Abstracts Archive - Page 1540 of 2425 - ACR Meeting Abstracts

Abstract Number: 1839 • 2016 ACR/ARHP Annual Meeting
Elevated Plasma Cell-Free Mitochondrial DNA Defines a Subgroup of Lupus Patients with Membranous Lupus Nephritis
David Fernandez¹, Maria A. Pabon², Mikhail Olferiev¹, Ana C. Hernandez², Faryal Malick², Leila Khalili¹, Augustine M. K. Choi², Kiichi Nakahira² and Mary K. Crow¹, ¹Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations, characterized by production of antibodies against nucleic acids and upregulation of type I…
Abstract Number: 1840 • 2016 ACR/ARHP Annual Meeting
A Dichotomy of Regulatory Immunome Is Related to Disease Activity in Juvenile Systemic Lupus Erythematosus
Joo Guan Yeo^1,2, Thaschawee Arkachaisri^1,3, Justin Hung Tiong Tan¹, Jing Yao Leong⁴, Lena Das¹, Loshinidevi D/O Thana Bathi², Phyllis Chen² and Salvatore Albani^3,4, ¹Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, ²Singhealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ³Duke-National University of Singapore Medical School, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore
Background/Purpose: The pathogenesis of SLE involves disturbances to the homeostatic balance between the immune effector and regulatory system. The conventional mono-dimensional mechanistic interrogation of one…
Abstract Number: 1841 • 2016 ACR/ARHP Annual Meeting
Dysregulation of the Splicing Machinery Components in Leukocytes from Patients with Systemic Lupus Erythematosus: Influence on Autoimmune and Atherothrombotic Mechanisms
Chary Lopez-Pedrera¹, Sergio Pedraza-Arévalo², Mercedes del Río-Moreno², Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon³, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Ivan Arias de la Rosa³, Eduardo Collantes-Estévez¹, Pedro Segui¹, Maria Jose Cuadrado⁴, Justo P Castaño², Raul M Luque² and Carlos Perez-Sanchez¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Department of Cell Biology, Physiology and Immunology. University of Cordoba, Hospital Universitario Reina Sofia (HURS), Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), CIBERobn, and ceiA3, Córdoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: The aim of this study was to evaluate whether alterations in the splicing-machinery could influence the development and activity of the disease and the…
Abstract Number: 1842 • 2016 ACR/ARHP Annual Meeting
Pentraxin 3 Level Positively Correlated with Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus Patients
Yifang Mei, Xiaoping Sun, Yuxia Shao, Huanhuan Zhan and Zhiyi Zhang, Department of Rheumatology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
Background/Purpose: Systemic lupus erythematosus (SLE) is a kind of chronic and autoimmune disease with variable multi-system involvement of unknown causes, which is characterized by periods…
Abstract Number: 1843 • 2016 ACR/ARHP Annual Meeting
Single Cell Expression Quantitative Trait Loci (eQTL) Analysis of Established SLE-Risk Loci in Lupus Patient Monocytes
Yogita Ghodke-Puranik¹, Zhongbo Jin¹, Wei Fan², Mark A. Jensen³, Jessica M. Dorschner¹, Danielle Vsetecka¹, Shreyasee Amin⁴, Ashima Makol⁴, Floranne C. Ernste⁵, Thomas Osborn⁴, Kevin Moder⁴, Vaidehi Chowdhary⁴ and Timothy B. Niewold⁶, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China, ³Department of Immunology and Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁶Rheumatology and Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: While most of the confirmed SLE-risk loci are in or near genes with immune system function, a major unanswered question is how these loci…
Abstract Number: 1844 • 2016 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Ameliorate the Deficiencies in Immunomodulatory and Phagocytic Capacities of Lupus Macrophages
Wei Deng¹, Weiwei Chen¹, Zhuoya Zhang², Saisai Huang¹, Wei Kong¹, Xuebing Feng¹ and Lingyun Sun¹, ¹Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Evidence has accumulated that umbilical cord (UC)-derived mesenchymal stem cells (MSCs) show therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…
Abstract Number: 1845 • 2016 ACR/ARHP Annual Meeting
TGF-β-Induced Tissue Fibrosis Is Abrogated in Mice Containing a Constitutive Genetic Deletion of Nox4 (Nox4 knockout)
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Excessive deposition of collagen and other connective tissue components in the skin and multiple internal organs is characteristic of Systemic Sclerosis (SSc). Besides the…
Abstract Number: 1846 • 2016 ACR/ARHP Annual Meeting
Cutaneous and Visceral Fibrosis Induced By Endothelial Cell-Specific Constitutive Activation of TGF-β1 Signaling in Mice
Peter J. Wermuth, Kellan R. Carney, Fabian A. Mendoza, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Microvascular damage is an early event in Systemic Sclerosis (SSc) pathogenesis and may represent the initiating stimulus for the subsequent establishment and progression of…
Abstract Number: 1848 • 2016 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulates Collagen Type III Synthesis Via β-Catenin Activation in Vitro and in Vivo
Jin Zhang¹, Gibran Shaikh², Carmen Corciulo³, Tuere Wilder³, Miguel Perez-Aso¹, Aranzazu Mediero¹ and Bruce Cronstein¹, ¹Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, NYU School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Fibrosis of skin and other organs is a hallmark of Scleroderma. We and others have previously reported that A2AR plays a role in skin…
Abstract Number: 1849 • 2016 ACR/ARHP Annual Meeting
Fibroblast Growth Factor 9/ Fibroblast Growth Factor Receptor 3 Signaling Is Upstream of Several Profibrotic Pathways and Induces Fibroblast Activation and Tissue Fibrosis in SSc
Tatjana Mallano¹, Alfiya Distler¹, Clara Dees¹, Jingang Huang², Debomita Chakraborty³, Oliver Distler^4,5, Georg Schett⁶ and Joerg H.W Distler⁷, ¹Department of Internal Medicine III, Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ³Department of Internal Medicine III, Institute of Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁴Center of Exper Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ⁶Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
FGF9 / FGFR3 signaling is upstream of several profibrotic pathways and induces fibroblast activation and tissue fibrosis in SSc Background/Purpose: Systemic sclerosis (SSc)…
Abstract Number: 1850 • 2016 ACR/ARHP Annual Meeting
Optimization of a Murine Model to Recapitulate Dermal and Pulmonary Features of SSc
Tomoya Watanabe¹, Tetsuya Nishimoto², Jonathan Heywood³, Stanley Hoffman⁴, Logan Mlakar⁴ and Carol A. Feghali-Bostwick⁵, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Rheumataology, Medical University of South Carolina, Chareston, SC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. Traditionally, daily subcutaneous injections of BLM for 4-6…
Abstract Number: 1851 • 2016 ACR/ARHP Annual Meeting
The Effect of Narrow Band Ultraviolet A1 Light on Bleomycin-Induced Mouse Model of Scleroderma
Diana Karpec^1,2, Romualdas Rudys², Laima Leonaviciene², Zygmunt Mackiewicz², Ruta Bradunaite², Gailute Kirdaite², Rita Rugiene² and Algirdas Venalis^2,3, ¹Clinics of Rheumatology, Traumatology-Orthopedics and Reconstructive Surgery, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania, ²State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania, ³Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania
Background/Purpose: Ultraviolet A1 (UVA1) phototherapy implications for systemic sclerosis still remain the area of research. The aim of the study was to evaluate narrow band…
Abstract Number: 1852 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Sirtuin 7 By Lung Fibroblasts from Patients with Scleroderma Contributes to Elevated Collagen Production
Anne E. Wyman^1,2, Zahid Noor¹, Nevins W. Todd^1,2, Irina G. Luzina^1,2 and Sergei P. Atamas^1,2, ¹University of Maryland School of Medicine, Baltimore, MD, ²Baltimore VA Medical Center, Baltimore, MD
Background/Purpose: Pulmonary fibrosis is a severe complication of systemic sclerosis (SSc). Changes in the expression levels of sirtuins (SIRTs), a family of NAD+-dependent histone deacetylases,…
Abstract Number: 1853 • 2016 ACR/ARHP Annual Meeting
Klf5+/-;Fli1+/- Mice Recapitulate Protracted Wound Healing and Cardiac and Intestinal Involvement Associated with Systemic Sclerosis
Kouki Nakamura¹, Yoshihide Asano², Takuya Miyagawa³, Megumi Hirabayashi³, Takashi Yamashita³, Ryosuke Saigusa¹, Shunsuke Miura², Tetsuo Toyama^3,4, Takehiro Takahashi¹, Yohei Ichimura¹, Takashi Taniguchi¹, Ayumi Yoshizaki³, Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis. Although the most recognizable manifestation is skin disease, SSc can…
Abstract Number: 1854 • 2016 ACR/ARHP Annual Meeting
Increased Percentage of CD204/CD206 Double Positive Monocytes Correlates with Specific Lung and Skin Involvement Parameters and an “Active” Capillaroscopic Pattern of Microangiopathy in Systemic Sclerosis Patients
Stefano Soldano¹, Paola Contini², Amelia Chiara Trombetta³, Barbara Ruaro⁴, Sabrina Paolino⁴, Carmen Pizzorni⁴, Renata Brizzolara⁴, Paola Montagna⁴, Alberto Sulli⁴ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genoa, Italy, ²Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ³Department of Internal Medicine, University of Genova,, Research Laboratory and Academic Division of Clinical Rheumatology, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy
Background/Purpose: Immune cell activation plays a crucial role in the pathogenesis of systemic sclerosis (SSc), and macrophages may be important mediators in this complex pathway…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].