorticoid Injection for Tenosynovitis in Patients with Rheumatoid Arthritis – a Randomised, Double-Blind, Controlled Study

    Mads Ammitzbøll-Danielsen1,2, Mikkel Ostergaard2,3, Viktoria Fana4, Daniel Glinatsi2,5, Uffe Møller Døhn6, Lykke Midtbøll Ørnbjerg7, Esperanza Naredo8 and Lene Terslev6, 1Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, 2Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 3Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 4Center for Rheumatology and Spine Diseases, Rigshospitalet , Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, 5Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Glostrup, Denmark, 6Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, 7Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 8Rheumatology, Hospital General Universitario Gregorio Marañón and Universidad Complutense, Madrid, Spain

    Background/Purpose:                                                              The aim of this study was to compare the efficacy of intramuscular versus ultrasound (US)-guided peritendinous glucocorticoid injection in providing disease control after…
  • Abstract Number: 1974 • 2016 ACR/ARHP Annual Meeting

    Is Ultrasound of the Hands Enough to Reveal Ongoing Subclinical Inflammation in Rheumatoid Arthritis Patients in Clinical Remission According to Composite Scores?

    Hilde Berner Hammer1, Tore K Kvien2 and Lene Terslev3, 1Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark

    Background/Purpose: Several studies have shown the presence of subclinical inflammation by ultrasound (US) in rheumatoid arthritis (RA) patients despite clinical remission according to clinical composite…
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