Abstracts Archive - Page 1521 of 2425 - ACR Meeting Abstracts

Abstract Number: 1553 • 2016 ACR/ARHP Annual Meeting
Declining Flare Rates in the First Five Years of RA Disease, but Not after
Shafay Raheel¹, Cynthia S. Crowson², Eric L. Matteson¹ and Elena Myasoedova¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Flare or episodic worsening of disease activity is an important aspect of the disease experience for patients with rheumatoid arthritis (RA). Improving trends towards…
Abstract Number: 1554 • 2016 ACR/ARHP Annual Meeting
Longitudinal Trajectories of the Weighted Lansbury Articular Indices and Standard Joint Counts Are Similarly Correlated with Trajectories of Physical Function in Early Inflammatory Arthritis
Siok Hoon Lily Lim¹, Susan J. Bartlett², Gilles Boire³, Boulos Haraoui⁴, Edward Keystone⁵, J Carter Thorne⁶, Janet E. Pope⁷, Diane Tin⁸, Vivian P. Bykerk⁹, Carol Hitchon¹⁰ and Canadian Early Arthritis Cohort (CATCH), ¹Pediatrics, University of MAnitoba, Winnipeg, MB, Canada, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁴Institute de Rheumatologie, Montreal, QC, Canada, ⁵Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷University of Western Ontario, St Joseph's Health Care, London, ON, Canada, ⁸The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁰University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Residual disease activity impacts functional status and quality of life (QoL) in patients with early rheumatoid arthritis (ERA). Large weight bearing joints are more…
Abstract Number: 1555 • 2016 ACR/ARHP Annual Meeting
E-Comorbidity: Evaluation of the Validity of Electronic Comorbidity Assessment in Identifying Comorbid Conditions Among Patients with Rheumatoid and Psoriatic Arthritis
Yasser M. El Miedany¹, Maha El Gaafary^2,3, Sally Youssef⁴, Sami Bahlas⁵, Mohammed Hegazi⁶ and Ihab Ahmed⁷, ¹Rheumatology, Darent Valley Hospital, Dartford, United Kingdom, ²Community, Environmental and Occupational Medicine, Ain Shams University, Abbassia, Egypt, ³Community, Environmental and Occupational Medicine, Ain Shams University, Cairo, Egypt, ⁴Rheumatology and Rehabilitation Departmennt, Ain Shams University, Cairo, Egypt, ⁵Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, ⁶Medicine, Al Adan Hospital, Kuwait, Kuwait, ⁷Medicine, Cairo University, Cairo, Egypt
Background/Purpose: 1. to assess the validity of an electronically comorbidity assessment strategy to identify comorbid conditions among RA and PsA patients in standard practice. 2.…
Abstract Number: 1556 • 2016 ACR/ARHP Annual Meeting
Assessment of the Burden of Comorbidities By the Rheumatic Disease Comorbidity Index in Early Rheumatoid Arthritis Patients at Disease Onset
Veerle Stouten¹, Diederik De Cock¹, Rene Westhovens^1,2, Johan Joly², Kristien Van der Elst^2,3 and Patrick Verschueren^1,2, ¹KU Leuven Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, Leuven, Belgium, ²Rheumatology, University Hospitals Leuven, Leuven, Belgium, ³KU Leuven, Department of Public Health and Primary Care, Skeletal Biology and Engineering Research Center, Leuven, Belgium
Background/Purpose: Rheumatoid Arthritis (RA) is associated with a high prevalence of comorbidities, negatively affecting outcomes like disease activity and physical function. However, not all comorbid…
Abstract Number: 1557 • 2016 ACR/ARHP Annual Meeting
3-D Explant Method Facilitates the Study of Lymphocytes in Synovium and Reveals a Population of Resident Memory-like T Cells in Rheumatoid Arthritis
Lauren Henderson¹, Deepak Rao², Nikola Teslovich^3,4, Sandra King⁵, Fumitaka Mizoguchi⁶, Sarah Ameri⁶, Allyn Morris⁷, Christopher Elco⁸, James Lederer⁹, Scott Martin¹⁰, Barry Simmons¹⁰, John Wright¹⁰, Michael Brenner², Soumya Raychaudhuri^{11,12,13,14,15}, Peter Nigrovic^1,16 and Robert Fuhlbrigge^17,18, ¹Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, ⁵Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁸Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁹Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁰Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ¹¹Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹²Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ¹³Partners Center for Personalized Genetic Medicine, Boston, MA, ¹⁴Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, ¹⁵Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ¹⁶Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ¹⁷Immunology, Boston Children's Hospital, Boston, MA, ¹⁸Dermatology, Brigham and Women’s Hospital, Boston, MA
Background/Purpose: Tissue resident memory T (TRM) cells survive indefinitely in barrier tissues and mediate swift immunologic memory responses at sites of microbe entry. TRM cells…
Abstract Number: 1558 • 2016 ACR/ARHP Annual Meeting
Lower Expression of a Novel Cytoplasmic Long Noncoding RNA NR_122076 Contributes to Proliferation, Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis
Yaoyao Zou, Siqi Xu, Qian Qiu, Shan Zeng, Maohua Shi, Youjun Xiao, Mingcheng Huang and Hanshi Xu, Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Guangzhou, China
Background/Purpose: Emerging evidence indicates that long noncoding RNAs (lncRNAs) play critical regulatory roles in various human diseases, especially in cancers and inflammatory disorders. However, the…
Abstract Number: 1559 • 2016 ACR/ARHP Annual Meeting
Shared Genetic Predisposition in Rheumatoid Arthritis–Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: A Genetic Association Study
Pierre-Antoine Juge¹, Raphaël Borie², Caroline Kannengiesser³, Steven Gazal³, Patrick Revy⁴, Lidwine Wemeau-Stervinou⁵, Marie-Pierre Debray⁶, Sébastien Ottaviani⁷, Sylvain Adam-Marchand⁸, Nadia Nathan⁹, Gabriel Thabut¹⁰, Christophe Richez¹¹, Hilario Nunes¹², Isabelle Callebaut¹³, Aurélien Justet², Nicolas Leulliot¹⁴, Amélie Bonnefond¹⁵, David Salgado¹⁶, Pascal Richette¹⁷, Jean-Pierre Desvignes¹⁶, Huguette Lioté¹⁸, Philippe Froguel¹⁵, Yannick Allanore¹⁹, Olivier Sand¹⁵, Claire Dromer²⁰, René-Marc Flipo²¹, Annick Clément⁹, Christophe Béroud²², Jean Sibilia²³, Baptiste Coustet^1,24, Vincent Cottin²⁵, Marie-Christophe Boissier²⁶, Benoit Wallaert²⁷, Thierry Schaeverbeke²⁸, Florence Dasto le Moal²⁹, Aline Frazier¹⁷, Christelle Ménard³⁰, Martin Soubrier³¹, Nathalie Saidenberg²⁹, Dominique Valeyre³², Serge Amselem⁹, Catherine Boileau³, Bruno Crestani² and Philippe Dieudé¹, ¹Rhumatologie, Hôpital Bichat - Claude Bernard, Paris, France, ²Pneumologie A, Hôpital Bichat - Claude Bernard, Paris, France, ³Génétique, Hôpital Bichat - Claude Bernard, Paris, France, ⁴Laboratory of Genome Dynamics in the Immune System, Institut Imagine, Paris, France, ⁵Pneumologie, CHRU de Lille, Lille, France, ⁶Université Paris-Diderot, Paris, France, ⁷Rheumatologie, Hôpital Bichat - Claude Bernard, Paris, France, ⁸Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, ⁹Pneumologie pédiatrique, Hôpital Trousseau, Paris, France, ¹⁰Pneumologie B, Hôpital Bichat - Claude Bernard, Paris, France, ¹¹Rhumatologie, Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, ¹²Pneumologie B, Hôpital Avicenne, Paris, France, ¹³CNRS UMR_7590, Paris, France, ¹⁴Laboratoire de cristallographie et RMN biologiques, UMR CNRS 8015, Paris, France, ¹⁵CNRS UMR_8199, Lille, France, ¹⁶UMR_S 910, Marseille, France, ¹⁷Rhumatologie, Hôpital Lariboisière, Paris, France, ¹⁸Pneumologie A, Hôpital Tenon, Paris, France, ¹⁹Rhumatologie A, Hôpital Cochin, Paris, France, ²⁰Imagerie Thoracique et Cardiovasculaire, CHU Bordeaux, Bordeaux, France, ²¹Rhumatologie, CHU Lille, Lille, France, ²²INSERM UMR_S 910, Marseille, France, ²³Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²⁴Rheumatology, Université Paris Descartes, Hopital Cochin, Paris, France, ²⁵Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, ²⁶Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²⁷Pneumology, CHRU, Lille CEDEX, France, ²⁸Rheumatology, CHU Bordeaux, Bordeaux, France, ²⁹Rhumatologie, Hôpital Avicenne, Paris, France, ³⁰Pneumologie Pédiatrique, Hôpital Trousseau, Paris, France, ³¹Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ³²Department of Pneumology, Avicenne Hospital (AP-HP), Bobigny, France
Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality for rheumatoid arthritis (RA) patients. Despite its high prevalence and mortality, little…
Abstract Number: 1560 • 2016 ACR/ARHP Annual Meeting
A Unique Immune Signature in Patients with Active Rheumatoid Arthritis but Normal C-Reactive Protein Levels: Potential for New Therapeutic Targets?
Claire Bradford¹, Rosa González-Serrano¹, Andrew Cole¹, Shashank Ramakrishnan¹, Giampiero Marra¹, Coziana Ciurtin², Elizabeth Jury¹ and Jessica Manson³, ¹Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, ²Rheumatology Department, University College London, London, United Kingdom, ³Rheumatology Department, University College London Hospital, London, United Kingdom
Background/Purpose: Using musculoskeletal ultrasound (US) to assess joint erosions and disease activity in patients with seropositive rheumatoid arthritis (RA) an atypical subgroup was identified with…
Abstract Number: 1561 • 2016 ACR/ARHP Annual Meeting
Associations of HLA-DRB1 Haplotypes with Disease Characteristics and All-Cause Mortality in Rheumatoid Arthritis
Lilli Mauer¹, Ted R Mikuls², Bryant R. England¹, Grant W. Cannon³, Gail S. Kerr⁴, Geoffrey M. Thiele⁵, Liron Caplan⁶, Michael J. Duryee⁷ and Andreas M. Reimold⁸, ¹Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Salt Lake City VA Medical Center and University of Utah Division of Rheumatology, Salt Lake City, UT, ⁴Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ⁷Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁸Rheumatology, VAMC and University of Texas Southwestern, Dallas, TX
Background/Purpose : Numerous genetic susceptibility loci have been identified in RA. The HLA-DRB1 shared epitope (SE) sequence is most strongly associated, though there has been…
Abstract Number: 1562 • 2016 ACR/ARHP Annual Meeting
Interaction Between Antibodies to Paraoxonase 1 and PON1 rs662 Polymorphism: New Clues to Understand HDL Dysfunction and Oxidative Stress in Rheumatoid Arthritis
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Raquel López-Mejías³, Patricia López¹, Francisco Javier Ballina-García², Francisco Abal⁴, Miguel Angel Gonzalez-Gay^3,5 and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁴Centro de Salud Sariego, Siero, Servicio de Salud del Principado de Asturias (SESPA), Siero, Spain, ⁵School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: Traditional and non-traditional cardiovascular (CV) risk factors underlie CV disease occurrence in rheumatoid arthritis (RA). Recently, a functional impairment of HDL antioxidant capacity has…
Abstract Number: 1563 • 2016 ACR/ARHP Annual Meeting
Enhanced Expression of mRNA for Response Gene to Complement 32 in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis
Yu Matsueda¹, Tatsuo Nagai², Tetsuya Tomita³, Hideki Yoshikawa³, Sumiaki Tanaka¹ and Shunsei Hirohata¹, ¹Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ²Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ³Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by hyperplasia of synovial lining cells, consisting of macrophage-like type A synoviocytes and fibroblast-like type…
Abstract Number: 1564 • 2016 ACR/ARHP Annual Meeting
The Comprehensive Analysis for the Transcriptional Organization of Stimuli Responses in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients
Haruka Tsuchiya¹, Shuji Sumitomo¹, Kazuyoshi Ishigaki², Akari Suzuki², Yuta Kochi², Mineto Ota¹, Yumi Tsuchida¹, Hiroshi Inui³, Shuji Taketomi³, Yuho Kadono⁴, Sakae Tanaka³, Keishi Fujio¹ and Kazuhiko Yamamoto^1,2, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ³Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ⁴Department of Orthopaedic Surgery, Graduate School of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Fibroblast-like synoviocyte (FLS) is expected to be a novel therapeutic target for rheumatoid arthritis (RA) because of their contribution to pathogenesis. FLS expresses…
Abstract Number: 1565 • 2016 ACR/ARHP Annual Meeting
Gene Modules Correlated with Disease Activity and Abatacept Treatment Identified with Weighted Gene Co-Expression Network Analysis of CD4+ T Cell Subsets of RA
Shuji Sumitomo¹, Yasuo Nagafuchi¹, Yumi Tsuchida¹, Haruka Tsuchiya¹, Mineto Ota¹, Kazuyoshi ishigaki², Shinichiro Nakachi¹, Rika Kato¹, Keiichi Sakurai¹, Norio Hanata¹, Shoko Tateishi³, Hiroko Kanda³, Akari Suzuki⁴, Yuta Kochi⁴, Keishi Fujio¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, The Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan, ³Department of Immunotherapy Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ⁴Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
Background/Purpose: Although there are several reports of transcriptome analysis of peripheral blood mononuclear cells (PBMC) in RA, analysis of detailed CD4+ subset and the effect…
Abstract Number: 1566 • 2016 ACR/ARHP Annual Meeting
Histone Lysine Methylation and STAT3 Differentially Regulate Constitutive and IL-6-Induced MMPs Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts
Yasuto Araki^1,2, Takuma Tsuzuki Wada^2,3, Yoshimi Aizaki^1,2, Kazuhiro Yokota¹, Hiroshi Kajiyama¹, Yu Funakubo Asanuma¹, Kojiro Sato¹, Hiromi Oda⁴ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan, ³Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma, Japan, ⁴Orthopedic Surgery, Faculty of Medicine, Saitama Medical Univeristy, Morohongo Moroyama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes progressive joint destruction. In spite of the modern medications, including biologic reagents, it…
Abstract Number: 1567 • 2016 ACR/ARHP Annual Meeting
A Functional Genomic Screen of Rheumatoid Arthritis Risk Genes in Primary Human T Cells Reveals DDX6 As a Negative Modulator of Cytokine Expression
Rumey Ishizawar¹, Chantel Lester², Jing Cui³, John Doench⁴, Robert Plenge⁵ and Michael Brenner⁶, ¹Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Broad Institute of MIT and Harvard, Cambridge, MA, ⁵Genetics & Pharmacogenomics, Merck Research Laboratories, Merck & Co., Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In rheumatoid arthritis (RA), genome-wide association studies have identified over 100 risk alleles. A major challenge is identifying causal genes in RA risk loci. As…

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