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  • Abstract Number: 2411 • 2017 ACR/ARHP Annual Meeting

    In-Hospital Risk of Asthma in Patients with Rheumatoid Arthritis: A Cross-Sectional Nationwide Analysis

    Yiming Luo1, Jiehui Xu2, Yumeng Wen1, Alvaro Ramos-Rodriguez3, Changchuan Jiang1, Shuyang Fang1, Mustafa Kagalwalla1 and Neha Ohri4, 1Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, 3Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, 4Division of Rheumatology, Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) and asthma are both chronic inflammatory disorders. Lung pathology is a well-known extra-articular manifestation of RA and previous studies have shown…
  • Abstract Number: 2412 • 2017 ACR/ARHP Annual Meeting

    Mortality and Clinical Features in Rheumatoid Arthritis and Interstitial Lung Disease

    Cristina Vadillo Font1, Maria Asunción Nieto2, Leticia Leon3, Luis Rodriguez-Rodriguez4, Judit Font Urgelles1, Esperanza Pato Cour1, Juan Angel Jover5 and Lydia A Alcazar6, 1Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 2Pneumology. Hospital Clínico San Carlos, MD PhD, Madrid, Spain, 3Rheumatology, Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 4Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 5Rheumatology. Hospital Clínico San Carlos, MD PhD, Madrid, Spain, 6Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain

    Background/Purpose: Interstitial lung disease (ILD) is the most common extra-articular manifestation in Rheumatoid Arthritis (RA) generating higher mortality in these patients. The objective is to…
  • Abstract Number: 2413 • 2017 ACR/ARHP Annual Meeting

    Assessment of the Most Distal Sensory Nerves in Patients with Rheumatoid Arthritis with Normal Value of Standard Nerve Conduction Studies

    Kyung Min Ko1, Sun Im2 and Su-Jin Moon3, 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 2Bucheon St. Mary's Hospital, College of Medicine, The Catholc University of Korea, Bucheon, Korea, Republic of (South), 3Bucheon St. Mary's Hospital, Division of rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Bucheon, Korea, Republic of (South)

    Background/Purpose: Although it is generally accepted that peripheral neuropathy can occur in patients with rheumatoid arthritis (RA), most previous studies were conducted in RA patients…
  • Abstract Number: 2414 • 2017 ACR/ARHP Annual Meeting

    Knowledge and Adherence to Current Immunization Recommendations in Patients with Rheumatoid Arthritis in Mexico

    Andrea Sofia Cepeda-Perez1, Nina Tello Winniczuk2 and Alejandro Diaz-Borjon2, 1Internal Medicine, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico, 2Internal Medicine and Rheumatology, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico

    Background/Purpose: Patients with RA have a two to four-fold increased risk of developing infections than the general population. This is due to both, the disease…
  • Abstract Number: 2415 • 2017 ACR/ARHP Annual Meeting

    Immunogenicity and Persistence of a Prime-Boost Re-Vaccination Strategy for Pneumococcal Vaccines (13-Valent Pneumococcal Conjugate Vaccine + 23-Valent Pneumococcal Polysaccharide Vaccine) in Patients with Rheumatoid Arthritis: A Pilot Study

    Mathilde Bahuaud1, Constance BEAUDOUIN2, Anna Molto3, Odile Launay4, Frederic Batteux5 and Maxime Dougados6, 1Université Paris Descartes, Sorbonne Paris Cité AP-HP, Département d’Immunologie Biologique, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Paris, France, Paris, France, 2Cochin Hospital, APHP, Rheumatology B, Paris, France, 3Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, 4Université Paris Descartes, Sorbonne Paris Cité AP-HP, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Fédération d'Infectiologie, Paris, France; Inserm, F-CRIN I-REIVAC., Paris, France, 5Immunology, APHP Hopital Cochin, Paris, France, 6Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at an increased risk of some serious vaccine-preventable infections, like Pneumococcal infections. Since 2013, French vaccine recommendations committee…
  • Abstract Number: 2416 • 2017 ACR/ARHP Annual Meeting

    Histopathological Change Caused By Biological Treatment in Rheumatoid Arthritis Synovial Tissue

    Ayako Kubota, Toru Suguro, Masayuki Sekiguchi and Kazuaki Tsuchiya, Toho University Omori Medical Center, Tokyo, Japan

    Background/Purpose: Multiple studies addressing the effects of biologics on the synovial tissue in rheumatoid arthritis (RA) patients have been reported. There are, however, few studies…
  • Abstract Number: 2417 • 2017 ACR/ARHP Annual Meeting

    Occult Coronary Plaque Presence and Burden Predict Cardiovascular Events in Patients with Rheumatoid Arthritis

    George Karpouzas1, Joel Estis2, John Todd2 and Matthew Budoff3, 1Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Singulex, Alameda, California, Alameda, CA, 3Cardiology, Harbor-UCLA Medical Center, Torrance, CA

    Background/Purpose: Patients with Rheumatoid Arthritis (RA) experience higher cardiovascular (CV) morbidity compared to controls. Coronary computed tomography angiography (CCTA) accurately detects plaque presence, burden and…
  • Abstract Number: 2418 • 2017 ACR/ARHP Annual Meeting

    Tissue-Engineered Human Skeletal Muscle Model of Rheumatoid Arthritis

    Catherine E. Oliver1, Brittany N. Davis1, James Hong1, Kim M. Huffman2 and George A. Truskey3, 1Duke University, Durham, NC, 2School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC, 3BME, Duke University, Durham, NC

    Background/Purpose: In rheumatoid arthritis (RA) reduced muscle function clearly contributes to disability. Due to a lack of accurate in vitro RA models, the underlying mechanisms…
  • Abstract Number: 2419 • 2017 ACR/ARHP Annual Meeting

    Immunomodulatory Effects of Bone-Marrow Mesenchymal Stem Cells in Rheumatoid Arthitis: Influence of Disease Activity

    Benjamín Fernández-Gutiérrez1, Jose Ramon Lamas2, Yaiza Lopiz3, Cristina Lajas4, Lydia A Alcazar5 and Luis Rodriguez-Rodriguez6, 1Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 2Rheumatology, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, 3Cirugía Ortopédica y Traumatología, Hospital Clínico San Carlos, Madrid, Spain, 4Rheumatology Department, Hospital Clínical San Carlos, Madrid, Spain, 5Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, 6Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain

    Background/Purpose: To analyze the effect of demographic and clinical related characteristics of rheumatoid arthritis (RA) patients in the immunomodulatory effects of mesenchymal stem cells (MSCs).…
  • Abstract Number: 2420 • 2017 ACR/ARHP Annual Meeting

    Mass Cytometry Analysis of CD4+ T Cells in Patients with Rheumatoid Arthritis

    Laura Su1, Daniel del Alcazar2 and Adam Marc2, 1University of Pennsylvania, Philadelphia, PA, 2Medicine, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: CD4+ T cells play a key role in the initiation and progression of RA. Past studies have identified impaired function and regulation of several…
  • Abstract Number: 2421 • 2017 ACR/ARHP Annual Meeting

    Aberrant Expression of CaMK4 in CD4 Positive T Cells Predicts Poor Response to Treatment in Patients with Active Rheumatoid Arthritis

    Tomohiro Koga1, Tomohito Sato1, Masataka Umeda2, Shoichi Fukui2, Ayako Nishino1, Shinya Kawashiri2, Naoki Iwamoto2, Kunihiro Ichinose2, Mami Tamai1, Tomoki Origuchi3, Hideki Nakamura2 and Atsushi Kawakami4, 1Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, 4Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease arising from a breakdown of peripheral tolerance, which leads to aberrant Th1- or Th17-driven immune…
  • Abstract Number: 2422 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis (RA) Synovial Fluid Treg Cells Secrete IL-17 and at the Same Time Are Potent Suppressors of Tresp Cell Proliferation, TNF-α and Interferon γ Production

    Lorena Valdeolivas-De Opazo1, Paula Fortea-Gordo1, Marta Benito-Miguel1,2, Alejandro Villalba1, Gema Bonilla1, Diana Peiteado1, Alejandro Balsa1, Pilar Aguado1, Paloma Sanchez-Mateos3, Amaya Puig-Kröger4, Emilio Martín-Mola1 and Maria Eugenia Miranda-Carus1, 1Rheumatology, Hospital La Paz-IdiPAZ, Madrid, Spain, 2Biochemistry, Centro de Ciencias de la Salud San Rafael. Universidad Antonio de Nebrija, Madrid, Spain, 3Immunology, Hospital Gregorio Marañon, Madrid, Spain, 4Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain

    Background/Purpose: IL-17-expressing FoxP3 regulatory T cells have been described, and their suppressive capacity has been questioned. An inflammatory environment seems to favor IL-17 secretion by…
  • Abstract Number: 2423 • 2017 ACR/ARHP Annual Meeting

    Patients with Active Rheumatoid Arthritis but Normal Levels of Acute Phase Proteins Have Altered Regulatory T Cell Function and Rapidly Progress to Biological Therapies

    Claire Bradford1, Shashank Ramakrishnan1, Andrew Cole2, Coziana Ciurtin3, Elizabeth Jury1 and Jessica Manson4, 1Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, 2Centre for Rheumatolofy Research, University College London, London, United Kingdom, 3Rheumatology Department, University College London, London, United Kingdom, 4University College London Hospitals NHS Trust, London, United Kingdom

    Background/Purpose: An atypical subgroup of patients with seropositive rheumatoid arthritis (RA) was identified with active disease (confirmed by Power Doppler ultrasound (PDUS)) but normal levels…
  • Abstract Number: 2424 • 2017 ACR/ARHP Annual Meeting

    CD8-Positive Lymphocytes in Biopsy Specimens Predict Spontaneous Regression of Lymphoproliferative Disorders in Patients with Rheumatoid Arthritis Treated with Methotrexate

    Tomohiro Kameda1, Hiroaki Dobashi1, Masayuki Inoo2, Ikuko Onishi2, Noriyuki Kurata2, Mikiya Kato1, Atsushi Kondo1, Risa Wakiya1, Hiromi Shimada1, Shusaku Nakashima1, Miharu Izumikawa1 and Norimitsu Kadowaki1, 1Internal Medicine Division of Hematology, Rheumatology, and Respiratory Medicine, Kagawa University, Kagawa, Japan, 2Utazu hospital, Kagawa, Japan

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a high risk of developing lymphoproliferative disorders (LPDs). LPDs that develop in patients treated with methotrexate (MTX) are…
  • Abstract Number: 2425 • 2017 ACR/ARHP Annual Meeting

    Decline in CD8+IFNγ+ Subset but Rise in CD8+IL17+ on Methotrexate Treatment in Rheumatoid Arthritis

    Amit Sandhu1, Varun Dhir2, Shabeer Ahmad1, Prabhdeep Kaur1, Veena Dhawan3 and Archana Bhatnagar4, 1Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India, 3Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 4Biochemistry, Panjab University, Chandigarh, India

    Background/Purpose: CD8 T cells comprise 40 % of all T cells in the synovial compartment and are detectable in he preclinical stages as well. They…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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