Abstracts Archive - Page 1544 of 2425 - ACR Meeting Abstracts

Abstract Number: 1900 • 2016 ACR/ARHP Annual Meeting
Anti-Topoisomerase Positive Systemic Sclerosis – Prognosis Infaust?
Maaike Boonstra¹, Gaia A. Beerends², Hans U. Scherer², Tom W.J. Huizinga¹ and Jeska K. de Vries-Bouwstra¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-topoisomerase antibodies (ATA) in systemic sclerosis have been associated with poorer prognosis including diffuse skin involvement, pulmonary fibrosis, cardiac involvement and increased mortality. However,…
Abstract Number: 1901 • 2016 ACR/ARHP Annual Meeting
Screening for Pulmonary Arterial Hypertension in an Unselected Prospective Systemic Sclerosis Cohort
Els Vandecasteele¹, Benny Drieghe², Karin Melsens³, Kristof Thevissen², Michel De Pauw⁴, Ellen Deschepper⁵, Saskia Decuman⁵, Karolien Bonroy², Yves Piette⁶, Filip De Keyser⁵, Guy Brusselle² and Vanessa Smith², ¹Dep ofCcardiology, University Hospital Ghent, Ghent, Belgium, ²University Hospital Ghent, Ghent, Belgium, ³Department of Internal Medicine, Ghent University, Ghent, Belgium, ⁴Dep of cardiology, University Hospital Ghent, Ghent, Belgium, ⁵Ghent University, Ghent, Belgium, ⁶Dep of Rheumatology, University Hospital Ghent, Ghent, Belgium
Background/Purpose: Screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) improves outcome. The DETECT screening algorithm (DETECT-algorithm) is recommended in a high-risk SSc subgroup.…
Abstract Number: 1902 • 2016 ACR/ARHP Annual Meeting
Detecting the Pulmonary Vascular Involvement and the Changes in Gene Activation Profiles at Early Stage of Systemic Sclerosis in Patients with Raynaud Phenomenon
Yoshinobu Koyama¹, Soichiro Fuke², Yoshiharu Sato³ and Toshie Higuchi⁴, ¹Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, ²Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, ³DNA Chip Research Inc, Yokohama, Japan, ⁴Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan
Background/Purpose: Raynaud phenomenon (RP) is known to precede other disease manifestations of systemic sclerosis (SSc), and classically viewed as reversible vasospasm due to functional changes…
Abstract Number: 1903 • 2016 ACR/ARHP Annual Meeting
Determining Disease Course in Localized Scleroderma: A Prospective Cohort Study
Jack O'Brien¹ and Heidi Jacobe², ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA, Dallas, TX, ²Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Localized scleroderma (LS) is characterized by skin sclerosis, producing devastating impairment in those affected. It was previously thought to “burn out” within 5 years,…
Abstract Number: 1904 • 2016 ACR/ARHP Annual Meeting
Elevated GITRL Is Associated with Multi-Organ Involvement and Increased Disease Activity of Primarty Sjogren’s Syndrome and Promotes Pathogenic Th1/17 Differentiation
Xiaolin Sun¹, Yuzhou Gan Sr.², Jing He³ and Zhanguo Li⁴, ¹People's hospital,Peking University, Beijing, China, ²Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ³Peking Univerisity People's Hospital, Beijing, China, ⁴Peking University People's Hospital, Beijing, China
Background/Purpose: Accumulating data showed that Glucocorticoid-induced Tumor Necrosis Factor Receptor Family-related Protein (GITR), with its ligand (GITRL), plays an important role in promoting T-cell-mediated immunity…
Abstract Number: 1905 • 2016 ACR/ARHP Annual Meeting
Therapeutic Targeting of JAK/STAT Pathway Inhibits Follicular Helper T Cell Maturation and Function
Flora Sagez and Jacques-Eric Gottenberg, Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: T follicular helper (Tfh) cells represent a CD4+T cell subset specialized to provide help to B cells and to induce memory B cell and…
Abstract Number: 1906 • 2016 ACR/ARHP Annual Meeting
Impact of Environmental Factors and Inflammation on Alterations of the Total Peripheral T-Cell Compartment in Granulomatosis with Polyangiitis
Anja Kerstein¹, Silke Schueler¹, Otávio Cabral-Marques¹, Juliane Fazio², Robert Haesler³, Antje Mueller¹, Silke Pitann¹, Dietrich Kabelitz², Frank Moosig⁴, Sebastian Klapa⁵, Christian Haas⁶, Gabriela Riekemasten¹, Steffen Wolters¹ and Peter Lamprecht¹, ¹Department of Rheumatology, Vasculitis Center UKSH, University of Lübeck, Luebeck, Germany, ²Institute of Immunology, Christian-Albrechts-University of Kiel, Kiel, Germany, ³Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, ⁴Rheumatology Center Schleswig-Holstein Mitte, Neumuenster, Germany, ⁵Section Maritime Medicine, Institute of Experimental Medicine, Christian-Albrechs-University of Kiel c/o German Naval Medical Institute, Kronshagen, Germany, ⁶Division of Nephrology, Department of Internal Medicine 1, University of Lübeck, Luebeck, Germany
Background/Purpose: Autoimmune diseases are driven by a combination of predisposing genetic and environmental factors resulting in self-perpetuating chronic inflammation and tissue damage. In granulomatosis with…
Abstract Number: 1907 • 2016 ACR/ARHP Annual Meeting
T-Bet Regulates Ahr-Mediated Th-17 Differentiation Independently of IFNγ
Masahiro Yokosawa, Yuya Kondo, Shunta Kaneko, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Our previous reports showed that the development of collagen-induced arthritis was suppressed in T-bet transgenic (T-bet Tg) mice. The regulatory mechanism might relate to…
Abstract Number: 1908 • 2016 ACR/ARHP Annual Meeting
Identification of a Novel Pro-Inflammatory T Cell Epitope from His-tRNA-Synthetase Associated with Interstitial Lung Disease in Anti-Jo-1 Positive Patients
Angeles Shunashy Galindo-Feria¹, Inka Albrecht², Antonella Notarnicola², Maryam Dastmalchi², Anatoly Dubnovitsky³, Tatiana Sandalova³, Genadiy Kozhukh³, Lars Rönnblom⁴, Adnane Achour⁵, Vivianne Malmström⁶ and Ingrid E. Lundberg², ¹Department of Medicine., Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine Solna and Department of Infectious Diseases,, Science for Life Laboratory, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden, ⁴Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ⁵Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁶Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Previous studies have demonstrated that CD4+ T cells from peripheral blood of anti-histidyl-tRNA synthetase (anti-His-tRNA) also known as anti-Jo-1 positive patients proliferate in response…
Abstract Number: 1909 • 2016 ACR/ARHP Annual Meeting
The Transcription Factor Fra2 Is Playing a Key Role in Treg Development and Autoimmunity
Florian Renoux¹, Mara Stellato², Daniela Impellizzieri³, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jeorg HW Distler⁶, Gabriela Kania², Onur Boyman³ and Oliver Distler², ¹Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Decreased numbers or altered functions of regulatory T cells (Tregs) have been reported in many inflammatory rheumatic diseases, and Tregs are considered promising…
Abstract Number: 1910 • 2016 ACR/ARHP Annual Meeting
IL-21 Inhibits Treg Differentiation and Function in SLE By Modulating GATA-3 and CTLA-4
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Studies indicate quantitative and qualitative Treg insufficiencies underlying the dysregulated immune response in SLE. However, it is unknown what mechanisms drive the Treg dysfunction…
Abstract Number: 1911 • 2016 ACR/ARHP Annual Meeting
Potent and Selective Tyk2 Inhibitor Highly Efficacious in Rodent Models of Inflammatory Bowel Disease and Psoriasis
Wenyan Miao¹, Craig Masse¹, Jeremy Greenwood², Rosana Kapeller¹ and William Westlin¹, ¹Nimbus Therapeutics, Cambridge, MA, ²Schrodinger Inc., New York, NY
Background/Purpose: Tyk2 is a member of the JAK family kinases and is a key mediator of IL-12, IL-23, and type I interferon signaling. These cytokines…
Abstract Number: 1912 • 2016 ACR/ARHP Annual Meeting
A New Avenue of Immune Regulation Conferred By Self-Glycerophospholipids Via Mobilization and Migration of Myeloid-Derived Suppressor Cells
Ramesh Halder¹ and Ram R. Singh^1,2,3, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ³Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA
Background/Purpose: Lipids function as essential components of biological membranes, as signaling molecules, and as energy storage molecules. Glycerol-based phospholipids, called glycerophospholipids (GPL), are the most…
Abstract Number: 1913 • 2016 ACR/ARHP Annual Meeting
B Cell Depletion Therapy Impact CD8 T Cells in ANCA-Associated Vasculitis
Antoine Néel^1,2, Marie Bucchia³, Aurelie Caristan¹, Mélanie Néel², Marie Rimbert⁴, Christian Agard¹, Maryvonne Hourmant⁵, Gaelle Tilly², Michelle Yap², François Perrin¹, Pascal Godmer⁶, Julie Graveleau¹, Sophie Brouard², Celine Bressollette⁷, Fadi Fakhouri⁸, Mohamed Hamidou⁹ and Nicolas Degauque², ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²INSERM U1064, Nantes, France, ³Pediatrics, Nantes University Hospital, Nantes, France, ⁴Immunology Laboratory, Nantes University Hospital, Nantes, France, ⁵Nephrology, Nantes University Hospital, Nantes, France, ⁶CH Vannes, Vannes, France, ⁷Virology Laboratory, Nantes University Hospital, Nantes, France, ⁸Nephrology Department, Nantes University Hospital, Nantes, France, ⁹Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France
Background/Purpose: In anti-neutrophil cytoplasmic antibodies associated vasculitis (AAV), several clues suggest that the efficacy of B cell depletion therapy lies beyond the suppression of ANCA-producing…
Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting
Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis
Adrienn Markovics¹, Timea Ocsko¹, Robert S. Katz², Edit I Buzas³, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Semmelweis University, Budapest, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…

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